List of works - Stefania Ferrari

2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives

scientific article

2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1

scientific article

2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes

scientific article published on 30 January 2014

Antibacterial agent discovery using thymidylate synthase biolibrary screening.

scientific article

Aza-boronic acids as non-beta-lactam inhibitors of AmpC-beta-lactamase.

scientific article

Biochemical effects of riluzole on Leishmania parasites

scientific article published on December 2012

Biochemistry: Anchors away

scientific article

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity.

scientific article published on 8 March 2017

Comparing Drug Images and Repurposing Drugs with BioGPS and FLAPdock: The Thymidylate Synthase Case.

scientific article published on 12 July 2016

Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth

scientific article published on 13 August 2018

Constrained dansyl derivatives reveal bacterial specificity of highly conserved thymidylate synthases

scientific article published in March 2008

Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding.

scientific article published on 2 December 2009

Dimer-monomer equilibrium of human thymidylate synthase monitored by fluorescence resonance energy transfer

scientific article

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

scientific article

Homodimeric enzymes as drug targets.

scientific article published on January 2010

Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.

scientific article published on April 2015

Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening

scientific article

Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine

scientific article published in February 2005

Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase

scientific article

Inhibitor specificity via protein dynamics: insights from the design of antibacterial agents targeted against thymidylate synthase

scientific article

Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: Novel strategies to overcome cancer chemoresistance.

scientific article published on 31 October 2015

Internalization and Stability of a Thymidylate Synthase Peptide Inhibitor in Ovarian Cancer Cells

article published in 2014

Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)-carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors

scientific article

Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells.

scientific article published on 31 July 2013

Novel 3-benzoyl-2-piperazinylquinoxaline derivatives as potential antitumor agents

Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth

scientific article published on 12 February 2014

Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs

scientific article

Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase

scientific article

Sequence-based identification of specific drug target regions in the thymidylate synthase enzyme family

scientific article published on March 2008

Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors

article

Structure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors

scientific article

Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: evaluation of in vitro anti-cancer and anti-folate activities

scientific article published on 18 April 2007

Targeting the Trypanosomatidic Enzymes Pteridine Reductase and Dihydrofolate Reductase

The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment

scientific article published on 11 March 2015

The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition

scientific article published on 28 September 2005

The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism

scientific article

Thymidylate synthase structure, function and implication in drug discovery.

scientific article

Update on antifolate drugs targets

scientific article

Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase

scientific article

X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors

scientific article

List of works by Stefania Ferrari

2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives

2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1

2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes

Antibacterial agent discovery using thymidylate synthase biolibrary screening.

Aza-boronic acids as non-beta-lactam inhibitors of AmpC-beta-lactamase.

Biochemical effects of riluzole on Leishmania parasites

Biochemistry: Anchors away

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity.

Comparing Drug Images and Repurposing Drugs with BioGPS and FLAPdock: The Thymidylate Synthase Case.

Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth

Constrained dansyl derivatives reveal bacterial specificity of highly conserved thymidylate synthases

Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding.

Dimer-monomer equilibrium of human thymidylate synthase monitored by fluorescence resonance energy transfer

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

Homodimeric enzymes as drug targets.

Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.

Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening

Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine

Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase

Inhibitor specificity via protein dynamics: insights from the design of antibacterial agents targeted against thymidylate synthase

Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: Novel strategies to overcome cancer chemoresistance.

Internalization and Stability of a Thymidylate Synthase Peptide Inhibitor in Ovarian Cancer Cells

Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)-carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors

Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells.

Novel 3-benzoyl-2-piperazinylquinoxaline derivatives as potential antitumor agents

Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth

Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs

Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase

Sequence-based identification of specific drug target regions in the thymidylate synthase enzyme family

Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors

Structure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors

Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: evaluation of in vitro anti-cancer and anti-folate activities

Targeting the Trypanosomatidic Enzymes Pteridine Reductase and Dihydrofolate Reductase

The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment

The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition

The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism

Thymidylate synthase structure, function and implication in drug discovery.

Update on antifolate drugs targets

Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase

X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors