List of works by Edward Rockenstein

A blood-brain barrier (BBB) disrupter is also a potent α-synuclein (α-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD)

scientific article

A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy

scientific article

A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease

scientific article published on 27 September 2016

A longitudinal study of behavioral deficits in an AβPP transgenic mouse model of Alzheimer's disease

scientific article published on January 2011

A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies

scientific article

A β-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain ⬇️

scientific article published on November 2, 2010

APP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesis

scientific article

Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo ⬇️

scientific article published on 24 March 2014

Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy

scientific article published on 19 March 2015

Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer

scientific article published on 24 January 2013

Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway

scientific article

Alpha-synuclein deficient mice are resistant to toxin-induced multiple system atrophy

scientific article published on April 2010

Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases

scientific article

Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease

scientific article published on June 2003

Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity

scientific article

Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid

scientific article

Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy

scientific article published on 13 October 2015

Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy

scientific article published on 13 January 2017

Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission

scientific article published on September 2012

Antidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophy

scientific article

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

scientific article

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.

scientific article published on 4 December 2017

Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment

scientific article published in January 2014

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

scientific article published on February 2005

Axonopathy in an α-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated α-synuclein

scientific article published on 9 January 2013

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

scientific article

Beneficial effects of a neurotrophic peptidergic mixture persist for a prolonged period following treatment interruption in a transgenic model of Alzheimer's disease

scientific article published on 25 July 2011

Beta-synuclein regulates Akt activity in neuronal cells. A possible mechanism for neuroprotection in Parkinson's disease

scientific article

Biological transgenic mouse models of Alzheimer's disease

scientific article published on January 2008

Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology

scientific article

Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease.

scientific article

Cerebrolysin modulates pronerve growth factor/nerve growth factor ratio and ameliorates the cholinergic deficit in a transgenic model of Alzheimer's disease

scientific article

Cerebrolysin™ efficacy in a transgenic model of tauopathy: role in regulation of mitochondrial structure

scientific article

Chronic administration of the neurotrophic agent cerebrolysin ameliorates the behavioral and morphological changes induced by neonatal ventral hippocampus lesion in a rat model of schizophrenia

scientific article

Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy

scientific article published on 05 January 2017

Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies

scientific article published on 15 December 2017

Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease

scientific article published on 28 September 2012

Corrigendum to “Patterns of gene dysregulation in the frontal cortex of patients with HIV encephalitis”

article

Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice

scientific article

Detection of peri-synaptic amyloid-β pyroglutamate aggregates in early stages of Alzheimer's disease and in AβPP transgenic mice using a novel monoclonal antibody

scientific article

Development of a new treatment for Alzheimer's disease and Parkinson's disease using anti-aggregatory beta-synuclein-derived peptides

scientific article

Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy

scientific article

Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy

scientific article published on 2 May 2017

Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters

scientific article

Disease-Modifying Effect of Adiponectin in Model of α-Synucleinopathies

scientific article

Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H β-synuclein

scientific article published on 26 September 2012

Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein

scientific article published on October 2011

ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo

scientific article

Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice

scientific article published on September 2013

Effects of Cerebrolysin on neurogenesis in an APP transgenic model of Alzheimer's disease

scientific article published on 28 November 2006

Effects of Novel Calpain Inhibitors in Transgenic Animal Model of Parkinson's disease/dementia with Lewy bodies

scientific article published in Scientific Reports

Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease

scientific article published in June 2005

Effects of the cholesterol-lowering compound methyl-beta-cyclodextrin in models of alpha-synucleinopathy

scientific article published on August 2006

Enhanced lysosomal pathology caused by beta-synuclein mutants linked to dementia with Lewy bodies

scientific article

Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP.

scientific article published in April 2004

Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD.

scientific article

Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy

scientific article published on 16 January 2012

Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse model

scientific article published on January 2012

Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease.

scientific article

HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders

scientific article

HIV-1 Tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: implications for HIV-associated neurocognitive disorders

scientific article

High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease

scientific article published on 15 July 2005

Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies

scientific article published on 19 May 2014

Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson's disease

scientific article

Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

article

In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility

scientific article

Increased BACE1 activity inhibits peripheral nerve regeneration after injury

scientific article

Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis

scientific article

Increased CDK5 expression in HIV encephalitis contributes to neurodegeneration via tau phosphorylation and is reversed with Roscovitine

scientific article

Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau.

scientific article

Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein.

scientific article published in November 2002

Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease

scientific article published on 2 February 2016

LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation

scientific article published in Nature Communications

Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease

scientific article published on 14 May 2015

Lentivirus mediated delivery of neurosin promotes clearance of wild-type α-synuclein and reduces the pathology in an α-synuclein model of LBD.

scientific article published on 17 April 2012

Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice

scientific article on November 2008

Longitudinal live imaging of retinal α-synuclein::GFP deposits in a transgenic mouse model of Parkinson's Disease/Dementia with Lewy Bodies

scientific article published on 8 July 2016

Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies

scientific article

Lysosomal pathology associated with alpha-synuclein accumulation in transgenic models using an eGFP fusion protein.

scientific article

Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases

scientific article

MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy

scientific article published on 17 October 2017

Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy

scientific article

Multiple system atrophy: experimental models and reality

scientific article published on 20 October 2017

Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis

scientific article

Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

scientific article published on March 2003

Neprilysin regulates amyloid Beta peptide levels

scientific article published on January 2004

Neprilysin-2 is an important β-amyloid degrading enzyme

scientific article on December 2010

Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer's disease model

scientific article

Neuro-peptide treatment with Cerebrolysin improves the survival of neural stem cell grafts in an APP transgenic model of Alzheimer disease

scientific article published on 9 May 2015

Neurodegeneration in a transgenic mouse model of multiple system atrophy is associated with altered expression of oligodendroglial-derived neurotrophic factors

scientific article

Neurofibrillary and neurodegenerative pathology in APP-transgenic mice injected with AAV2-mutant TAU: neuroprotective effects of Cerebrolysin

scientific article

Neurogranin binds α-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease

scientific article published on 19 October 2014

Neuronal to oligodendroglial α-synuclein redistribution in a double transgenic model of multiple system atrophy

scientific article published on March 2012

Neuropeptide Treatment with Cerebrolysin Enhances the Survival of Grafted Neural Stem Cell in an α-Synuclein Transgenic Model of Parkinson's Disease

scientific article published on January 2015

Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease

scientific article published on January 2009

Neuroprotective effects of Cerebrolysin in triple repeat Tau transgenic model of Pick's disease and fronto-temporal tauopathies

scientific article published on 26 November 2015

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

scientific article

Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders

scientific article

Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity

scientific article published on 24 May 2016

Neurotoxic effects of the HCV core protein are mediated by sustained activation of ERK via TLR2 signaling

scientific article published on 10 June 2011

Neurotrophic effects of Cerebrolysin in the Mecp2(308/Y) transgenic model of Rett syndrome

scientific article published on 04 July 2008

Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials

scientific article

Novel strategies for Alzheimer's disease treatment

scientific article published on December 2007

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

scientific article

Oligomer-prone E57K-mutant alpha-synuclein exacerbates integration deficit of adult hippocampal newborn neurons in transgenic mice

scientific article

Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease

scientific article (publication date: 29 April 2011)

Pathogenesis of hepatitis C virus coinfection in the brains of patients infected with HIV.

scientific article published on 15 June 2007

Patterns of gene dysregulation in the frontal cortex of patients with HIV encephalitis

scientific article

Peptides of presenilin-1 bind the amyloid precursor protein ectodomain and offer a novel and specific therapeutic approach to reduce ß-amyloid in Alzheimer's disease

scientific article

Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo.

scientific article published on 9 January 2017

Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease

2011 scientific article

Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses

scientific article published on 11 February 2013

Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders

scientific article published on 24 September 2011

Polyamine pathway contributes to the pathogenesis of Parkinson disease ⬇️

scientific article published on September 13, 2010

Preserved functional autonomic phenotype in adult mice overexpressing moderate levels of human alpha-synuclein in oligodendrocytes

scientific article

Prion infection promotes extensive accumulation of α-synuclein in aged human α-synuclein transgenic mice

scientific article

Prodegenerative IκBα expression in oligodendroglial α-synuclein models of multiple system atrophy

scientific article published on 17 December 2013

Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models

scientific article

Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model

scientific article published on July 2016

Regional comparison of the neurogenic effects of CNTF-derived peptides and cerebrolysin in AβPP transgenic mice

scientific article published on January 2011

Rifampicin reduces alpha-synuclein in a transgenic mouse model of multiple system atrophy

scientific article

Role of Protein Aggregation in Mitochondrial Dysfunction and Neurodegeneration in Alzheimer's and Parkinson's Diseases ⬇️

scientific article published on January 1, 2003

Role of neurotrophic factor alterations in the neurodegenerative process in HIV associated neurocognitive disorders

scientific article

Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus

scientific article

S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease

scientific journal article

Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy

scientific article

Systemic Central Nervous System (CNS)-targeted Delivery of Neuropeptide Y (NPY) Reduces Neurodegeneration and Increases Neural Precursor Cell Proliferation in a Mouse Model of Alzheimer Disease

scientific article

TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease

scientific article

Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

scientific article published on 28 August 2005

The Amazon rain forest plant Uncaria tomentosa (cat's claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles

scientific article published in Scientific Reports

The HIV Protein gp120 Alters Mitochondrial Dynamics in Neurons

scientific article

The Role of alpha-synuclein assembly and metabolism in the pathogenesis of Lewy body disease

scientific article

The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration

scientific article published on 19 January 2017

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

scientific article

The cannabinoid CB₂ receptor agonist AM1241 enhances neurogenesis in GFAP/Gp120 transgenic mice displaying deficits in neurogenesis

scientific article published on January 2014

The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease

scientific article published in Scientific Reports

The temporal expression pattern of alpha-synuclein modulates olfactory neurogenesis in transgenic mice

scientific article published on 11 May 2015

Time course and progression of wild type α-synuclein accumulation in a transgenic mouse model

scientific article

Toll-like receptor pathway gene expression is associated with human immunodeficiency virus-associated neurodegeneration

scientific article published in December 2007

Transgenic animal models of neurodegenerative diseases and their application to treatment development

scientific article published on 17 August 2007

Transgenic models of alpha-synuclein pathology: past, present, and future

scientific article

Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice

scientific article

Widespread microRNA dysregulation in multiple system atrophy - disease-related alteration in miR-96.

scientific article

alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease

scientific article

alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells

scientific article

α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy

scientific article

α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease

scientific article published on 5 January 2016

α-synuclein conformational antibodies fused to penetratin are effective in models of Lewy body disease

scientific article published on 16 June 2016

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