List of works - Pavlína Řezáčová

A novel structurally characterized haloacid dehalogenase superfamily phosphatase from Thermococcus thioreducens with diverse substrate specificity

scientific article published on 30 July 2019

A phenylnorstatine inhibitor binding to HIV-1 protease: geometry, protonation, and subsite-pocket interactions analyzed at atomic resolution.

scientific article published in April 2004

A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation

scientific article

Atomic resolution crystal structure of Sapp2p, a secreted aspartic protease from Candida parapsilosis

scientific article

Backbone resonance assignments of the outer membrane lipoprotein FrpD from Neisseria meningitidis

scientific article published on 09 December 2012

Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms

scientific article

Carborane-based carbonic anhydrase inhibitors

scientific article

Carborane-based carbonic anhydrase inhibitors: insight into CAII/CAIX specificity from a high-resolution crystal structure, modeling, and quantum chemical calculations.

scientific article published on 18 September 2014

Cobalt Bis(dicarbollide) Alkylsulfonamides: Potent and Highly Selective Inhibitors of Tumor Specific Carbonic Anhydrase IX

scientific article published on 28 December 2020

Conformationally constrained nucleoside phosphonic acids--potent inhibitors of human mitochondrial and cytosolic 5'(3')-nucleotidases

scientific article

Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata

scientific article

Crystal structure and putative function of small Toprim domain-containing protein from Bacillus stearothermophilus

scientific article

Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide.

scientific article

Crystal structure of native β-N-acetylhexosaminidase isolated from Aspergillus oryzae sheds light onto its substrate specificity, high stability, and regulation by propeptide

scientific article

Crystal structure of the cold-adapted haloalkane dehalogenase DpcA from Psychrobacter cryohalolentis K5

scientific article published on 24 April 2019

Crystal structures of the effector-binding domain of repressor Central glycolytic gene Regulator fromBacillus subtilisreveal ligand-induced structural changes upon binding of several glycolytic intermediates

scientific article

Crystallization and diffraction analysis of β-N-acetylhexosaminidase from Aspergillus oryzae.

scientific article

Crystallization and preliminary crystallographic characterization of the iron-regulated outer membrane lipoprotein FrpD from Neisseria meningitidis

scientific article published on 28 August 2010

Crystallographic analysis of new psychrophilic haloalkane dehalogenases: DpcA from Psychrobacter cryohalolentis K5 and DmxA from Marinobacter sp. ELB17.

scientific article published on 25 May 2013

Current and Novel Inhibitors of HIV Protease

scientific article

Design of HIV protease inhibitors based on inorganic polyhedral metallacarboranes

scientific article

Engineering enzyme stability and resistance to an organic cosolvent by modification of residues in the access tunnel

scientific article

Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir

scientific article

Feasibility and constraints of particle targeting using the antigen-antibody interaction.

scientific article published on 29 October 2013

Identification of carbonic anhydrase I immunodominant epitopes recognized by specific autoantibodies which indicate an improved prognosis in patients with malignancy after autologous stem cell transplantation.

scientific article published on October 2010

Inhibition of HIV protease by monoclonal antibodies.

scientific article

Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex

article

Kinetic and structural characterization of an alternatively spliced variant of human mitochondrial 5'(3')-deoxyribonucleotidase

scientific article

Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus

scientific article published on 21 June 2018

Kinetic, thermodynamic and structural analysis of tamiphosphor binding to neuraminidase of H1N1 (2009) pandemic influenza

scientific article

Metallacarborane Sulfamides: Unconventional, Specific, and Highly Selective Inhibitors of Carbonic Anhydrase IX

scientific article published on 16 October 2019

Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir

scientific article

Molecular analysis of the HIV-1 resistance development: enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants

scientific article

Molecular mechanism for the action of the anti-CD44 monoclonal antibody MEM-85

scientific article published on 09 June 2015

Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif

scientific article

Mutations in HIV-1 gag and pol Compensate for the Loss of Viral Fitness Caused by a Highly Mutated Protease

scientific article

New techniques for membrane protein crystallization tested on photosystem II core complex of Pisum sativum

scientific article published on 01 December 2006

Ninety-Nine Is Not Enough: Molecular Characterization of Inhibitor-Resistant Human Immunodeficiency Virus Type 1 Protease Mutants with Insertions in the Flap Region

scientific article

Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia.

scientific article

Potent inhibition of drug-resistant HIV protease variants by monoclonal antibodies

article

QM/MM calculations reveal the different nature of the interaction of two carborane-based sulfamide inhibitors of human carbonic anhydrase II.

scientific article

Ranking Power of the SQM/COSMO Scoring Function on Carbonic Anhydrase II-Inhibitor Complexes

scientific article published on 8 January 2018

Regular arrangement of periodates bound to lysozyme

scientific article published on 16 August 2005

Stabilization of antibody structure upon association to a human carbonic anhydrase IX epitope studied by X-ray crystallography, microcalorimetry, and molecular dynamics simulations

scientific article

Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni

scientific article

Structural and functional analysis of a novel haloalkane dehalogenase with two halide-binding sites

scientific article

Structural basis for inhibition of mycobacterial and human adenosine kinase by 7-substituted 7-(Het)aryl-7-deazaadenine ribonucleosides

scientific article

Structural basis of the interaction between the putative adhesion-involved and iron-regulated FrpD and FrpC proteins of Neisseria meningitidis

scientific article published on 13 January 2017

Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases

scientific article (publication date: May 2003)

Structure of the effector-binding domain of deoxyribonucleoside regulator DeoR from Bacillus subtilis

scientific article

Structure of the effector-binding domain of the arabinose repressor AraR from Bacillus subtilis

scientific article

Structure-aided design of novel inhibitors of HIV protease based on a benzodiazepine scaffold.

scientific article

Structures of human cytosolic and mitochondrial nucleotidases: implications for structure-based design of selective inhibitors.

scientific article

Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX

scientific article published on 18 May 2020

The crystal structure of protease Sapp1p from Candida parapsilosis in complex with the HIV protease inhibitor ritonavir

scientific article

The crystal structure of the effector-binding domain of the trehalose repressor TreR from Bacillus subtilis 168 reveals a unique quarternary assembly

scientific article

The crystal structure of the secreted aspartic protease 1 from Candida parapsilosis in complex with pepstatin A

scientific article

The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX

scientific article published on 01 December 2020

Thermodynamic and structural analysis of HIV protease resistance to darunavir - analysis of heavily mutated patient-derived HIV-1 proteases

scientific article

Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor

scientific article published on 9 March 2015

Validation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemia

scientific article

List of works by Pavlína Řezáčová

A novel structurally characterized haloacid dehalogenase superfamily phosphatase from Thermococcus thioreducens with diverse substrate specificity

A phenylnorstatine inhibitor binding to HIV-1 protease: geometry, protonation, and subsite-pocket interactions analyzed at atomic resolution.

A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation

Atomic resolution crystal structure of Sapp2p, a secreted aspartic protease from Candida parapsilosis

Backbone resonance assignments of the outer membrane lipoprotein FrpD from Neisseria meningitidis

Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms

Carborane-based carbonic anhydrase inhibitors

Carborane-based carbonic anhydrase inhibitors: insight into CAII/CAIX specificity from a high-resolution crystal structure, modeling, and quantum chemical calculations.

Cobalt Bis(dicarbollide) Alkylsulfonamides: Potent and Highly Selective Inhibitors of Tumor Specific Carbonic Anhydrase IX

Conformationally constrained nucleoside phosphonic acids--potent inhibitors of human mitochondrial and cytosolic 5'(3')-nucleotidases

Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata

Crystal structure and putative function of small Toprim domain-containing protein from Bacillus stearothermophilus

Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide.

Crystal structure of native β-N-acetylhexosaminidase isolated from Aspergillus oryzae sheds light onto its substrate specificity, high stability, and regulation by propeptide

Crystal structure of the cold-adapted haloalkane dehalogenase DpcA from Psychrobacter cryohalolentis K5

Crystal structures of the effector-binding domain of repressor Central glycolytic gene Regulator fromBacillus subtilisreveal ligand-induced structural changes upon binding of several glycolytic intermediates

Crystallization and diffraction analysis of β-N-acetylhexosaminidase from Aspergillus oryzae.

Crystallization and preliminary crystallographic characterization of the iron-regulated outer membrane lipoprotein FrpD from Neisseria meningitidis

Crystallographic analysis of new psychrophilic haloalkane dehalogenases: DpcA from Psychrobacter cryohalolentis K5 and DmxA from Marinobacter sp. ELB17.

Current and Novel Inhibitors of HIV Protease

Design of HIV protease inhibitors based on inorganic polyhedral metallacarboranes

Engineering enzyme stability and resistance to an organic cosolvent by modification of residues in the access tunnel

Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir

Feasibility and constraints of particle targeting using the antigen-antibody interaction.

Identification of carbonic anhydrase I immunodominant epitopes recognized by specific autoantibodies which indicate an improved prognosis in patients with malignancy after autologous stem cell transplantation.

Inhibition of HIV protease by monoclonal antibodies.

Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex

Kinetic and structural characterization of an alternatively spliced variant of human mitochondrial 5'(3')-deoxyribonucleotidase

Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus

Kinetic, thermodynamic and structural analysis of tamiphosphor binding to neuraminidase of H1N1 (2009) pandemic influenza

Metallacarborane Sulfamides: Unconventional, Specific, and Highly Selective Inhibitors of Carbonic Anhydrase IX

Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir

Molecular analysis of the HIV-1 resistance development: enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants

Molecular mechanism for the action of the anti-CD44 monoclonal antibody MEM-85

Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif

Mutations in HIV-1 gag and pol Compensate for the Loss of Viral Fitness Caused by a Highly Mutated Protease

New techniques for membrane protein crystallization tested on photosystem II core complex of Pisum sativum

Ninety-Nine Is Not Enough: Molecular Characterization of Inhibitor-Resistant Human Immunodeficiency Virus Type 1 Protease Mutants with Insertions in the Flap Region

Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia.

Potent inhibition of drug-resistant HIV protease variants by monoclonal antibodies

QM/MM calculations reveal the different nature of the interaction of two carborane-based sulfamide inhibitors of human carbonic anhydrase II.

Ranking Power of the SQM/COSMO Scoring Function on Carbonic Anhydrase II-Inhibitor Complexes

Regular arrangement of periodates bound to lysozyme

Stabilization of antibody structure upon association to a human carbonic anhydrase IX epitope studied by X-ray crystallography, microcalorimetry, and molecular dynamics simulations

Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni

Structural and functional analysis of a novel haloalkane dehalogenase with two halide-binding sites

Structural basis for inhibition of mycobacterial and human adenosine kinase by 7-substituted 7-(Het)aryl-7-deazaadenine ribonucleosides

Structural basis of the interaction between the putative adhesion-involved and iron-regulated FrpD and FrpC proteins of Neisseria meningitidis

Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases

Structure of the effector-binding domain of deoxyribonucleoside regulator DeoR from Bacillus subtilis

Structure of the effector-binding domain of the arabinose repressor AraR from Bacillus subtilis

Structure-aided design of novel inhibitors of HIV protease based on a benzodiazepine scaffold.

Structures of human cytosolic and mitochondrial nucleotidases: implications for structure-based design of selective inhibitors.

Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX

The crystal structure of protease Sapp1p from Candida parapsilosis in complex with the HIV protease inhibitor ritonavir

The crystal structure of the effector-binding domain of the trehalose repressor TreR from Bacillus subtilis 168 reveals a unique quarternary assembly

The crystal structure of the secreted aspartic protease 1 from Candida parapsilosis in complex with pepstatin A

The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX

Thermodynamic and structural analysis of HIV protease resistance to darunavir - analysis of heavily mutated patient-derived HIV-1 proteases

Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor

Validation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemia