List of works - Natacha Rochel

1α,20S-Dihydroxyvitamin D3 Interacts with Vitamin D Receptor: Crystal Structure and Route of Chemical Synthesis

scientific article published on 31 August 2017

1α,25(OH)2-3-epi-vitamin D3, a natural physiological metabolite of vitamin D3: its synthesis, biological activity and crystal structure with its receptor

scientific article

9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice

scientific article published in June 2015

A set of baculovirus transfer vectors for screening of affinity tags and parallel expression strategies

scientific article

A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects

scientific article

Adaptability of the Vitamin D nuclear receptor to the synthetic ligand Gemini: remodelling the LBP with one side chain rotation

scientific article

Allosteric Regulation in the Ligand Binding Domain of Retinoic Acid Receptorγ.

scientific article

Architecture of DNA Bound RAR heterodimers

scientific article published on January 2014

Aromatic-Based Design of Highly Active and Noncalcemic Vitamin D Receptor Agonists

scientific article published on 22 May 2018

Carborane-based design of a potent vitamin D receptor agonist.

scientific article published on 27 October 2015

Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies

scientific article published on 19 September 2006

Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings

scientific article

Communication between the ERRalpha homodimer interface and the PGC-1alpha binding surface via the helix 8-9 loop

scientific article

Conformational editing of intrinsically disordered protein by α-methylation

scientific article

Coordination Chemistry of the Carboxylate Type Siderophore Rhizoferrin: The Iron(III) Complex and Its Metal Analogs

scientific article published on 01 October 1996

Crystal structure of a vitamin D3 analog, ZK203278, showing dissociated profile

scientific article

Crystal structure of hereditary vitamin D-resistant rickets--associated mutant H305Q of vitamin D nuclear receptor bound to its natural ligand

scientific article

Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid

scientific article

Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects

scientific article

Crystal structure of the vitamin D nuclear receptor ligand binding domain in complex with a locked side chain analog of calcitriol

scientific article

Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a rec

scientific article published in April 2004

Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands

scientific article

Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia

scientific article published on 07 December 2020

DNA recognition by retinoic acid nuclear receptors

scientific article published on 31 March 2020

Dependence of the lytic activity of the N-terminal domain of human perforin on membrane lipid composition--implications for T-cell self-preservation

scientific article published on 01 October 1997

Design and synthesis of active vitamin D analogs

scientific article published on 24 March 2010

Design, synthesis, evaluation, and structure of vitamin D analogues with furan side chains

scientific article

Detection of nucleic acid-nuclear hormone receptor complexes with mass spectrometry

scientific article

Diastereotopic and deuterium effects in gemini

scientific article

Effects of ligand binding on the association properties and conformation in solution of retinoic acid receptors RXR and RAR.

scientific article published in March 2001

Enhancing Binding Affinity of an Intrinsically Disordered Protein by α-Methylation of Key Amino Acid Residues

Erratum to “Restricted Diversity of Antigen Binding Residues of Antibodies Revealed by Computational Alanine Scanning of 227 Antibody–Antigen Complexes” [J. Mol. Biol., 426, 2014, 3729–3743]

scientific article published on 11 February 2015

Expression of functional full-length hSRC-1 in eukaryotic cells using modified vaccinia virus Ankara and baculovirus

scientific article

Functional and structural characterization of the insertion region in the ligand binding domain of the vitamin D nuclear receptor.

scientific article

Investigation of 20S-hydroxyvitamin D3 analogs and their 1α-OH derivatives as potent vitamin D receptor agonists with anti-inflammatory activities.

scientific article published on 24 January 2018

Iron release from transferrin by pyoverdin and elastase from Pseudomonas aeruginosa.

scientific article

Large-scale expression and purification of the human vitamin D receptor and its ligand-binding domain for structural studies

scientific article published on December 1999

Ligand binding domain of vitamin D receptors

scientific article published on January 2006

List of Contributors

Modulation of RXR-DNA complex assembly by DNA context

scientific article published on 23 November 2018

Modulators of vitamin D nuclear receptor: recent advances from structural studies

scientific article published on January 2014

Molecular determinants of MED1 interaction with the DNA bound VDR-RXR heterodimer

scientific article published on 29 September 2020

Monitoring of the retinoic acid receptor-retinoid X receptor dimerization upon DNA binding by native mass spectrometry

scientific article published on 30 October 2015

Novel 1alpha,25-dihydroxyvitamin D3 analogues with the side chain at C12.

scientific article published in March 2006

Phosphorylation of the retinoic acid receptor alpha induces a mechanical allosteric regulation and changes in internal dynamics

scientific article

Probing a Water Channel near the A-Ring of Receptor-Bound 1α,25-Dihydroxyvitamin D3 with Selected 2α-Substituted Analogues†

scientific article published on 01 August 2006

Purification of the human RARgamma ligand-binding domain and crystallization of its complex with all-trans retinoic acid.

scientific article published on January 1997

Quercetin potentializes the respective cytotoxic activity of gemcitabine or doxorubicin on 3D culture of AsPC-1 or HepG2 cells, through the inhibition of HIF-1α and MDR1

scientific article published on 14 October 2020

RARbeta ligand-binding domain bound to an SRC-1 co-activator peptide: purification, crystallization and preliminary X-ray diffraction analysis

scientific article published on 20 October 2004

Rational design of RAR-selective ligands revealed by RARbeta crystal structure

scientific article

Recurrent activating mutations of PPARγ associated with luminal bladder tumors

scientific article published in Nature Communications

Restricted diversity of antigen binding residues of antibodies revealed by computational alanine scanning of 227 antibody-antigen complexes

scientific article

Retinoic acid receptors recognize the mouse genome through binding elements with diverse spacing and topology.

scientific article

Signature of the oligomeric behaviour of nuclear receptors at the sequence and structural level

scientific article

Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology

scientific article

Silicon analogues of the retinoid agonists TTNPB and 3-methyl-TTNPB, disila-TTNPB and disila-3-methyl-TTNPB: chemistry and biology

scientific article published on September 2007

Solution Behavior of the Intrinsically Disordered N-Terminal Domain of Retinoid X Receptor α in the Context of the Full-Length Protein

scientific article published on 03 March 2016

Solution Structures of PPARγ2/RXRα Complexes

scientific article published on 18 December 2012

Structural Basis for Ligand Activity in VDR

Structural Studies of Vitamin D Nuclear Receptor Ligand-Binding Properties

scientific article published on 27 November 2015

Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor

scientific article

Structural analysis and biological activities of BXL0124, a gemini analog of vitamin D

scientific article

Structural analysis of VDR complex with ZK168281 antagonist

scientific article published on 05 August 2020

Structural analysis of nuclear receptors: from isolated domains to integral proteins

scientific article published on 25 August 2011

Structural and functional insights into the ligand-binding domain of a nonduplicated retinoid X nuclear receptor from the invertebrate chordate amphioxus

scientific article

Structural aspects of Vitamin D endocrinology

scientific article published on 28 February 2017

Structural basis for DNA recognition and allosteric control of the retinoic acid receptors RAR-RXR

scientific article published on 01 September 2020

Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors

scientific article

Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin D nuclear receptor

scientific article

Structural basis for α-helix mimicry and inhibition of protein-protein interactions with oligourea foldamers

scientific article published on 16 September 2020

Structural basis of natural promoter recognition by the retinoid X nuclear receptor

scientific article

Structural insights into the molecular mechanism of vitamin D receptor activation by lithocholic acid involving a new mode of ligand recognition

scientific article

Structural investigation of the ligand binding domain of the zebrafish VDR in complexes with 1alpha,25(OH)2D3 and Gemini: purification, crystallization and preliminary X-ray diffraction analysis

scientific article

Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA

scientific journal article

Structure-activity relationship study of vitamin D analogs with oxolane group in their side chain

scientific article published on 2 April 2017

Structure-based design of a superagonist ligand for the vitamin D nuclear receptor

scientific article

Structure-function relationships and crystal structures of the vitamin D receptor bound 2 alpha-methyl-(20S,23S)- and 2 alpha-methyl-(20S,23R)-epoxymethano-1 alpha,25-dihydroxyvitamin D3

scientific article

Structure–function relationships in nuclear receptors: the facts

scientific article published on 19 April 2015

Structure–function study of gemini derivatives with two different side chains at C-20, Gemini-0072 and Gemini-0097

scientific article

Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction

scientific article

Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor

scientific article

Synthesis, structure, and biological activity of des-side chain analogues of 1α,25-dihydroxyvitamin D3 with substituents at C18

scientific article

Synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition

scientific article

The Tumor Suppressor FBW7 and the Vitamin D Receptor Are Mutual Cofactors in Protein Turnover and Transcriptional Regulation

scientific article published on 03 January 2019

The molecular mechanisms underlying the ERα-36-mediated signaling in breast cancer

scientific article published on 12 December 2016

The tumor suppressor FBW7 and the vitamin D receptor are mutual cofactors

The use of fluorescent intrabodies to detect endogenous gankyrin in living cancer cells

scientific article

The “Phantom Effect” of the Rexinoid LG100754: Structural and Functional Insights

scientific article

List of works by Natacha Rochel

1α,20S-Dihydroxyvitamin D3 Interacts with Vitamin D Receptor: Crystal Structure and Route of Chemical Synthesis

1α,25(OH)2-3-epi-vitamin D3, a natural physiological metabolite of vitamin D3: its synthesis, biological activity and crystal structure with its receptor

9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice

A set of baculovirus transfer vectors for screening of affinity tags and parallel expression strategies

A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects

Adaptability of the Vitamin D nuclear receptor to the synthetic ligand Gemini: remodelling the LBP with one side chain rotation

Allosteric Regulation in the Ligand Binding Domain of Retinoic Acid Receptorγ.

Architecture of DNA Bound RAR heterodimers

Aromatic-Based Design of Highly Active and Noncalcemic Vitamin D Receptor Agonists

Carborane-based design of a potent vitamin D receptor agonist.

Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies

Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings

Communication between the ERRalpha homodimer interface and the PGC-1alpha binding surface via the helix 8-9 loop

Conformational editing of intrinsically disordered protein by α-methylation

Coordination Chemistry of the Carboxylate Type Siderophore Rhizoferrin: The Iron(III) Complex and Its Metal Analogs

Crystal structure of a vitamin D3 analog, ZK203278, showing dissociated profile

Crystal structure of hereditary vitamin D-resistant rickets--associated mutant H305Q of vitamin D nuclear receptor bound to its natural ligand

Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid

Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects

Crystal structure of the vitamin D nuclear receptor ligand binding domain in complex with a locked side chain analog of calcitriol

Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a rec

Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands

Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia

DNA recognition by retinoic acid nuclear receptors

Dependence of the lytic activity of the N-terminal domain of human perforin on membrane lipid composition--implications for T-cell self-preservation

Design and synthesis of active vitamin D analogs

Design, synthesis, evaluation, and structure of vitamin D analogues with furan side chains

Detection of nucleic acid-nuclear hormone receptor complexes with mass spectrometry

Diastereotopic and deuterium effects in gemini

Effects of ligand binding on the association properties and conformation in solution of retinoic acid receptors RXR and RAR.

Enhancing Binding Affinity of an Intrinsically Disordered Protein by α-Methylation of Key Amino Acid Residues

Erratum to “Restricted Diversity of Antigen Binding Residues of Antibodies Revealed by Computational Alanine Scanning of 227 Antibody–Antigen Complexes” [J. Mol. Biol., 426, 2014, 3729–3743]

Expression of functional full-length hSRC-1 in eukaryotic cells using modified vaccinia virus Ankara and baculovirus

Functional and structural characterization of the insertion region in the ligand binding domain of the vitamin D nuclear receptor.

Investigation of 20S-hydroxyvitamin D3 analogs and their 1α-OH derivatives as potent vitamin D receptor agonists with anti-inflammatory activities.

Iron release from transferrin by pyoverdin and elastase from Pseudomonas aeruginosa.

Large-scale expression and purification of the human vitamin D receptor and its ligand-binding domain for structural studies

Ligand binding domain of vitamin D receptors

List of Contributors

Modulation of RXR-DNA complex assembly by DNA context

Modulators of vitamin D nuclear receptor: recent advances from structural studies

Molecular determinants of MED1 interaction with the DNA bound VDR-RXR heterodimer

Monitoring of the retinoic acid receptor-retinoid X receptor dimerization upon DNA binding by native mass spectrometry

Novel 1alpha,25-dihydroxyvitamin D3 analogues with the side chain at C12.

Phosphorylation of the retinoic acid receptor alpha induces a mechanical allosteric regulation and changes in internal dynamics

Probing a Water Channel near the A-Ring of Receptor-Bound 1α,25-Dihydroxyvitamin D3 with Selected 2α-Substituted Analogues†

Purification of the human RARgamma ligand-binding domain and crystallization of its complex with all-trans retinoic acid.

Quercetin potentializes the respective cytotoxic activity of gemcitabine or doxorubicin on 3D culture of AsPC-1 or HepG2 cells, through the inhibition of HIF-1α and MDR1

RARbeta ligand-binding domain bound to an SRC-1 co-activator peptide: purification, crystallization and preliminary X-ray diffraction analysis

Rational design of RAR-selective ligands revealed by RARbeta crystal structure

Recurrent activating mutations of PPARγ associated with luminal bladder tumors

Restricted diversity of antigen binding residues of antibodies revealed by computational alanine scanning of 227 antibody-antigen complexes

Retinoic acid receptors recognize the mouse genome through binding elements with diverse spacing and topology.

Signature of the oligomeric behaviour of nuclear receptors at the sequence and structural level

Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology

Silicon analogues of the retinoid agonists TTNPB and 3-methyl-TTNPB, disila-TTNPB and disila-3-methyl-TTNPB: chemistry and biology

Solution Behavior of the Intrinsically Disordered N-Terminal Domain of Retinoid X Receptor α in the Context of the Full-Length Protein

Solution Structures of PPARγ2/RXRα Complexes

Structural Basis for Ligand Activity in VDR

Structural Studies of Vitamin D Nuclear Receptor Ligand-Binding Properties

Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor

Structural analysis and biological activities of BXL0124, a gemini analog of vitamin D

Structural analysis of VDR complex with ZK168281 antagonist

Structural analysis of nuclear receptors: from isolated domains to integral proteins

Structural and functional insights into the ligand-binding domain of a nonduplicated retinoid X nuclear receptor from the invertebrate chordate amphioxus

Structural aspects of Vitamin D endocrinology

Structural basis for DNA recognition and allosteric control of the retinoic acid receptors RAR-RXR

Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors

Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin D nuclear receptor

Structural basis for α-helix mimicry and inhibition of protein-protein interactions with oligourea foldamers

Structural basis of natural promoter recognition by the retinoid X nuclear receptor

Structural insights into the molecular mechanism of vitamin D receptor activation by lithocholic acid involving a new mode of ligand recognition

Structural investigation of the ligand binding domain of the zebrafish VDR in complexes with 1alpha,25(OH)2D3 and Gemini: purification, crystallization and preliminary X-ray diffraction analysis

Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA

Structure-activity relationship study of vitamin D analogs with oxolane group in their side chain

Structure-based design of a superagonist ligand for the vitamin D nuclear receptor

Structure-function relationships and crystal structures of the vitamin D receptor bound 2 alpha-methyl-(20S,23S)- and 2 alpha-methyl-(20S,23R)-epoxymethano-1 alpha,25-dihydroxyvitamin D3

Structure–function relationships in nuclear receptors: the facts

Structure–function study of gemini derivatives with two different side chains at C-20, Gemini-0072 and Gemini-0097