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List of works by Bart Staels

0312: Characterization of human valvular interstitial cells isolated from normal and fibrocalcified aortic valves

0374 Leptin and its receptor in human calcific aortic valve: expression and functional implications

1.P.174 The mitochondrion is the principal target for nutritional and pharmacological control of triglyceride metabolism

scholarly article by R.K. Berge et al published October 1997 in Atherosclerosis

1.P.194 Thiazolidinediones exert a hypotriglyceridemic effect by a distinct, but complementary mechanism relative to fibrates

1.P.199 The underlying mechanism of the hypolipidemic effect of 3-thia fatty acids

11. Nuclear receptors as targets to modulate HDL levels

11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis

scientific article published on 9 January 2013

1334 CORRELATION OF HUMAN LIVER PPAR GENE EXPRESSION WITH HISTOLOGICAL SEVERITY OF NASH AND ASSOCIATED METABOLIC DERANGEMENTS: RATIONALE FOR TARGETED THERAPY

article

2.P.139 Effects of oral isotretinoin (13-cis retinoic acid) on lipoprotein(a) and HDL subclasses lpA-I and lpA-I: A-II in healthy volunteers

2FS05-4 Nuclear receptors controlling the metabolic syndrome and atherosclerosis

2P-0529 A novel family of compounds with beneficial effects in mouse models of dyslipidemia and ischemic stroke

375 Psoriasis-like inflammation in K14PPARβ/δ transgenic mice selectively overexpressing PPARβ/δ in keratinocytes

scholarly article by F. Dezoteux published in October 2017

3P-0818 GFT14, a novel compound with hypolipidemic and neuroprotective properties

3P-0834 Transcriptional regulation of the apolipoprotein A5 gene by insulin

article

4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part I: synthesis and pharmacological evaluation

scientific article published on 19 January 2008

4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural variations

scientific article published on April 2009

4.P.263 Coordinate regulation of the expression of the fatty acid transporter protein (FATP) and acyl CoA synthetase (ACS) genes by PPARα and PPARγ activators

article

4.P.304 HDL (high density lipoprotein) and LDL (low density lipoprotein) receptors regulation in human adrenal cortex

4.P.367 Transcription factor genes controlling high density lipoprotein metabolism

article

445 PPARA GENE LEVEL DIFFERENTLY AFFECTS LIPID METABOLISM AND INFLAMMATION IN APOLIPOPROTEIN E2 KNOCK-IN MICE

article

446 ATHEROSCLEROTIC LESION REMODELLING IN REV-ERBα-DEFICIENT MICE

50 PPARA ACTIVATION DIFFERENTLY AFFECTS MICROPARTICLE CONTENT IN ATHEROSCLEROTIC LESIONS AND LIVER OF A MOUSE MODEL OF ATHEROSCLEROSIS AND NASH

839 SERUM APOLIPOPROTEIN CIII LEVELS DECLINE AFTER WEIGHT LOSS INDUCED IMPROVEMENT IN HEPATIC STEATOSIS

A Mathematical Model of the Liver Circadian Clock Linking Feeding and Fasting Cycles to Clock Function.

scientific article

A New Method including the Quantification of Circulating Mirnas Allows the Efficient Identification of Nash Patients at Risk who should be Treated

A Post-Hoc Analysis ofthe Golden505 Trial Demonstrates Histological and Cardiometabolic Efficacy of Elafibranor-120 Mg in Patients with Moderate or Severe Nash That Are Eligible for Pharmacotherapy

article published in 2016

A blood-based biomarker panel (NIS4) for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis: a prospective derivation and global validation study

scientific article published on 04 August 2020

A central role for cholesterol metabolism and inflammation during the inhibition of non-alcoholic steatohepatitis with a synthetic PPARα agonist

A dynamic CTCF chromatin binding landscape promotes DNA hydroxymethylation and transcriptional induction of adipocyte differentiation

scientific article published on 2 September 2014

A fully dissociated compound of plant origin for inflammatory gene repression

scientific article

A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population.

scientific article published on 6 June 2013

A new non-invasive diagnostic score to monitor change in disease activity and predict fibrosis evolution in patients with NASH

A pan-PPAR ligand induces hepatic fatty acid oxidation in PPARalpha-/- mice possibly through PGC-1 mediated PPARdelta coactivation

scientific article published on 3 July 2009

A paradigm for gene regulation: inflammation, NF-kappaB and PPAR.

scientific article published on January 2003

A review of bile acid sequestrants: potential mechanism(s) for glucose-lowering effects in type 2 diabetes mellitus

scientific article published on May 2009

A role of PPARgamma in reproduction?

scientific article published in May 2005

A truncated human peroxisome proliferator-activated receptor alpha splice variant with dominant negative activity.

scientific article published on September 1999

ATF6α downregulation of PPARα promotes lipotoxicity-induced tubulointerstitial fibrosis

scientific article published on 11 January 2019

Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice.

scientific article published on 24 October 2007

Abstract 14384: Light Therapy Improves Circadian Blood Pressure Control and Glucose Homeostasis in Rotating Night Shift Workers via Mechanisms Independent of Melatonin

scientific article published in 2020

Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators

scientific article published in June 1998

Activation of intestinal peroxisome proliferator-activated receptor-α increases high-density lipoprotein production

scientific article published on 26 July 2012

Activation of junB by PKC and PKA signal transduction through a novel cis-acting element

scientific article

Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages

scientific article (publication date: 2 October 1998)

Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes

scientific article

Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells

scientific article published on March 2008

Acute antiinflammatory properties of statins involve peroxisome proliferator-activated receptor-alpha via inhibition of the protein kinase C signaling pathway

scientific article published on 5 January 2006

Acyl-CoA synthetase mRNA expression is controlled by fibric-acid derivatives, feeding and liver proliferation

scientific article published on 01 September 1993

Adipose tissue macrophages (ATM) of obese patients are releasing increased levels of prolactin during an inflammatory challenge: a role for prolactin in diabesity?

scientific article published on 18 December 2013

Adventitial Tertiary Lymphoid Organs as Potential Source of MicroRNA Biomarkers for Abdominal Aortic Aneurysm

scientific article published on 18 May 2015

Age-related phenotypes in the staggerer mouse expand the RORalpha nuclear receptor's role beyond the cerebellum

scientific article

Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis

scientific article published in September 2004

Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice

scientific article published on October 1997

Altered PPARγ Expression Promotes Myelin-Induced Foam Cell Formation in Macrophages in Multiple Sclerosis

scientific article published on 07 December 2020

Alternative human liver transcripts of TCF7L2 bind to the gluconeogenesis regulator HNF4α at the protein level

scientific article published on 26 January 2014

Alternative macrophages in atherosclerosis: not always protective!

scientific article published on 19 February 2018

An increased flux through the glucose 6-phosphate pool in enterocytes delays glucose absorption in Fxr-/- mice

scientific article published on 9 February 2009

An optimized protocol with a stepwise approach to identify specific nuclear receptor ligands from cultured mammalian cells

scientific article published on 07 July 2021

An oxidative stress paradox: time for a conceptual change?

scientific article published in October 2016

Anacetrapib, but not evacetrapib, impairs endothelial function in CETP-transgenic mice in spite of marked HDL-C increase

scientific article published on 16 January 2017

Angiotensin AT1 receptor antagonist irbesartan decreases lesion size, chemokine expression, and macrophage accumulation in apolipoprotein E-deficient mice

scientific article published on September 2001

Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression

scientific article published on 10 June 2017

Antipsychotic drug action on SREBPs-related lipogenesis and cholesterogenesis in primary rat hepatocytes

scientific article

Apolipoprotein A-IV messenger ribonucleic acid abundance is regulated in a tissue-specific manner

scientific article published in April 1990

Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators

scientific article (publication date: 16 May 2003)

Apolipoprotein CIII

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

scientific article published in 2022

Apolipoprotein a5-deficiency promotes cardiac glucose metabolism and protects against acute myocardial stresses

Arterial Pulsatility and Circulating von Willebrand Factor in Patients on Mechanical Circulatory Support

Association Between a Thyroid Hormone Receptor-α Gene Polymorphism and Blood Pressure but Not With Coronary Heart Disease Risk

article

Association between liver X receptor alpha gene polymorphisms and risk of metabolic syndrome in French populations

scientific article published on 22 January 2008

Atheroprotective effect of human apolipoprotein A5 in a mouse model of mixed dyslipidemia

scientific article published on 24 July 2008

Atherosclerosis: Recent trials, new targets and future directions

scientific article published on 08 May 2015

Author Correction: Transcriptional network analysis implicates altered hepatic immune function in NASH development and resolution

scientific article published on 01 July 2019

BEXAROTENE-ACTIVATED RXR/LXR HETERODIMER IN LIVER MODULATES TRIGLYCERIDE METABOLISM BUT NOT CHOLESTEROL HOMEOSTASIS IN VIVO

Bariatric surgery, lipoprotein metabolism and cardiovascular risk

scientific article published on August 2015

Basal transcriptional activity and cyclic adenosine 3',5'-monophosphate responsiveness of the human cytochrome P450scc promoter transfected into MA-10 Leydig cells

scientific article published on February 1993

Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology.

scientific article published on 4 May 2011

Beneficial effects of fenofibrate on plaque thrombogenicity and plaque stability in atherosclerotic rabbits

scientific article published on 23 April 2008

Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice

scientific article

Bile Acid Alterations Are Associated With Insulin Resistance, but Not With NASH, in Obese Subjects

scientific article

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

scientific article published on 15 February 2017

Bile acid alterations in nonalcoholic fatty liver disease, obesity, insulin resistance and type 2 diabetes: what do the human studies tell?

scientific article published on 01 June 2019

Bile acid metabolism and the pathogenesis of type 2 diabetes

scientific article published in June 2011

Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease

scientific article

Bile acid sequestrants and the treatment of type 2 diabetes mellitus

scientific article published on January 2007

Bile acid sequestrants for lipid and glucose control

scientific article

Bile acid sequestrants: glucose-lowering mechanisms

scientific article published on 26 October 2010

Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration

scientific article

Bile acids associate with glucose metabolism, but do not predict conversion from impaired fasting glucose to diabetes

scientific article published on 27 November 2019

Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor

scientific article (publication date: February 2003)

Bile acids, farnesoid X receptor, atherosclerosis and metabolic control

scientific article

Bone marrow p16INK4a-deficiency does not modulate obesity, glucose homeostasis or atherosclerosis development

scientific article (publication date: 2012)

Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo

scientific article published on 28 August 2006

Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model

scientific article published on 19 January 2019

Brinster et al. reply

scientific article published in Nature

CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway

scientific article published on 09 October 2020

CIDEA interacts with liver X receptors in white fat cells

scientific article published on 22 February 2011

CX₃CL1 (fractalkine) and its receptor CX₃CR1 regulate atopic dermatitis by controlling effector T cell retention in inflamed skin

scientific article

Cardiac hypertrophy is enhanced in PPAR -/- mice in response to chronic pressure overload

article

Cardiovascular Protection by Sodium Glucose Cotransporter 2 Inhibitors: Potential Mechanisms

scientific article

Cardiovascular Protection by Sodium Glucose Cotransporter 2 Inhibitors: Potential Mechanisms

scientific article published on 30 May 2017

Cardiovascular biology: a cholesterol tether

scientific article

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

scientific article

Cdkn2a/p16Ink4a regulates fasting-induced hepatic gluconeogenesis through the PKA-CREB-PGC1α pathway

scientific article published on May 2014

Cell culture conditions determine apolipoprotein CIII secretion and regulation by fibrates in human hepatoma HepG2 cells

scientific article published on January 1999

Cell-derived microparticles in atherosclerosis: biomarkers and targets for pharmacological modulation?

scientific article published on July 2012

Cell-specific dysregulation of microRNA expression in obese white adipose tissue

scientific article

ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver

scientific article published on March 2008

Changes in IgG Fc receptor expression induced by phorbol 12-myristate 13-acetate treatment of THP-1 monocytic leukemia cells

scientific article published in January 1992

Characterization of new PPARgamma agonists: analysis of telmisartan's structural components

scientific article published on March 2009

Characterization of new PPARgamma agonists: benzimidazole derivatives - the importance of position 2.

scientific article

Characterization of new PPARgamma agonists: benzimidazole derivatives-importance of positions 5 and 6, and computational studies on the binding mode

scientific article published on 3 July 2010

Characterization of the Human PPARα Promoter: Identification of a Functional Nuclear Receptor Response Element

article

Characterization of the human PPARalpha promoter: identification of a functional nuclear receptor response element

scientific article published in May 2002

Cholesterol 7α-Hydroxylase Deficiency in Mice on an APOE*3-Leiden Background Increases Hepatic ABCA1 mRNA Expression and HDL-Cholesterol

scientific article published on 28 September 2006

Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma

scientific article

Cholesteryl ester transfer protein modulates the effect of liver X receptor agonists on cholesterol transport and excretion in the mouse

scientific article published on 16 December 2003

Cholesteryl-ester transfer protein (CETP): A Kupffer cell marker linking hepatic inflammation with atherogenic dyslipidemia?

Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα.

scientific article

Circadian and glucocorticoid regulation of Rev-erbalpha expression in liver

scientific article published on 01 October 2000

Circadian control of epigenetic modifications modulates metabolism.

scientific article published on August 2011

Circadian control of metabolism and pathological consequences of clock perturbations.

scientific article published in August 2017

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle

article published in the Proceedings of the National Academy of Sciences of the United States of America

Circadian rhythmicity and metabolism: integration of metabolic and environmental signals

scientific article published in August 2013

Circulating PCSK9 levels are not associated with the severity of hepatic steatosis and NASH in a high-risk population

scientific article published on 13 September 2018

Circumventing glucocorticoid-mediated hyperinsulinemia via the activation of PPARalpha.

scientific article published on 15 August 2009

Clinical significance of electrocardiographic markers of myocardial damage prior to aortic valve replacement

scientific article published on 29 January 2020

Coenzyme Q as an antiadipogenic factor.

scientific article published on 23 November 2010

Colesevelam lowers glucose and lipid levels in type 2 diabetes: the clinical evidence

scientific article

Combination therapy of statins and fibrates in the management of cardiovascular risk

scientific article

Combinatorial regulation of hepatic cytoplasmic signaling and nuclear transcriptional events by the OGT/REV-ERBα complex

article published in the Proceedings of the National Academy of Sciences of the United States of America

Comment on Patel et al. ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity. Diabetes 2016;65:85–95

article

Comparison of expression and regulation of the high-density lipoprotein receptor SR-BI and the low-density lipoprotein receptor in human adrenocortical carcinoma NCI-H295 cells

scientific article published on April 1999

Complete functional rescue of the ABCA1-/- mouse by human BAC transgenesis

scientific article

Control of Cell Identity by the Nuclear Receptor HNF4 in Organ Pathophysiology

scientific article published on 28 September 2020

Control of gene expression by the retinoic acid-related orphan receptor alpha in HepG2 human hepatoma cells

scientific article

Control of metabolism by nutrient-regulated nuclear receptors acting in the brain

scientific article published on 17 October 2011

Control of nuclear receptor activities in metabolism by post-translational modifications

scientific article published on 07 April 2011

Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators

scientific article published on November 1997

Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity

scientific article

Coupled and uncoupled induction of fos and jun transcription by different second messengers in cells of hematopoietic origin

scientific article published in January 1990

Cross-omics analysis revealed gut microbiome-related metabolic pathways underlying atherosclerosis development after antibiotics treatment

scientific article published on 13 March 2020

Cross-talk between statins and PPARalpha in cardiovascular diseases: clinical evidence and basic mechanisms

scientific article published on April 2008

DCo(H2)ding the metabolic functions of SIRT1 in the intestine

DHA-derived oxylipins, neuroprostanes and protectins, differentially and dose-dependently modulate the inflammatory response in human macrophages: Putative mechanisms through PPAR activation

scientific article published on 14 December 2016

DNA Binding-Independent Induction of I B Gene Transcription by PPAR

article

DNA Binding-Independent Induction of IκBα Gene Transcription by PPARα

scientific article published in May 2002

DPP-4 inhibitors in the treatment of type 2 diabetes

scientific article published on 13 December 2011

Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study

scientific article published on 26 October 2017

Daytime variations in perioperative myocardial injury – Authors' reply

scientific article published in The Lancet

Deletion of the nuclear receptor RORα in macrophages does not modify the development of obesity, insulin resistance and NASH

scientific article published on 03 December 2020

Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity

scientific article

Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor α agonists

article by Yukiyoshi Yamazaki et al published August 2007 in Bioorganic & Medicinal Chemistry Letters

Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis

scientific article

Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice.

scientific article published on 18 December 2012

Development and implementation of a cell-based assay to discover agonists of the nuclear receptor REV-ERBα

scientific article published on 25 June 2018

Developmental and pharmacological regulation of apolipoprotein C-II gene expression. Comparison with apo C-I and apo C-III gene regulation

scientific journal article

Developmental extinction of liver lipoprotein lipase mRNA expression might be regulated by an NF-1-like site

scientific article published on August 1993

Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model

scientific article published on 20 March 2019

Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis

scientific article published in August 2008

Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse

scientific article

Different ways to regulate the PPARalpha stability.

scientific article

Differential unfolded protein response in skeletal muscle from non-diabetic glucose tolerant or intolerant patients with obesity before and after bariatric surgery

scientific article published on 21 February 2020

Distinct but complementary contributions of PPAR isotypes to energy homeostasis.

scientific article

Does endoplasmic reticulum stress participate in APD-induced hepatic metabolic dysregulation?

scientific article published on 10 September 2011

Down-regulation of hepatic lipase gene expression and activity by fenofibrate ⬇️

scientific article published on January 24, 1992

Downregulation of the tumour suppressor p16INK4A contributes to the polarisation of human macrophages toward an adipose tissue macrophage (ATM)-like phenotype

scientific article

Drug Insight: mechanisms of action and therapeutic applications for agonists of peroxisome proliferator-activated receptors

scientific article published on February 2007

Drug repurposing screen identifies novel small molecule compounds with potent antifibrotic properties

article published in 2017

Dual peroxisome proliferator-activated receptor α/δ agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects

scientific article

Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers

scientific article

Dyslipidemia shifts the tissue factor/tissue factor pathway inhibitor balance toward increased thrombogenicity in atherosclerotic plaques

Dysregulated lipid metabolism links NAFLD to cardiovascular disease

scientific article published on 30 September 2020

EMBO workshop on immunology and metabolism

scientific article published on 15 April 2011

Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates

scientific article published on 20 December 2005

Effect of 6-Benzoyl-benzothiazol-2-one scaffold on the pharmacological profile of α-alkoxyphenylpropionic acid derived PPAR agonists

scientific article published on 01 December 2020

Effect of oxime ether incorporation in acyl indole derivatives on PPAR subtype selectivity

scientific article

Effect of rosiglitazone treatment on plaque inflammation and collagen content in nondiabetic patients: data from a randomized placebo-controlled trial

scientific article

Effects of F 12511, a potent ACAT inhibitor, on human adrenocortical cells in culture

article

Effects of Microdesmis keayana alkaloids on vascular parameters of erectile dysfunction

scientific article published on June 2009

Effects of Pinus pinaster and Pinus koraiensis seed oil supplementation on lipoprotein metabolism in the rat

article

Effects of sex steroids on hepatic and lipoprotein lipase activity and mRNA in the rat.

scientific article published in January 1993

Effects of the PPAR-α agonist fenofibrate on acute and short-term consequences of brain ischemia

scientific article

Effects of the new dual PPAR α/δ agonist GFT505 on lipid and glucose homeostasis in abdominally obese patients with combined dyslipidemia or impaired glucose metabolism

scientific article

Efficacy and safety of initial combination treatment with sitagliptin and pioglitazone--a factorial study

scientific article published on 29 August 2013

Efficacy and safety of sitagliptin added to ongoing metformin and pioglitazone combination therapy in a randomized, placebo-controlled, 26-week trial in patients with type 2 diabetes

scientific article published on 30 October 2012

Efficacy of peroxisome proliferator-activated receptor agonists in diabetes and coronary artery disease

scientific article published on July 2009

Efficient gene regulation by PPAR gamma and thiazolidinediones in skeletal muscle and heart

scientific article published in August 2002

Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

scientific article

Emerging small molecule drugs

scientific article

Endogenous cannabinoid receptor CB1 activation promotes vascular smooth-muscle cell proliferation and neointima formation

scientific article published on 11 March 2013

Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver

scientific article published on 01 May 2020

Endospanin-2 enhances skeletal muscle energy metabolism and running endurance capacity.

scientific article published on 3 May 2018

Endotheliopathy is induced by plasma from critically-ill patients and associated with organ failure in severe COVID-19

scientific article published on 24 September 2020

Enterocyte superoxide dismutase 2 deletion drives obesity

Epicardial fat amount is associated with the magnitude of left ventricular remodeling in aortic stenosis

scientific article published on 17 October 2018

Erratum: Temporal changes in bile acid levels and 12α-hydroxylation after Roux-en-Y gastric bypass surgery in type 2 diabetes

scholarly article published in International Journal of Obesity

Erratum: The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

scholarly article published in Obesity

Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle

scientific article

Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease

scientific article published on 31 May 2012

Expression and Localization of Peroxisome Proliferator-Activated Receptors and Nuclear Factor κB in Normal and Lesional Psoriatic Skin

Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR.

scientific article

Expression of human apolipoprotein A-I/C-III/A-IV gene cluster in mice reduces atherogenesis in response to a high fat-high cholesterol diet.

scientific article published in July 2001

Expression of the Peroxisome Proliferator-activated Receptor Gene Is Stimulated by Stress and Follows a Diurnal Rhythm

scientific article published in Journal of Biological Chemistry

Extracorporal albumin dialysis (MARS) improves cholestasis and normalizes low apo A-I levels in a patient with benign recurrent intrahepatic cholestasis (BRIC).

scientific article published on January 2002

FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity

scientific article (publication date: June 2003)

FXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements

scientific article published on 28 June 2019

FXR-deficiency confers increased susceptibility to torpor.

scientific article published on 12 October 2007

FXR: More than a Bile Acid Receptor?

FXR: a promising target for the metabolic syndrome?

scientific article published on 6 April 2007

Failing FXR expression in the liver links aging to hepatic steatosis

Farnesoid X Receptor Activation in Brain Alters Brown Adipose Tissue Function via the Sympathetic System

scientific article published on 01 January 2021

Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets.

scientific article published on 06 October 2016

Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression

scientific article (publication date: August 2003)

Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity

scientific article

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

scientific article

Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes.

scientific article published on 25 March 2013

Farnesoid X receptor represses hepatic lipase gene expression

scientific article published on September 2004

Farnesoid X receptor: a new player in glucose metabolism?

scientific article published in March 2005

Fasting the Microbiota to Improve Metabolism?

scientific article published in October 2017

Fenofibrate increases homocystinemia through a PPARalpha-mediated mechanism

scientific article published in March 2004

Fenofibrate inhibits endothelin-1 expression by peroxisome proliferator-activated receptor α-dependent and independent mechanisms in human endothelial cells

scientific article published on 17 January 2013

Fenofibrate modifies transaminase gene expression via a peroxisome proliferator activated receptor α-dependent pathway

article

Fenofibrate reverses the decline in HDL cholesterol in mice overexpressing human phospholipid transfer protein

scientific article

Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis, and elongation in mice

scientific article

Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, exerts anticonvulsive properties

scientific article

Ffar2 expression regulates leukaemic cell growth in vivo.

scientific article published on 5 September 2017

Fibrates and future PPARalpha agonists in the treatment of cardiovascular disease

scientific article

Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation

scientific article published on 29 August 2002

Fibrates down-regulate hepatic scavenger receptor class B type I protein expression in mice.

scientific article

Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates

scientific article

Fibrates in CVD: a step towards personalised medicine

scientific article published in May 2010

Fibrates increase human REV-ERBalpha expression in liver via a novel peroxisome proliferator-activated receptor response element

scientific article published on 01 March 1999

Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor

scientific article published on August 1995

Fibrates influence the expression of genes involved in lipoprotein metabolism in a tissue-selective manner in the rat

scientific journal article

Fibrates suppress bile acid synthesis via PPARα-mediated down-regulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase gene expression

article

Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression

scientific article published in November 2001

Fibrates, glitazones, and peroxisome proliferator-activated receptors

scientific article

Fluid retention mediated by renal PPARgamma

scientific article published in August 2005

Free leptin, carotid plaque phenotype and relevance to related symptomatology: insights from the OPAL-Lille carotid endarterectomy study

scientific article

From cardiac mitochondrial dysfunction to clinical arrhythmias

scientific article published on 3 March 2015

Function of the transcriptional regulating protein of 132 kDa (TReP-132) on human P450scc gene expression

scientific article (publication date: November 2002)

Functional genomics of the CDKN2A/B locus in cardiovascular and metabolic disease: what have we learned from GWASs?

scientific article

GFT505 for the treatment of nonalcoholic steatohepatitis and type 2 diabetes

scientific article

GIANT: galaxy-based tool for interactive analysis of transcriptomic data

scientific article published on 16 November 2020

General molecular biology and architecture of nuclear receptors

scientific article published on January 2012

Generation and characterization of a humanized PPARδ mouse model

scientific article

Genetically-engineered animals as research models for atherosclerosis: their use for the characterization of PPAR agonists in the treatment of cardiometabolic disorders

scientific article published on May 2007

Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites

scientific article published on 12 December 2011

Genomic and non-genomic interactions of PPARalpha with xenobiotic-metabolizing enzymes

scientific article published in September 2004

Giardia muris infection in mice is associated with a protective interleukin 17A response and induction of peroxisome proliferator-activated receptor alpha

scientific article

Global suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-alpha activator fenofibrate

scientific article published on 5 February 2004

Glucose regulates the expression of the farnesoid X receptor in liver

scientific journal article

Glucose sensing O-GlcNAcylation pathway regulates the nuclear bile acid receptor farnesoid X receptor (FXR).

scientific article published on 24 March 2014

Glucose-lowering effects of intestinal bile acid sequestration through enhancement of splanchnic glucose utilization

scientific article published on 11 April 2014

Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation

scientific article published on 01 November 2019

Growth hormone normalizes hepatic lipase in hypothyroid rat liver

scientific journal article

Growth hormone normalizes low-density lipoprotein receptor gene expression in hypothyroid rats

article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HDL does not influence the polarization of human monocytes toward an alternative phenotype

scientific article published on 08 January 2014

HDL in children with CKD promotes endothelial dysfunction and an abnormal vascular phenotype

scientific article

HMG-CoA reductase inhibition and PPAR- alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured endothelial cells

scientific article

Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology

scientific article published on 01 December 2018

Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c

scientific article

Hepatic PPARα is critical in the metabolic adaptation to sepsis

scientific article published on 21 January 2019

Hepatic de novo synthesis of glucose 6-phosphate is not affected in peroxisome proliferator-activated receptor alpha-deficient mice but is preferentially directed toward hepatic glycogen stores after a short term fast

scientific article published on 19 December 2003

Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4alpha

scientific article

Hepatic glucose sensing is required to preserve β cell glucose competence

scientific article published on 15 March 2013

Hepatic molecular signatures highlight the sexual dimorphism of Non-Alcoholic SteatoHepatitis (NASH)

scientific article published on 11 May 2020

Hepatic trans-Golgi action coordinated by the GTPase ARFRP1 is crucial for lipoprotein lipidation and assembly.

scientific article

Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients.

scientific article

Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα

scientific article published on 11 April 2019

Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

scientific article

High level expression of PPARγ in differentiated colon epithelium

Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1.

scientific article

Human Alternative Macrophages Populate Calcified Areas of Atherosclerotic Lesions and Display Impaired RANKL-Induced Osteoclastic Bone Resorption Activity

scientific article published on 24 April 2017

Human Aortic Valve Interstitial Cells Display Proangiogenic Properties During Calcific Aortic Valve Disease

scientific article published on 05 November 2020

Human adipose tissue macrophages display activation of cancer-related pathways

scientific article

Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways.

scientific article published on 24 February 2011

Human retinoic acid receptor-related orphan receptor alpha1 overexpression protects neurones against oxidative stress-induced apoptosis

scientific article published in March 2006

Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis

scientific article (publication date: 13 September 2002)

Hypolipidemic effects of R103757, a potent stereoselective inhibitor of microsomal triglyceride transfer protein (MTP)

IAP survivin regulates atherosclerotic macrophage survival

scientific article published on 25 January 2007

IP receptor-dependent activation of PPARgamma by stable prostacyclin analogues

scientific article

IUPHAR-DB: new receptors and tools for easy searching and visualization of pharmacological data

scientific article (publication date: 2011)

Identification of Rev-erbalpha as a physiological repressor of apoC-III gene transcription

scientific article

Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis

scientific article

Impact of endotoxin challenge in obese pigs

scientific article published in June 2014

Impact of light therapy on rotating night shift workers: the EuRhythDia study

scientific article published in 2022

Impaired alternative macrophage differentiation of peripheral blood mononuclear cells from obese subjects

scientific article published on 22 December 2011

Impaired expression of the inducible cAMP early repressor accounts for sustained adipose CREB activity in obesity

scientific article published on 12 October 2011

Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function

scientific article published on 05 October 2016

Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice

scientific article

Inactivation of the Nuclear Orphan Receptor COUP-TFII by Small Chemicals

scientific article

Increased ABCA1 activity protects against atherosclerosis

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes.

scientific article

Increased atherosclerotic lesions in LDL receptor deficient mice with hematopoietic nuclear receptor Rev-erbα knock- down

scientific article published on 20 August 2013

Increased removal of beta-very low density lipoproteins after ethinyl estradiol is associated with increased mRNA levels for hepatic lipase, lipoprotein lipase, and the low density lipoprotein receptor in Watanabe heritable hyperlipidemic rabbits

scientific article published on 01 November 1991

Induction of CXCR2 receptor by peroxisome proliferator-activated receptor gamma in human macrophages

scientific article published on 21 February 2008

Induction of IκBα Expression as a Mechanism Contributing to the Anti-inflammatory Activities of Peroxisome Proliferator-activated Receptor-α Activators

scientific article published in Journal of Biological Chemistry

Induction of MDR2 P-glycoprotein (PGP) by fibrates is mediated by peroxisome proliferator-activated receptor alpha (PPARα) in the mouse

Induction of hepatic ABC transporter expression is part of the PPARalpha-mediated fasting response in the mouse

scientific article

Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake

scientific article

Induction of the phospholipid transfer protein gene accounts for the high density lipoprotein enlargement in mice treated with fenofibrate

scientific article

Inflammation, dyslipidaemia, diabetes and PPars: pharmacological interest of dual PPARalpha and PPARgamma agonists

scientific article

Influence of Roux-en-Y gastric bypass on plasma bile acid profiles: a comparative study between rats, pigs and humans.

scientific article published on 22 March 2016

Inhibition of adipocyte differentiation by RORalpha.

scientific article published on 18 May 2009

Inhibition of cytokine production by the herbicide atrazine. Search for nuclear receptor targets

scientific article

Inhibition of progesterone production in human luteinized granulosa cells treated with LXR agonists

article

Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion.

scientific article published on 20 April 2015

Innate lymphoid cells contribute to allergic airway disease exacerbation by obesity.

scientific article published on 4 April 2016

Insulin-mediated down-regulation of apolipoprotein A5 gene expression through the phosphatidylinositol 3-kinase pathway: role of upstream stimulatory factor

scientific article

Inter-subject differences in constitutive expression levels of the clock gene in man.

scientific article published in March 2007

Interindividual Heterogeneity of SGLT2 Expression and Function in Human Pancreatic Islets

scientific article published on 02 January 2020

International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors

scientific article

Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin

scientific article

Intestinal ABCA1 directly contributes to HDL biogenesis in vivo

scientific article published on 16 March 2006

Intestinal FXR-mediated FGF15 production contributes to diurnal control of hepatic bile acid synthesis in mice

scientific article published on 7 June 2010

Intestinal bile acid receptors are key regulators of glucose homeostasis

scientific article published on 16 November 2016

Intestine-specific regulation of PPARalpha gene transcription by liver X receptors

scientific article published on 19 June 2008

Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice

scientific article published on 29 January 2010

Introduction on the ATVB Review Series “Nuclear Receptors in Metabolism and Cardiovascular Disease”

article

Is the current therapeutic armamentarium in diabetes enough to control the epidemic and its consequences? What are the current shortcomings?

scientific article published on 20 June 2009

Keratinocyte Expression of A20/TNFAIP3 Controls Skin Inflammation Associated with Atopic Dermatitis and Psoriasis

scientific article published on 14 August 2018

Ketone Body Therapy Protects From Lipotoxicity and Acute Liver Failure Upon Pparα Deficiency

scientific article

Kruppel-like factor KLF10 is a link between the circadian clock and metabolism in liver

scientific article

Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity

scientific article published in February 2010

LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease

scientific article

LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice

scientific article

Lack of toxic effects of F 12511, a novel potent inhibitor of acyl-coenzyme A: cholesterol O-acyltransferase, on human adrenocortical cells in culture

scientific article

Leptin

scientific article published in The Lancet

Leptin induces osteoblast differentiation of human valvular interstitial cells via the Akt and ERK pathways

scientific article published on 18 March 2017

Lesion progression in apoE-deficient mice: implication of chemokines and effect of the AT1 angiotensin II receptor antagonist irbesartan

scientific article

Light therapy improves diurnal blood pressure control in night shift workers via reduction of catecholamines: the EuRhythDia study

scientific article published in 2021

Lipid ligand-activated transcription factors regulating lipid storage and release in human macrophages

scientific article published on 27 January 2009

Lipidomics and metabolomics signatures of SARS-CoV-2 mediators/receptors in peripheral leukocytes, jejunum and colon

scientific article published on 08 November 2021

Lipoprotein lipase expression in undifferentiated hepatoma cells is regulated by progesterone and protein kinase A.

scientific article published on October 1992

Liver X Receptor (LXR) activation negatively regulates visfatin expression in macrophages

scientific article published on 08 December 2010

Liver X Receptor Activation Potentiates the Lipopolysaccharide Response in Human Macrophages

article

Liver X Receptor Regulates Triglyceride Absorption Through Intestinal Down-regulation of Scavenger Receptor Class B, Type 1.

scientific article published on 18 November 2015

Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages

scientific article

Liver X receptor activation decreases chylomicron assembly and improves post-prandial triglyceridemia via intestinal sr-bi downregulation

Liver X receptor activation induces the uptake of cholesteryl esters from high density lipoproteins in primary human macrophages

scientific article

Liver X receptor activation stimulates iron export in human alternative macrophages.

scientific article published on 13 September 2013

Liver X receptor modulators: effects on lipid metabolism and potential use in the treatment of atherosclerosis

scientific article published on 03 December 2008

Liver X receptors and the control of cholesterol homeostasis: potential therapeutic targets for the treatment of atherosclerosis

scientific article

Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression

scientific article published on 03 September 2015

Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet feeding

scientific article published on 09 March 2019

Localization of the human OB gene (OBS) to chromosome 7q32 by fluorescence in situ hybridization

scientific article

Long-term prognostic value of preprocedural adiponectin levels in patients undergoing percutaneous coronary intervention

scientific article published on 15 August 2013

M1 and M2 macrophage proteolytic and angiogenic profile analysis in atherosclerotic patients reveals a distinctive profile in type 2 diabetes

article

MPO is partially associated with neutrophil deleterious effect in acute cerebral ischemia

scientific article published on 28 February 2020

MS326 LXR ACTIVATION WITH TO901317 AND GW3965 IN MICE: DIFFERENTIAL EFFECTS ON LIVER AND INTESTINE, BUT NO NEGATIVE IMPACT ON BONE

Macrophage function and polarization in cardiovascular disease: a role of estrogen signaling?

scientific article published on 2 May 2013

Macrophage phenotypes and their modulation in atherosclerosis

scientific article published on 07 July 2014

Macrophage phenotypes in atherosclerosis.

scientific article

Macrophage polarization in metabolic disorders: functions and regulation

scientific article published on October 2011

Macrophage subsets in atherosclerosis.

scientific article

Macrophage-specific inactivation of the nuclear receptor ROR-alpha leads to increased atherosclerosis in mouse

Mathematical models converge on PGC1α as the key metabolic integrator of SIRT1 and AMPK regulation of the circadian clock

scientific article published on 25 June 2019

Measuring biomarkers to assess the therapeutic effects of PPAR agonists?

scientific article

Mechanisms Underlying the Functional Cooperation Between PPARα and GRα to Attenuate Inflammatory Responses

scientific article published on 09 August 2019

Meta-Analysis of Abdominal Aortic Aneurysm in Patients With Coronary Artery Disease

scientific article published on 14 August 2015

Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR

scientific article published on 25 April 2019

Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR

scientific article published on 01 June 2019

Metabolic effects of bile acid sequestration: impact on cardiovascular risk factors

scientific article published on 08 February 2016

Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice

scientific article

Metabolism of Apolipoproteins AI and AII in a Patient with Paradoxical Reduction in High-Density Lipoprotein Due to Ciprofibrate

scientific article published on 01 July 1999

Metformin and pioglitazone: Effectively treating insulin resistance

scientific article published on January 2006

Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk.

scientific article published on 17 February 2014

MiR-206 controls LXR-alpha expression and promotes LXR-mediated cholesterol efflux in macrophages

MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids

scientific article published on 11 May 2015

Mitochondria and endoplasmic reticulum: Targets for a better insulin sensitivity in skeletal muscle?

scientific article

Mitochondrial Dysfunction as an Arrhythmogenic Substrate

scientific article published on 01 May 2013

Mo-W6:1 Metabolic and vascular control by lipid-sensing nuclear receptors: Role of the peroxisome proliferator-activated receptor-alpha as a mediator of the pleiotropic effects of statins

Modulating liver inflammation: a crucial role for cholesterol

article published in 2008

Modulation of hepatic inflammatory risk markers of cardiovascular diseases by PPAR-alpha activators: clinical and experimental evidence

scientific article

Modulation of inflammatory M1-macrophages phenotype by valvular interstitial cells

scientific article published in 2022

Molecular Actions of PPARα in Lipid Metabolism and Inflammation

scientific article published on 01 October 2018

Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity

scientific article published on December 2005

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

scientific article published in November 2014

Morphologic and electroretinographic phenotype of SR-BI knockout mice after a long-term atherogenic diet.

scientific article published on 6 May 2009

Murine models to investigate pharmacological compounds acting as ligands of PPARs in dyslipidemia and atherosclerosis

scientific article published on October 2003

MuscleJ: a high-content analysis method to study skeletal muscle with a new Fiji tool

scientific article published on 06 August 2018

Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients

scientific article published on 13 June 2014

NR1D1 controls skeletal muscle calcium homeostasis through myoregulin repression

scientific article published in 2022

Natalizumab Treatment Modulates Peroxisome Proliferator-Activated Receptors Expression in Women with Multiple Sclerosis.

scientific article published on 18 December 2016

Naturally improving insulin resistance with amorfrutins

scientific article

Near-infrared light activatable hydrogels for metformin delivery

scientific article published on 01 August 2019

Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor alpha agonists via inhibition of CCAAT box/enhancer-binding protein beta

scientific article

Neonatal extinction of liver lipoprotein lipase expression

scientific article published in July 1992

New insights into obesity genes

scientific article published on December 1996

New roles for PPARs in cholesterol homeostasis

Next-Generation Sequencing (NGS) of two independent cohorts identifies eleven circulating miRNAs for diagnosis of NASH and fibrosis

Niemann-Pick C1 like 1 gene expression is down-regulated by LXR activators in the intestine

scientific article published on 5 January 2006

No short-term effect of oral isotretinoin (13-cis retinoic acid) on lipoprotein(a) and HDL subclasses LP-A-I and LP-A-I:A-II in healthy volunteers

scientific article published on 01 July 1999

Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice

scientific article published on April 2004

Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives

scientific article

Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity Of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice.

scientific article published on 22 December 2017

Nuclear bile acid signaling through the farnesoid X receptor

scientific article

Nuclear receptors linking circadian rhythms and cardiometabolic control.

scientific article

Nuclear transcription factors: new opportunities for lipid lowering

scientific article

Nur77turing Macrophages in Atherosclerosis

O-GlcNAcylation Links ChREBP and FXR to Glucose-Sensing

scientific article

O37 Le récepteur nucléaire FXR régule la fonction et la différenciation adipocytaire en interférant avec la voie Wnt/β-caténine et en induisant la voie de signalisation de PPARγ

O78 Le GFT505, premier co-agoniste PPAR α/δ, a une double action favorable sur les paramètres lipidiques et glucidiques chez les sujets pré-diabétiques

O85 Les macrophages du tissu adipeux : une nouvelle cible potentielle pour les agonistes des récepteurs nucléaires LXR (Liver X Receptors)

O89 Suppression of the tumour suppressor p16ink4a drives human macrophages towards a phenotype resembling adipose tissue macrophages (ATMs)

O90 Régulation de la visfatin au sein des macrophages primaires par les récepteurs nucléaires PPAR (Peroxisome Proliferator-Activated Receptor) gamma et LXR (Liver X Receptors)

ORP4L Facilitates Macrophage Survival via G-Protein-Coupled Signaling: ORP4L-/- Mice Display a Reduction of Atherosclerosis

scientific article published on 11 October 2016

Obesity Paradox in the Clinical Significance of Effective Prosthetic Orifice Area After Aortic Valve Replacement

scientific article published on 13 June 2018

Obesity resistant mechanisms in the Lean polygenic mouse model as indicated by liver transcriptome and expression of selected genes in skeletal muscle

scientific article

Omentin-1, epicardial fat and coronary artery disease

scholarly article by Cedric Klein et al published December 2016 in Atherosclerosis

On the mechanism for PPAR agonists to enhance ABCA1 gene expression

scientific article published on 19 January 2009

Opposite in vitro and in vivo regulation of hepatic apolipoprotein A-I gene expression by retinoic acid. Absence of effects on apolipoprotein A-II gene expression

scientific article published on October 1994

Opposite regulation of hepatic lipase and lecithin: cholesterol acyltransferase by glucocorticoids in rats

scientific journal article

Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice

scientific article published on June 1996

Organizing combinatorial transcription factor recruitment at cis-regulatory modules

scientific article

Overview of nomenclature of nuclear receptors

scientific article

Overview of the Measurement of Lipids and Lipoproteins in Mice

Overweight induced by chronic risperidone exposure is correlated with overexpression of the SREBP-1c and FAS genes in mouse liver

scientific article published on 19 February 2011

Oxidized low-density lipoprotein and peroxisome-proliferator-activated receptor alpha down-regulate platelet-activating-factor receptor expression in human macrophages

scientific article

Oxidized phospholipids activate PPARα in a phospholipase A2-dependent manner

scientific article published on 01 April 2000

P222 Expression différentielle de transcrits alternatifs de TCF7L2 dans le foie humain diabétique, et leur induction par l’insuline dans les cellules hépatiques HepG2

P263 STEATOSIS-INDEPENDENT PREVENTION OF LIVER FIBROSIS VIA THE TRANSREPRESSIVE ACTIVITY OF PPARa

PLPNA3 Status in Nash is Associated with Increased Histological Severity at Baseline but Not with Response to Therapy in the Golden-505 Elafibranor Trial

PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysis

scientific article

PPAR SUMOylation: some useful experimental tips

scientific article published in January 2013

PPAR Tissue Distribution and Interactions with Other Hormone-Signaling Pathways

scientific article published on 01 December 1996

PPAR agonists and the metabolic syndrome

scientific article published on July 2007

PPAR agonists: multimodal drugs for the treatment of type-2 diabetes

scientific article published on December 2007

PPAR alpha inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a

scientific article

PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance

scientific article published in December 2001

PPAR: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases

scientific article published on December 2006

PPARS, metabolic disease and atherosclerosis

scientific article

PPARalpha activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation

scientific article published on 18 December 2003

PPARalpha agonists suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes

scientific article published on 14 March 2007

PPARalpha and PPARgamma dual agonists for the treatment of type 2 diabetes and the metabolic syndrome

scientific article

PPARalpha blocks glucocorticoid receptor alpha-mediated transactivation but cooperates with the activated glucocorticoid receptor alpha for transrepression on NF-kappaB

scholarly article

PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4.

scientific article published in November 2002

PPARalpha regulates the production of serum Vanin-1 by liver

scientific article published on 15 October 2013

PPARalpha, but not PPARgamma, activators decrease macrophage-laden atherosclerotic lesions in a nondiabetic mouse model of mixed dyslipidemia

scientific article published on 30 June 2005

PPARgamma activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes

scientific article published in April 1998

PPARgamma and atherosclerosis

scientific article

PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD.

scientific article

PPARs/RXRs in Cardiovascular Physiology and Disease

scientific article

PPARs: a potential target for a disease-modifying strategy in stroke

scientific article published on June 2013

PPARα activation differently affects microparticle content in atherosclerotic lesions and liver of a mouse model of atherosclerosis and NASH

article

PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

scientific article published on 19 February 2015

PPARα is involved in the multitargeted effects of a pretreatment with atorvastatin in experimental stroke

scientific article published on 23 May 2013

PPARβ in macrophages and atherosclerosis

scientific article published on 20 December 2016

PPARβ/δ activation induces enteroendocrine L cell GLP-1 production

scientific article

PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties

article

PPARδ, but not PPARα, activates PGC-1α gene transcription in muscle

article

Paired biopsy analysis of human liver transcriptome before and 1 year after bariatric surgery identifies a restricted set of inflammation- and extracellular matrix-related genes as pivotal in NASH and fibrosis pathogenesis

article

Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic β-cells

scientific article published on November 2013

Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPARalpha).

scientific article published in April 2005

Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease

scientific article

Paullinia pinnata extracts rich in polyphenols promote vascular relaxation via endothelium-dependent mechanisms

scientific article published on April 2006

Peri-operative acute kidney injury upon cardiac surgery time-of-day

scientific article published on 19 July 2018

Perilipin2/adipophilin and ApoA-1 team up to combat atherosclerosis

Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis

scientific article published on 13 December 2021

Peroxisome Proliferator-Activated Receptor γ Induces the Expression of Tissue Factor Pathway Inhibitor-1 (TFPI-1) in Human Macrophages.

scientific article published on 27 December 2016

Peroxisome Proliferator-Activated Receptors Mediate Pleiotropic Actions of Statins

Peroxisome Proliferator-Activated Receptors at the Crossroads of Obesity, Diabetes, and Cardiovascular Disease

article by Andries J. Gilde et al published November 2006 in Journal of the American College of Cardiology

Peroxisome Proliferator-Activated Receptors-α and -γ, and cAMP-Mediated Pathways, Control Retinol-Binding Protein-4 Gene Expression in Brown Adipose Tissue

article

Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity

scientific article published in Journal of Biological Chemistry

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

scientific article published in Journal of Biological Chemistry

Peroxisome proliferator--activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension

scientific article published in February 2002

Peroxisome proliferator-activated receptor (PPAR) agonists decrease lipoprotein lipase secretion and glycated LDL uptake by human macrophages

scientific article published in February 2002

Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism

scientific journal article

Peroxisome proliferator-activated receptor activators inhibit oxidized low-density lipoprotein-induced endothelin-1 secretion in endothelial cells

scientific article

Peroxisome proliferator-activated receptor alpha (PPARalpha ) turnover by the ubiquitin-proteasome system controls the ligand-induced expression level of its target genes

scientific article

Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice

scientific article

Peroxisome proliferator-activated receptor alpha controls cellular cholesterol trafficking in macrophages

scientific article

Peroxisome proliferator-activated receptor alpha gene variants influence progression of coronary atherosclerosis and risk of coronary artery disease

scientific article published in March 2002

Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets.

scientific article published on June 2006

Peroxisome proliferator-activated receptor alpha in metabolic disease, inflammation, atherosclerosis and aging

scientific article

Peroxisome proliferator-activated receptor alpha induces NADPH oxidase activity in macrophages, leading to the generation of LDL with PPAR-alpha activation properties

scientific article published on 11 November 2004

Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme

scientific article (publication date: 29 August 2003)

Peroxisome proliferator-activated receptor alpha is not rate-limiting for the lipoprotein-lowering action of fish oil.

scientific article

Peroxisome proliferator-activated receptor alpha reduces cholesterol esterification in macrophages

scientific article

Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis

scientific article

Peroxisome proliferator-activated receptor γ activators inhibit interleukin-12 production in murine dendritic cells

article

Peroxisome proliferator-activated receptor γ regulates genes involved in insulin/insulin-like growth factor signaling and lipid metabolism during adipogenesis through functionally distinct enhancer classes.

scientific article published on 27 November 2013

Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis

scientific article

Peroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in mice

scientific article

Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines

scientific article published on 8 August 2001

Peroxisome proliferator-activated receptor-γ activation induces 11β-hydroxysteroid dehydrogenase type 1 activity in human alternative macrophages.

scientific article published on 29 December 2011

Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation

scientific article

Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation

scientific article

Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells

scientific article published on May 2004

Peroxisome proliferator-activated receptors and inflammation: from basic science to clinical applications

scientific article published on 01 December 2003

Peroxisome proliferator-activated receptors in inflammation control

scientific article

Peroxisome proliferator-activated receptors in reproductive tissues: from gametogenesis to parturition

scientific article

Peroxisome proliferator-activated receptors--from active regulators of macrophage biology to pharmacological targets in the treatment of cardiovascular disease

scientific article

Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice

scientific article

Peroxisome proliferator-activated receptors: good and bad

Peroxisome proliferator-activated receptors: new targets for the pharmacological modulation of macrophage gene expression and function ⬇️

scientific article published on October 1, 2003

Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation

scientific article

Peroxisome proliferator-activator receptor-α activator (PPAR-α) dose not inhibit the activation of human hepatic stellate cells by IL-1β

article published in 2003

Peroxisome proliterator-activated receptors, orphans with ligands and functions

Peroxisome-proliferator-activated receptor-alpha activation protects brain capillary endothelial cells from oxygen-glucose deprivation-induced hyperpermeability in the blood-brain barrier.

scientific article

Perspectives on the use of super-enhancers as a defining feature of cell/tissue-identity genes

scientific article published on 12 May 2020

Pharmacological interventions in human HDL metabolism

scientific article published on December 2013

Pharmacology of PPARalpha, PPARgamma and dual PPARalpha/gamma agonists in clinical development

scientific article published in August 2003

Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity

scientific article

Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease

scientific article

Plasma BCAA changes in Patients with NAFLD are Sex Dependent

scientific article published on 09 April 2020

Plasma bile acids are not associated with energy metabolism in humans

scientific article

Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis

scientific article

Potential regulatory role of the farnesoid X receptor in the metabolic syndrome

scientific article

Potential roles of ROR-alpha in cardiovascular endocrinology

scientific article

Pro-inflammatory properties for thiazolidinediones.

scientific article

Profiling serum bile acid glucuronides in humans: gender divergences, genetic determinants, and response to fenofibrate. ⬇️

scientific article published on 12 June 2013

Progesterone inhibits human breast cancer cell growth through transcriptional upregulation of the cyclin-dependent kinase inhibitor p27Kip1 gene

scientific article published on 27 September 2005

Proteasomal degradation of retinoid X receptor alpha reprograms transcriptional activity of PPARgamma in obese mice and humans

scientific article

Prothrombotic factors in histologically proven nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

scientific article

RORgt Inhibition in the Liver Prevents Hepatic Fibrosis Progression, a Proof of Concept Study with a Potent, First in Class, Hepatocentric RORgt Inverse Agonist

Rapid and body weight-independent improvement of endothelial and high-density lipoprotein function after Roux-en-Y gastric bypass: role of glucagon-like peptide-1.

scientific article published on 11 February 2015

Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1.

scientific article

Reduction of atherosclerosis by the peroxisome proliferator-activated receptor alpha agonist fenofibrate in mice

scientific article published on 10 October 2002

Regulation of CLA-1 (CD36 and limp II analogous I) by activators of peroxisome proliferator activated receptors (PPARS)

Regulation of Lipoprotein Metabolism by Thiazolidinediones Occurs through a Distinct but Complementary Mechanism Relative to Fibrates

scientific article published on 01 September 1997

Regulation of apo A-I gene expression by fibrates ⬇️

scientific article published on April 1, 1998

Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha

scientific journal article

Regulation of endothelial nitric oxide synthase by PPAR agonists: molecular and clinical perspectives

scientific article published in April 2004

Regulation of human apoA-I by gemfibrozil and fenofibrate through selective peroxisome proliferator-activated receptor alpha modulation

scientific article published on 23 December 2004

Regulation of lipid and lipoprotein metabolism by PPAR activators

scientific article

Regulation of lipid and lipoprotein metabolism by retinoids

scientific article

Regulation of macrophage functions by PPAR-alpha, PPAR-gamma, and LXRs in mice and men.

scientific article published on 06 March 2008

Regulation of macrophage lipoprotein lipase expression by activators of peroxisome proliferator-activated receptors

Regulation of rat liver apolipoprotein A-I, apolipoprotein A-II and acyl-coenzyme A oxidase gene expression by fibrates and dietary fatty acids

scientific journal article

Regulation of steroidogenesis in NCI-H295 cells: a cellular model of the human fetal adrenal

scientific article published on March 1993

Regulation of steroidogenesis in NCI-H295 cells: a cellular model of the human fetal adrenal

article

Regulation of the scavenger receptor BI and the LDL receptor by activators of aldosterone production, angiotensin II and PMA, in the human NCI-H295R adrenocortical cell line

scientific article published on April 2003

Relationship between Baseline Hepatic Disease Severity and the Cardiometabolic and Anti-Inflammatory Effects of Elafibranor in Patients with Non-Alcoholic Steatohepatitis

Response to the Letter by Finn et al

article

Retinoid X receptors: common heterodimerization partners with distinct functions

scientific article published on 30 July 2010

Retinoid-related orphan receptor gamma regulates several genes that control metabolism in skeletal muscle cells: links to modulation of reactive oxygen species production

scientific article

Retinoids Issued from Hepatic Stellate Cell Lipid Droplet Loss as Potential Signaling Molecules Orchestrating a Multicellular Liver Injury Response

scientific article published on 13 September 2018

Retinoids and nuclear retinoid receptors in white and brown adipose tissues: physiopathologic aspects

scientific article

Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids

scientific article published on August 1998

Retrograde cholesterol transport in the human Caco-2/TC7 cell line: a model to study trans-intestinal cholesterol excretion in atherogenic and diabetic dyslipidemia

scientific article published on 28 October 2016

Rev-erb alpha gives a time cue to metabolism

scientific article published on 24 August 2007

Rev-erb-alpha: an integrator of circadian rhythms and metabolism

scientific article

Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

scientific article

Rev-erb-α regulates atrophy-related genes to control skeletal muscle mass.

scientific article published on 30 October 2017

Rev-erbalpha2 mRNA encodes a stable protein with a potential role in circadian clock regulation

scientific article

Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR heterodimer in the liver

scientific article

Rimonabant, a selective cannabinoid CB1 receptor antagonist, inhibits atherosclerosis in LDL receptor-deficient mice

scientific article

Risperidone-induced metabolic dysfunction is attenuated by Curcuma longa extract administration in mice.

scientific article published on 16 October 2017

Role of bile acids and bile acid receptors in metabolic regulation

scientific article published on January 2009

Role of proinflammatory CD68(+) mannose receptor(-) macrophages in peroxiredoxin-1 expression and in abdominal aortic aneurysms in humans.

scientific article

Role of the PPAR family of nuclear receptors in the regulation of metabolic and cardiovascular homeostasis: new approaches to therapy

scientific article

Role of the nuclear receptor Rev-erb-alpha in the development of atherosclerosis

article

Role of the nuclear receptor Rev-erb-alpha in the development of vascular calcification

article

Role of the peroxisome proliferator-activated receptors (PPAR) in atherosclerosis

scientific article

Roles of PPARs in NAFLD: potential therapeutic targets

scientific article published on 25 October 2011

Rosiglitazone, a peroxisome proliferator-activated receptor-gamma, inhibits the Jun NH(2)-terminal kinase/activating protein 1 pathway and protects the heart from ischemia/reperfusion injury

scientific article published in May 2002

Roux-en-Y gastric bypass increases systemic but not portal bile acid concentrations by decreasing hepatic bile acid uptake in minipigs

Rupture of the atherosclerotic plaque: does a good animal model exist?

scientific article

S 26948: a new specific peroxisome proliferator activated receptor gamma modulator with potent antidiabetes and antiatherogenic effects

scientific article published on 17 August 2007

SREBF2-embedded mir33 links the nuclear bile acid receptor FXR to cholesterol and lipoprotein metabolism

STATINS INCREASE EXPRESSION OF PLA2G7 IN MOUSE PERITONEAL MACROPHAGES

SULF2 strongly prediposes to fasting and postprandial triglycerides in patients with obesity and type 2 diabetes mellitus

scientific article

SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR

scientific article

Safety issues and prospects for future generations of PPAR modulators

scientific article

Saturated Fatty Acids Promote GDF15 Expression in Human Macrophages through the PERK/eIF2/CHOP Signaling Pathway

scientific article published on 08 December 2020

Screening strategy to generate cell specific recombination: a case report with the RIP-Cre mice

scientific article published on 20 June 2015

Selective PPAR modulators, dual and pan PPAR agonists: multimodal drugs for the treatment of type 2 diabetes and atherosclerosis

scientific article published on September 2006

Sex-regulated gene dosage effect of PPARα on synaptic plasticity

article

Short-term activation of liver X receptors inhibits osteoblasts but long-term activation does not have an impact on murine bone in vivo

article

Skeletal muscle functions around the clock

scientific article published on September 2015

Soaping up type 2 diabetes with bile acids?: the link between glucose and bile acid metabolism in humans tightens: quality matters!

scientific article published on December 2013

Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis

scientific article

Sox17 regulates liver lipid metabolism and adaptation to fasting

scientific article

Statin induction of liver fatty acid-binding protein (L-FABP) gene expression is peroxisome proliferator-activated receptor-alpha-dependent

scientific article published on 27 August 2004

Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I

scientific article

Structural and functional changes in HDL with low grade and chronic inflammation

scientific article published on 5 March 2015

Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.

scientific article

Studies towards the conception of new selective PPARβ/δ ligands

scientific article published in 2006

Suppression of Pro-inflammatory Adhesion Molecules by PPAR-δ in Human Vascular Endothelial Cells

scientific article published on 29 November 2007

Synchronized human skeletal myotubes of lean, obese and type 2 diabetic patients maintain circadian oscillation of clock genes

scientific article published on 19 October 2016

Synthesis and evaluation of new polyenic compounds as potential PPARs modulators

Synthesis of benzopyran derivatives as PPARα and/or PPARγ activators

scientific article published on 30 October 2019

Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity

scientific article published on August 2005

Systemic and distal repercussions of liver-specific peroxisome proliferator-activated receptor-alpha control of the acute-phase response

scientific article published on 6 March 2008

TReP-132 controls cell proliferation by regulating the expression of the cyclin-dependent kinase inhibitors p21WAF1/Cip1 and p27Kip1

scientific article

TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone

scientific article

Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction.

scientific article published on 4 April 2017

Tau deletion promotes brain insulin resistance

scientific article

Telomerase activation in atherosclerosis and induction of telomerase reverse transcriptase expression by inflammatory stimuli in macrophages

scientific article published on 24 November 2010

Temporal changes in bile acid levels and 12α-hydroxylation after Roux-en-Y gastric bypass surgery in type 2 diabetes.

scientific article published on 20 January 2015

Th-W60:3 Acute anti-inflammatory properties of statins involve peroxisome proliferator-activated receptor-alpha via inhibition of the PKC signalling pathway

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

scientific article published on 28 July 2015

The Farnesoid X Receptor (FXR) as modulator of bile acid metabolism

scientific article published in December 2004

The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism ⬇️

scientific article

The GLP1R Agonist Liraglutide Reduces Hyperglucagonemia Induced by the SGLT2 Inhibitor Dapagliflozin via Somatostatin Release

scientific article published on 01 August 2019

The Identification of Novel Small Molecule Compounds with Potent Anti-Fibrotic Properties by Phenotypic Screening of Primary Human Stellate Cells

The LPS/D-Galactosamine-Induced Fulminant Hepatitis Model to Assess the Role of Ligand-Activated Nuclear Receptors on the NLRP3 Inflammasome Pathway In Vivo

scientific article published on 01 January 2019

The Nuclear Receptor Rev-erb-α Controls the Development of Vascular Calcification

article

The PPARa-regulated dermatopontin is an important contributor to the liver fibrotic response in mouse models and has relevance to fibrosis progression in non-alcoholic fatty liver disease patients

The PPARalpha activator fenofibrate slows down the progression of the left ventricular dysfunction in porcine tachycardia-induced cardiomyopathy

scientific article published in June 2007

The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation

scientific article published on 25 September 2008

The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ.

scientific article published on 26 October 2017

The RXR Agonist Bexarotene Improves Cholesterol Homeostasis and Inhibits Atherosclerosis Progression in a Mouse Model of Mixed Dyslipidemia

article

The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patient

scientific article

The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in patients with dyslipidemia

scientific article

The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

scientific article

The Sodium-Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model

scientific article published on 4 January 2017

The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene

scientific article published on 11 February 2003

The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression

scientific article

The anti-obesity effect of rimonabant is associated with an improved serum lipid profile

scientific article published in January 2005

The circadian clock and liver function in health and disease

scientific article published on 28 March 2019

The conundrum of the functional relationship between transcription factors and chromatin

scientific article published in 2022

The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor

scientific article

The coronary artery disease-associated gene C6ORF105 is expressed in human macrophages under the transcriptional control of PPARγ

article

The dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 exerts anti-diabetic effects in db/db mice without peroxisome proliferator-activated receptor gamma-associated adverse cardiac effects

scientific article

The effect of sensitisation to insulin with pioglitazone on fasting and postprandial lipid metabolism, lipoprotein modification by lipases, and lipid transfer activities in type 2 diabetic patients.

scientific article published on 21 January 2006

The effects of fibrates and thiazolidinediones on plasma triglyceride metabolism are mediated by distinct peroxisome proliferator activated receptors (PPARs).

scientific article published on February 1997

The effects of probucol on lipoprotein metabolism in the rat

scientific article published on 01 August 1991

The elongation complex components BRD4 and MLLT3/AF9 are transcriptional coactivators of nuclear retinoid receptors

scientific article

The expanding role of the bile acid receptor FXR in the small intestine

scientific article

The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue

scientific article published on July 1996

The farnesoid X receptor induces fetuin-B gene expression in human hepatocytes

scientific article

The farnesoid X receptor induces very low density lipoprotein receptor gene expression

scientific article published on May 2004

The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice

scientific journal article

The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition

scientific article published on 16 May 2005

The farnesoid X receptor regulates adipocyte differentiation and function by promoting peroxisome proliferator-activated receptor-gamma and interfering with the Wnt/beta-catenin pathways.

scientific article

The farnesoid X receptor: a novel drug target?

scientific article

The fibrate-activated PPARalpha/p16INK4A pathway inhibits vascular smooth muscle cell proliferation and vascular occlusion

scientific article

The gene encoding acyl-CoA-binding protein is subject to metabolic regulation by both sterol regulatory element-binding protein and peroxisome proliferator-activated receptor alpha in hepatocytes

scientific article published on 15 December 2004

The gene encoding fibrinogen-beta is a target for retinoic acid receptor-related orphan receptor alpha

scientific article published on 7 June 2005

The glucocorticoid receptor is a co-regulator of the orphan nuclear receptor Nurr1

The hepatic orosomucoid/α1-acid glycoprotein gene cluster is regulated by the nuclear bile acid receptor FXR.

scientific article published on 16 July 2013

The human hepatocyte cell lines IHH and HepaRG: models to study glucose, lipid and lipoprotein metabolism

scientific article published on 18 May 2012

The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

article

The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice.

scientific article

The logic of transcriptional regulator recruitment architecture at cis-regulatory modules controlling liver functions

scientific article published on 11 April 2017

The mitochondrion is the principal target for nutritional and pharmacological control of plasma triglyceride

scientific article published on 01 January 1999

The natural protective mechanism against hyperglycemia in vascular endothelial cells: roles of the lipid peroxidation product 4-hydroxydodecadienal and peroxisome proliferator-activated receptor delta

scientific article

The neuron-derived orphan receptor 1 (NOR1) is induced upon human alternative macrophage polarization and stimulates the expression of markers of the M2 phenotype

scientific article published on 26 April 2015

The novel antibacterial compound walrycin A induces human PXR transcriptional activity

scientific article

The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and atherosclerosis

The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis

The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis

The nuclear orphan receptor Nur77 is a lipotoxicity sensor regulating glucose-induced insulin secretion in pancreatic β-cells

scientific article

The nuclear receptor FXR inhibits Glucagon-Like Peptide-1 secretion in response to microbiota-derived Short-Chain Fatty Acids

scientific article published on 13 January 2020

The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity

scientific journal article

The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages

scientific article

The nuclear receptors Rev-erbs and RORs integrate circadian rhythms and metabolism.

scientific article published on June 2008

The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates

scientific article

The organization, promoter analysis, and expression of the human PPARgamma gene

scientific article (publication date: 25 July 1997)

The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response

scientific article

The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation

scientific article

The orphan nuclear receptor Rev-erbalpha: a transcriptional link between circadian rhythmicity and cardiometabolic disease

scientific article published on April 2007

The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation

scientific article published on July 1996

The protein kinase C signaling pathway regulates a molecular switch between transactivation and transrepression activity of the peroxisome proliferator-activated receptor alpha

scientific article published on 6 May 2004

The role of PPARs in atherosclerosis

scientific article

The role of the orphan nuclear receptor Rev-Erb alpha in adipocyte differentiation and function

scientific article

The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells

scientific article

The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells

scientific article (publication date: 18 October 2002)

The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice

article

The tumour suppressor CDKN2A/p16INK4a regulates adipogenesis and bone marrow-dependent development of perivascular adipose tissue

scientific article

The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct

scientific article

The ubiquitous transcription factor CTCF promotes lineage-specific epigenomic remodeling and establishment of transcriptional networks driving cell differentiation.

scientific article published on January 2015

Therapeutic roles of peroxisome proliferator-activated receptor agonists

scientific article

Therapeutical effects of PPAR agonists assessed by biomarker modulation.

scientific article

Thiazolidinediones and PPARγ agonists: time for a reassessment

scientific article published on 17 April 2012

Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma

scientific article

Time to Check the Clock in Cardiovascular Research and Medicine

Timed physical exercise does not influence circadian rhythms and glucose tolerance in rotating night shift workers: The EuRhythDia study

scientific article published on 01 May 2020

Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients

article by D. Auboeuf et al published 1 August 1997 in Diabetes

Tissue factor pathway inhibitor-2 gene methylation is associated with low expression in carotid atherosclerotic plaques

scientific article published on 19 October 2008

Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis.

scientific article published on 5 February 2009

Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance

scientific article published on 17 April 2017

Topical ivermectin improves allergic skin inflammation.

scientific article published on 4 January 2017

Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human -Cells and Adipose Tissue and Strong Association With Type 2 Diabetes

article

Transcription of the human genes for cytochrome P450scc and P450c17 is regulated differently in human adrenal NCI-H295 cells than in mouse adrenal Y1 cells

scientific article published on February 1997

Transcription profiling in the liver of undernourished male rat offspring reveals altered lipid metabolism pathways and predisposition to hepatic steatosis

scientific article published on 22 October 2019

Transcription, adipocyte differentiation, and obesity

scholarly article by Johan Auwerx et al published July 1996 in Journal of Molecular Medicine

Transcriptional Network Analysis Implicates Altered Hepatic Immune Function in NASH development and resolution

scientific article published on 14 June 2019

Transcriptional activation of apolipoprotein CIII expression by glucose may contribute to diabetic dyslipidemia

scientific journal article

Transcriptional induction of rat liver apolipoprotein A-I gene expression by glucocorticoids requires the glucocorticoid receptor and a labile cell-specific protein

scientific article published on July 1996

Transcriptional regulation of apolipoprotein A-I gene expression by the nuclear receptor RORalpha

scientific article published on September 1997

Transcriptional regulation of apolipoprotein A5 gene expression by the nuclear receptor RORalpha

scientific article

Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha

scientific article

Transcriptional regulation of human Rev-erbalpha gene expression by the orphan nuclear receptor retinoic acid-related orphan receptor alpha

scientific article

Transcriptional regulation of macrophage cholesterol trafficking by PPARalpha and LXR.

scientific article published on December 2006

Transcriptional regulation of macrophage cholesterol trafficking by PPARα and LXR: Figure 1

scientific article published in 2007

Transducin-like enhancer of split-1 is expressed and functional in human macrophages

scientific article published on 30 December 2015

Transient impairment of the adaptive response to fasting in FXR-deficient mice

scientific article

Transient increase in obese gene expression after food intake or insulin administration

scientific article

Two regulatory elements of similar structure and placed in tandem account for the repressive activity of the first intron of the human apolipoprotein A-II gene

scientific article published on September 1996

Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens

scientific article published in Nature

Understanding lipid metabolism through hepatic steat-omics

scientific article published on 01 June 2019

Unlike PPARγ, PPARα or PPARβ/δ activation does not promote human monocyte differentiation toward alternative macrophages

article

Variable effects of different corticosteroids on plasma lipids, apolipoproteins, and hepatic apolipoprotein mRNA levels in rats

scientific journal article

Variation in the PPARα gene is associated with altered function in vitro and plasma lipid concentrations in Type II diabetic subjects

article

Vascular Endothelial Damage in the Pathogenesis of Organ Injury in Severe COVID-19

scholarly article by Annabelle Dupont published in 2021

Vasoactivity, antioxidant and aphrodisiac properties of Caesalpinia benthamiana roots

scientific article published on 21 November 2007

Visfatin is induced by peroxisome proliferator-activated receptor gamma in human macrophages.

scientific article

Von Willebrand Factor As a Biological Sensor of Blood Flow in Percutaneous Cardiac Procedures ⬇️

scholarly article

Von Willebrand Factor Multimers during Transcatheter Aortic-Valve Replacement

scientific article published in July 2016

W02-P-012 The APOE2 knock-in mouse as a model for type III hyperlipidemia and steatohepatitis

W15-IS-001 PPARS as targets for anti-atherosclerotic therapies

W15-IS-002 Role of farnesoid X receptor (FXR) in control of plasma lipid levels

W15-O-003 Atheroprotective effect of the rexinoid targretin in a murine model of atherosclerosis

W15-P-004 PPAR-alpha deficiency aggravates diabetes in OB/OB mice

W15-P-005 Regulation of genes encoding intestinal cholesterol transporters by nuclear receptors in human CACO-2/TC7 enterocytes

article

W40 FXR-DEFICIENCY IMPROVES GLUCOSE AND ENERGY HOMEOSTASIS IN GENETIC OBESITY

We-W43:4 Proprotein convertase subtilisin/kexin type 9 is regulated by insulin, SREBP-1C and PPARalpha

When the Clock stops ticking, metabolic syndrome explodes

scientific article published in January 2006

Which is the eligible patient to be treated with pioglitazone? The expert view

scientific article published in November 2011

[4-(2H-1,2,3-benzotriazol-2-yl)phenoxy]alkanoic acids as agonists of peroxisome proliferator-activated receptors (PPARs).

scientific article published on April 2006

miR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages

scientific article

p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages.

scientific article published on 2 June 2011

von Willebrand Factor as a Biological Sensor of Blood Flow to Monitor Percutaneous Aortic Valve Interventions

article by Eric Van Belle et al published 27 March 2015 in Circulation Research

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