List of works by Andrea Mozzarelli

"Muscle to meat" molecular events and technological transformations: the proteomics insight

scientific article published on 19 April 2012

A two-step process controls the formation of the bienzyme cysteine synthase complex

scientific article

ATP binding to human serine racemase is cooperative and modulated by glycine

scientific article

Academia-Industry Collaboration in Blood Substitute Development: Issues, Case Histories and a Proposal

article

Active site plasticity in D-amino acid oxidase: a crystallographic analysis

scientific article

Allosteric communication between alpha and beta subunits of tryptophan synthase: modelling the open-closed transition of the alpha subunit

scientific article published on 18 April 2006

Allosteric mechanism of haemoglobin: rupture of salt-bridges raises the oxygen affinity of the T-structure 1 1Edited by D. Rees

scientific article published on 01 August 1998

Anticooperative ligand binding properties of recombinant ferric Vitreoscilla homodimeric hemoglobin: a thermodynamic, kinetic and X-ray crystallographic study

scientific article

Asymmetry of the active site loop conformation between subunits of glutamate-1-semialdehyde aminomutase in solution

scientific article published on 31 July 2013

Biochemistry of Hemoglobin

Bound water at protein-protein interfaces: partners, roles and hydrophobic bubbles as a conserved motif

scientific article (publication date: 2011)

CO Rebinding Kinetics and Molecular Dynamics Simulations Highlight Dynamic Regulation of Internal Cavities in Human Cytoglobin

scientific article

CO Rebinding Kinetics to Myoglobin- and R-State-Hemoglobin-Doped Silica Gels in the Presence of Glycerol

scientific article published in June 2004

Catalytic and regulatory properties of D-glyceraldehyde-3-phosphate dehydrogenase in the crystal. Spectral properties and chemical reactivity of a chromophoric acyl-enzyme intermediate

scientific article published on February 1977

Catalytic competence of O-acetylserine sulfhydrylase in the crystal probed by polarized absorption microspectrophotometry

scientific article

Characterization of ligand migration mechanisms inside hemoglobins from the analysis of geminate rebinding kinetics

scientific article

Chemistry and Biochemistry of Oxygen Therapeutics

Chemogenomic strategies to expand the bioactive chemical space.

scientific article

Chemogenomics of pyridoxal 5'-phosphate dependent enzymes

scientific article published on 19 December 2011

Circular dichroism spectroscopy of tertiary and quaternary conformations of human hemoglobin entrapped in wet silica gels

scientific article

Combination of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action

scientific article published on 21 October 2019

Complexity in modeling and understanding protonation states: computational titration of HIV-1-protease-inhibitor complexes

scientific article

Computational titration analysis of a multiprotic HIV-1 protease-ligand complex.

scientific article

Confinement and crowding effects on tryptophan synthase α2β2complex

scholarly article by Barbara Pioselli published in March 2005

Conformational probes of O-acetylserine sulfhydrylase: fluorescence of tryptophans 50 and 161

Control of ionizable residues in the catalytic mechanism of tryptophan synthase from Salmonella typhimurium

scientific article published on 10 October 2007

Cooperative Oxygen Binding toScapharca inaequivalvisHemoglobin in the Crystal

scientific article published in Journal of Biological Chemistry

Correlation of protein functional properties in the crystal and in solution: the case study of T-state hemoglobin

scientific article published on July 2002

Covalent Inhibitors of Plasmodium falciparum Glyceraldehyde 3-Phosphate Dehydrogenase with Antimalarial Activity in Vitro

scientific article published on 20 February 2019

Cryocrystallography and microspectrophotometry of a mutant (alpha D60N) tryptophan synthase alpha 2 beta 2 complex reveals allosteric roles of alpha Asp60

scientific article

Crystal structure of the beta Ser178--> Pro mutant of tryptophan synthase. A "knock-out" allosteric enzyme

scientific article

Crystal structures of a new class of allosteric effectors complexed to tryptophan synthase

scientific article

Crystals of tryptophan indole-lyase and tyrosine phenol-lyase form stable quinonoid complexes

scientific article

Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target

scientific article

Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR.

scientific article published on 31 August 2016

Design and synthesis of trans-2-substituted-cyclopropane-1-carboxylic acids as the first non-natural small molecule inhibitors of O-acetylserine sulfhydrylase

article by Laura Amori et al published 2012 in MedChemComm

Design of O -Acetylserine Sulfhydrylase Inhibitors by Mimicking Nature

scientific article

Determination of Microscopic Rate Constants for CO Binding and Migration in Myoglobin Encapsulated in Silica Gels

scientific article published in October 2005

Development of a novel, hemolysis-resistant reagent for assessment of α-amylase in biological fluids.

scientific article published in July 2013

Different roles of protein dynamics and ligand migration in non-symbiotic hemoglobins AHb1 and AHb2 from Arabidopsis thaliana

article

Discovery of covalent inhibitors of glyceraldehyde-3-phosphate dehydrogenase, a target for the treatment of malaria

scientific article

Drug discovery targeting amino acid racemases

scientific article

Dynamics of green fluorescent protein mutant2 in solution, on spin-coated glasses, and encapsulated in wet silica gels

scientific article published on May 2002

Effect of pH and Monovalent Cations on the Formation of Quinonoid Intermediates of the Tryptophan Synthase α2β2Complex in Solution and in the Crystal

scientific article published in Journal of Biological Chemistry

Electrophoretic analysis of PEGylated hemoglobin-based blood substitutes

scholarly article by Luca Ronda published in January 2011

Energetics of the protein-DNA-water interaction

scientific article

Energy-based prediction of amino acid-nucleotide base recognition

scientific article published on 01 September 2008

Engineering hemoglobin to enable homogenous PEGylation without modifying protein functionality

scientific article published on 15 June 2020

Engineering tyrosine electron transfer pathways decreases oxidative toxicity in hemoglobin: implications for blood substitute design

scientific article published on 28 July 2016

Enhanced geminate ligand rebinding upon photo-dissociation of silica gel-embedded myoglobin–CO

scientific article published in October 2001

Environment effects on the oscillatory unfolding kinetics of GFP.

scientific article

Evidence for Two Geminate Rebinding States Following Laser Photolysis of R State Hemoglobin Encapsulated in Wet Silica Gels

scientific article published in June 2005

Evidence of discrete substates and unfolding pathways in green fluorescent protein

scientific article

Evolution of allosteric models for hemoglobin

scientific article published on August 2007

Expanding the chemical space of human serine racemase inhibitors

scientific article published on 4 August 2015

Experimental basis for a new allosteric model for multisubunit proteins

scientific article

Experiments on Hemoglobin in Single Crystals and Silica Gels Distinguish among Allosteric Models.

scientific article

Exploring O-acetylserine sulfhydrylase-B isoenzyme from Salmonella typhimurium by fluorescence spectroscopy

scientific article published on 16 October 2010

Exploring and exploiting allostery: Models, evolution, and drug targeting

scientific article published on 28 October 2010

Exploring methionine γ-lyase structure-function relationship via microspectrophotometry and X-ray crystallography

scientific article

Exploring the pyridoxal 5′-phosphate-dependent enzymes

article

Fine tuning of the active site modulates specificity in the interaction of O-acetylserine sulfhydrylase isozymes with serine acetyltransferase

scientific article published on 19 September 2012

From protein structure to function via single crystal optical spectroscopy

scientific article

Functional and spectroscopic characterization of half-liganded iron-zinc hybrid hemoglobin: evidence for conformational plasticity within the T state.

scientific article

Functional characterization of heme proteins encapsulated in wet nanoporous silica gels.

scientific article

Functional properties of the active core of human cystathionine beta-synthase crystals.

scientific article

Geminate rebinding in R-state hemoglobin: kinetic and computational evidence for multiple hydrophobic pockets

scientific article

Getting it right: modeling of pH, solvent and "nearly" everything else in virtual screening of biological targets

scientific article

HINT predictive analysis of binding between retinol binding protein and hydrophobic ligands.

scientific article published in September 2000

Haemoglobin-based oxygen carriers: research and reality towards an alternative to blood transfusions

scientific article

Hemocyanin from E. californicum encapsulated in silica gels: oxygen binding and conformational states.

scientific article published on 25 April 2007

Hemoglobin Reactivity and Regulation

Hemoglobin, an "evergreen" red protein

scientific article published on 08 April 2009

Hemoglobin-based oxygen carriers as blood substitutes

scientific article published in October 2008

High and low oxygen affinity conformations of T state hemoglobin

scientific article

Histidine E7 Dynamics Modulates Ligand Exchange between Distal Pocket and Solvent in AHb1 fromArabidopsis thaliana

scientific article published on 14 April 2011

Human kynurenine aminotransferase II - reactivity with substrates and inhibitors

scholarly article by Elisabetta Passera published in April 2011

Human serine racemase is allosterically modulated by NADH and reduced nicotinamide derivatives

scholarly article by Stefano Bruno published in August 2016

Identification of a Small Molecule that Increases Hemoglobin Oxygen Affinity and Reduces SS Erythrocyte Sickling

scientific article

Identification of the geometric requirements for allosteric communication between the alpha- and beta-subunits of tryptophan synthase

scientific article published on 3 February 2005

Identification of the structural determinants for the stability of substrate and aminoacrylate external Schiff bases in O-acetylserine sulfhydrylase-A.

scientific article published in July 2010

Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach

scientific article

Insight into GFPmut2 pH Dependence by Single Crystal Microspectrophotometry and X-ray Crystallography

scientific article published on 17 September 2018

Insight of Saffron Proteome by Gel-Electrophoresis.

scientific article published on 29 January 2016

Interaction of serine acetyltransferase with O-acetylserine sulfhydrylase active site: evidence from fluorescence spectroscopy

scientific article published on 29 June 2005

International Consortium for Development of Hemoglobin-Based Oxygen Carriers, Oxygen Therapeutics and Multifunctional Resuscitation Fluids–A White Paper

article

Is cooperative oxygen binding by hemoglobin really understood?

scientific article

Is cooperative oxygen binding by hemoglobin really understood?

article

Is the protein profile of pig Longissimus dorsi affected by gender and diet?

scientific article published on 02 July 2019

Isozyme-specific ligands for O-acetylserine sulfhydrylase, a novel antibiotic target

scientific article

Kinetics of acid-induced spectral changes in the GFPmut2 chromophore

scientific article published in January 2005

Ligand migration and hexacoordination in type 1 non-symbiotic rice hemoglobin

scientific article

Ligand migration in nonsymbiotic hemoglobin AHb1 from Arabidopsis thaliana

scientific article

Ligand migration through the internal hydrophobic cavities in human neuroglobin

scientific article published on 22 October 2009

Ligand-induced tertiary relaxations during the T-to-R quaternary transition in hemoglobin

scientific article

Low affinity PEGylated hemoglobin from Trematomus bernacchii, a model for hemoglobin-based blood substitutes

scientific article

Magnesium and calcium ions differentially affect human serine racemase activity and modulate its quaternary equilibrium toward a tetrameric form.

scientific article published on 9 January 2017

Mapping the energetics of water-protein and water-ligand interactions with the "natural" HINT forcefield: predictive tools for characterizing the roles of water in biomolecules

scientific article published on 2 February 2006

MediaChrom: Discovering a Class of Pyrimidoindolone-Based Polarity-Sensitive Dyes

scientific article published on 16 October 2015

Microspectrophotometry for structural enzymology

scientific article

Modulation of expression and polymerization of hemoglobin Polytaur, a potential blood substitute

scholarly article by Serena Faggiano published in January 2011

Molecular insights into dimerization inhibition of c-Maf transcription factor

scholarly article by Sara Pellegrino published in December 2014

Monovalent cations affect dynamic and functional properties of the tryptophan synthase alpha 2 beta 2 complex

scientific article published in July 1995

Moonlighting O-acetylserine sulfhydrylase: New functions for an old protein

scientific article

Muscle and meat: new horizons and applications for proteomics on a farm to fork perspective

scientific article published on 08 February 2013

Mutational Effects at the Subunit Interfaces of Human Hemoglobin:  Evidence for a Unique Sensitivity of the T Quaternary State to Changes in the Hinge Region of the α1β2 Interface†

article

New insights into allosteric mechanisms from trapping unstable protein conformations in silica gels

scholarly article

Novel allosteric effectors of the tryptophan synthase alpha(2)beta(2) complex identified by computer-assisted molecular modeling

scientific article

Ormosil gels doped with engineered catechol 1,2 dioxygenases for chlorocatechol bioremediation

scientific article published on 26 February 2014

Oxygen and nitric oxide rebinding kinetics in nonsymbiotic hemoglobin AHb1 from Arabidopsis thaliana

scientific article

Oxygen binding and sensing proteins

scientific article

Oxygen binding to Arabidopsis thaliana AHb2 nonsymbiotic hemoglobin: evidence for a role in oxygen transport

article

Oxygen binding to heme proteins in solution, encapsulated in silica gels, and in the crystalline state

scientific article published on January 2008

PEGylation promotes hemoglobin tetramer dissociation.

scientific article published in July 2009

Plasticity of the Tryptophan Synthase Active Site Probed by31P NMR Spectroscopy

scientific article published in Journal of Biological Chemistry

Polymerized and polyethylene glycol-conjugated hemoglobins: A globin-based calibration curve for dynamic light scattering analysis

scholarly article by Serena Faggiano published in June 2010

Protein crystal microspectrophotometry

scientific article

Proteomic analysis of pork meat in the production of cooked ham.

scientific article

Proteomics of Parma Dry-Cured Ham: Analysis of Salting Exudates

scientific article published on 29 June 2017

Pyridoxal 5'-phosphate enzymes as targets for therapeutic agents

scientific article published on January 2007

Rational Design of a User-Friendly Aptamer/Peptide-Based Device for the Detection of Staphylococcus aureus

scientific article published on 02 September 2020

Rational Design, Synthesis, and Preliminary Structure-Activity Relationships of α-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella typhimurium O-Acetylserine Sulfhydrylase

scientific article published on 19 February 2016

Regulation of human serine racemase activity and dynamics by halides, ATP and malonate

article

Robust Classification of “Relevant” Water Molecules in Putative Protein Binding Sites

scientific article published on 31 January 2008

Role of aspartate-133 and histidine-458 in the mechanism of tryptophan indole-lyase from Proteus vulgaris

scientific article published in September 2003

Role of pyridoxal 5'-phosphate in the structural stabilization of O-acetylserine sulfhydrylase.

scientific article

Role of tertiary structures on the Root effect in fish hemoglobins

scientific article

Selectivity of 3-bromo-isoxazoline inhibitors between human and Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenases

scientific article published on 19 April 2016

Serine racemase: a key player in neuron activity and in neuropathologies

scientific article published on June 2013

Simple, Intuitive Calculations of Free Energy of Binding for Protein−Ligand Complexes. 3. The Free Energy Contribution of Structural Water Molecules in HIV-1 Protease Complexes

article

Simple, intuitive calculations of free energy of binding for protein-ligand complexes. 1. Models without explicit constrained water

scientific article published in June 2002

Simple, intuitive calculations of free energy of binding for protein-ligand complexes. 2. Computational titration and pH effects in molecular models of neuraminidase-inhibitor complexes

scientific article published in October 2003

Site-directed mutations of human hemoglobin at residue 35beta: a residue at the intersection of the alpha1beta1, alpha1beta2, and alpha1alpha2 interfaces

scientific article

Snapshots of the cystine lyase C-DES during catalysis. Studies in solution and in the crystalline state

scientific article

Special Issue on "Cofactor-dependent proteins: Evolution, chemical diversity and bio-applications".

scientific article published on 10 June 2015

Spectroscopic and functional characterization of T state hemoglobin conformations encapsulated in silica gels

scientific article published in November 2004

Structural insight into the interaction of O-acetylserine sulfhydrylase with competitive, peptidic inhibitors by saturation transfer difference-NMR.

scientific article

Structural plasticity and functional implications of internal cavities in distal mutants of type 1 non-symbiotic hemoglobin AHb1 from Arabidopsis thaliana.

scientific article

Structure and Oxygen Affinity of Crystalline des-His-146β Human Hemoglobin in the T State

scientific article published in Journal of Biological Chemistry

Structure and oxygen affinity of crystalline desArg141 alpha human hemoglobin A in the T state.

scientific article

Structure, mechanism, and conformational dynamics of O-acetylserine sulfhydrylase from Salmonella typhimurium: comparison of A and B isozymes

scientific article

Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin

scientific article

Sulfur mobilization in cyanobacteria: the catalytic mechanism of L-cystine C-S lyase (C-DES) from synechocystis

scientific article

Surface-exposed tryptophan residues are essential for O-acetylserine sulfhydrylase structure, function, and stability

scientific article

T State Hemoglobin Binds Oxygen Noncooperatively with Allosteric Effects of Protons, Inositol Hexaphosphate, and Chloride

scientific article published in Journal of Biological Chemistry

Targeting cystalysin, a virulence factor of treponema denticola-supported periodontitis

scientific article

Tertiary and Quaternary Allostery in Tetrameric Hemoglobin from Scapharca inaequivalvis

scientific article

The Roles of Water in the Protein Matrix: A Largely Untapped Resource for Drug Discovery.

scientific article

The consequences of scoring docked ligand conformations using free energy correlations.

scientific article

The molecular pathway for the allosteric regulation of tryptophan synthase

scientific article

The multifaceted pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase

scientific article published on 28 April 2011

The reactivity with CO of AHb1 and AHb2 from Arabidopsis thaliana is controlled by the distal HisE7 and internal hydrophobic cavities

scientific article published on 14 February 2007

Time-resolved fluorescence of O-acetylserine sulfhydrylase

scientific article published in January 1999

Time-resolved fluorescence of O-acetylserine sulfhydrylase catalytic intermediates

scientific article published in December 1997

Time-resolved fluorescence of tryptophan synthase

scientific article published in August 1996

Time-resolved methods in Biophysics. 2. Monitoring haem proteins at work with nanosecond laser flash photolysis

scientific article

Tools for building a comprehensive modeling system for virtual screening under real biological conditions: The Computational Titration algorithm

scientific article

Towards a novel haemoglobin-based oxygen carrier: Euro-PEG-Hb, physico-chemical properties, vasoactivity and renal filtration.

scientific article published on 20 March 2008

Tracking unfolding and refolding of single GFPmut2 molecules

scientific article

Trapping Hemoglobin in Rigid Matrices: Fine Tuning of Oxygen Binding Properties by Modulation of Encapsulation Protocols

scholarly article by Stefano Bruno et al published January 2007 in Artificial Cells, Blood Substitutes, and Biotechnology

Trapping of the thioacylglyceraldehyde-3-phosphate dehydrogenase intermediate from Bacillus stearothermophilus. Direct evidence for a flip-flop mechanism

scientific article

Tryptophan synthase: a mine for enzymologists

scientific article

Tyrosine phenol-lyase and tryptophan indole-lyase encapsulated in wet nanoporous silica gels: Selective stabilization of tertiary conformations

scientific article published on April 2004

Unfolding of Green Fluorescent Protein mut2 in wet nanoporous silica gels.

scientific article

Unfolding of pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase probed by time-resolved tryptophan fluorescence.

scientific article

Unintended consequences? Water molecules at biological and crystallographic protein-protein interfaces

scientific article

Water: How to evaluate its contribution in protein-ligand interactions

article by Pietro Cozzini et al published 2005 in International Journal of Quantum Chemistry

X-ray crystallography marries spectroscopy to unveil structure and function of biological macromolecules

scientific article published on 01 June 2011

pH dependence of tryptophan synthase catalytic mechanism: I. The first stage, the beta-elimination reaction

scientific article published on 26 April 2004

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