List of works - Israel Silman

A neutral molecule in a cation-binding site: specific binding of a PEG-SH to acetylcholinesterase from Torpedo californica

scientific article

Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity

scientific article

Acetylcholinesterase: From 3D structure to function

scientific article

Acid beta-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy

scientific article

An idea whose time has come

scientific article

Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations

scientific article

Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme

scientific article

Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1

scientific article

Characterization of gene-activated human acid- -glucosidase: Crystal structure, glycan composition, and internalization into macrophages

scientific article

Complexes of Alkylene-Linked Tacrine Dimers withTorpedo californicaAcetylcholinesterase: Binding of Bis(5)-tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge

scientific article published on 01 September 2006

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

scientific article

Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase

scientific article published on 01 August 2005

Crystal Structure of Thioflavin T Bound to the Peripheral Site of Torpedo californica Acetylcholinesterase Reveals How Thioflavin T Acts as a Sensitive Fluorescent Reporter of Ligand Binding to the Acylation Site

scientific article

Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease

scientific article

Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime

scientific article

Cyclodextrin-mediated crystallization of acid β-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues

scientific article

Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization

scientific article

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations

scientific article

Function and structure of inherently disordered proteins

scientific article

Molecular basis of reduced glucosylceramidase activity in the most common Gaucher disease mutant, N370S

scientific article

Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system

scientific article

Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules

scientific article

Shoot-and-Trap: Use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography

scientific article

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes

scientific article

Structure of a complex of the potent and specific inhibitor BW284C51 with Torpedo californica acetylcholinesterase

scientific article

The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad

scientific article

The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix

scientific article

Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography

scientific article

X-ray structure of human acid-β-glucosidase, the defective enzyme in Gaucher disease

scientific article

List of works by Israel Silman

A neutral molecule in a cation-binding site: specific binding of a PEG-SH to acetylcholinesterase from Torpedo californica

Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity

Acetylcholinesterase: From 3D structure to function

Acid beta-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy

An idea whose time has come

Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations

Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme

Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1

Characterization of gene-activated human acid- -glucosidase: Crystal structure, glycan composition, and internalization into macrophages

Complexes of Alkylene-Linked Tacrine Dimers withTorpedo californicaAcetylcholinesterase: Binding of Bis(5)-tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase

Crystal Structure of Thioflavin T Bound to the Peripheral Site of Torpedo californica Acetylcholinesterase Reveals How Thioflavin T Acts as a Sensitive Fluorescent Reporter of Ligand Binding to the Acylation Site

Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease

Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime

Cyclodextrin-mediated crystallization of acid β-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues

Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations

Function and structure of inherently disordered proteins

Molecular basis of reduced glucosylceramidase activity in the most common Gaucher disease mutant, N370S

Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system

Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules

Shoot-and-Trap: Use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes

Structure of a complex of the potent and specific inhibitor BW284C51 with Torpedo californica acetylcholinesterase

The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad

The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix

Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography

X-ray structure of human acid-β-glucosidase, the defective enzyme in Gaucher disease