List of works - Hélène Munier-Lehmann

1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors

scientific article published on 17 June 2020

1H, 13C and 15N resonance assignment and secondary structure of Mycobacterium tuberculosis adenylate kinase

scientific article published in January 2001

3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

scientific article published in August 2003

A new family of inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

scientific article

A novel polyaminocarboxylate compound to treat murine pulmonary aspergillosis by interfering with zinc metabolism

scientific article published on 9 April 2018

A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2.

scientific article

A real-time cell-binding assay reveals dynamic features of STxB-Gb3 co-internalization and STxB-mediated cargo delivery into cancer cells

scientific article published on 30 May 2020

Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.

scientific article published in April 2008

Administration of Zinc Chelators Improves Survival of Mice Infected with Aspergillus fumigatus both in Monotherapy and in Combination with Caspofungin

scientific article published on 11 July 2016

AutomiG, a biosensor to detect alterations in miRNA biogenesis and in small RNA silencing guided by perfect target complementarity

scientific article (publication date: 2013)

Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans

scientific article published in August 2003

Correction: Two Classes of Bacterial IMPDHs according to Their Quaternary Structures and Catalytic Properties

scientific article published on 29 April 2015

Corrigenda to "Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents" [Bioorg Med Chem 24 (2016) 5172-5182].

scientific article

Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation

scientific article

Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors.

scientific article published in May 2003

Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone

scientific article published on 15 October 2010

Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

scientific article published in December 2004

Drug design and identification of potent leads against mycobacterium tuberculosis thymidine monophosphate kinase.

scientific article published on January 2012

Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents

scientific article published on 24 August 2016

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism

scientific article

Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

scientific article

First-in-class allosteric inhibitors of bacterial IMPDHs

scientific article published on 02 February 2019

From sequence to structure to function: a case study

High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery

scientific article

High-level production of recombinant sulfide-reactive hemoglobin I from Lucina pectinata in Escherichia coli. High yields of fully functional holoprotein synthesis in the BLi5 E. coli strain

scientific article published in December 2004

High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses

scientific article

Identification of a small molecule that primes the type I interferon response to cytosolic DNA.

scientific article

Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A.

scientific article published on 18 January 2018

Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity

scientific article (publication date: 2013)

Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT.

scientific article published on 23 November 2017

Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy.

scientific article published in February 2004

LEA3D: a computer-aided ligand design for structure-based drug design.

scientific article published in April 2005

Metalloprotease vsm is the major determinant of toxicity for extracellular products of Vibrio splendidus

scientific article published on 03 October 2008

MgATP regulates allostery and fiber formation in IMPDHs

scientific article

Multiple microfermentor battery: a versatile tool for use with automated parallel cultures of microorganisms producing recombinant proteins and for optimization of cultivation protocols

scientific article

Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis

scientific article

Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications.

scientific article

On dihydroorotate dehydrogenases and their inhibitors and uses

scientific article

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

scientific article published on 30 June 2015

Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH).

scientific article published on 6 January 2015

Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response

scientific article published on 14 August 2017

Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase

scientific article published on 23 July 2009

Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth

scientific article published on 2 October 2007

Reaction of human UMP-CMP kinase with natural and analog substrates

scientific article (publication date: April 2003)

Relationship between bacterial virulence and nucleotide metabolism: a mutation in the adenylate kinase gene renders Yersinia pestis avirulent

scientific article published on July 2003

Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors

scientific article published on 10 April 2020

Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors

scientific article

Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay

scientific article published on 26 October 2018

Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening

scientific article published on January 2015

Structural and dynamic studies on ligand-free adenylate kinase from Mycobacterium tuberculosis revealed a closed conformation that can be related to the reduced catalytic activity

scientific article

Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation

scientific article

Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase

scientific article

Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors

scientific article published on 6 March 2018

Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity

scientific article published on 25 April 2008

Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme

scientific article

Synergy of the antibiotic colistin with echinocandin antifungals in Candida species

scientific article

Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase.

scientific article published in October 2006

Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors

scientific article

Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis

scientific article

Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors

Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

scientific article published in October 2002

Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase

scientific article published on 18 October 2011

Synthesis of sulfamide analogues of deoxthymidine monophosphate as potential inhibitors of mycobacterial cell wall biosynthesis

scientific article published on 11 January 2018

The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components

scientific article

The composition of the culture medium influences the β-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of β-1,3-glucan synthesis

scientific article

The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.

scientific article

The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3'-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition

scientific article

Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

scientific article published in September 2003

Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes

scientific article

Two classes of bacterial IMPDHs according to their quaternary structures and catalytic properties

scientific article

Unique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinase

scientific journal article

List of works by Hélène Munier-Lehmann

1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors

1H, 13C and 15N resonance assignment and secondary structure of Mycobacterium tuberculosis adenylate kinase

3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

A new family of inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

A novel polyaminocarboxylate compound to treat murine pulmonary aspergillosis by interfering with zinc metabolism

A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2.

A real-time cell-binding assay reveals dynamic features of STxB-Gb3 co-internalization and STxB-mediated cargo delivery into cancer cells

Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.

Administration of Zinc Chelators Improves Survival of Mice Infected with Aspergillus fumigatus both in Monotherapy and in Combination with Caspofungin

AutomiG, a biosensor to detect alterations in miRNA biogenesis and in small RNA silencing guided by perfect target complementarity

Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans

Correction: Two Classes of Bacterial IMPDHs according to Their Quaternary Structures and Catalytic Properties

Corrigenda to "Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents" [Bioorg Med Chem 24 (2016) 5172-5182].

Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation

Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors.

Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone

Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

Drug design and identification of potent leads against mycobacterium tuberculosis thymidine monophosphate kinase.

Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism

Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

First-in-class allosteric inhibitors of bacterial IMPDHs

From sequence to structure to function: a case study

High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery

High-level production of recombinant sulfide-reactive hemoglobin I from Lucina pectinata in Escherichia coli. High yields of fully functional holoprotein synthesis in the BLi5 E. coli strain

High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses

Identification of a small molecule that primes the type I interferon response to cytosolic DNA.

Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A.

Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity

Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT.

Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy.

LEA3D: a computer-aided ligand design for structure-based drug design.

Metalloprotease vsm is the major determinant of toxicity for extracellular products of Vibrio splendidus

MgATP regulates allostery and fiber formation in IMPDHs

Multiple microfermentor battery: a versatile tool for use with automated parallel cultures of microorganisms producing recombinant proteins and for optimization of cultivation protocols

Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis

Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications.

On dihydroorotate dehydrogenases and their inhibitors and uses

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH).

Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response

Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase

Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth

Reaction of human UMP-CMP kinase with natural and analog substrates

Relationship between bacterial virulence and nucleotide metabolism: a mutation in the adenylate kinase gene renders Yersinia pestis avirulent

Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors

Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors

Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay

Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening

Structural and dynamic studies on ligand-free adenylate kinase from Mycobacterium tuberculosis revealed a closed conformation that can be related to the reduced catalytic activity

Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation

Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase

Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors

Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity

Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme

Synergy of the antibiotic colistin with echinocandin antifungals in Candida species

Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase.

Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors

Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis

Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors

Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase

Synthesis of sulfamide analogues of deoxthymidine monophosphate as potential inhibitors of mycobacterial cell wall biosynthesis

The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components

The composition of the culture medium influences the β-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of β-1,3-glucan synthesis

The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.

The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3'-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition

Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes

Two classes of bacterial IMPDHs according to their quaternary structures and catalytic properties

Unique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinase