List of works - Maria Deak

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

scientific article

14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK

scientific article

A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

scientific article

ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster

scientific article published on June 2002

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

scientific article

Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

scientific article published on 30 August 2016

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

scientific article

Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains

scientific article

Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor

scientific article

Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket

scientific article

Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16.

scientific article

Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo

scientific article

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

scientific article

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

scientific article

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

scientific article

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

scientific article

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

scientific article

Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS.

scientific article published on March 2007

Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate

scientific article

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

scientific article published in August 2003

In vivo role of the phosphate groove of PDK1 defined by knockin mutation

scientific article published on 11 October 2005

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

scientific article published on September 2010

Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B.

scientific article published on September 2003

Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1

scientific article

Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1

scientific article

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase

scientific article published on July 2014

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366

scientific journal article

Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity

scientific article

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

scientific article

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

scientific article

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

scientific article

Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo

scientific article (publication date: 2 August 2002)

Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: identification of mitochondrial fission factor as a new AMPK substrate

scientific article published on 13 February 2015

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion

scientific article

Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry

scientific article published on 24 August 2010

Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress

scientific article

Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation

scientific article

Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.

scientific article published on March 2005

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

scientific article published on January 2012

Standardized LC×LC-ELSD Fractionation Procedure for the Identification of Minor Bioactives via the Enzymatic Screening of Natural Extracts

scientific article

Structural basis for the recruitment of glycogen synthase by glycogenin

scientific article

Structural insights into the recognition of substrates and activators by the OSR1 kinase

scientific article

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

scientific article

Structure of the OSR1 kinase, a hypertension drug target

scientific article

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

scientific article published on 23 October 2009

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

scientific article

Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells

scientific article

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

scientific article

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

scientific article

The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

scientific journal article

The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

scientific article published on March 2006

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

scientific article

List of works by Maria Deak

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK

A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains

Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor

Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket

Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16.

Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS.

Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

In vivo role of the phosphate groove of PDK1 defined by knockin mutation

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B.

Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1

Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366

Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo

Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: identification of mitochondrial fission factor as a new AMPK substrate

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion

Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry

Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress

Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation

Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

Standardized LC×LC-ELSD Fractionation Procedure for the Identification of Minor Bioactives via the Enzymatic Screening of Natural Extracts

Structural basis for the recruitment of glycogen synthase by glycogenin

Structural insights into the recognition of substrates and activators by the OSR1 kinase

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

Structure of the OSR1 kinase, a hypertension drug target

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate