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List of works by Saadi Khochbin

A bromodomain-DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT.

scientific article

A six gene expression signature defines aggressive subtypes and predicts outcome in childhood and adult acute lymphoblastic leukemia

scientific article

A specific CBP/p300-dependent gene expression programme drives the metabolic remodelling in late stages of spermatogenesis.

scientific article published on 13 February 2014

A unified phylogeny-based nomenclature for histone variants

scientific article

Accumulation of histone H1(0) during early Xenopus laevis development

scientific article published on 01 June 1995

Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin

scientific article

Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription

scientific article published on 25 March 2014

Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein

scientific article

Antisense RNA and p53 regulation in induced murine cell differentiation

scientific article published on October 28, 1992

Application of bromodeoxyuridine incorporation measurements to the determination of cell distribution within the S phase of the cell cycle

scientific article published on 01 September 1988

Arsenic trioxide rewires mantle cell lymphoma response to bortezomib

scientific article

Assembly and mechanosensory function of focal adhesions: experiments and models.

scientific article

Asymmetric nuclear reprogramming in somatic cell nuclear transfer?

scientific article published on January 2008

Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells

scientific article

Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock

scientific article

Bromodomain-dependent stage-specific male genome programming by Brdt

scientific journal article

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin

scientific article

Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy

scientific journal article

Cancer hallmarks sustained by ectopic activations of placenta/male germline genes.

scientific article published on 11 July 2013

Cdyl: a new transcriptional co-repressor

scientific article published on 8 August 2003

Cell cycle-related accumulation of H1(0) mRNA: induction in murine erythroleukemia cells.

scientific article published on June 1991

Characterization of Post-Meiotic Male Germ Cell Genome Organizational States

scientific article published on 01 January 2018

Characterization of a mutated p53 exhibiting a cell cycle-related nuclear translocation.

scientific article published on October 1994

Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein ⬇️

scientific article published on December 1, 1992

Characterization of the two H1(zero)-encoding genes from Xenopus laevis.

scientific article published in April 1997

Chromatin and epigenetics: dynamic organization meets regulated function

scientific article published in August 2003

Chromatin-to-nucleoprotamine transition is controlled by the histone H2B variant TH2B

scientific journal article

Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor

scientific article

Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia

scientific article published on 20 December 2017

Combined proteomic and in silico approaches to decipher post-meiotic male genome reprogramming in mice.

scientific article published on August 2012

Control of the histone-acetyltransferase activity of Tip60 by the HIV-1 transactivator protein, Tat

scientific article (publication date: 6 July 1999)

Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

scientific article

Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells

scientific article

Design and Synthesis of Cyclopeptide Analogues of the Potent Histone Deacetylase Inhibitor FR235222

scientific article published on 01 October 2007

Developmental regulation and butyrate-inducible transcription of the Xenopus histone H1(0) promoter.

scientific article

Developmentally regulated chromatin acetylation and histone H1(0) accumulation

scientific article published on 01 August 1995

Differences in nuclear positioning of 1q12 pericentric heterochromatin in normal and tumor B lymphocytes with 1q rearrangements.

scientific article

Differential Recognition of Histone H10 by Monoclonal Antibodies during Cell Differentiation and the Arrest of Cell Proliferation ⬇️

scientific article published on January 9, 1998

Differential histone modifications mark mouse imprinting control regions during spermatogenesis.

scientific article published on 25 January 2007

Differentiation of NUT midline carcinoma by epigenomic reprogramming

scientific article

Du nouveau dans la compréhension de la reprogrammation postméiotique du génome mâle

scientific article published on 01 February 2010

Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters

scientific article published on April 2016

Early events in murine erythroleukemia cells induced to differentiate: variation of the cell cycle parameters in relation to p53 accumulation

scientific article published on 01 December 1988

Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers

scientific article published on May 2013

Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells

scientific article

Epigenetic perturbations and cancer: innovative therapeutic strategies against cancer ⬇️

scientific article published on 01 November 2010

Establishment of male-specific epigenetic information.

scientific article

Exogenous Expression of Human Protamine 1 (hPrm1) Remodels Fibroblast Nuclei into Spermatid-like Structures.

scientific article

Expression of serpinb6 serpins in germ and somatic cells of mouse gonads

scientific article

Flow cytofluorimetric determination of protein distribution throughout the cell cycle

scientific article published on 01 July 1989

From meiosis to postmeiotic events: the secrets of histone disappearance.

scientific article published on 15 December 2009

Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers

scientific journal article

Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1

scientific article

Genome-scale acetylation-dependent histone eviction during spermatogenesis

scientific article published on 05 March 2014

Genome-wide mapping of histone H4 serine-1 phosphorylation during sporulation in Saccharomyces cerevisiae

scientific article

HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo

scientific journal article

HDAC6 a new cellular stress surveillance factor.

scientific article published on 15 October 2007

HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates

scientific journal article

HDAC6 controls the kinetics of platelet activation

scientific article published on 06 September 2012

HDAC6-p97/VCP controlled polyubiquitin chain turnover

scientific journal article

HDAC6-ubiquitin interaction controls the duration of HSF1 activation after heat shock.

scientific article

HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses

scientific article published on 7 July 2005

HMGB4, a novel member of the HMGB family, is preferentially expressed in the mouse testis and localizes to the basal pole of elongating spermatids.

scientific article published on 5 November 2008

HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation

scientific article

Higher concentrations of histone macroH2A in the Barr body are correlated with higher nucleosome density

scientific article published on 01 November 2000

Histone Acylation beyond Acetylation: Terra Incognita in Chromatin Biology.

scientific article

Histone Variant H2A.L.2 Guides Transition Protein-Dependent Protamine Assembly in Male Germ Cells.

scientific article

Histone deacetylase 6 is a FoxO transcription factor-dependent effector in skeletal muscle atrophy

scientific article

Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression.

scientific article published on 13 February 2005

Histone deacetylase complexes: functional entities or molecular reservoirs

scientific article published on 01 April 2001

Histone variants and sensing of chromatin functional states.

scientific article

Histone variants: critical determinants in tumour heterogeneity

scientific article published on 11 June 2019

Histone variants: essential actors in the male genome programing.

scientific article published on 20 November 2017

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification

scientific article

Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers

scientific journal article

Identification of a novel BET bromodomain inhibitor-sensitive, gene regulatory circuit that controls Rituximab response and tumour growth in aggressive lymphoid cancers.

scientific article published on 04 July 2013

Identity crisis in pulmonary arterial hypertension.

scientific article published in January 2018

In the Heart of a Dynamic Chromatin ⬇️

scientific article published on April 22, 2011

In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation

scientific journal article

Induced malignant genome reprogramming in somatic cells by testis-specific factors ⬇️

scientific article published on April 21, 2011

Induction of H1(0)-gene expression in B16 murine melanoma cells

scientific article published on 01 September 1992

Induction of autophagy and autophagy-dependent apoptosis in diffuse large B-cell lymphoma by a new antimalarial artemisinin derivative, SM1044.

scientific article published on 26 December 2017

Inhibition of BET Proteins Reduces Right Ventricle Hypertrophy and Pulmonary Hypertension Resulting from Combined Hypoxia and Pulmonary Inflammation

scientific article published on 30 July 2018

Involvement of retinoblastoma protein and HBP1 in histone H1(0) gene expression

scientific article

Lessons from yeast on emerging roles of the ATAD2 protein family in gene regulation and genome organization.

scientific article

Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity

scientific article published on 4 September 2014

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark

scientific article

MS_HistoneDB, a manually curated resource for proteomic analysis of human and mouse histones.

scientific article

Malignant genome reprogramming by ATAD2 ⬇️

scientific article published on 03 July 2013

Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally

scientific article

Misregulation of histone acetylation in Sertoli cell-only syndrome and testicular cancer

scientific article published on 01 December 2003

Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins

scientific article

Molecular models for post-meiotic male genome reprogramming.

scientific article published on 6 January 2011

Monitoring the interaction between DNA and a transcription factor (MEF2A) using fluorescence correlation spectroscopy.

scientific article

Motor-driven marginal band coiling promotes cell shape change during platelet activation.

scientific article

Mouse oocytes and early embryos express multiple histone H1 subtypes

scientific journal article

Multiple control level governing H10 mRNA and protein accumulation.

scientific article published in May 1991

Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition

scientific article

Muscle hypertrophy in hypoxia with inflammation is controlled by bromodomain and extra-terminal domain proteins.

scientific article published on 21 September 2017

New hypotheses for large-scale epigenome alterations in somatic cancer cells: a role for male germ-cell-specific regulators.

scientific article published in October 2009

Nut Directs p300-Dependent, Genome-Wide H4 Hyperacetylation in Male Germ Cells

scientific article published on 01 September 2018

PenDA, a rank-based method for personalized differential analysis: Application to lung cancer

scientific article published on 11 May 2020

Pericentric heterochromatin reprogramming by new histone variants during mouse spermiogenesis.

scientific article

Persian role in flowering of Islamic science

scientific article published in Nature

Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis.

scientific article

Preface to the "epigenetics and development" special issue.

scientific article published in January 2009

Pregnancy exposure to atmospheric pollution and meteorological conditions and placental DNA methylation

scientific article published on 21 June 2018

Proteomic strategy for the identification of critical actors in reorganization of the post-meiotic male genome

scientific article published on 04 October 2011

Purification and Analysis of Male Germ Cells from Adult Mouse Testis.

scientific article published in January 2017

Real-time imaging of histone H4 hyperacetylation in living cells

scientific article

Receptor-Independent Ectopic Activity of Prolactin Predicts Aggressive Lung Tumors and Indicates HDACi-Based Therapeutic Strategies

scientific article published on 6 March 2014

Recovery of RNA from flow-sorted fixed cells

scientific article published on 01 January 1990

Regulated hyperacetylation of core histones during mouse spermatogenesis: involvement of histone deacetylases

scientific article published on 01 December 2000

Regulation of histone H1(0) accumulation during induced differentiation of murine erythroleukemia cells

scientific article published on 01 January 1991

Regulation of protein turnover by acetyltransferases and deacetylases.

scientific article

Relationship between core histone acetylation and histone H1(0) gene activity

scientific article published on September 1994

Remodeling somatic nuclei via exogenous expression of protamine 1 to create spermatid-like structures for somatic nuclear transfer

scientific article published on 6 October 2016

Role of the tetradecapeptide repeat domain of human histone deacetylase 6 in cytoplasmic retention.

scientific article published on 3 September 2004

Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation.

scientific article

Spermiogenesis: histone acetylation triggers male genome reprogramming

scientific article

Stress-induced transcription of satellite III repeats.

scientific article published on 29 December 2003

Structure of p300 in complex with acyl-CoA variants.

scientific article published on 31 October 2016

Sustaining cancer through addictive ectopic gene activation

scientific article published on January 2014

Systematic screen reveals new functional dynamics of histones H3 and H4 during gametogenesis

scientific article

Tat-controlled protein acetylation

scientific article (publication date: 4 October 2002)

The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway

scientific journal article

The Role of Bromodomain Testis-Specific Factor, BRDT, in Cancer: A Biomarker and A Possible Therapeutic Target

scientific article

The growing landscape of tubulin acetylation: lysine 40 and many more.

scientific article published on July 2016

The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat

scientific article (publication date: 27 July 2001)

The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling

scientific article (publication date: April 2003)

The mystery of histone disappearance during spermatogenesis

scientific article published in June 2017

The origin and utility of histone deacetylases.

scientific article published on December 1997

The tale of protein lysine acetylation in the cytoplasm.

scientific article

The viral control of cellular acetylation signaling.

scientific article

Tip60 acetyltransferase activity is controlled by phosphorylation

scientific article (publication date: 14 February 2003)

Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation

scientific article

Transgenerational inheritance of chromatin states

Two catalytic domains are required for protein deacetylation.

scientific article published on 6 November 2005

UV laser footprinting and protein-DNA crosslinking. Application to chromatin.

scientific article

Variation of H1(0) content throughout the cell cycle in regenerating rat liver

scientific article published on 01 April 1995

What do linker histones do in chromatin?

scientific article published on March 1997

When are the BET factors the most sensitive to bromodomain inhibitors?

scientific article published on 14 February 2013

[Cross-fire over the nucleosome: molecular basis of post-meiotic male haploid genome compaction]

scientific article published on 30 May 2012

[Epigenetics of the sperm cell]

scientific article published on 01 September 2006

[HDAC6 orchestrates cell defense responses against cytotoxic protein aggregates]

scientific article published on 01 January 2008

[Intrusion of male epigenome regulators in somatic cancer cells]

scientific article published on 01 August 2008

[Nucleosome differentiation: role of histone H2A variants]

scientific article published on 01 November 2003

[Organizing the sperm nucleus]

scientific article published on 01 September 2004

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