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List of works by Jean-Denis Docquier

1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases

scientific article

4-(N-Alkyl- and -Acyl-amino)-1,2,4-triazole-3-thione Analogs as Metallo-β-Lactamase Inhibitors: Impact of 4-Linker on Potency and Spectrum of Inhibition

scientific article published on 23 July 2020

Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization

article

An update on β-lactamase inhibitor discovery and development.

scientific article published on 7 November 2017

Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam

scientific article published on 20 June 2018

BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa

scientific article published on 2 November 2009

Biochemical Characterization of CPS-1, a Subclass B3 Metallo-β-Lactamase from a Chryseobacterium piscium Soil Isolate

scientific article published on 14 December 2015

Biochemical Characterization of VIM-39, a VIM-1-Like Metallo-β-Lactamase Variant from a Multidrug-Resistant Klebsiella pneumoniae Isolate from Greece

scientific article

Biochemical and Structural Characterization of the Subclass B1 Metallo- -Lactamase VIM-4

scientific article

Biochemical characterization of the POM-1 metallo-β-lactamase from Pseudomonas otitidis

scientific article published on 15 December 2014

Biochemical characterization of the TEM-107 extended-spectrum β-lactamase in a Klebsiella pneumoniae isolate from South Korea

scientific article published on 12 September 2011

Biochemical characterization of the THIN-B metallo-beta-lactamase of Janthinobacterium lividum

scientific article

Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound

scientific article published on 5 April 2016

CENTA as a chromogenic substrate for studying beta-lactamases.

scientific article

Carbapenem resistance in Pseudomonas aeruginosa isolates: an example of interaction between different mechanisms

scientific article

Chryseobacterium gleum in a man with prostatectomy in Senegal: a case report and review of the literature.

scientific article

Clonal relatedness and conserved integron structures in epidemiologically unrelated Pseudomonas aeruginosa strains producing the VIM-1 metallo-{beta}-lactamase from different Italian hospitals

scientific article

Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases.

scientific article published on 18 December 2017

Crystal Structure of the Narrow-Spectrum OXA-46 Class D  -Lactamase: Relationship between Active-Site Lysine Carbamylation and Inhibition by Polycarboxylates

scientific article

Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum β-Lactamase and its Complex with Moxalactam and Imipenem

scientific article

Crystal structure of a cold-adapted class C beta-lactamase

scientific article

Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases

scientific article

Deciphering multifactorial resistance phenotypes in Acinetobacter baumannii by genomics and targeted label-free proteomics.

scientific article published on 19 December 2017

Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol.

scientific article published on 10 June 2017

Discovery of <b>ANT3310</b>, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and <i>Acinetobacter baumannii</i>

scientific article published on 11 December 2020

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

scientific article published on 16 December 2019

Discovery of a Novel Metallo-β-Lactamase Inhibitor That Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae

scientific article published on 12 March 2018

Editorial overview: anti-infectives: towards novel antiviral and antibacterial drugs? Current approaches to address a growing medical need

scientific article published on 22 October 2014

Effect of High N-Acetylcysteine Concentrations on Antibiotic Activity against a Large Collection of Respiratory Pathogens

scientific article (publication date: December 2016)

Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D  -lactamase OXA-10 by rational protein design

scientific article

Expanding the Repertoire of Carbapenem-Hydrolyzing Metallo-ß-Lactamases by Functional Metagenomic Analysis of Soil Microbiota

scientific article

FIM-1, a new acquired metallo-β-lactamase from a Pseudomonas aeruginosa clinical isolate from Italy

scientific article published on 31 October 2012

Genetic and biochemical characterisation of CTX-M-37 extended-spectrum β-lactamase from an Enterobacter cloacae clinical isolate from Mongolia.

scientific article

Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States.

scientific article published on November 2010

High-Resolution Crystal Structure of the Subclass B3 Metallo- -Lactamase BJP-1: Rational Basis for Substrate Specificity and Interaction with Sulfonamides

scientific article

IMP-12, a new plasmid-encoded metallo-beta-lactamase from a Pseudomonas putida clinical isolate

scientific article

Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents.

scientific article published on 15 August 2017

Intermolecular interactions of the extended recognition site of VIM-2 metallo-β-lactamase with 1,2,4-triazole-3-thione inhibitors. Validations of a polarizable molecular mechanics potential by ab initio QC

scientific article published on 10 November 2020

Major enzymatic factors involved in bacterial penicillin resistance in Burkina Faso.

scientific article published in February 2007

Metallo-beta-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues

scientific article published on 16 January 2007

Molecular basis of selective inhibition and slow reversibility of avibactam against class D carbapenemases: a structure-guided study of OXA-24 and OXA-48

scientific article

Molecular heterogeneity of bla(VIM-2)-containing integrons from Pseudomonas aeruginosa plasmids encoding the VIM-2 metallo-beta-lactamase

scientific article published on 01 February 2001

Multidrug-resistant Pseudomonas aeruginosa producing PER-1 extended-spectrum serine-beta-lactamase and VIM-2 metallo-beta-lactamase.

scientific article published in September 2001

Nosocomial infections caused by multidrug-resistant isolates of pseudomonas putida producing VIM-1 metallo-beta-lactamase

scientific article

Nosocomial outbreak caused by multidrug-resistant Pseudomonas aeruginosa producing IMP-13 metallo-beta-lactamase

scientific article

Novel acquired metallo-beta-lactamase gene, bla(SIM-1), in a class 1 integron from Acinetobacter baumannii clinical isolates from Korea

scientific article

OXA-372, a novel carbapenem-hydrolysing class D β-lactamase from a Citrobacter freundii isolated from a hospital wastewater plant

scientific article

Occurrence of conjugative IncF-type plasmids harboring the blaCTX-M-15 gene in Enterobacteriaceae isolates from newborns in Tunisia

scientific article published on 8 October 2014

Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases

scientific article

Postgenomic scan of metallo-beta-lactamase homologues in rhizobacteria: identification and characterization of BJP-1, a subclass B3 ortholog from Bradyrhizobium japonicum

scientific article

Regulation of neuraminidase expression in Streptococcus pneumoniae.

scientific article

SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model

scientific article published on 30 November 2018

Simple microdilution test for detection of metallo-beta-lactamase production in Pseudomonas aeruginosa

scientific article

Structural Insight into Potent Broad-Spectrum Inhibition with Reversible Recyclization Mechanism: Avibactam in Complex with CTX-M-15 and Pseudomonas aeruginosa AmpC  -Lactamases

scientific article

Structure-Function Relationships of Class D Carbapenemases.

scientific article

Structure-based approach for identification of novel phenylboronic acids as serine-β-lactamase inhibitors.

scientific article

Synthesis of linear and cyclic guazatine derivatives endowed with antibacterial activity

scientific article published on 14 October 2014

Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors

scientific article

Type M Resistance to Macrolides Is Due to a Two-Gene Efflux Transport System of the ATP-Binding Cassette (ABC) Superfamily

article

VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa

scientific article published on 21 February 2020

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