List of works by Michele Pagano

A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis.

scientific article published on 19 November 2012

A peptidomimetic siRNA transfection reagent for highly effective gene silencing.

scientific article published on 17 May 2006

A randomized trial of vaginal prostaglandin E(2) gel and dinoprostone vaginal insert for induction of labor at term

scientific article published on 01 July 1998

AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity

scientific article published on 14 April 2021

APC/C (Cdh1) controls the proteasome-mediated degradation of E2F3 during cell cycle exit

scientific article

APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase

scientific article published on August 2007

APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation.

scientific article published on 11 January 2009

APC/CCdh1 is required for the termination of chromosomal passenger complex activity upon mitotic exit

scientific article published on 15 September 2020

APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.

scientific article

Activation of protein kinase C triggers its ubiquitination and degradation

scientific article

Altered expression of p27 and Skp2 proteins in prostate cancer of African-American patients.

scientific article

American Idol and NIH Grant Review

scientific article published on 01 August 2006

Association of cdk2 Kinase with the Transcription Factor E2F During S Phase ⬇️

scientific article published on February 28, 1992

Beware the baited hook of publicity

scientific article published on 01 December 2001

Binding of the human E2F transcription factor to the retinoblastoma protein but not to cyclin A is abolished in HPV-16-immortalized cells

scientific article published on September 1, 1992

CRL4<sup>AMBRA1</sup> is a master regulator of D-type cyclins

scientific article published on 14 April 2021

Cdh1, a substrate-recruiting component of anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin

scientific article

Cdh1: a master G0/G1 regulator.

scientific article published on July 2008

Cdk1: the dominant sibling of Cdk2

scientific article published on 01 August 2005

Cell Division, a new open access online forum for and from the cell cycle community

scientific article

Cell cycle and cancer: critical events at the G1 restriction point.

scientific article published on January 1996

Clinical relevance of SKP2 alterations in metastatic melanoma

scientific article

Constitutive phosphorylation of aurora-a on ser51 induces its stabilization and consequent overexpression in cancer

scientific article

Control of cell growth by the SCF and APC/C ubiquitin ligases

scientific article

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis

scientific article

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

scientific article (publication date: June 2003)

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase

scientific article (publication date: 11 March 2004)

Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress

scientific article published on 05 June 2012

Critical role for IL-1β in DNA damage-induced mucositis.

scientific article published on 27 January 2014

Cyclin A is required at two points in the human cell cycle

scientific article

Cyclin A, cell cycle control and oncogenesis ⬇️

scientific article published on January 1, 1991

Cyclin D1 is a nuclear protein required for cell cycle progression in G1

scientific article

Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts.

scientific article published on July 1994

Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs

scientific article published on 23 May 2019

Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2

scientific article published on 24 September 2016

Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair

scientific article

DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation

scientific article

DRE-1: an evolutionarily conserved F box protein that regulates C. elegans developmental age.

scientific article published in March 2007

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

scientific article (publication date: 6 November 2003)

Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.

scientific article published on 15 December 2014

Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth.

scientific article published on 28 June 2006

Degradation of cyclin A is regulated by acetylation.

scientific article published on June 2009

Deregulated degradation of the cdk inhibitor p27 and malignant transformation.

scientific article

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

scientific article

Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4.

scientific article published on November 1994

Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression.

scientific article published on September 1994

Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation

scientific article published on 07 January 2021

Dissecting the role of ubiquitylation in the DNA damage response checkpoint in G2.

scientific article published on January 2010

Don't run biomedical science as a business.

scientific article published in July 2017

Don't skip the G1 phase: how APC/CCdh1 keeps SCFSKP2 in check.

scientific article published on 14 July 2004

Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases

scientific article published on September 1998

Dual mode of degradation of Cdc25 A phosphatase

scientific article

Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest.

scientific article published on March 1997

Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis

scientific article published on 24 August 2020

Epigenetic suppression of FBXL7 promotes metastasis

scientific article published on 22 October 2020

Experimental tests to definitively determine ubiquitylation of a substrate.

scientific article published on January 2005

FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress

scientific article

FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress.

scientific article

FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade

scientific article

FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster

scientific article published on 02 March 2020

FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas

scientific journal article

FBXW5 controls centrosome number.

scientific article published on August 2011

FEM1 proteins are ancient regulators of SLBP degradation

scientific article published on 24 January 2017

Fbw7γ-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.

scientific article

Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival

scientific article

Fenton's pre-treatment of mature landfill leachate.

scientific article published in February 2004

GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK.

scientific article published in July 2017

GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase

scientific article published on 17 June 2019

Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments

scientific article published on 21 September 2020

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

scientific article

Hypertension and diabetes mellitus are associated with cardiovascular events in the elderly without cardiovascular disease. Results of a 15-year follow-up in a Mediterranean population

scientific article published on 20 June 2008

INTS3 controls the hSSB1-mediated DNA damage response

scientific article published on 28 September 2009

Identification of a family of human F-box proteins

scientific article

Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma

scientific article published on 01 January 2000

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

scientific article

Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex

scientific article

Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas

scientific article published on 01 May 2001

JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes

scientific article

KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state

scientific article

Lead removal and recovery from battery industry wastewaters by soluble starch xanthate.

scientific article published in July 2002

Linking metabolism and cell cycle progression via the APC/CCdh1 and SCFβTrCP ubiquitin ligases

scientific article published on 15 December 2011

Loss of p27KIP1 expression in fully-staged node-negative breast cancer: association with lack of hormone receptors in T1a/b, but not T1c infiltrative ductal carcinoma.

scientific article published in December 2011

Low expression of p27 and low proliferation index do not correlate in hairy cell leukaemia

scientific article published on 01 October 2000

Low prepregnancy ideal weight:height ratio in women with hyperemesis gravidarum.

scientific article

Mechanism of p53 degradation

scientific article published on 01 April 1997

Mechanisms and function of substrate recruitment by F-box proteins.

scientific article published on 09 May 2013

Mixed ubiquitin chains regulate DNA repair

scientific article published on 01 December 2019

Modification of Cul1 regulates its association with proteasomal subunits

scientific article published on 28 April 2006

Modifications of cell cycle controlling nuclear proteins by transforming growth factor beta in the HaCaT keratinocyte cell line.

scientific article published on August 1992

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

NS5A Promotes Constitutive Degradation of IP3R3 to Counteract Apoptosis Induced by Hepatitis C Virus

article

Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions

scientific article

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1

scientific article published on 27 June 2019

Olive husk: an alternative sorbent for removing heavy metals from aqueous streams.

scientific article published in September 2003

Oncogenic aberrations of cullin-dependent ubiquitin ligases

scientific article published on March 2004

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

scientific article

PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading.

scientific article published on 9 July 2018

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

scientific article

PHOTACs enable optical control of protein degradation

scientific article published on 21 February 2020

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth

scientific article published on 14 June 2017

Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle

scientific article

Previous preterm cesarean delivery: identification of a new risk factor for uterine rupture in VBAC candidates.

scientific article

Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer ⬇️

scientific article published on August 15, 1997

Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation.

scientific article

Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division

scientific article

Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase

scientific article published on 7 March 2013

Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation.

scientific article published on March 1997

Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation

scientific article

Role of F-box protein betaTrcp1 in mammary gland development and tumorigenesis

scientific journal article

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

scientific article

Role of the Cdc25A phosphatase in human breast cancer

scientific article published on September 2000

Role of the F-box protein Skp2 in lymphomagenesis

scientific article

Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

scientific article (publication date: 11 July 2003)

Role of the ubiquitin proteasome system in the heart

scientific article

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

scientific article (publication date: 4 August 1995)

S-phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phase

scientific article published on April 2002

S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

scientific article

SCF ubiquitin ligase-targeted therapies.

scientific article

SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation

scientific article

SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket

scientific article

SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins

scientific article

SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma

scientific article

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response

scientific article

SPOP Mutations or ERG Rearrangements Result in Enhanced Levels of ERG to Promote Cell Invasion in Prostate Cancer

scientific article published on September 2015

Skp2 contains a novel cyclin A binding domain that directly protects cyclin A from inhibition by p27Kip1.

scientific article published on 14 June 2006

Skp2, the FoxO1 hunter

scientific article published on 01 March 2005

SnapShot: F Box Proteins II

scientific article published on 01 June 2009

SnapShot: F box proteins I

scientific article published on 01 June 2009

Specific small molecule inhibitors of Skp2-mediated p27 degradation

scientific article

Stability of Wake-Sleep Cycles Requires Robust Degradation of the PERIOD Protein.

scientific article published on 24 October 2017

Stabilizers and Destabilizers Controlling Cell Cycle Oscillators

scientific article (publication date: April 2006)

Stimulation of prostate cancer cellular proliferation and invasion by the androgen receptor co-activator ARA70

scientific article

Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase

scientific article

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

scientific article

Substrate recognition and ubiquitination of SCFSkp2/Cks1 ubiquitin-protein isopeptide ligase.

scientific article published on 4 April 2007

Systematic analysis and nomenclature of mammalian F-box proteins

scientific article

TIMELESS Forms a Complex with PARP1 Distinct from Its Complex with TIPIN and Plays a Role in the DNA Damage Response

scientific article published on 7 October 2015

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint

scientific article

The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers

scientific article published on 13 December 2018

The F-box protein family.

scientific article

The G protein-coupled receptor GPR31 promotes membrane association of KRAS.

scientific article published on 15 June 2017

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein

scientific article published on 18 May 2008

The Integrator complex controls the termination of transcription at diverse classes of gene targets

scientific article

The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target

scientific article published on 03 December 2021

The SCF ubiquitin ligase: insights into a molecular machine

scientific article

The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells

scientific article published on 20 March 2017

The ULK1-FBXW5-SEC23B nexus controls autophagy

scientific article published on 31 December 2018

The acidic tail domain of human Cdc34 is required for p27Kip1 ubiquitination and complementation of a cdc34 temperature sensitive yeast strain.

scientific article published on 26 October 2005

The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period

scientific article

The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas

scientific article published on 01 April 1997

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

scientific article (publication date: March 2001)

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

scientific article

The pRb-Cdh1-p27 autoamplifying network

scientific article published on 01 February 2007

The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival

scientific article

Three different binding sites of Cks1 are required for p27-ubiquitin ligation

scientific article (publication date: November 2002)

Thrombin induces tumor cell cycle activation and spontaneous growth by down-regulation of p27Kip1, in association with the up-regulation of Skp2 and MiR-222

scientific article published on 07 April 2009

Tumor suppressor function of androgen receptor coactivator ARA70alpha in prostate cancer

scientific article

Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation

scientific article published on 23 May 2019

ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer

scientific article published on 17 May 2021

USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110

scientific article

Ubiquitin-dependent degradation of cyclin B is accelerated in polyploid megakaryocytes.

scientific article published in January 1998

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

scientific journal article

Varshavsky's contributions.

scientific article

Wagging the dogma; tissue-specific cell cycle control in the mouse embryo.

scientific article published in September 2004

Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor

scientific article published on 01 May 2000

Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes

scientific article

betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis

scientific article

cdc2 protein kinase: structure-function relationships

scientific article published on January 1, 1992

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

scientific article

β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression

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