List of works - Peter Cherepanov

3′-Processing and strand transfer catalysed by retroviral integrasein crystallo

scientific article

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

scientific article

A bipartite structural organization defines the SERINC family of HIV-1 restriction factors

scientific article published on 06 January 2020

A supramolecular assembly mediates lentiviral DNA integration ⬇️

scientific article published on January 2017

A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

scientific article

Activities, Crystal Structures, and Molecular Dynamics of Dihydro-1 H -isoindole Derivatives, Inhibitors of HIV-1 Integrase

scientific article

Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites

scientific article

Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration

scientific article published on 18 September 2013

Cdt1 stabilizes an open MCM ring for helicase loading

scientific article published on 23 June 2017

Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis

scientific article

Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication

scientific article published on December 2004

Correction: Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration

scientific article published on 10 October 2016

Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.

scientific article published on February 2016

Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ

scientific article published on 07 October 2020

Crystal structure of human CDC7 kinase in complex with its activator DBF4

scientific article

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6

scientific article published on 01 May 2019

Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses.

scientific article

Expression of HIV-1 integrase in CEM cells inhibits HIV-1 replication

scientific article published on March 2004

Functional and structural characterization of the integrase from the prototype foamy virus

scientific article

HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases

scientific article published on 25 January 2016

HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome

scientific article

HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

scientific article (publication date: 3 January 2003)

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

scientific article

Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75

scientific article

Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

scientific article

In search of authentic inhibitors of HIV-1 integration

scientific article

Integrase illuminated

scientific article

Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding.

scientific article published on 11 February 2014

Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration.

scientific article

Key determinants of target DNA recognition by retroviral intasomes

scientific article published on 30 April 2015

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

scientific article

LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro

scientific article published on 7 December 2006

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

scientific article

Lys-34, dispensable for integrase catalysis, is required for preintegration complex function and human immunodeficiency virus type 1 replication

scientific article published on October 2005

Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients

scientific article published in 2022

Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.

scientific article

Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology

scientific article published on January 2005

New class of HIV integrase inhibitors that block viral replication in cell culture

scientific article published on July 2002

POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication

scientific article published on 11 September 2018

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

scientific article published on 06 November 2020

Proceedings of the Frontiers of Retrovirology Conference 2016.

scientific article published on 26 September 2016

Retroviral DNA Integration

scientific article

Retroviral Integrase Structure and DNA Recombination Mechanism

scientific article

Retroviral intasome assembly and inhibition of DNA strand transfer

scientific article

Retroviral intasomes arising

scientific article

Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer

scientific article published on 13 September 2019

Role of Yersinia murine toxin in survival of Yersinia pestis in the midgut of the flea vector

scientific article

SARS-CoV-2 can recruit a heme metabolite to evade antibody immunity

scientific article

Solution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA.

scientific article

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

scientific article

Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)

scientific article

Structural basis for functional tetramerization of lentiviral integrase

scientific article (publication date: July 2009)

Structural basis for nuclear import of splicing factors by human Transportin 3

scientific article

Structural basis for retroviral integration into nucleosomes.

scientific article

Structural basis for spumavirus GAG tethering to chromatin ⬇️

scientific article

Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

scientific article published on 17 August 2021

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

scientific article

Structural basis of second-generation HIV integrase inhibitor action and viral resistance

scientific article

Structural biology of retroviral DNA integration

scientific article published on 8 January 2011

Structural insights into the retroviral DNA integration apparatus.

scientific article published on February 2011

Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors.

scientific article published on 24 July 2017

Structure-based modeling of the functional HIV-1 intasome and its inhibition

scientific article

Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness

scientific article published on 7 September 2006

The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights

scientific article

The SET complex acts as a barrier to autointegration of HIV-1

scientific article

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication

scientific article

The mechanism of retroviral integration from X-ray structures of its key intermediates ⬇️

scientific article published on November 11, 2010

The structural biology of HIV-1: mechanistic and therapeutic insights

scientific article published on 16 March 2012

Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity

scientific article

Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin

scientific article

env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors

scientific article

pH6 antigen of Yersinia pestis interacts with plasma lipoproteins and cell membranes

scientific article published on 16 November 2002

List of works by Peter Cherepanov

3′-Processing and strand transfer catalysed by retroviral integrasein crystallo

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

A bipartite structural organization defines the SERINC family of HIV-1 restriction factors

A supramolecular assembly mediates lentiviral DNA integration ⬇️

A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

Activities, Crystal Structures, and Molecular Dynamics of Dihydro-1 H -isoindole Derivatives, Inhibitors of HIV-1 Integrase

Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites

Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration

Cdt1 stabilizes an open MCM ring for helicase loading

Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis

Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication

Correction: Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration

Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.

Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ

Crystal structure of human CDC7 kinase in complex with its activator DBF4

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6

Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses.

Expression of HIV-1 integrase in CEM cells inhibits HIV-1 replication

Functional and structural characterization of the integrase from the prototype foamy virus

HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases

HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome

HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75

Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

In search of authentic inhibitors of HIV-1 integration

Integrase illuminated

Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding.

Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration.

Key determinants of target DNA recognition by retroviral intasomes

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

Lys-34, dispensable for integrase catalysis, is required for preintegration complex function and human immunodeficiency virus type 1 replication

Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients

Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.

Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology

New class of HIV integrase inhibitors that block viral replication in cell culture

POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

Proceedings of the Frontiers of Retrovirology Conference 2016.

Retroviral DNA Integration

Retroviral Integrase Structure and DNA Recombination Mechanism

Retroviral intasome assembly and inhibition of DNA strand transfer

Retroviral intasomes arising

Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer

Role of Yersinia murine toxin in survival of Yersinia pestis in the midgut of the flea vector

SARS-CoV-2 can recruit a heme metabolite to evade antibody immunity

Solution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA.

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)

Structural basis for functional tetramerization of lentiviral integrase

Structural basis for nuclear import of splicing factors by human Transportin 3

Structural basis for retroviral integration into nucleosomes.

Structural basis for spumavirus GAG tethering to chromatin ⬇️

Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

Structural basis of second-generation HIV integrase inhibitor action and viral resistance

Structural biology of retroviral DNA integration

Structural insights into the retroviral DNA integration apparatus.

Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors.

Structure-based modeling of the functional HIV-1 intasome and its inhibition

Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness

The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights

The SET complex acts as a barrier to autointegration of HIV-1

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication

The mechanism of retroviral integration from X-ray structures of its key intermediates ⬇️

The structural biology of HIV-1: mechanistic and therapeutic insights

Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity

Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin

env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors

pH6 antigen of Yersinia pestis interacts with plasma lipoproteins and cell membranes