List of works - Norbert Sträter

2-Substituted α,β-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes

scientific article published on 28 February 2020

A bicarbonate ion as a general base in the mechanism of peptide hydrolysis by dizinc leucine aminopeptidase

scientific article

A glutamate residue in the catalytic center of the yeast chorismate mutase restricts enzyme activity to acidic conditions

scientific article

A large hinge bending domain rotation is necessary for the catalytic function of Escherichia coli 5'-nucleotidase.

scientific article

A unique serpin P1' glutamate and a conserved β-sheet C arginine are key residues for activity, protease recognition and stability of serpinA12 (vaspin)

scientific article

Active-site mobility revealed by the crystal structure of arylmalonate decarboxylase from Bordetella bronchiseptica

scientific article

Amylose recognition and ring-size determination of amylomaltase

scientific article

Analysis of a rare functional truncating mutation rs61757459 in vaspin (SERPINA12) on circulating vaspin levels

scientific article published on 12 June 2013

Api88 is a novel antibacterial designer peptide to treat systemic infections with multidrug-resistant Gram-negative pathogens

scientific article

Basic Residues of β-Sheet A Contribute to Heparin Binding and Activation of Vaspin (Serpin A12).

scientific article published on 9 December 2016

Cellular function and molecular structure of ecto-nucleotidases.

scientific article

Characterization of the Domain Orientations of E. coli 5'-Nucleotidase by Fitting an Ensemble of Conformers to DEER Distance Distributions

scientific article published on 23 December 2015

Contribution of the two domains of E. coli 5'-nucleotidase to substrate specificity and catalysis.

scientific article published on 17 January 2013

Cosubstrate-induced dynamics of D-3-hydroxybutyrate dehydrogenase from Pseudomonas putida

scientific article

Crystal Structure of Apo- and Metalated Thiolate containing RNase S as Structural Basis for the Design of Artificial Metalloenzymes by Peptide-Protein Complementation

scientific article

Crystal structure and catalytic mechanism of chloromuconolactone dehalogenase ClcF from Rhodococcus opacus 1CP

scientific article

Crystal structure and substrate binding mode of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3)

scientific article published on 18 July 2018

Crystal structure of NTPDase2 in complex with the sulfoanthraquinone inhibitor PSB-071

scientific article

Crystal structure of Thermotoga maritima alpha-glucosidase AglA defines a new clan of NAD+-dependent glycosidases

scientific article (publication date: 23 May 2003)

Crystal structure of a supercharged variant of the human enteropeptidase light chain

scientific article

Crystal structure of cleaved vaspin (serpinA12)

scientific article

Crystal structure of hexokinase KlHxk1 of Kluyveromyces lactis: a molecular basis for understanding the control of yeast hexokinase functions via covalent modification and oligomerization

scientific article

Crystal structure of human platelet phosphofructokinase-1 locked in an activated conformation

scientific article

Crystal structure of the T state of allosteric yeast chorismate mutase and comparison with the R state

scientific article

Crystal structure of the human ecto-5'-nucleotidase (CD73): insights into the regulation of purinergic signaling

scientific article

Crystal structure of the plasmid maintenance system epsilon/zeta: functional mechanism of toxin zeta and inactivation by epsilon 2 zeta 2 complex formation

scientific article

Crystal structures of recombinant human purple Acid phosphatase with and without an inhibitory conformation of the repression loop

scientific article

Crystallization and preliminary X-ray diffraction studies of the epsilonzeta addiction system encoded by Streptococcus pyogenes plasmid pSM19035.

scientific article published on 24 April 2001

Crystallization and preliminary crystallographic analysis of human muscle phosphofructokinase, the main regulator of glycolysis

scientific article

Crystallization and preliminary crystallographic data of purple acid phosphatase from red kidney bean

scientific article published on March 20, 1992

Crystallographic evidence for a domain motion in rat nucleoside triphosphate diphosphohydrolase (NTPDase) 1

scientific article

Crystallographic snapshots along the reaction pathway of nucleoside triphosphate diphosphohydrolases

scientific article

Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors

scientific article published on 05 January 2021

E. coli 5'-nucleotidase undergoes a hinge-bending domain rotation resembling a ball-and-socket motion.

scientific article published on May 2001

Ecto-5'-nucleotidase: Structure function relationships

scientific article

Expression and purification of the ligand-binding domain of peroxisome proliferator-activated receptor alpha (PPARalpha).

scientific article

Fluorine-containing 6,7-dialkoxybiaryl-based inhibitors for phosphodiesterase 10 A: synthesis and in vitro evaluation of inhibitory potency, selectivity, and metabolism

scientific article published on 11 April 2014

Functional linkage of adenine nucleotide binding sites in mammalian muscle 6-phosphofructokinase

scientific article

Glycosylation of human vaspin (SERPINA12) and its impact on serpin activity, heparin binding and thermal stability.

scientific article

Identification of residues important for NAD+ binding by the Thermotoga maritima alpha-glucosidase AglA, a member of glycoside hydrolase family 4.

scientific article

In vivo phosphorylation and in vitro autophosphorylation-inactivation of Kluyveromyces lactis hexokinase KlHxk1

scientific article

Insect-derived proline-rich antimicrobial peptides kill bacteria by inhibiting bacterial protein translation at the 70S ribosome

scientific article published on 12 September 2014

Localization and orientation of heavy-atom cluster compounds in protein crystals using molecular replacement.

scientific article published on 19 January 2013

Mechanism of Fe(III)-Zn(II) purple acid phosphatase based on crystal structures

scientific article

Membrane Phospholipids and Polyphosphates as Cofactors and Binding Molecules of SERPINA12 (vaspin)

scientific article published on 24 April 2020

Molecular architecture and structural basis of allosteric regulation of eukaryotic phosphofructokinases

scientific article

Mono-ADP-ribosylation sites of human CD73 inhibit its adenosine-generating enzymatic activity

publication published on 27 December 2021

New crystal forms of NTPDase1 from the bacterium Legionella pneumophila

scientific article published on 22 February 2013

Posttranslational incorporation of noncanonical amino acids in the RNase S system by semisynthetic protein assembly

scientific article published on 01 January 2014

Proline-rich Antimicrobial Peptides Optimized for Binding to Escherichia coli Chaperone DnaK.

scientific article published on 19 July 2016

RNase T1 variant RV cleaves single-stranded RNA after purines due to specific recognition by the Asn46 side chain amide

scientific article published in March 2004

Rational design of oncocin derivatives with superior protease stabilities and antibacterial activities based on the high-resolution structure of the oncocin-DnaK complex

scientific article

Recombinant expression of a unique chloromuconolactone dehalogenase ClcF from Rhodococcus opacus 1CP and identification of catalytically relevant residues by mutational analysis

scientific article published on 27 July 2012

Regulatory Function of Hexokinase 2 in Glucose Signaling in Saccharomyces cerevisiae.

scientific article published on August 2016

Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid.

scientific article

Structural and functional studies on a thermostable polyethylene terephthalate degrading hydrolase from Thermobifida fusca

scientific article

Structural basis of the stereospecificity of bacterial B12-dependent 2-hydroxyisobutyryl-CoA mutase.

scientific article published on 26 February 2015

Structural identification of DnaK binding sites within bovine and sheep bactenecin Bac7

scientific article

Structural insight into activation mechanism of Toxoplasma gondii nucleoside triphosphate diphosphohydrolases by disulfide reduction

scientific article

Structural insight into signal conversion and inactivation by NTPDase2 in purinergic signaling

scientific article

Structural relationship between the mammalian Fe(III)-Fe(II) and the Fe(III)-Zn(II) plant purple acid phosphatases

scientific article

Structural studies on the forward and reverse binding modes of peptides to the chaperone DnaK

scientific article

Structure and allosteric regulation of eukaryotic 6-phosphofructokinases.

scientific article published on August 2013

Structure and function of the abasic site specificity pocket of an AP endonuclease from Archaeoglobus fulgidus

scientific article

Structure of DNA helicase RepA in complex with sulfate at 1.95 A resolution implicates structural changes to an "open" form

scientific article (publication date: May 2003)

Structures of Legionella pneumophila NTPDase1 in complex with polyoxometallates

scientific article

Surface supercharged human enteropeptidase light chain shows improved solubility and refolding yield.

scientific article published on 16 November 2010

The ATP/ADP substrate specificity switch between Toxoplasma gondii NTPDase1 and NTPDase3 is caused by an altered mode of binding of the substrate base

scientific article

The X-ray Crystal Structure of Human β-Hexosaminidase B Provides New Insights into Sandhoff Disease ⬇️

scientific article (publication date: 2 May 2003)

The crystal structure of Toxoplasma gondii nucleoside triphosphate diphosphohydrolase 1 represents a conformational intermediate in the reductive activation mechanism of the tetrameric enzyme

scientific article

Two-metal ion mechanism of bovine lens leucine aminopeptidase: active site solvent structure and binding mode of L-leucinal, a gem-diolate transition state analogue, by X-ray crystallography

scientific article

Understanding the Structural Basis of Adhesion GPCR Functions.

scientific article published on January 2016

Vaspin inhibits kallikrein 7 by serpin mechanism

scientific article

α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors.

scientific article

List of works by Norbert Sträter

2-Substituted α,β-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes

A bicarbonate ion as a general base in the mechanism of peptide hydrolysis by dizinc leucine aminopeptidase

A glutamate residue in the catalytic center of the yeast chorismate mutase restricts enzyme activity to acidic conditions

A large hinge bending domain rotation is necessary for the catalytic function of Escherichia coli 5'-nucleotidase.

A unique serpin P1' glutamate and a conserved β-sheet C arginine are key residues for activity, protease recognition and stability of serpinA12 (vaspin)

Active-site mobility revealed by the crystal structure of arylmalonate decarboxylase from Bordetella bronchiseptica

Amylose recognition and ring-size determination of amylomaltase

Analysis of a rare functional truncating mutation rs61757459 in vaspin (SERPINA12) on circulating vaspin levels

Api88 is a novel antibacterial designer peptide to treat systemic infections with multidrug-resistant Gram-negative pathogens

Basic Residues of β-Sheet A Contribute to Heparin Binding and Activation of Vaspin (Serpin A12).

Cellular function and molecular structure of ecto-nucleotidases.

Characterization of the Domain Orientations of E. coli 5'-Nucleotidase by Fitting an Ensemble of Conformers to DEER Distance Distributions

Contribution of the two domains of E. coli 5'-nucleotidase to substrate specificity and catalysis.

Cosubstrate-induced dynamics of D-3-hydroxybutyrate dehydrogenase from Pseudomonas putida

Crystal Structure of Apo- and Metalated Thiolate containing RNase S as Structural Basis for the Design of Artificial Metalloenzymes by Peptide-Protein Complementation

Crystal structure and catalytic mechanism of chloromuconolactone dehalogenase ClcF from Rhodococcus opacus 1CP

Crystal structure and substrate binding mode of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3)

Crystal structure of NTPDase2 in complex with the sulfoanthraquinone inhibitor PSB-071

Crystal structure of Thermotoga maritima alpha-glucosidase AglA defines a new clan of NAD+-dependent glycosidases

Crystal structure of a supercharged variant of the human enteropeptidase light chain

Crystal structure of cleaved vaspin (serpinA12)

Crystal structure of hexokinase KlHxk1 of Kluyveromyces lactis: a molecular basis for understanding the control of yeast hexokinase functions via covalent modification and oligomerization

Crystal structure of human platelet phosphofructokinase-1 locked in an activated conformation

Crystal structure of the T state of allosteric yeast chorismate mutase and comparison with the R state

Crystal structure of the human ecto-5'-nucleotidase (CD73): insights into the regulation of purinergic signaling

Crystal structure of the plasmid maintenance system epsilon/zeta: functional mechanism of toxin zeta and inactivation by epsilon 2 zeta 2 complex formation

Crystal structures of recombinant human purple Acid phosphatase with and without an inhibitory conformation of the repression loop

Crystallization and preliminary X-ray diffraction studies of the epsilonzeta addiction system encoded by Streptococcus pyogenes plasmid pSM19035.

Crystallization and preliminary crystallographic analysis of human muscle phosphofructokinase, the main regulator of glycolysis

Crystallization and preliminary crystallographic data of purple acid phosphatase from red kidney bean

Crystallographic evidence for a domain motion in rat nucleoside triphosphate diphosphohydrolase (NTPDase) 1

Crystallographic snapshots along the reaction pathway of nucleoside triphosphate diphosphohydrolases

Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors

E. coli 5'-nucleotidase undergoes a hinge-bending domain rotation resembling a ball-and-socket motion.

Ecto-5'-nucleotidase: Structure function relationships

Expression and purification of the ligand-binding domain of peroxisome proliferator-activated receptor alpha (PPARalpha).

Fluorine-containing 6,7-dialkoxybiaryl-based inhibitors for phosphodiesterase 10 A: synthesis and in vitro evaluation of inhibitory potency, selectivity, and metabolism

Functional linkage of adenine nucleotide binding sites in mammalian muscle 6-phosphofructokinase

Glycosylation of human vaspin (SERPINA12) and its impact on serpin activity, heparin binding and thermal stability.

Identification of residues important for NAD+ binding by the Thermotoga maritima alpha-glucosidase AglA, a member of glycoside hydrolase family 4.

In vivo phosphorylation and in vitro autophosphorylation-inactivation of Kluyveromyces lactis hexokinase KlHxk1

Insect-derived proline-rich antimicrobial peptides kill bacteria by inhibiting bacterial protein translation at the 70S ribosome

Localization and orientation of heavy-atom cluster compounds in protein crystals using molecular replacement.

Mechanism of Fe(III)-Zn(II) purple acid phosphatase based on crystal structures

Membrane Phospholipids and Polyphosphates as Cofactors and Binding Molecules of SERPINA12 (vaspin)

Molecular architecture and structural basis of allosteric regulation of eukaryotic phosphofructokinases

Mono-ADP-ribosylation sites of human CD73 inhibit its adenosine-generating enzymatic activity

New crystal forms of NTPDase1 from the bacterium Legionella pneumophila

Posttranslational incorporation of noncanonical amino acids in the RNase S system by semisynthetic protein assembly

Proline-rich Antimicrobial Peptides Optimized for Binding to Escherichia coli Chaperone DnaK.

RNase T1 variant RV cleaves single-stranded RNA after purines due to specific recognition by the Asn46 side chain amide

Rational design of oncocin derivatives with superior protease stabilities and antibacterial activities based on the high-resolution structure of the oncocin-DnaK complex

Recombinant expression of a unique chloromuconolactone dehalogenase ClcF from Rhodococcus opacus 1CP and identification of catalytically relevant residues by mutational analysis

Regulatory Function of Hexokinase 2 in Glucose Signaling in Saccharomyces cerevisiae.

Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid.

Structural and functional studies on a thermostable polyethylene terephthalate degrading hydrolase from Thermobifida fusca

Structural basis of the stereospecificity of bacterial B12-dependent 2-hydroxyisobutyryl-CoA mutase.

Structural identification of DnaK binding sites within bovine and sheep bactenecin Bac7

Structural insight into activation mechanism of Toxoplasma gondii nucleoside triphosphate diphosphohydrolases by disulfide reduction

Structural insight into signal conversion and inactivation by NTPDase2 in purinergic signaling

Structural relationship between the mammalian Fe(III)-Fe(II) and the Fe(III)-Zn(II) plant purple acid phosphatases

Structural studies on the forward and reverse binding modes of peptides to the chaperone DnaK

Structure and allosteric regulation of eukaryotic 6-phosphofructokinases.

Structure and function of the abasic site specificity pocket of an AP endonuclease from Archaeoglobus fulgidus

Structure of DNA helicase RepA in complex with sulfate at 1.95 A resolution implicates structural changes to an "open" form

Structures of Legionella pneumophila NTPDase1 in complex with polyoxometallates

Surface supercharged human enteropeptidase light chain shows improved solubility and refolding yield.

The ATP/ADP substrate specificity switch between Toxoplasma gondii NTPDase1 and NTPDase3 is caused by an altered mode of binding of the substrate base

The X-ray Crystal Structure of Human β-Hexosaminidase B Provides New Insights into Sandhoff Disease ⬇️

The crystal structure of Toxoplasma gondii nucleoside triphosphate diphosphohydrolase 1 represents a conformational intermediate in the reductive activation mechanism of the tetrameric enzyme

Two-metal ion mechanism of bovine lens leucine aminopeptidase: active site solvent structure and binding mode of L-leucinal, a gem-diolate transition state analogue, by X-ray crystallography

Understanding the Structural Basis of Adhesion GPCR Functions.

Vaspin inhibits kallikrein 7 by serpin mechanism

α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors.