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List of works by Christian Johannes Gloeckner

A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.

scientific article

A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.

scientific article published on 8 March 2017

A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover ⬇️

scientific article published on 18 October 2017

A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes

scientific article

A visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology

scientific article

ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2

scientific article

ARMS2 is a constituent of the extracellular matrix providing a link between familial and sporadic age-related macular degenerations

scientific article

ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2?

scientific article published on 12 January 2013

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

scientific journal article

Analysis of the expression pattern of the schizophrenia-risk and intellectual disability gene TCF4 in the developing and adult brain suggests a role in development and plasticity of cortical and hippocampal neurons.

scientific article

Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival

scientific article published on 09 March 2020

Applying SILAC for the differential analysis of protein complexes

scientific article published in January 2014

Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding

scientific article published on 13 November 2019

Autophosphorylation on S614 inhibits the activity and the transforming potential of BRAF.

scientific article published on 21 June 2016

Biochemical and kinetic properties of the complex Roco G-protein cycle

scientific article published on 01 November 2018

Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity.

scientific article published on 10 September 2012

Differential analysis of Saccharomyces cerevisiae mitochondria by free flow electrophoresis

scientific article published on 17 August 2006

Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice

scientific article

First model of dimeric LRRK2: the challenge of unrevealing the structure of a multidomain Parkinson's-associated protein

scientific article published on December 2016

Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p

scientific article

Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43)

scientific article published on 17 August 2018

Identification of paracrine neuroprotective candidate proteins by a functional assay-driven proteomics approach

scientific article published on 23 April 2008

Improved mass spectrometric identification of gel-separated hydrophobic membrane proteins after sodium dodecyl sulfate removal by ion-pair extraction

scientific article published in December 2004

Interspecies comparison of gene structure and computational analysis of gene regulation of 17beta-hydroxysteroid dehydrogenase type 1.

scientific article

LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis

scientific article published on 31 July 2019

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

scientific article

LRRK2 transport is regulated by its novel interacting partner Rab32

scientific article

Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain

scientific article

Mass spectrometric identification of novel posttranslational modification sites in Huntingtin.

scientific article published on June 2012

Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice

scientific article published on 08 September 2020

Membrane-initiated effects of progesterone on calcium dependent signaling and activation of VEGF gene expression in retinal glial cells

article

Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy

scientific article

Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3

scientific article

Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

scientific article published in April 2010

Phosphorylation Modulates the Subcellular Localization of SOX11.

scientific article

Proteomic analysis of the porcine interphotoreceptor matrix

scientific article published in September 2005

Prothymosin-α interacts with mutant huntingtin and suppresses its cytotoxicity in cell culture.

scientific article published on 22 November 2011

Regulation of LRRK2: insights from structural and biochemical analysis.

scientific article

Relationship of Pax6 activity levels to the extent of eye development in the mouse, Mus musculus

scientific article published on 18 June 2008

Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43

scientific article published on 09 March 2022

Strep/FLAG tandem affinity purification (SF-TAP) to study protein interactions

scientific article published on 01 August 2009

Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts

scientific journal article

Tandem affinity purification of protein complexes from mammalian cells by the Strep/FLAG (SF)-TAP tag.

scientific article published in January 2009

The Enhancer of split transcription factor Her8a is a novel dimerisation partner for Her3 that controls anterior hindbrain neurogenesis in zebrafish

scientific article

The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions.

scientific article

The LRRK2 N-terminal domain influences vesicle trafficking: impact of the E193K variant

scientific article published on 02 March 2020

The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1.

scientific article published on 28 February 2018

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

scientific article

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

scientific article

The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase.

scientific article published on 17 June 2011

The role of the plexin-A2 receptor in Sema3A and Sema3B signal transduction

scientific article

USP9X stabilizes XIAP to regulate mitotic cell death and chemoresistance in aggressive B-cell lymphoma

scientific article published on 16 June 2016

Understanding the role of genetic variability in LRRK2 in Indian population

scientific article published on 28 November 2018

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