List of works - Birgitta Henriques-Normark

A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis

scholarly article

An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps

scientific article published in February 2006

An individual-based network model to evaluate interventions for controlling pneumococcal transmission

scientific article

BCG Skin Infection Triggers IL-1R-MyD88-Dependent Migration of EpCAMlow CD11bhigh Skin Dendritic cells to Draining Lymph Node During CD4+ T-Cell Priming

scientific article

Bacterial adhesins in host-microbe interactions.

scientific article published on June 2009

Bacterial evasion of innate defense at epithelial linings

scientific article

Bacterial vaccines and antibiotic resistance

scientific article

Capsular expression in Streptococcus pneumoniae negatively affects spontaneous and antibiotic-induced lysis and contributes to antibiotic tolerance

scientific article

Capsule and D-alanylated lipoteichoic acids protect Streptococcus pneumoniae against neutrophil extracellular traps

scientific article published on 09 January 2007

Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the Invasive Respiratory Infection Surveillance Initiati

scientific article published in 2021

Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence.

scientific article

Cinobufagin Modulates Human Innate Immune Responses and Triggers Antibacterial Activity.

scientific article

Clinical and microbiological characteristics of severe Streptococcus pyogenes disease in Europe

scientific article published on 21 January 2009

Clinical efficacy of polyspecific intravenous immunoglobulin therapy in patients with streptococcal toxic shock syndrome: a comparative observational study

scientific article published on 13 June 2014

Clinical isolates of Streptococcus pneumoniae bind the complement inhibitor C4b-binding protein in a PspC allele-dependent fashion

scientific article

Clinical manifestations of invasive pneumococcal disease by vaccine and non-vaccine types

scientific article published on 16 October 2014

Clinical utility of PCR for common viruses in acute respiratory illness

scientific article published on 24 February 2014

Commensal pathogens, with a focus on Streptococcus pneumoniae, and interactions with the human host

scientific article published on 19 March 2010

Comparison of the Impact of Pneumococcal Conjugate Vaccine 10 or Pneumococcal Conjugate Vaccine 13 on Invasive Pneumococcal Disease in Equivalent Populations

scientific article published on 3 August 2017

Comprehensive antigen screening identifies Moraxella catarrhalis proteins that induce protection in a mouse pulmonary clearance model

scientific article

Contribution of host, bacterial factors and antibiotic treatment to mortality in adult patients with bacteraemic pneumococcal pneumonia ⬇️

scientific article published on February 26, 2013

Correction to 'The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold'

scholarly article published in Open Biology

Determination of accessory gene patterns predicts the same relatedness among strains of Streptococcus pneumoniae as sequencing of housekeeping genes does and represents a novel approach in molecular epidemiology

scientific article published on 26 December 2007

Differences in potency of intravenous polyspecific immunoglobulin G against streptococcal and staphylococcal superantigens: implications for therapy of toxic shock syndrome

scientific article published in March 2004

Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies

scientific article

Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infection

scientific article (publication date: 2013)

ETosis: a novel cell death pathway

scientific article

Effect of childhood pneumococcal conjugate vaccination on invasive disease in older adults of 10 European countries: implications for adult vaccination

scientific article published on 24 October 2018

Effect of high-valency pneumococcal conjugate vaccines on invasive pneumococcal disease in children in SpIDnet countries: an observational multicentre study

scientific article published on 27 March 2017

Effects of PCV7 and PCV13 on invasive pneumococcal disease and carriage in Stockholm, Sweden

scientific article published on 21 January 2016

Effects of Streptococcus pneumoniae strain background on complement resistance

scientific article (publication date: 2011)

Emergence of hypervirulent mutants resistant to early clearance during systemic serotype 1 pneumococcal infection in mice and humans

scientific article published on 16 January 2014

Emerging concepts in the pathogenesis of the Streptococcus pneumoniae: From nasopharyngeal colonizer to intracellular pathogen

scientific article published on 17 July 2019

Epidemiology of severe Streptococcus pyogenes disease in Europe.

scientific article published on 7 May 2008

Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences

scientific article

Factor H binding proteins protect division septa on encapsulated Streptococcus pneumoniae against complement C3b deposition and amplification

scientific article published in Nature Communications

Focal targeting by human β-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis.

scientific article

Genomic Characterization of the Emerging Pathogen Streptococcus pseudopneumoniae

scientific article published on 25 June 2019

Grad-seq in a Gram-positive bacterium reveals exonucleolytic sRNA activation in competence control

scientific article published on 30 March 2020

Gradient acoustic focusing of sub-micron particles for separation of bacteria from blood lysate

scientific article published on 28 February 2020

Gram-Positive Type IV Pili and Competence

scientific article published on 01 January 2019

Identification of a family of effectors secreted by the type III secretion system that are conserved in pathogenic Chlamydiae

scientific article

Immunomodulatory Effects of Pneumococcal Extracellular Vesicles on Cellular and Humoral Host Defenses.

scientific article

Impact of AmpC Derepression on Fitness and Virulence: the Mechanism or the Pathway?

scientific article published on 25 October 2016

Impaired release of antimicrobial peptides into nasal fluid of hyper-IgE and CVID patients

scientific article

Improvement of CRB-65 as a prognostic scoring system in adult patients with bacteraemic pneumococcal pneumonia ⬇️

scientific article published on March 3, 2011

Improvement of CRB-65 as a prognostic tool in adult patients with community-acquired pneumonia

scientific article

Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia

scientific article

Influenza A Virus Infection Predisposes Hosts to Secondary Infection with Different Streptococcus pneumoniae Serotypes with Similar Outcome but Serotype-Specific Manifestation

scientific article published on 19 September 2016

International quality assurance study for characterization of Streptococcus pyogenes

scientific article published on 31 January 2007

Intraclonal variations among Streptococcus pneumoniae isolates influence the likelihood of invasive disease in children

scientific article

Lysogenic transfer of group A Streptococcus superantigen gene among Streptococci

scientific article

Mannose receptor-derived peptides neutralize pore-forming toxins and reduce inflammation and development of pneumococcal disease

scientific article published on 28 September 2020

Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis

scientific article published on 13 March 2009

Membrane particles evoke a serotype-independent cross-protection against pneumococcal infection that is dependent on the conserved lipoproteins MalX and PrsA

scientific article published on 01 June 2022

Molecular and clinical characteristics of invasive group A streptococcal infection in Sweden

scientific article published on 10 July 2007

Myeloid differentiation factor 88-dependent signalling controls bacterial growth during colonization and systemic pneumococcal disease in mice.

scientific article

Neutrophil extracellular traps: casting the NET over pathogenesis.

scientific article published on 8 January 2007

Persistent infection with Helicobacter pylori and the development of gastric cancer

scientific article published on January 2003

Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis

scientific article published on 02 August 2013

Pilus adhesin RrgA interacts with complement receptor 3, thereby affecting macrophage function and systemic pneumococcal disease

scientific article

Pneumococcal Carriage in Children under Five Years in Uganda-Will Present Pneumococcal Conjugate Vaccines Be Appropriate?

scientific article

Pneumococcal meningitis is promoted by single cocci expressing pilus adhesin RrgA

scientific article

Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival

scientific article published on 12 November 2018

Prevalence of community-acquired bacteraemia in Guinea-Bissau: an observational study

scientific article

Reduced In Vitro Susceptibility of Streptococcus pyogenes to β-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread

scientific article published on 25 March 2020

Reply to Arends and Harkisoen

scientific article published on 13 October 2014

Reply to Theilacker, et al.

scientific article published on 19 December 2017

Respiratory viruses associated with community-acquired pneumonia in children: matched case-control study

scientific article published on 15 June 2015

Secretion of a pneumococcal type II secretion system pilus correlates with DNA uptake during transformation.

scientific article published on 03 February 2014

Serotype and molecular diversity of nasopharyngeal Streptococcus pneumoniae isolates from children before and after vaccination with the ten-valent pneumococcal conjugate vaccine (PCV10) in Ethiopia

scientific article published on 10 May 2019

Sinusitis and pneumonia hospitalization after introduction of pneumococcal conjugate vaccine

scientific article published on 10 November 2014

Small molecule inhibitors of the Yersinia type III secretion system impair the development of Chlamydia after entry into host cells

scientific article

Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle

scientific article published on 17 January 2007

Sortase-mediated assembly and surface topology of adhesive pneumococcal pili

scientific article

Streptococcus pneumoniae Senses a Human-like Sialic Acid Profile via the Response Regulator CiaR.

scientific article published on 31 August 2016

Streptococcus pneumoniae evades human dendritic cell surveillance by pneumolysin expression

scientific article published on July 2009

Structural and Functional Insights into Peptidoglycan Access for the Lytic Amidase LytA of Streptococcus pneumoniae

scientific article

Structure of the competence pilus major pilin ComGC in Streptococcus pneumoniae.

scientific article published on 28 June 2017

Studies on the Antibacterial Effects of Statins - In Vitro and In Vivo ⬇️

scientific article published on August 30, 2011

The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation

scientific article

The Role of Minor Pilins in Assembly and Function of the Competence Pilus of Streptococcus pneumoniae

scientific article published in 2021

The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold

scientific article

The capsule sensitizes Streptococcus pneumoniae to alpha-defensins human neutrophil proteins 1 to 3.

scientific article published on 12 May 2008

The epidemiology of pneumococcal infections--the Swedish experience

scientific article published on 01 December 2009

The fallacies of hope: will we discover new antibiotics to combat pathogenic bacteria in time?

scientific article published on November 2006

The function and biological role of toll-like receptors in infectious diseases: an update

scientific article published on June 2008

The impact of the ancillary pilus-1 protein RrgA of Streptococcus pneumoniae on colonization and disease

scientific article published on 01 March 2020

The influence of in vitro fitness defects on pneumococcal ability to colonize and to cause invasive disease

scientific article

The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection.

scientific article

The pneumococcus: epidemiology, microbiology, and pathogenesis

scientific article published on July 2013

The rise and fall of bacterial clones: Streptococcus pneumoniae

scientific article

Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection

scientific article

Two crystal structures of pneumococcal pilus sortase C provide novel insights into catalysis and substrate specificity

scientific article

Unaltered pneumococcal carriage prevalence due to expansion of non-vaccine types of low invasive potential 8years after vaccine introduction in Stockholm, Sweden

scientific article published on 26 July 2016

Uptake of extracellular DNA: competence induced pili in natural transformation of Streptococcus pneumoniae

scientific article

Variation in Inflammatory Response during Pneumococcal Infection Is Influenced by Host-Pathogen Interactions but Associated with Animal Survival

scientific article published on 19 January 2016

lytA-based identification methods can misidentify Streptococcus pneumoniae

scientific article published on 29 March 2016

pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion.

scientific article

List of works by Birgitta Henriques-Normark

A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis

An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps

An individual-based network model to evaluate interventions for controlling pneumococcal transmission

BCG Skin Infection Triggers IL-1R-MyD88-Dependent Migration of EpCAMlow CD11bhigh Skin Dendritic cells to Draining Lymph Node During CD4+ T-Cell Priming

Bacterial adhesins in host-microbe interactions.

Bacterial evasion of innate defense at epithelial linings

Bacterial vaccines and antibiotic resistance

Capsular expression in Streptococcus pneumoniae negatively affects spontaneous and antibiotic-induced lysis and contributes to antibiotic tolerance

Capsule and D-alanylated lipoteichoic acids protect Streptococcus pneumoniae against neutrophil extracellular traps

Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the Invasive Respiratory Infection Surveillance Initiati

Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence.

Cinobufagin Modulates Human Innate Immune Responses and Triggers Antibacterial Activity.

Clinical and microbiological characteristics of severe Streptococcus pyogenes disease in Europe

Clinical efficacy of polyspecific intravenous immunoglobulin therapy in patients with streptococcal toxic shock syndrome: a comparative observational study

Clinical isolates of Streptococcus pneumoniae bind the complement inhibitor C4b-binding protein in a PspC allele-dependent fashion

Clinical manifestations of invasive pneumococcal disease by vaccine and non-vaccine types

Clinical utility of PCR for common viruses in acute respiratory illness

Commensal pathogens, with a focus on Streptococcus pneumoniae, and interactions with the human host

Comparison of the Impact of Pneumococcal Conjugate Vaccine 10 or Pneumococcal Conjugate Vaccine 13 on Invasive Pneumococcal Disease in Equivalent Populations

Comprehensive antigen screening identifies Moraxella catarrhalis proteins that induce protection in a mouse pulmonary clearance model

Contribution of host, bacterial factors and antibiotic treatment to mortality in adult patients with bacteraemic pneumococcal pneumonia ⬇️

Correction to 'The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold'

Determination of accessory gene patterns predicts the same relatedness among strains of Streptococcus pneumoniae as sequencing of housekeeping genes does and represents a novel approach in molecular epidemiology

Differences in potency of intravenous polyspecific immunoglobulin G against streptococcal and staphylococcal superantigens: implications for therapy of toxic shock syndrome

Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies

Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infection

ETosis: a novel cell death pathway

Effect of childhood pneumococcal conjugate vaccination on invasive disease in older adults of 10 European countries: implications for adult vaccination

Effect of high-valency pneumococcal conjugate vaccines on invasive pneumococcal disease in children in SpIDnet countries: an observational multicentre study

Effects of PCV7 and PCV13 on invasive pneumococcal disease and carriage in Stockholm, Sweden

Effects of Streptococcus pneumoniae strain background on complement resistance

Emergence of hypervirulent mutants resistant to early clearance during systemic serotype 1 pneumococcal infection in mice and humans

Emerging concepts in the pathogenesis of the Streptococcus pneumoniae: From nasopharyngeal colonizer to intracellular pathogen

Epidemiology of severe Streptococcus pyogenes disease in Europe.

Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences

Factor H binding proteins protect division septa on encapsulated Streptococcus pneumoniae against complement C3b deposition and amplification

Focal targeting by human β-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis.

Genomic Characterization of the Emerging Pathogen Streptococcus pseudopneumoniae

Grad-seq in a Gram-positive bacterium reveals exonucleolytic sRNA activation in competence control

Gradient acoustic focusing of sub-micron particles for separation of bacteria from blood lysate

Gram-Positive Type IV Pili and Competence

Identification of a family of effectors secreted by the type III secretion system that are conserved in pathogenic Chlamydiae

Immunomodulatory Effects of Pneumococcal Extracellular Vesicles on Cellular and Humoral Host Defenses.

Impact of AmpC Derepression on Fitness and Virulence: the Mechanism or the Pathway?

Impaired release of antimicrobial peptides into nasal fluid of hyper-IgE and CVID patients

Improvement of CRB-65 as a prognostic scoring system in adult patients with bacteraemic pneumococcal pneumonia ⬇️

Improvement of CRB-65 as a prognostic tool in adult patients with community-acquired pneumonia

Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia

Influenza A Virus Infection Predisposes Hosts to Secondary Infection with Different Streptococcus pneumoniae Serotypes with Similar Outcome but Serotype-Specific Manifestation

International quality assurance study for characterization of Streptococcus pyogenes

Intraclonal variations among Streptococcus pneumoniae isolates influence the likelihood of invasive disease in children

Lysogenic transfer of group A Streptococcus superantigen gene among Streptococci

Mannose receptor-derived peptides neutralize pore-forming toxins and reduce inflammation and development of pneumococcal disease

Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis

Membrane particles evoke a serotype-independent cross-protection against pneumococcal infection that is dependent on the conserved lipoproteins MalX and PrsA

Molecular and clinical characteristics of invasive group A streptococcal infection in Sweden

Myeloid differentiation factor 88-dependent signalling controls bacterial growth during colonization and systemic pneumococcal disease in mice.

Neutrophil extracellular traps: casting the NET over pathogenesis.

Persistent infection with Helicobacter pylori and the development of gastric cancer

Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis

Pilus adhesin RrgA interacts with complement receptor 3, thereby affecting macrophage function and systemic pneumococcal disease

Pneumococcal Carriage in Children under Five Years in Uganda-Will Present Pneumococcal Conjugate Vaccines Be Appropriate?

Pneumococcal meningitis is promoted by single cocci expressing pilus adhesin RrgA

Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival

Prevalence of community-acquired bacteraemia in Guinea-Bissau: an observational study

Reduced In Vitro Susceptibility of Streptococcus pyogenes to β-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread

Reply to Arends and Harkisoen

Reply to Theilacker, et al.

Respiratory viruses associated with community-acquired pneumonia in children: matched case-control study

Secretion of a pneumococcal type II secretion system pilus correlates with DNA uptake during transformation.

Serotype and molecular diversity of nasopharyngeal Streptococcus pneumoniae isolates from children before and after vaccination with the ten-valent pneumococcal conjugate vaccine (PCV10) in Ethiopia

Sinusitis and pneumonia hospitalization after introduction of pneumococcal conjugate vaccine

Small molecule inhibitors of the Yersinia type III secretion system impair the development of Chlamydia after entry into host cells

Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle

Sortase-mediated assembly and surface topology of adhesive pneumococcal pili

Streptococcus pneumoniae Senses a Human-like Sialic Acid Profile via the Response Regulator CiaR.

Streptococcus pneumoniae evades human dendritic cell surveillance by pneumolysin expression

Structural and Functional Insights into Peptidoglycan Access for the Lytic Amidase LytA of Streptococcus pneumoniae

Structure of the competence pilus major pilin ComGC in Streptococcus pneumoniae.