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List of works by Daniel Durocher

A Pif1-dependent threshold separates DNA double-strand breaks and telomeres

A Strategy for Modulation of Enzymes in the Ubiquitin System

scientific article

A Web Resource for Improved Analysis of AP-MS Protein Interaction Data

scientific article published in May 2013

A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice

scientific article

A consensus set of genetic vulnerabilities to ATR inhibition

scientific article published on 11 September 2019

A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator

scientific article

A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae.

scientific article published on 9 October 2008

A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery

scientific article

A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions

scientific article

A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres

scientific article published on 3 August 2017

A siRNA-based screen for genes involved in chromosome end protection

scientific article

A substrate binding model for the KEOPS tRNA modifying complex

scientific article published on 04 December 2020

A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses

scientific journal article

APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation

scientific article published on February 2008

ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice

scientific article published on 4 December 2017

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

scientific article

Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular Machine

scientific article

Bacterial signal transduction: a FHAscinating glimpse at the origins of phospho-dependent signal transduction

scientific article published in February 2003

CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition

scientific article published on 20 April 2022

CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation

scientific article

Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length

scientific article

Chromatin and DNA repair: the benefits of relaxation

Combinatorial interactions regulating cardiac transcription

scientific article published on January 1998

Combinatorial interactions regulating cardiac transcription

Control of homologous recombination by the HROB-MCM8-MCM9 pathway

scientific article published on 29 August 2019

DNA Repair Has a New FAN1 Club

DNA Repair: DNA Polymerase ζ and Rev1 Break in

DNA damage signalling targets the kinetochore to promote chromatin mobility

scientific article published on February 2016

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

scientific article

De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks

scientific article

Dun1 Counts on Rad53 to Be Turned On

Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability

scientific article

Engineering a DNA damage response without DNA damage

scientific article published on 28 July 2008

Erratum: Corrigendum: A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery

scientific article published in Nature

Functional characterization of a PROTAC directed against BRAF mutant V600E

scientific article published on 10 August 2020

Genome-scale chemogenomic CRISPR screens in human cells using the TKOv3 library

scientific article published on 05 February 2021

Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome

scientific article

HELB Is a Feedback Inhibitor of DNA End Resection

scientific journal article

Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency

scientific article published on 27 November 2017

Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture

scientific article published on 19 January 2012

Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival

scientific article published on 23 July 2021

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

scientific article

OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function

scientific article

OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

scientific article

PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint

scientific journal article

PP4 is a γH2AX phosphatase required for recovery from the DNA damage checkpoint.

scientific article published on 7 November 2008

Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process

scientific article

Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease ⬇️

scientific article published on February 8, 2011

RMI1 promotes DNA replication fork progression and recovery from replication fork stress

scientific article

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

scientific article

Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp.

scientific article

Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system

scientific article

Regulation of DNA Damage Responses by Ubiquitin and SUMO ⬇️

scientific article published on February 14, 2013

Regulatory ubiquitylation in response to DNA double-strand breaks

scientific article published on 18 February 2009

Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer

scientific article

SHLD2 promotes class switch recombination by preventing inactivating deletions within the Igh locus

scientific article published on 17 June 2020

Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation

scientific article published in August 2005

Shieldin – the protector of DNA ends

scientific article published on 04 April 2019

Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes

scholarly article

Srs2 enables checkpoint recovery by promoting disassembly of DNA damage foci from chromatin

scientific article published on 05 October 2011

Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis

scientific article

Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2

scientific article

Structural basis of Rad53 kinase activation by dimerization and activation segment exchange

scientific article

Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors

scientific article (publication date: 28 August 2014)

Synthetic Lethality in Cancer Therapeutics: The Next Generation

scientific article published in 2021

Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX.

scientific article

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

scientific article (publication date: 10 January 2002)

Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks

scientific article

Telomere Protection: An Act of God

The CRAPome: a contaminant repository for affinity purification-mass spectrometry data

scientific article

The F-box protein Dia2 overcomes replication impedance to promote genome stability in Saccharomyces cerevisiae.

scientific article

The FHA domain

scientific article

The FHA domain is a modular phosphopeptide recognition motif.

scientific article

The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination

scientific article

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

scientific article

The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage.

scientific article published on 13 April 2017

The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination

scientific journal article

The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors

scientific article

The control of DNA repair by the cell cycle

scientific article published on December 2016

The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase

scientific article

The structural basis of modified nucleosome recognition by 53BP1

scientific article

The ubiquitous role of ubiquitin in the DNA damage response

scientific article

Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer

scientific article published on January 2011

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV

scientific article

gammaH2AX as a checkpoint maintenance signal

scientific article

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