List of works - Karsten Niefind

1.6 angstroms structure of an NAD+-dependent quinate dehydrogenase from Corynebacterium glutamicum

scientific article

A novel esterase subfamily with α/β-hydrolase fold suggested by structures of two bacterial enzymes homologous to L-homoserine O-acetyl transferases

scientific article

Crystal structure and snapshots along the reaction pathway of a family 51 -L-arabinofuranosidase

scientific article

Crystal structure of D-hydantoinase from Bacillus stearothermophilus: insight into the stereochemistry of enantioselectivity

scientific article

Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit

scientific article

Crystal structure of creatininase from Pseudomonas putida: a novel fold and a case of convergent evolution

scientific article

Enzyme-substrate complexes of the quinate/shikimate dehydrogenase from Corynebacterium glutamicum enable new insights in substrate and cofactor binding, specificity, and discrimination

scientific article

Evolved to be active: sulfate ions define substrate recognition sites of CK2alpha and emphasise its exceptional role within the CMGC family of eukaryotic protein kinases

scientific article

First inactive conformation of CK2 alpha, the catalytic subunit of protein kinase CK2

scientific article

First structure of protein kinase CK2 catalytic subunit with an effective CK2β-competitive ligand

scientific article

Low-density crystal packing of human protein kinase CK2 catalytic subunit in complex with resorufin or other ligands: a tool to study the unique hinge-region plasticity of the enzyme without packing bias

scientific article

Protein kinase CK2 inhibition is associated with the destabilization of HIF-1α in human cancer cells

scientific article

The CK2 alpha/CK2 beta interface of human protein kinase CK2 harbors a binding pocket for small molecules

scientific article

The catalytic subunit of human protein kinase CK2 structurally deviates from its maize homologue in complex with the nucleotide competitive inhibitor emodin

scientific article

The crystal structure of R-specific alcohol dehydrogenase from Lactobacillus brevis suggests the structural basis of its metal dependency

scientific article (publication date: 21 March 2003)

The interaction of CK2α and CK2β, the subunits of protein kinase CK2, requires CK2β in a preformed conformation and is enthalpically driven

scientific article

The protein kinase CK2(Andante) holoenzyme structure supports proposed models of autoregulation and trans-autophosphorylation

scientific article

The structure of L-hydantoinase from Arthobacter aurescens leads to an understanding of dihydropyrimidinase substrate and enantio specificity

scientific article

The structure of a bacterial L-amino acid oxidase from Rhodococcus opacus gives new evidence for the hydride mechanism for dehydrogenation

scientific article

The three-dimensional structure of AKR11B4, a glycerol dehydrogenase from Gluconobacter oxydans, reveals a tryptophan residue as an accelerator of reaction turnover

scientific article

Unexpected active-site flexibility in the structure of human neutrophil elastase in complex with a new dihydropyrimidone inhibitor

scientific article

X-ray structure of a dihydropyrimidinase from Thermus sp. at 1.3 A resolution

scientific article

List of works by Karsten Niefind

1.6 angstroms structure of an NAD+-dependent quinate dehydrogenase from Corynebacterium glutamicum

A novel esterase subfamily with α/β-hydrolase fold suggested by structures of two bacterial enzymes homologous to L-homoserine O-acetyl transferases

Crystal structure and snapshots along the reaction pathway of a family 51 -L-arabinofuranosidase

Crystal structure of D-hydantoinase from Bacillus stearothermophilus: insight into the stereochemistry of enantioselectivity

Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit

Crystal structure of creatininase from Pseudomonas putida: a novel fold and a case of convergent evolution

Enzyme-substrate complexes of the quinate/shikimate dehydrogenase from Corynebacterium glutamicum enable new insights in substrate and cofactor binding, specificity, and discrimination

Evolved to be active: sulfate ions define substrate recognition sites of CK2alpha and emphasise its exceptional role within the CMGC family of eukaryotic protein kinases

First inactive conformation of CK2 alpha, the catalytic subunit of protein kinase CK2

First structure of protein kinase CK2 catalytic subunit with an effective CK2β-competitive ligand

Low-density crystal packing of human protein kinase CK2 catalytic subunit in complex with resorufin or other ligands: a tool to study the unique hinge-region plasticity of the enzyme without packing bias

Protein kinase CK2 inhibition is associated with the destabilization of HIF-1α in human cancer cells

The CK2 alpha/CK2 beta interface of human protein kinase CK2 harbors a binding pocket for small molecules

The catalytic subunit of human protein kinase CK2 structurally deviates from its maize homologue in complex with the nucleotide competitive inhibitor emodin

The crystal structure of R-specific alcohol dehydrogenase from Lactobacillus brevis suggests the structural basis of its metal dependency

The interaction of CK2α and CK2β, the subunits of protein kinase CK2, requires CK2β in a preformed conformation and is enthalpically driven

The protein kinase CK2(Andante) holoenzyme structure supports proposed models of autoregulation and trans-autophosphorylation

The structure of L-hydantoinase from Arthobacter aurescens leads to an understanding of dihydropyrimidinase substrate and enantio specificity

The structure of a bacterial L-amino acid oxidase from Rhodococcus opacus gives new evidence for the hydride mechanism for dehydrogenation

The three-dimensional structure of AKR11B4, a glycerol dehydrogenase from Gluconobacter oxydans, reveals a tryptophan residue as an accelerator of reaction turnover

Unexpected active-site flexibility in the structure of human neutrophil elastase in complex with a new dihydropyrimidone inhibitor

X-ray structure of a dihydropyrimidinase from Thermus sp. at 1.3 A resolution