List of works - Pål Stenmark

A comparison of X-ray and calculated structures of the enzyme MTH1.

scientific article published on 27 June 2016

A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family

scientific article published on 16 November 2017

A neurotoxin that specifically targets Anopheles mosquitoes

scientific article published on 28 June 2019

A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases

scientific article published on 16 May 2022

A prokaryotic alternative oxidase present in the bacterium Novosphingobium aromaticivorans

scientific article published in September 2003

Botulinum and Tetanus Neurotoxins

scientific article published on 02 November 2018

Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins

scientific article

Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy

scientific article published on 17 March 2020

Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes

scientific article

Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

scientific article published in April 2017

Cotranslational Folding of a Pentarepeat β-Helix Protein

scientific article published on 27 October 2018

Cotranslational folding of a pentarepeat β-helix protein

Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana

scientific article published on 16 January 2019

Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding.

scientific article published on 12 April 2018

Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron Interaction

scientific article

Crystal Structure of the Botulinum Neurotoxin Type G Binding Domain: Insight into Cell Surface Binding

scientific article

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor

scientific article published on 29 November 2016

Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity

scientific article published on 27 December 2017

Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II

scientific article

Crystal structure of CaiB, a type-III CoA transferase in carnitine metabolism

scientific article published on November 2004

Crystal structure of human MTH1 and the 8-oxo-dGMP product complex

scientific article

Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition

scientific article

Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T.

scientific article

Crystal structure of the P2 C-repressor: a binder of non-palindromic direct DNA repeats

scientific article

Crystal structure of the bacteriophage P2 integrase catalytic domain

scientific article

Crystal structure of the catalytic domain of the Weissella oryzae botulinum-like toxin

scientific article published on 20 May 2019

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2

scientific journal article

Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX-type gene cluster

scientific article

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target

scientific article published on 22 June 2020

Crystals of the ribonucleotide reductase R2 protein from Chlamydia trachomatis obtained by heavy-atom co-crystallization

scientific article published on 23 January 2004

DNA compaction by the bacteriophage protein Cox studied on the single DNA molecule level using nanofluidic channels

scientific article

Development of a chemical probe against NUDT15

scientific article published on 20 July 2020

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

scientific article published on 15 January 2016

EPR studies of the mitochondrial alternative oxidase. Evidence for a diiron carboxylate center

scientific article (publication date: 15 November 2002)

Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models

scientific article published on 16 January 2019

Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors

scientific article published on 3 July 2017

Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space

scientific article published on 20 September 2017

GRETA, a new multifermenter system for structural genomics and process optimization

scientific article published on 19 September 2006

Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis

article

Glycans Confer Specificity to the Recognition of Ganglioside Receptors by Botulinum Neurotoxin A.

scientific article

Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold

scientific article published in February 2018

Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition

scientific article

Identification and characterization of a novel botulinum neurotoxin.

scientific article published on 3 August 2017

Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium.

scientific article published on 26 January 2018

Inhibition of chlamydial class Ic ribonucleotide reductase by C-terminal peptides from protein R2.

scientific article published on 04 October 2011

Kinetic and structural characterization of <scp>NUDT15</scp> and <scp>NUDT18</scp> as catalysts of isoprene pyrophosphate hydrolysis

scientific article published in 2024

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

scientific article

Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity

scientific article published on 24 February 2020

Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin.

scientific article published on 25 November 2017

Membrane-bound diiron carboxylate proteins

scientific article (publication date: 2003)

MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP

scientific article published on 01 November 2018

MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool

scientific article published on 06 March 2020

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine

scientific article

Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction.

scientific article published on 11 September 2017

Organellar oligopeptidase (OOP) provides a complementary pathway for targeting peptide degradation in mitochondria and chloroplasts

scientific article published on 16 September 2013

Purification, modeling, and analysis of botulinum neurotoxin subtype A5 (BoNT/A5) from Clostridium botulinum strain A661222.

scientific article published on 22 April 2011

Reaction Mechanism of Human PAICS Elucidated by Quantum Chemical Calculations

scientific article published in 2022

Screening for functional expression and overexpression of a family of diiron-containing interfacial membrane proteins using the univector recombination system

scientific article published on January 2003

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

scientific article

Structural and Biochemical Characterization of Botulinum Neurotoxin Subtype B2 Binding to Its Receptors

scientific article published on 17 September 2020

Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1

scientific article

Structural basis for the interaction of the chaperone Cbp3 with newly synthesized cytochrome b during mitochondrial respiratory chain assembly

scientific article published on 19 September 2019

Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC.

scientific article published on 21 November 2017

Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs

scientific article published on 10 June 2019

Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity.

scientific article published on 14 March 2018

Structural insight into DNA binding and oligomerization of the multifunctional Cox protein of bacteriophage P2

scientific article

Structural studies of tri-functional human GART

scientific article

Structure and steroid isomerase activity of Drosophila glutathione transferase E14 essential for ecdysteroid biosynthesis

scientific article published on 16 December 2019

Structure of dual receptor binding to botulinum neurotoxin B

scientific article

Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion

scientific article published on 06 September 2021

Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy

scientific article published on 10 June 2006

Structures of the hydrolase domain of human 10-formyltetrahydrofolate dehydrogenase and its complex with a substrate analogue

scientific article published on 18 October 2006

Synaptotagmin Binding to Botulinum Neurotoxins

scientific article published on 18 December 2019

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

scientific article published on 17 January 2018

The ALFA-tag is a highly versatile tool for nanobody-based bioscience applications

scientific article published on 27 September 2019

The C repressor of the P2 bacteriophage

scientific article published on 22 December 2015

The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions.

scientific article

The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site

scientific article

The crystal structure of the bifunctional deaminase/reductase RibD of the riboflavin biosynthetic pathway in Escherichia coli: implications for the reductive mechanism

scientific article

The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer

scientific article

The manganese ion of the heterodinuclear Mn/Fe cofactor in Chlamydia trachomatis ribonucleotide reductase R2c is located at metal position 1.

scientific article published on 08 December 2011

The radical site in chlamydial ribonucleotide reductase defines a new R2 subclass

scientific article

The structure of human collapsin response mediator protein 2, a regulator of axonal growth

scientific article

The structure of the PP2A regulatory subunit B56 gamma: the remaining piece of the PP2A jigsaw puzzle

scientific article

The structure of the tetanus toxin reveals pH-mediated domain dynamics

scientific article published on 23 June 2017

Vinylic MIDA Boronates: New Building Blocks for the Synthesis of Aza-Heterocycles

scientific article published on 25 March 2015

List of works by Pål Stenmark

A comparison of X-ray and calculated structures of the enzyme MTH1.

A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family

A neurotoxin that specifically targets Anopheles mosquitoes

A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases

A prokaryotic alternative oxidase present in the bacterium Novosphingobium aromaticivorans

Botulinum and Tetanus Neurotoxins

Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins

Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy

Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes

Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Cotranslational Folding of a Pentarepeat β-Helix Protein

Cotranslational folding of a pentarepeat β-helix protein

Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana

Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding.

Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron Interaction

Crystal Structure of the Botulinum Neurotoxin Type G Binding Domain: Insight into Cell Surface Binding

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor

Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity

Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II

Crystal structure of CaiB, a type-III CoA transferase in carnitine metabolism

Crystal structure of human MTH1 and the 8-oxo-dGMP product complex

Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition

Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T.

Crystal structure of the P2 C-repressor: a binder of non-palindromic direct DNA repeats

Crystal structure of the bacteriophage P2 integrase catalytic domain

Crystal structure of the catalytic domain of the Weissella oryzae botulinum-like toxin

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2

Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX-type gene cluster

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target

Crystals of the ribonucleotide reductase R2 protein from Chlamydia trachomatis obtained by heavy-atom co-crystallization

DNA compaction by the bacteriophage protein Cox studied on the single DNA molecule level using nanofluidic channels

Development of a chemical probe against NUDT15

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

EPR studies of the mitochondrial alternative oxidase. Evidence for a diiron carboxylate center

Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models

Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors

Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space

GRETA, a new multifermenter system for structural genomics and process optimization

Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis

Glycans Confer Specificity to the Recognition of Ganglioside Receptors by Botulinum Neurotoxin A.

Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold

Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition

Identification and characterization of a novel botulinum neurotoxin.

Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium.

Inhibition of chlamydial class Ic ribonucleotide reductase by C-terminal peptides from protein R2.

Kinetic and structural characterization of <scp>NUDT15</scp> and <scp>NUDT18</scp> as catalysts of isoprene pyrophosphate hydrolysis

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity

Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin.

Membrane-bound diiron carboxylate proteins

MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP

MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine

Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction.

Organellar oligopeptidase (OOP) provides a complementary pathway for targeting peptide degradation in mitochondria and chloroplasts

Purification, modeling, and analysis of botulinum neurotoxin subtype A5 (BoNT/A5) from Clostridium botulinum strain A661222.

Reaction Mechanism of Human PAICS Elucidated by Quantum Chemical Calculations

Screening for functional expression and overexpression of a family of diiron-containing interfacial membrane proteins using the univector recombination system

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Structural and Biochemical Characterization of Botulinum Neurotoxin Subtype B2 Binding to Its Receptors

Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1

Structural basis for the interaction of the chaperone Cbp3 with newly synthesized cytochrome b during mitochondrial respiratory chain assembly

Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC.

Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs

Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity.

Structural insight into DNA binding and oligomerization of the multifunctional Cox protein of bacteriophage P2

Structural studies of tri-functional human GART

Structure and steroid isomerase activity of Drosophila glutathione transferase E14 essential for ecdysteroid biosynthesis

Structure of dual receptor binding to botulinum neurotoxin B

Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion

Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy

Structures of the hydrolase domain of human 10-formyltetrahydrofolate dehydrogenase and its complex with a substrate analogue

Synaptotagmin Binding to Botulinum Neurotoxins

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

The ALFA-tag is a highly versatile tool for nanobody-based bioscience applications

The C repressor of the P2 bacteriophage

The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions.

The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site

The crystal structure of the bifunctional deaminase/reductase RibD of the riboflavin biosynthetic pathway in Escherichia coli: implications for the reductive mechanism