List of works - George Minasov

1.80 Angstrom Resolution Crystal Structure of NSP16 - NSP10 Complex from SARS-CoV-2

scholarly article by George Minasov published in 2020

2'-O methylation of RNA cap in SARS-CoV-2 captured by serial crystallography

scholarly article by Mateusz Wilamowski et al published 25 May 2021 in Proceedings of the National Academy of Sciences of the United States of America

2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects

scientific article (publication date: 12 June 2003)

2′-O-[2-[2-(N,N-Dimethylamino)ethoxy]ethyl] Modified Oligonucleotides: Symbiosis of Charge Interaction Factors and Stereoelectronic Effects

A Conserved Surface Loop in Type I Dehydroquinate Dehydratases Positions an Active Site Arginine and Functions in Substrate Binding

scientific article

A “Hydrat-Ion” Spine in a B-DNA Minor Groove

scientific article published in 1999

Abstract 4751: Structure and inhibition of mitogen-activated protein kinase kinase 4 (MEK4): A prostate cancer pro-invasion protein

Adherence to Bürgi–Dunitz stereochemical principles requires significant structural rearrangements in Schiff-base formation: insights from transaldolase complexes

scientific article

An Unusual Cation-Binding Site and Distinct Domain-Domain Interactions Distinguish Class II Enolpyruvylshikimate-3-phosphate Synthases

scientific article published on 26 January 2016

An efficient and possibly general packing mode for crystals of B-DNA oligonucleotides

An ultrahigh resolution structure of TEM-1 beta-lactamase suggests a role for Glu166 as the general base in acylation

scientific article

Atomic-resolution crystal structures of B-DNA reveal specific influences of divalent metal ions on conformation and packing

scientific article

Automating crystallographic structure determination calculations

Characterization of Fibrinogen Binding by Glycoproteins Srr1 and Srr2 of Streptococcus agalactiae

scientific article

Characterization of the Deoxynucleotide Triphosphate Triphosphohydrolase (dNTPase) Activity of the EF1143 Protein from Enterococcus faecalis and Crystal Structure of the Activator-Substrate Complex

scientific article

Correction to Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2′-O-Ribonucleic Acid Modifications

scholarly article published in Biochemistry

Crystal Structure of Homo-DNA and Nature's Choice of Pentose over Hexose in the Genetic System

scientific article published on 01 August 2006

Crystal Structures of YkuI and Its Complex with Second Messenger Cyclic Di-GMP Suggest Catalytic Mechanism of Phosphodiester Bond Cleavage by EAL Domains

scientific article

Crystal Structures of the SpoIID Lytic Transglycosylases Essential for Bacterial Sporulation

scientific article

Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA

scientific article

Crystal structure of an RNA duplex containing phenyl-ribonucleotides, hydrophobic isosteres of the natural pyrimidines

scientific article

Crystal structure of anapoform ofShigella flexneriArsH protein with an NADPH-dependent FMN reductase activity

scientific article

Crystal structure of the novel PaiA N-acetyltransferase from Thermoplasma acidophilum involved in the negative control of sporulation and degradative enzyme production

scientific article

Crystal structures of the components of the Staphylococcus aureus leukotoxin ED.

scientific article published on January 2016

Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments

scientific article

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

scientific article

Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs

scientific article

Functional implications from crystal structures of the conserved Bacillus subtilis protein Maf with and without dUTP

scientific article

High-resolution structures of the SARS-CoV-2 2'-O-methyltransferase reveal strategies for structure-based inhibitor design

scientific article published on 29 September 2020

Identification of novel small molecule inhibitors against NS2B/NS3 serine protease from Zika virus

scientific article (publication date: March 2017)

Independent Movement, Dimerization and Stability of Tandem Repeats of Chicken Brain α-Spectrin

scholarly article by Hideki Kusunoki published in November 2004

Insights into the Mechanism of Type I Dehydroquinate Dehydratases from Structures of Reaction Intermediates

scientific article

Large Scale Structural Rearrangement of a Serine Hydrolase from Francisella tularensis Facilitates Catalysis

scientific article

Mechanisms of Allosteric Activation and Inhibition of the Deoxyribonucleoside Triphosphate Triphosphohydrolase from Enterococcus faecalis

scientific article

Metal ions and flexibility in a viral RNA pseudoknot at atomic resolution

scientific article

Noncovalent interaction energies in covalent complexes: TEM-1 ?-lactamase and ?-lactams

scholarly article by Xiaojun Wang published in February 2002

Noncovalent interaction energies in covalent complexes: TEM-1 beta-lactamase and beta-lactams

scientific article

Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications

scientific article

Recognition and resistance in TEM beta-lactamase

scientific article

Structural analysis of GNAT acetyltransferases and protein acetylation

Structural analysis of a 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase with an N-terminal chorismate mutase-like regulatory domain

scientific article

Structural and Molecular Mechanism for Autoprocessing of MARTX Toxin of Vibrio cholerae at Multiple Sites

scientific article

Structural and functional analysis of betaine aldehyde dehydrogenase from Staphylococcus aureus

scientific article published on 25 April 2015

Structural aspects for evolution of beta-lactamases from penicillin-binding proteins

scientific article

Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh

scientific article

Structural basis of cleavage by RNase H of hybrids of arabinonucleic acids and RNA

scientific article

Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria

scientific article

Structural characterization of a hypothetical protein: a potential agent involved in trimethylamine metabolism in Catenulispora acidiphila

scientific article

Structural comparison of p-hydroxybenzoate hydroxylase (PobA) from Pseudomonas putida with PobA from other Pseudomonas spp. and other monooxygenases

scientific article published on 02 July 2019

Structural origins of the exonuclease resistance of a zwitterionic RNA

scientific article

Structural, kinetic and proteomic characterization of acetyl phosphate-dependent bacterial protein acetylation

scientific article

Structure and Function of the Ribosomal Frameshifting Pseudoknot RNA from Beet Western Yellow Virus

scholarly article by Martin Egli et al published May 2003 in Helvetica Chimica Acta

Structure and protective efficacy of the Staphylococcus aureus autocleaving protease EpiP.

scientific article published on 13 January 2014

Structure determination, refinement, and validation

scientific article published on January 2014

Structure of the Bacillus anthracis dTDP-L-rhamnose-biosynthetic enzyme dTDP-4-dehydrorhamnose 3,5-epimerase (RfbC).

scientific article published on 10 November 2017

Structure of the Bacillus anthracis dTDP-L-rhamnose-biosynthetic enzyme dTDP-4-dehydrorhamnose reductase (RfbD).

scientific article published on 6 November 2017

Structure of the Bacillus anthracis dTDP-L-rhamnose-biosynthetic enzyme glucose-1-phosphate thymidylyltransferase (RfbA).

scientific article published on 30 October 2017

Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis

scientific article published on July 2016

Structure of the LdcB LD-Carboxypeptidase Reveals the Molecular Basis of Peptidoglycan Recognition

scientific article

Structure of the Type III Secretion Effector Protein ExoU in Complex with Its Chaperone SpcU

scientific article

Structures of the surface exposed proteins of Gram positive bacteria

Studies of a chemically modified oligodeoxynucleotide containing a 5-atom amide backbone which exhibits improved binding to RNA.

scientific article published on April 2001

Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models.

scientific article

The 2.2 Å resolution crystal structure ofBacillus cereusNif3-family protein YqfO reveals a conserved dimetal-binding motif and a regulatory domain

scientific article

The Dickerson-Drew B-DNA Dodecamer Revisited at Atomic Resolution

scientific article published in 1999

The Dickerson-Drew B-DNA Dodecamer Revisited at Atomic ResolutionJ. Am. Chem. Soc.1999,121, 470−471].A “Hydrat-Ion” Spine in a B-DNA Minor Groove[J. Am. Chem. Soc.1999,121, 3590−3595

scientific article published in 1999

The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling

article

The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine

scientific article published on 20 April 2020

The deacylation mechanism of AmpC beta-lactamase at ultrahigh resolution

scientific article

The structural bases of antibiotic resistance in the clinically derived mutant beta-lactamases TEM-30, TEM-32, and TEM-34

scientific article

The structure of bradyzoite-specific enolase from Toxoplasma gondii reveals insights into its dual cytoplasmic and nuclear functions

scientific article

Thermodynamic cycle analysis and inhibitor design against beta-lactamase

scientific article

Trying to deduce function from structural variability and conservation

When structures of unknown proteins are determined, what is next?

X-ray crystal structure of a locked nucleic acid (LNA) duplex composed of a palindromic 10-mer DNA strand containing one LNA thymine monomer

X-ray crystallographic analysis of the hydration of A- and B-form DNA at atomic resolution

scientific article

List of works by George Minasov

1.80 Angstrom Resolution Crystal Structure of NSP16 - NSP10 Complex from SARS-CoV-2

2'-O methylation of RNA cap in SARS-CoV-2 captured by serial crystallography

2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects

2′-O-[2-[2-(N,N-Dimethylamino)ethoxy]ethyl] Modified Oligonucleotides: Symbiosis of Charge Interaction Factors and Stereoelectronic Effects

A Conserved Surface Loop in Type I Dehydroquinate Dehydratases Positions an Active Site Arginine and Functions in Substrate Binding

A “Hydrat-Ion” Spine in a B-DNA Minor Groove

Abstract 4751: Structure and inhibition of mitogen-activated protein kinase kinase 4 (MEK4): A prostate cancer pro-invasion protein

Adherence to Bürgi–Dunitz stereochemical principles requires significant structural rearrangements in Schiff-base formation: insights from transaldolase complexes

An Unusual Cation-Binding Site and Distinct Domain-Domain Interactions Distinguish Class II Enolpyruvylshikimate-3-phosphate Synthases

An efficient and possibly general packing mode for crystals of B-DNA oligonucleotides

An ultrahigh resolution structure of TEM-1 beta-lactamase suggests a role for Glu166 as the general base in acylation

Atomic-resolution crystal structures of B-DNA reveal specific influences of divalent metal ions on conformation and packing

Automating crystallographic structure determination calculations

Characterization of Fibrinogen Binding by Glycoproteins Srr1 and Srr2 of Streptococcus agalactiae

Characterization of the Deoxynucleotide Triphosphate Triphosphohydrolase (dNTPase) Activity of the EF1143 Protein from Enterococcus faecalis and Crystal Structure of the Activator-Substrate Complex

Correction to Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2′-O-Ribonucleic Acid Modifications

Crystal Structure of Homo-DNA and Nature's Choice of Pentose over Hexose in the Genetic System

Crystal Structures of YkuI and Its Complex with Second Messenger Cyclic Di-GMP Suggest Catalytic Mechanism of Phosphodiester Bond Cleavage by EAL Domains

Crystal Structures of the SpoIID Lytic Transglycosylases Essential for Bacterial Sporulation

Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA

Crystal structure of an RNA duplex containing phenyl-ribonucleotides, hydrophobic isosteres of the natural pyrimidines

Crystal structure of anapoform ofShigella flexneriArsH protein with an NADPH-dependent FMN reductase activity

Crystal structure of the novel PaiA N-acetyltransferase from Thermoplasma acidophilum involved in the negative control of sporulation and degradative enzyme production

Crystal structures of the components of the Staphylococcus aureus leukotoxin ED.

Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs

Functional implications from crystal structures of the conserved Bacillus subtilis protein Maf with and without dUTP

High-resolution structures of the SARS-CoV-2 2'-O-methyltransferase reveal strategies for structure-based inhibitor design

Identification of novel small molecule inhibitors against NS2B/NS3 serine protease from Zika virus

Independent Movement, Dimerization and Stability of Tandem Repeats of Chicken Brain α-Spectrin

Insights into the Mechanism of Type I Dehydroquinate Dehydratases from Structures of Reaction Intermediates

Large Scale Structural Rearrangement of a Serine Hydrolase from Francisella tularensis Facilitates Catalysis

Mechanisms of Allosteric Activation and Inhibition of the Deoxyribonucleoside Triphosphate Triphosphohydrolase from Enterococcus faecalis

Metal ions and flexibility in a viral RNA pseudoknot at atomic resolution

Noncovalent interaction energies in covalent complexes: TEM-1 ?-lactamase and ?-lactams

Noncovalent interaction energies in covalent complexes: TEM-1 beta-lactamase and beta-lactams

Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications

Recognition and resistance in TEM beta-lactamase

Structural analysis of GNAT acetyltransferases and protein acetylation

Structural analysis of a 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase with an N-terminal chorismate mutase-like regulatory domain

Structural and Molecular Mechanism for Autoprocessing of MARTX Toxin of Vibrio cholerae at Multiple Sites

Structural and functional analysis of betaine aldehyde dehydrogenase from Staphylococcus aureus

Structural aspects for evolution of beta-lactamases from penicillin-binding proteins

Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh

Structural basis of cleavage by RNase H of hybrids of arabinonucleic acids and RNA

Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria

Structural characterization of a hypothetical protein: a potential agent involved in trimethylamine metabolism in Catenulispora acidiphila

Structural comparison of p-hydroxybenzoate hydroxylase (PobA) from Pseudomonas putida with PobA from other Pseudomonas spp. and other monooxygenases

Structural origins of the exonuclease resistance of a zwitterionic RNA

Structural, kinetic and proteomic characterization of acetyl phosphate-dependent bacterial protein acetylation

Structure and Function of the Ribosomal Frameshifting Pseudoknot RNA from Beet Western Yellow Virus

Structure and protective efficacy of the Staphylococcus aureus autocleaving protease EpiP.

Structure determination, refinement, and validation

Structure of the Bacillus anthracis dTDP-L-rhamnose-biosynthetic enzyme dTDP-4-dehydrorhamnose 3,5-epimerase (RfbC).

Structure of the Bacillus anthracis dTDP-L-rhamnose-biosynthetic enzyme dTDP-4-dehydrorhamnose reductase (RfbD).

Structure of the Bacillus anthracis dTDP-L-rhamnose-biosynthetic enzyme glucose-1-phosphate thymidylyltransferase (RfbA).

Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis

Structure of the LdcB LD-Carboxypeptidase Reveals the Molecular Basis of Peptidoglycan Recognition

Structure of the Type III Secretion Effector Protein ExoU in Complex with Its Chaperone SpcU

Structures of the surface exposed proteins of Gram positive bacteria

Studies of a chemically modified oligodeoxynucleotide containing a 5-atom amide backbone which exhibits improved binding to RNA.

Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models.

The 2.2 Å resolution crystal structure ofBacillus cereusNif3-family protein YqfO reveals a conserved dimetal-binding motif and a regulatory domain

The Dickerson-Drew B-DNA Dodecamer Revisited at Atomic Resolution

The Dickerson-Drew B-DNA Dodecamer Revisited at Atomic ResolutionJ. Am. Chem. Soc.1999,121, 470−471].A “Hydrat-Ion” Spine in a B-DNA Minor Groove[J. Am. Chem. Soc.1999,121, 3590−3595

The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling

The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine

The deacylation mechanism of AmpC beta-lactamase at ultrahigh resolution

The structural bases of antibiotic resistance in the clinically derived mutant beta-lactamases TEM-30, TEM-32, and TEM-34

The structure of bradyzoite-specific enolase from Toxoplasma gondii reveals insights into its dual cytoplasmic and nuclear functions

Thermodynamic cycle analysis and inhibitor design against beta-lactamase

Trying to deduce function from structural variability and conservation

When structures of unknown proteins are determined, what is next?

X-ray crystal structure of a locked nucleic acid (LNA) duplex composed of a palindromic 10-mer DNA strand containing one LNA thymine monomer

X-ray crystallographic analysis of the hydration of A- and B-form DNA at atomic resolution