List of works - Stephen Neidle

A G-Rich Sequence within the c-kit Oncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamics

scientific article

A G-quadruplex-binding compound shows potent activity in human gemcitabine-resistant pancreatic cancer cells

scientific article published on 22 July 2020

Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives

scientific article (publication date: 2007)

Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation ⬇️

scientific article published on January 28, 2012

Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplex

scientific article

Crystal structure of parallel quadruplexes from human telomeric DNA

scientific article

Crystal structure of the potassium form of an Oxytricha nova G-quadruplex

scientific article

Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library

scientific article

Dynamic self-assembly of DNA minor groove-binding ligand DB921 into nanotubes triggered by an alkali halide.

scientific article

Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA

scientific article

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.

scientific article published on 7 November 2017

G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome

scientific article

Highly prevalent putative quadruplex sequence motifs in human DNA

scientific article

Induced Fit Conformational Changes of a “Reversed Amidine” Heterocycle: Optimized Interactions in a DNA Minor Groove Complex

scientific article

Molecular Basis of Structure–Activity Relationships between Salphen Metal Complexes and Human Telomeric DNA Quadruplexes ⬇️

scientific article published on December 13, 2011

Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel

scientific article

Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X‐ray crystallography ⬇️

scientific article published on February 19, 2013

Quadruplex DNA: sequence, topology and structure

scientific article

Selectivity in ligand recognition of G-quadruplex loops

scientific article

Small-molecule Binding to the DNA Minor Groove Is Mediated by a Conserved Water Cluster ⬇️

scientific article published on January 16, 2013

Solid-phase synthesis of symmetrical 3,6-bispeptide-acridone conjugates

scientific article

Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove

scientific article

Structural Basis for Telomeric G-Quadruplex Targeting by Naphthalene Diimide Ligands ⬇️

scientific article published on January 31, 2012

Structural Basis of Telomeric RNA Quadruplex−Acridine Ligand Recognition ⬇️

scientific article published on February 3, 2011

Structural Insights into the Quadruplex-Duplex 3' Interface Formed from a Telomeric Repeat: A Potential Molecular Target

scientific article

Structural basis for binding of porphyrin to human telomeres

scientific article

Structural basis for the identification of an i-motif tetraplex core with a parallel-duplex junction as a structural motif in CCG triplet repeats

scientific article

Structural basis of DNA quadruplex recognition by an acridine drug

scientific article

Structure of a G-quadruplex-ligand complex

scientific article

Structure of an Unprecedented G-Quadruplex Scaffold in the Human c-kit Promoter

scientific article

Structure of the first parallel DNA quadruplex-drug complex

scientific article (publication date: 9 April 2003)

Structure-Based Design and Evaluation of Naphthalene Diimide G-Quadruplex Ligands As Telomere Targeting Agents in Pancreatic Cancer Cells ⬇️

scientific article published on April 2, 2013

Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form

scientific article

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

scientific article

Targeting multiple effector pathways in pancreatic ductal adenocarcinoma with a G-quadruplex-binding small molecule.

scientific article published on 22 January 2018

Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction

scientific article published on 01 September 2021

The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic–industrial partnership

scientific article

The mechanism of resistance in Escherichia coli to ridinilazole and other antibacterial head-to-head bis-benzimidazole compounds

scientific article published in 2022

Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes

scientific article

List of works by Stephen Neidle

A G-Rich Sequence within the c-kit Oncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamics

A G-quadruplex-binding compound shows potent activity in human gemcitabine-resistant pancreatic cancer cells

Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives

Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation ⬇️

Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplex

Crystal structure of parallel quadruplexes from human telomeric DNA

Crystal structure of the potassium form of an Oxytricha nova G-quadruplex

Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library

Dynamic self-assembly of DNA minor groove-binding ligand DB921 into nanotubes triggered by an alkali halide.

Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.

G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome

Highly prevalent putative quadruplex sequence motifs in human DNA

Induced Fit Conformational Changes of a “Reversed Amidine” Heterocycle: Optimized Interactions in a DNA Minor Groove Complex

Molecular Basis of Structure–Activity Relationships between Salphen Metal Complexes and Human Telomeric DNA Quadruplexes ⬇️

Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel

Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X‐ray crystallography ⬇️

Quadruplex DNA: sequence, topology and structure

Selectivity in ligand recognition of G-quadruplex loops

Small-molecule Binding to the DNA Minor Groove Is Mediated by a Conserved Water Cluster ⬇️

Solid-phase synthesis of symmetrical 3,6-bispeptide-acridone conjugates

Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove

Structural Basis for Telomeric G-Quadruplex Targeting by Naphthalene Diimide Ligands ⬇️

Structural Basis of Telomeric RNA Quadruplex−Acridine Ligand Recognition ⬇️

Structural Insights into the Quadruplex-Duplex 3' Interface Formed from a Telomeric Repeat: A Potential Molecular Target

Structural basis for binding of porphyrin to human telomeres

Structural basis for the identification of an i-motif tetraplex core with a parallel-duplex junction as a structural motif in CCG triplet repeats

Structural basis of DNA quadruplex recognition by an acridine drug

Structure of a G-quadruplex-ligand complex

Structure of an Unprecedented G-Quadruplex Scaffold in the Human c-kit Promoter

Structure of the first parallel DNA quadruplex-drug complex

Structure-Based Design and Evaluation of Naphthalene Diimide G-Quadruplex Ligands As Telomere Targeting Agents in Pancreatic Cancer Cells ⬇️

Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

Targeting multiple effector pathways in pancreatic ductal adenocarcinoma with a G-quadruplex-binding small molecule.

Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction

The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic–industrial partnership

The mechanism of resistance in Escherichia coli to ridinilazole and other antibacterial head-to-head bis-benzimidazole compounds

Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes