List of works - Gianluca Molla

A biosensor for all D-amino acids using evolved D-amino acid oxidase

scientific article published on 8 June 2008

A thermostable L-aspartate oxidase: a new tool for biotechnological applications

scientific article published on 31 January 2013

Advances in Enzymatic Synthesis of D-Amino Acids

scientific article published on 01 May 2020

Aminoacetone oxidase from Streptococcus oligofermentans belongs to a new three-domain family of bacterial flavoproteins

scientific article

Catalytic and redox properties of glycine oxidase from Bacillus subtilis.

scientific article published on 28 February 2009

Catalytic properties of D-amino acid oxidase in cephalosporin C bioconversion: a comparison between proteins from different sources.

scientific article published in March 2004

Cephalosporin C acylase: dream and(/or) reality.

scientific article published on 16 February 2013

Characterization of human D-amino acid oxidase

scientific article

Characterization of human DAAO variants potentially related to an increased risk of schizophrenia.

scientific article published on 5 December 2012

Characterization of the covalently bound anionic flavin radical in monoamine oxidase a by electron paramagnetic resonance.

scientific article published on 29 November 2007

Cholesterol oxidase from Brevibacterium sterolicum. The relationship between covalent flavinylation and redox properties.

scientific article published on 28 February 2001

Cholesterol oxidase: biotechnological applications

scientific article published on 16 October 2009

Cloning, sequencing and expression in E. coli of a D-amino acid oxidase cDNA from Rhodotorula gracilis active on cephalosporin C.

scientific article published in October 1997

Conversion of the dimeric D-amino acid oxidase from Rhodotorula gracilis to a monomeric form. A rational mutagenesis approach.

scientific article

D-amino acid oxidase inhibitors as a novel class of drugs for schizophrenia therapy.

scientific article

Dissecting the structural determinants of the stability of cholesterol oxidase containing covalently bound flavin

scientific article published on 7 April 2005

Effect of ligand binding on human D-amino acid oxidase: implications for the development of new drugs for schizophrenia treatment

scientific article

Engineering the properties of D-amino acid oxidases by a rational and a directed evolution approach

scientific article published on December 2007

Engineering the substrate specificity of D-amino-acid oxidase.

scientific article published on 20 May 2002

Enzymatic Detection of d-Amino Acids

scientific article published on 26 August 2011

Evolution of an acylase active on cephalosporin C

scientific article published on 31 October 2005

Expression in Escherichia coli and in vitro refolding of the human protein pLG72.

scientific article

Expression in Escherichia coli of the catalytic domain of human proline oxidase.

scientific article

Expression of an evolved engineered variant of a bacterial glycine oxidase leads to glyphosate resistance in alfalfa.

scientific article published on 4 June 2014

FAD binding in glycine oxidase from Bacillus subtilis.

scientific article published on 12 September 2009

Glycine oxidase from Bacillus subtilis: role of histidine 244 and methionine 261.

scientific article published on 8 May 2007

Glyphosate Resistance by Engineering the Flavoenzyme Glycine Oxidase

scientific article

Identification and role of ionizing functional groups at the active center of Rhodotorula gracilis D-amino acid oxidase

scientific article published in November 2001

Investigating the role of active site residues of Rhodotorula gracilis D-amino acid oxidase on its substrate specificity

scientific article published on 27 November 2006

Is rat an appropriate animal model to study the involvement of D-serine catabolism in schizophrenia? Insights from characterization of D-amino acid oxidase

scientific article published on 10 October 2011

Kinetic mechanisms of glycine oxidase from Bacillus subtilis

scientific article published in April 2003

L-amino acid oxidase as biocatalyst: a dream too far?

scientific article

Modulating D-amino acid oxidase substrate specificity: production of an enzyme for analytical determination of all D-amino acids by directed evolution.

scientific article published in June 2004

New biotech applications from evolved D-amino acid oxidases.

scientific article published on 10 March 2011

Novel biosensors based on optimized glycine oxidase.

scientific article published in July 2014

O2 reactivity of flavoproteins: dynamic access of dioxygen to the active site and role of a H+ relay system in D-amino acid oxidase

scientific article

On the mechanism of Rhodotorula gracilis D-amino acid oxidase: role of the active site serine 335.

scientific article published in October 2004

On the oxygen reactivity of flavoprotein oxidases: an oxygen access tunnel and gate in brevibacterium sterolicum cholesterol oxidase.

scientific article published on 9 July 2008

On the reaction of d-amino acid oxidase with dioxygen: O2 diffusion pathways and enhancement of reactivity

scientific article published on 23 December 2010

Optimization of D-amino acid oxidase for low substrate concentrations--towards a cancer enzyme therapy

scientific article

Optimization of glutaryl-7-aminocephalosporanic acid acylase expression in E. coli.

scientific article published on 28 May 2008

Optimization of human D-amino acid oxidase expression in Escherichia coli.

scientific article published on 2 June 2009

Overexpression in Escherichia coli of a recombinant chimeric Rhodotorula gracilis d-amino acid oxidase

scientific article published on 01 November 1998

Overexpression of a bacterial chymotrypsin: application for L-amino acid ester hydrolysis.

scientific article

Overexpression of a recombinant wild-type and His-tagged Bacillus subtilis glycine oxidase in Escherichia coli.

scientific article published in March 2002

Physiological functions of D-amino acid oxidases: from yeast to humans

scientific article

Production of recombinant cholesterol oxidase containing covalently bound FAD in Escherichia coli

scientific article

Properties and applications of microbial D-amino acid oxidases: current state and perspectives

scientific article published on 15 December 2007

Redox potentials and their pH dependence of D-amino-acid oxidase of Rhodotorula gracilis and Trigonopsis variabilis

scientific article published on 01 November 2000

Regulation of D-amino acid oxidase expression in the yeast Rhodotorula gracilis

scientific article published in September 2003

Relevance of the flavin binding to the stability and folding of engineered cholesterol oxidase containing noncovalently bound FAD.

scientific article published on 24 January 2008

Relevance of weak flavin binding in human D-amino acid oxidase

scientific article

Revisitation of the βCl-elimination reaction of D-amino acid oxidase: new interpretation of the reaction that sparked flavoprotein dehydrogenation mechanisms

scientific article

Role of arginine 285 in the active site of Rhodotorula gracilis D-amino acid oxidase. A site-directed mutagenesis study.

scientific article published on August 2000

Strategic manipulation of an industrial biocatalyst--evolution of a cephalosporin C acylase

scientific article published on 22 April 2014

Structural and kinetic analyses of the H121A mutant of cholesterol oxidase

scientific article published on November 2006

Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules

scientific article

Structure of a class III engineered cephalosporin acylase: comparisons with class I acylase and implications for differences in substrate specificity and catalytic activity

scientific article

Structure-function correlation in glycine oxidase from Bacillus subtilis.

scientific article published on 22 April 2004

Structure-function relationships in human D-amino acid oxidase.

scientific article published on 03 August 2012

Structure-function relationships in human d-amino acid oxidase variants corresponding to known SNPs

scientific article

Studies on the reaction mechanism of Rhodotorula gracilis D-amino-acid oxidase. Role of the highly conserved Tyr-223 on substrate binding and catalysis

scientific article published on 01 December 1999

Succinic Semialdehyde Dehydrogenase Deficiency: In Vitro and In Silico Characterization of a Novel Pathogenic Missense Variant and Analysis of the Mutational Spectrum of ALDH5A1

scientific article published on 13 November 2020

The x-ray structure of D-amino acid oxidase at very high resolution identifies the chemical mechanism of flavin-dependent substrate dehydrogenation

scientific article

Tryptophan 243 affects interprotein contacts, cofactor binding and stability in D-amino acid oxidase from Rhodotorula gracilis

scientific article published in February 2006

Yeast D-amino acid oxidase: structural basis of its catalytic properties

scientific article

pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase: effect on schizophrenia susceptibility

scientific article

List of works by Gianluca Molla

A biosensor for all D-amino acids using evolved D-amino acid oxidase

A thermostable L-aspartate oxidase: a new tool for biotechnological applications

Advances in Enzymatic Synthesis of D-Amino Acids

Aminoacetone oxidase from Streptococcus oligofermentans belongs to a new three-domain family of bacterial flavoproteins

Catalytic and redox properties of glycine oxidase from Bacillus subtilis.

Catalytic properties of D-amino acid oxidase in cephalosporin C bioconversion: a comparison between proteins from different sources.

Cephalosporin C acylase: dream and(/or) reality.

Characterization of human D-amino acid oxidase

Characterization of human DAAO variants potentially related to an increased risk of schizophrenia.

Characterization of the covalently bound anionic flavin radical in monoamine oxidase a by electron paramagnetic resonance.

Cholesterol oxidase from Brevibacterium sterolicum. The relationship between covalent flavinylation and redox properties.

Cholesterol oxidase: biotechnological applications

Cloning, sequencing and expression in E. coli of a D-amino acid oxidase cDNA from Rhodotorula gracilis active on cephalosporin C.

Conversion of the dimeric D-amino acid oxidase from Rhodotorula gracilis to a monomeric form. A rational mutagenesis approach.

D-amino acid oxidase inhibitors as a novel class of drugs for schizophrenia therapy.

Dissecting the structural determinants of the stability of cholesterol oxidase containing covalently bound flavin

Effect of ligand binding on human D-amino acid oxidase: implications for the development of new drugs for schizophrenia treatment

Engineering the properties of D-amino acid oxidases by a rational and a directed evolution approach

Engineering the substrate specificity of D-amino-acid oxidase.

Enzymatic Detection of d-Amino Acids

Evolution of an acylase active on cephalosporin C

Expression in Escherichia coli and in vitro refolding of the human protein pLG72.

Expression in Escherichia coli of the catalytic domain of human proline oxidase.

Expression of an evolved engineered variant of a bacterial glycine oxidase leads to glyphosate resistance in alfalfa.

FAD binding in glycine oxidase from Bacillus subtilis.

Glycine oxidase from Bacillus subtilis: role of histidine 244 and methionine 261.

Glyphosate Resistance by Engineering the Flavoenzyme Glycine Oxidase

Identification and role of ionizing functional groups at the active center of Rhodotorula gracilis D-amino acid oxidase

Investigating the role of active site residues of Rhodotorula gracilis D-amino acid oxidase on its substrate specificity

Is rat an appropriate animal model to study the involvement of D-serine catabolism in schizophrenia? Insights from characterization of D-amino acid oxidase

Kinetic mechanisms of glycine oxidase from Bacillus subtilis

L-amino acid oxidase as biocatalyst: a dream too far?

Modulating D-amino acid oxidase substrate specificity: production of an enzyme for analytical determination of all D-amino acids by directed evolution.

New biotech applications from evolved D-amino acid oxidases.

Novel biosensors based on optimized glycine oxidase.

O2 reactivity of flavoproteins: dynamic access of dioxygen to the active site and role of a H+ relay system in D-amino acid oxidase

On the mechanism of Rhodotorula gracilis D-amino acid oxidase: role of the active site serine 335.

On the oxygen reactivity of flavoprotein oxidases: an oxygen access tunnel and gate in brevibacterium sterolicum cholesterol oxidase.

On the reaction of d-amino acid oxidase with dioxygen: O2 diffusion pathways and enhancement of reactivity

Optimization of D-amino acid oxidase for low substrate concentrations--towards a cancer enzyme therapy

Optimization of glutaryl-7-aminocephalosporanic acid acylase expression in E. coli.

Optimization of human D-amino acid oxidase expression in Escherichia coli.

Overexpression in Escherichia coli of a recombinant chimeric Rhodotorula gracilis d-amino acid oxidase

Overexpression of a bacterial chymotrypsin: application for L-amino acid ester hydrolysis.

Overexpression of a recombinant wild-type and His-tagged Bacillus subtilis glycine oxidase in Escherichia coli.

Physiological functions of D-amino acid oxidases: from yeast to humans

Production of recombinant cholesterol oxidase containing covalently bound FAD in Escherichia coli

Properties and applications of microbial D-amino acid oxidases: current state and perspectives

Redox potentials and their pH dependence of D-amino-acid oxidase of Rhodotorula gracilis and Trigonopsis variabilis

Regulation of D-amino acid oxidase expression in the yeast Rhodotorula gracilis

Relevance of the flavin binding to the stability and folding of engineered cholesterol oxidase containing noncovalently bound FAD.

Relevance of weak flavin binding in human D-amino acid oxidase

Revisitation of the βCl-elimination reaction of D-amino acid oxidase: new interpretation of the reaction that sparked flavoprotein dehydrogenation mechanisms

Role of arginine 285 in the active site of Rhodotorula gracilis D-amino acid oxidase. A site-directed mutagenesis study.

Strategic manipulation of an industrial biocatalyst--evolution of a cephalosporin C acylase

Structural and kinetic analyses of the H121A mutant of cholesterol oxidase

Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules

Structure of a class III engineered cephalosporin acylase: comparisons with class I acylase and implications for differences in substrate specificity and catalytic activity

Structure-function correlation in glycine oxidase from Bacillus subtilis.

Structure-function relationships in human D-amino acid oxidase.

Structure-function relationships in human d-amino acid oxidase variants corresponding to known SNPs

Studies on the reaction mechanism of Rhodotorula gracilis D-amino-acid oxidase. Role of the highly conserved Tyr-223 on substrate binding and catalysis

Succinic Semialdehyde Dehydrogenase Deficiency: In Vitro and In Silico Characterization of a Novel Pathogenic Missense Variant and Analysis of the Mutational Spectrum of ALDH5A1

The x-ray structure of D-amino acid oxidase at very high resolution identifies the chemical mechanism of flavin-dependent substrate dehydrogenation

Tryptophan 243 affects interprotein contacts, cofactor binding and stability in D-amino acid oxidase from Rhodotorula gracilis

Yeast D-amino acid oxidase: structural basis of its catalytic properties

pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase: effect on schizophrenia susceptibility