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List of works by Silvia Sacchi

A biosensor for all D-amino acids using evolved D-amino acid oxidase

scientific article published on 8 June 2008

Age-Related Changes in D-Aspartate Oxidase Promoter Methylation Control Extracellular D-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging.

scientific article published on March 2016

Catalytic properties of D-amino acid oxidase in cephalosporin C bioconversion: a comparison between proteins from different sources.

scientific article published in March 2004

Characterization of human D-amino acid oxidase

scientific article

Characterization of human DAAO variants potentially related to an increased risk of schizophrenia.

scientific article published on 5 December 2012

D-Serine metabolism: new insights into the modulation of D-amino acid oxidase activity.

scientific article published on December 2013

D-amino acid oxidase inhibitors as a novel class of drugs for schizophrenia therapy.

scientific article

DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia.

scientific article published on 5 July 2018

Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients

scientific article

Direct chromatographic methods for enantioresolution of amino acids: recent developments

scientific article published on 15 July 2020

Effect of ligand binding on human D-amino acid oxidase: implications for the development of new drugs for schizophrenia treatment

scientific article

Engineering the substrate specificity of D-amino-acid oxidase.

scientific article published on 20 May 2002

Evidence for the interaction of D-amino acid oxidase with pLG72 in a glial cell line

scientific article

Expression in Escherichia coli and in vitro refolding of the human protein pLG72.

scientific article

Glial D-serine gates NMDA receptors at excitatory synapses in prefrontal cortex

scientific article published on 20 June 2011

High-Throughput Screening Strategy Identifies Allosteric, Covalent Human D-Amino Acid Oxidase Inhibitor

scientific article published on 21 August 2015

Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus.

scientific article

Investigating the role of active site residues of Rhodotorula gracilis D-amino acid oxidase on its substrate specificity

scientific article published on 27 November 2006

Is rat an appropriate animal model to study the involvement of D-serine catabolism in schizophrenia? Insights from characterization of D-amino acid oxidase

scientific article published on 10 October 2011

L-serine synthesis via the phosphorylated pathway in humans

scientific article published on 27 June 2020

Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers

scientific article published on 05 April 2019

Metabolism of the neuromodulator D-serine.

scientific article

Modulating D-amino acid oxidase substrate specificity: production of an enzyme for analytical determination of all D-amino acids by directed evolution.

scientific article published in June 2004

On the mechanism of Rhodotorula gracilis D-amino acid oxidase: role of the active site serine 335.

scientific article published in October 2004

Optimization of glutaryl-7-aminocephalosporanic acid acylase expression in E. coli.

scientific article published on 28 May 2008

Physiological functions of D-amino acid oxidases: from yeast to humans

scientific article

Reduced D-serine levels in the nucleus accumbens of cocaine-treated rats hinder the induction of NMDA receptor-dependent synaptic plasticity

scientific article published on 20 March 2013

Relevance of weak flavin binding in human D-amino acid oxidase

scientific article

Structure-function relationships in human D-amino acid oxidase.

scientific article published on 03 August 2012

Structure-function relationships in human d-amino acid oxidase variants corresponding to known SNPs

scientific article

THE FRESHWATER CYANOBACTERIUM PLANKTOTHRIX SP. FP1: MOLECULAR IDENTIFICATION AND DETECTION OF PARALYTIC SHELLFISH POISONING TOXINS

scientific article published on 01 June 2000

The degradation (by distinct pathways) of human D-amino acid oxidase and its interacting partner pLG72--two key proteins in D-serine catabolism in the brain.

scientific article published on 10 December 2013

The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson's disease patients

scientific article published on 20 June 2019

pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase: effect on schizophrenia susceptibility

scientific article

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