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List of works by Jean-Charles Fruchart

Accumulation of triglyceride-rich lipoprotein in subjects with abdominal obesity: the biguanides and the prevention of the risk of obesity (BIGPRO) 1 study

scientific article

Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages

scientific article (publication date: 2 October 1998)

Adipophilin enhances lipid accumulation and prevents lipid efflux from THP-1 macrophages: potential role in atherogenesis

scientific article (publication date: March 2004)

Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of beta-oxidation

scientific article

An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing

scientific article

Analysis of apolipoprotein A5, c3, and plasma triglyceride concentrations in genetically engineered mice

scientific article

Apoa5 Q139X truncation predisposes to late-onset hyperchylomicronemia due to lipoprotein lipase impairment

scientific article

Apolipoprotein A-II, HDL metabolism and atherosclerosis

scientific article

Apolipoprotein A-V modulates insulin secretion in pancreatic beta-cells through its interaction with midkine

scientific article

Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators

scientific article (publication date: 16 May 2003)

Apolipoprotein AII enrichment of HDL enhances their affinity for class B type I scavenger receptor but inhibits specific cholesteryl ester uptake

scientific article

Atherogenic lipoprotein particles in atherosclerosis

scientific article

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

scientific article

Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor

scientific article (publication date: February 2003)

Binding of apolipoproteins A to adipose cells: role of receptor sites in cholesterol efflux and purification of binding protein(s).

scientific article

Changes in fatty acid composition of cardiac mitochondrial phospholipids in rats fed rapeseed oil

scientific article published on April 1, 1978

Cloning and sequencing of cDNAs encoding the human hepatocyte nuclear factor 4 indicate the presence of two isoforms in human liver

scientific article (publication date: 30 September 1994)

Drug Insight: mechanisms of action and therapeutic applications for agonists of peroxisome proliferator-activated receptors

scientific article published on February 2007

Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial

scientific article

FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity

scientific article (publication date: June 2003)

Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression

scientific article (publication date: August 2003)

Functional characterization of human recombinant apolipoprotein AIV produced in Escherichia coli

scientific article

Genetically-engineered animals as research models for atherosclerosis: their use for the characterization of PPAR agonists in the treatment of cardiometabolic disorders

scientific article published on May 2007

Genomic and non-genomic interactions of PPARalpha with xenobiotic-metabolizing enzymes

scientific article published in September 2004

Glucose regulates LXRalpha subcellular localization and function in rat pancreatic beta-cells

scientific journal article

Glucose regulates the expression of the apolipoprotein A5 gene

scientific article

Glucose regulates the expression of the farnesoid X receptor in liver

scientific journal article

HDL and triglyceride as therapeutic targets

scientific article

HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events

scientific article

Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; Internat

scientific article

Identification of Rev-erbalpha as a physiological repressor of apoC-III gene transcription

scientific article

Induction of the fatty acid transport protein 1 and acyl-CoA synthase genes by dimer-selective rexinoids suggests that the peroxisome proliferator-activated receptor-retinoid X receptor heterodimer is their molecular target

scientific article

Insulin-mediated down-regulation of apolipoprotein A5 gene expression through the phosphatidylinositol 3-kinase pathway: role of upstream stimulatory factor

scientific article

Is apolipoprotein A5 a novel regulator of triglyceride-rich lipoproteins?

scientific article

Lipid free apolipoprotein E binds to the class B Type I scavenger receptor I (SR-BI) and enhances cholesteryl ester uptake from lipoproteins

scientific article (publication date: 27 September 2002)

Lipoprotein (a) as a predictor of coronary heart disease: the PRIME Study

scientific article

Liver X Receptor Activation Potentiates the Lipopolysaccharide Response in Human Macrophages

article

Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages

scientific article

Liver X receptor activation induces the uptake of cholesteryl esters from high density lipoproteins in primary human macrophages

scientific article

Liver X receptors and the control of cholesterol homeostasis: potential therapeutic targets for the treatment of atherosclerosis

scientific article

Liver X receptors: new players in atherogenesis?

scientific article

Measurement of arterial wall thickness as a surrogate marker for atherosclerosis

scientific article published on June 2004

Mechanism of action of fibrates on lipid and lipoprotein metabolism

scientific article

Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5

scientific article

Mode of action of fibrates in the regulation of triglyceride and HDL-cholesterol metabolism

scientific article

Modulation of hepatic inflammatory risk markers of cardiovascular diseases by PPAR-alpha activators: clinical and experimental evidence

scientific article

Murine models to investigate pharmacological compounds acting as ligands of PPARs in dyslipidemia and atherosclerosis

scientific article published on October 2003

New risk factors for atherosclerosis and patient risk assessment

scientific article published on June 2004

Niemann-Pick C1 like 1 gene expression is down-regulated by LXR activators in the intestine

scientific article published on 5 January 2006

Novel peroxisome proliferator activated receptor-alpha agonists

scientific article published on December 2007

PPARS, metabolic disease and atherosclerosis

scientific article

PPARalpha and PPARgamma dual agonists for the treatment of type 2 diabetes and the metabolic syndrome

scientific article

Peroxisome proliferator-activated receptor alpha induces NADPH oxidase activity in macrophages, leading to the generation of LDL with PPAR-alpha activation properties

scientific article published on 11 November 2004

Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme

scientific article (publication date: 29 August 2003)

Peroxisome proliferator-activated receptor-alpha (PPARalpha): at the crossroads of obesity, diabetes and cardiovascular disease

scientific article published on 20 March 2009

Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells

scientific article published on May 2004

Peroxisome proliferator-activated receptors: new targets for the pharmacological modulation of macrophage gene expression and function ⬇️

scientific article published on October 1, 2003

Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation

scientific article

Plasma cystatin-C and development of coronary heart disease: The PRIME Study

scientific article

Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis

scientific article

Potential regulatory role of the farnesoid X receptor in the metabolic syndrome

scientific article

Prevention of coronary heart disease in post-menopausal women.

scientific article

Protection against atherogenesis in mice mediated by human apolipoprotein A-IV

scientific article

Raising high-density lipoprotein cholesterol with reduction of cardiovascular risk: the role of nicotinic acid--a position paper developed by the European Consensus Panel on HDL-C.

scientific article

Reducing vascular events risk in patients with dyslipidaemia: an update for clinicians ⬇️

scientific article published on September 1, 2011

Regulation of lipid and lipoprotein metabolism by PPAR activators

scientific article

Residual macrovascular risk in 2013: what have we learned?

scientific article

Retinoic acid receptor-related orphan receptor alpha as a therapeutic target in the treatment of dyslipidemia and atherosclerosis

scientific article

Role of the PPAR family of nuclear receptors in the regulation of metabolic and cardiovascular homeostasis: new approaches to therapy

scientific article

Safety issues and prospects for future generations of PPAR modulators

scientific article

Selective PPAR modulators, dual and pan PPAR agonists: multimodal drugs for the treatment of type 2 diabetes and atherosclerosis

scientific article published on September 2006

Selective peroxisome proliferator-activated receptorα modulators (SPPARMα): The next generation of peroxisome proliferator-activated receptor α-agonists ⬇️

scientific article published on May 31, 2013

Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis

scientific article

Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I

scientific article

The RXR Agonist Bexarotene Improves Cholesterol Homeostasis and Inhibits Atherosclerosis Progression in a Mouse Model of Mixed Dyslipidemia

article

The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patient

scientific article

The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in patients with dyslipidemia

scientific article

The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice

scientific journal article

The liver X receptor ligand T0901317 down-regulates APOA5 gene expression through activation of SREBP-1c

scientific article published on 17 August 2004

The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages

scientific article

The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates

scientific article

The organization, promoter analysis, and expression of the human PPARgamma gene

scientific article (publication date: 25 July 1997)

The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response

scientific article

The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation

scientific article

The role of PPARs in atherosclerosis

scientific article

The science behind statins and fibrates.

scientific article

Therapeutic roles of peroxisome proliferator-activated receptor agonists

scientific article

Transcriptional regulation of apolipoprotein A5 gene expression by the nuclear receptor RORalpha

scientific article

Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha

scientific article

Transcriptional regulation of human Rev-erbalpha gene expression by the orphan nuclear receptor retinoic acid-related orphan receptor alpha

scientific article

Transcriptional regulation of macrophage cholesterol trafficking by PPARalpha and LXR.

scientific article published on December 2006

[Fundamental data on atherosclerosis].

scientific article

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