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List of works by Ann-Sofie Jemth

A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family

scientific article published on 16 November 2017

Addiction to MTH1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography-isotope-dilution tandem mass spectrometry.

scientific article

Correction to Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors

scientific article

Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

scientific article published in April 2017

Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana

scientific article published on 16 January 2019

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor

scientific article published on 29 November 2016

Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity

scientific article published on 27 December 2017

Crystal structure of human MTH1 and the 8-oxo-dGMP product complex

scientific article

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2

scientific journal article

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target

scientific article published on 22 June 2020

CyDNA: synthesis and replication of highly Cy-dye substituted DNA by an evolved polymerase.

scientific article

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

scientific article published on 15 January 2016

Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines.

scientific article published on 16 June 2017

Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems

scientific article published on 15 June 2017

Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis

article

Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold

scientific article published in February 2018

Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition

scientific article

Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1.

scientific article

Kinetic and structural characterization of <scp>NUDT15</scp> and <scp>NUDT18</scp> as catalysts of isoprene pyrophosphate hydrolysis

scientific article published in 2024

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

scientific article

MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP

scientific article published on 01 November 2018

MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool

scientific article published on 06 March 2020

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine

scientific article

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.

scientific article published on 23 July 2009

PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA

scientific article

PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.: FIGURE 2

scientific article published in Journal of Biological Chemistry

Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors

scientific article

Processing of protein ADP-ribosylation by Nudix hydrolases

scientific article published on June 2015

Production, Purification, and Characterization of ¹⁵N-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements.

scientific article published on 26 July 2015

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

scientific article

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

scientific article

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

scientific article

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

scientific article published on 17 January 2018

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies

scientific article

Validation and development of MTH1 inhibitors for treatment of cancer.

scientific article

dUTPase inhibition augments replication defects of 5-Fluorouracil.

scientific article published on April 2017

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