List of works - Alejandro Buschiazzo

A coiled coil switch mediates cold sensing by the thermosensory protein DesK.

scientific article published on 14 July 2015

A new generation of specific Trypanosoma cruzi trans-sialidase inhibitors

scientific article

A novel flagellar sheath protein, FcpA, determines filament coiling, translational motility and virulence for the Leptospira spirochete

scientific article published on 26 April 2016

Active nuclear import and cytoplasmic retention of activation-induced deaminase

scientific article published on 3 May 2009

Allosteric activation of bacterial response regulators: the role of the cognate histidine kinase beyond phosphorylation

scientific article published on 18 November 2014

An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete

scientific article published on 11 March 2020

Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase

scientific article published on 15 December 2006

Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance

scientific article published on 04 August 2018

Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm.

scientific article

Continuous fluorimetric assay for high-throughput screening of inhibitors of trans-sialidase from Trypanosoma cruzi

scientific article published in October 2006

Crystal Structure of the Metallo-β-Lactamase GOB in the Periplasmic Dizinc Form Reveals an Unusual Metal Site ⬇️

scientific article published on 25 July 2016

Crystal structure of Mycobacterium tuberculosis LppA, a lipoprotein confined to pathogenic mycobacteria

scientific article

Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: the carbohydrate binding mechanism involves residual sialidase activity

scientific article

Crystal structure of glycogen synthase: homologous enzymes catalyze glycogen synthesis and degradation

scientific article

Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase

scientific article

Crystallization and preliminary crystallographic analysis of PimA, an essential mannosyltransferase from Mycobacterium smegmatis

scientific article published on 22 April 2005

Crystallization of FcpA from Leptospira, a novel flagellar protein that is essential for pathogenesis.

scientific article

Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening

scientific article published on 24 December 2008

Draft Genome Sequences of 40 Pathogenic Leptospira Strains Isolated from Cattle in Uruguay

scientific article published on 21 November 2019

Evidence of adaptability in metal coordination geometry and active-site loop conformation among B1 metallo-beta-lactamases

scientific article

Expression, crystallization and preliminary X-ray crystallographic analysis of glucose-6-phosphate dehydrogenase from the human pathogen Trypanosoma cruzi in complex with substrate

scientific article published on 27 October 2011

FcpB Is a Surface Filament Protein of the Endoflagellum Required for the Motility of the Spirochete Leptospira.

scientific article

HemR is an OmpR/PhoB-like response regulator from Leptospira, which simultaneously effects transcriptional activation and repression of key haem metabolism genes

scientific article

Isolation of pathogenic Leptospira strains from naturally infected cattle in Uruguay reveals high serovar diversity, and uncovers a relevant risk for human leptospirosis

scientific article published on 13 September 2018

Kinetic and mechanistic analysis of Trypanosoma cruzi trans-sialidase reveals a classical ping-pong mechanism with acid/base catalysis

scientific article

Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira.

scientific article published on 23 February 2018

Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria

scientific article

Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine

scientific article published on 24 July 2020

Phylogenetic analysis of bovine leukemia viruses isolated in South America reveals diversification in seven distinct genotypes

article

Preliminary crystallographic studies of glycogen synthase from Agrobacterium tumefaciens

scientific article published on 21 February 2003

Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action

scientific article published on 12 December 2016

SIMBAD: a sequence-independent molecular-replacement pipeline

scientific article published on 08 June 2018

STRUCTURAL VIROLOGY. Conformational plasticity of a native retroviral capsid revealed by x-ray crystallography

scientific article

Sequence of a Trypanosoma rangeli gene closely related to Trypanosoma cruzi trans-sialidase.

scientific article

Sequence of the gene for a Trypanosoma cruzi protein antigenic during the chronic phase of human Chagas disease

scientific article

Snapshots of the Signaling Complex DesK:DesR in Different Functional States Using Rational Mutagenesis and X-ray Crystallography

Structural Basis for Feed-Forward Transcriptional Regulation of Membrane Lipid Homeostasis in Staphylococcus aureus

scientific article

Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis

scientific article

Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase

scientific article published on 17 May 2017

Structural and Enzymatic Insights into the ATP Binding and Autophosphorylation Mechanism of a Sensor Histidine Kinase

scientific article

Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase

scientific article

Structural and molecular basis of the peroxynitrite-mediated nitration and inactivation of Trypanosoma cruzi iron-superoxide dismutases (Fe-SODs) A and B: disparate susceptibilities due to the repair of Tyr35 radical by Cys83 in Fe-SODB through [...]

scientific article

Structural basis of lipid biosynthesis regulation in Gram-positive bacteria

scientific article published on 24 August 2006

Structural insights into bacterial resistance to cerulenin

scientific article

Structural insights into sialic acid enzymology

scientific article published on October 2008

Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase

scientific article published in May 2004

Structural plasticity and catalysis regulation of a thermosensor histidine kinase

scientific article

Structure of a human IgA1 Fab fragment at 1.55 Å resolution: potential effect of the constant domains on antigen-affinity modulation

scientific article

Structure ofMycobacterium tuberculosisRv2714, a representative of a duplicated gene family in Actinobacteria

scientific article

Swapping FAD binding motifs between plastidic and bacterial ferredoxin-NADP(H) reductases

scientific article

The Crystal Structure of Rv0813c from Mycobacterium tuberculosis Reveals a New Family of Fatty Acid-Binding Protein-Like Proteins in Bacteria

scientific article

The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis

scientific article

The crystal structure of the MAP kinase LmaMPK10 from Leishmania major reveals parasite-specific features and regulatory mechanisms

scientific article

The crystal structure of the malic enzyme from Candidatus Phytoplasma reveals the minimal structural determinants for a malic enzyme.

scientific article published on 6 April 2018

The crystal structure ofM. lepraeML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria

scientific article

The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase

scientific article published on 24 January 2003

The trans-sialidase from the african trypanosome Trypanosoma brucei

scientific article

Trypanosoma cruzi trans-Sialidase in Complex with a Neutralizing Antibody: Structure/Function Studies towards the Rational Design of Inhibitors

scientific article

Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile

scientific article

Trypanosoma rangeli sialidase: cloning, expression and similarity to T. cruzi trans-sialidase

scientific article published in December 1997

What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira

scientific article published on 18 February 2016

List of works by Alejandro Buschiazzo

A coiled coil switch mediates cold sensing by the thermosensory protein DesK.

A new generation of specific Trypanosoma cruzi trans-sialidase inhibitors

A novel flagellar sheath protein, FcpA, determines filament coiling, translational motility and virulence for the Leptospira spirochete

Active nuclear import and cytoplasmic retention of activation-induced deaminase

Allosteric activation of bacterial response regulators: the role of the cognate histidine kinase beyond phosphorylation

An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete

Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase

Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance

Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm.

Continuous fluorimetric assay for high-throughput screening of inhibitors of trans-sialidase from Trypanosoma cruzi

Crystal Structure of the Metallo-β-Lactamase GOB in the Periplasmic Dizinc Form Reveals an Unusual Metal Site ⬇️

Crystal structure of Mycobacterium tuberculosis LppA, a lipoprotein confined to pathogenic mycobacteria

Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: the carbohydrate binding mechanism involves residual sialidase activity

Crystal structure of glycogen synthase: homologous enzymes catalyze glycogen synthesis and degradation

Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase

Crystallization and preliminary crystallographic analysis of PimA, an essential mannosyltransferase from Mycobacterium smegmatis

Crystallization of FcpA from Leptospira, a novel flagellar protein that is essential for pathogenesis.

Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening

Draft Genome Sequences of 40 Pathogenic Leptospira Strains Isolated from Cattle in Uruguay

Evidence of adaptability in metal coordination geometry and active-site loop conformation among B1 metallo-beta-lactamases

Expression, crystallization and preliminary X-ray crystallographic analysis of glucose-6-phosphate dehydrogenase from the human pathogen Trypanosoma cruzi in complex with substrate

FcpB Is a Surface Filament Protein of the Endoflagellum Required for the Motility of the Spirochete Leptospira.

HemR is an OmpR/PhoB-like response regulator from Leptospira, which simultaneously effects transcriptional activation and repression of key haem metabolism genes

Isolation of pathogenic Leptospira strains from naturally infected cattle in Uruguay reveals high serovar diversity, and uncovers a relevant risk for human leptospirosis

Kinetic and mechanistic analysis of Trypanosoma cruzi trans-sialidase reveals a classical ping-pong mechanism with acid/base catalysis

Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira.

Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria

Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine

Phylogenetic analysis of bovine leukemia viruses isolated in South America reveals diversification in seven distinct genotypes

Preliminary crystallographic studies of glycogen synthase from Agrobacterium tumefaciens

Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action

SIMBAD: a sequence-independent molecular-replacement pipeline

STRUCTURAL VIROLOGY. Conformational plasticity of a native retroviral capsid revealed by x-ray crystallography

Sequence of a Trypanosoma rangeli gene closely related to Trypanosoma cruzi trans-sialidase.

Sequence of the gene for a Trypanosoma cruzi protein antigenic during the chronic phase of human Chagas disease

Snapshots of the Signaling Complex DesK:DesR in Different Functional States Using Rational Mutagenesis and X-ray Crystallography

Structural Basis for Feed-Forward Transcriptional Regulation of Membrane Lipid Homeostasis in Staphylococcus aureus

Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis

Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase

Structural and Enzymatic Insights into the ATP Binding and Autophosphorylation Mechanism of a Sensor Histidine Kinase

Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase

Structural and molecular basis of the peroxynitrite-mediated nitration and inactivation of Trypanosoma cruzi iron-superoxide dismutases (Fe-SODs) A and B: disparate susceptibilities due to the repair of Tyr35 radical by Cys83 in Fe-SODB through [...]

Structural basis of lipid biosynthesis regulation in Gram-positive bacteria

Structural insights into bacterial resistance to cerulenin

Structural insights into sialic acid enzymology

Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase

Structural plasticity and catalysis regulation of a thermosensor histidine kinase

Structure of a human IgA1 Fab fragment at 1.55 Å resolution: potential effect of the constant domains on antigen-affinity modulation

Structure ofMycobacterium tuberculosisRv2714, a representative of a duplicated gene family in Actinobacteria

Swapping FAD binding motifs between plastidic and bacterial ferredoxin-NADP(H) reductases

The Crystal Structure of Rv0813c from Mycobacterium tuberculosis Reveals a New Family of Fatty Acid-Binding Protein-Like Proteins in Bacteria

The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis

The crystal structure of the MAP kinase LmaMPK10 from Leishmania major reveals parasite-specific features and regulatory mechanisms

The crystal structure of the malic enzyme from Candidatus Phytoplasma reveals the minimal structural determinants for a malic enzyme.

The crystal structure ofM. lepraeML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria

The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase

The trans-sialidase from the african trypanosome Trypanosoma brucei

Trypanosoma cruzi trans-Sialidase in Complex with a Neutralizing Antibody: Structure/Function Studies towards the Rational Design of Inhibitors

Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile

Trypanosoma rangeli sialidase: cloning, expression and similarity to T. cruzi trans-sialidase

What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira