List of works - Florian Nachon

A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides

scientific article published on 06 March 2020

A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters

scientific article published on 16 April 2008

A step toward the reactivation of aged cholinesterases – Crystal structure of ligands binding to aged human butyrylcholinesterase ⬇️

scientific article published on August 16, 2012

Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation

scientific article

Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry

scientific article

Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase.

scientific article published in November 2017

Binding and hydrolysis of soman by human serum albumin

scientific article published on 29 December 2007

Characterization of four BCHE mutations associated with prolonged effect of suxamethonium

scientific article published on 06 October 2020

Characterization of organophosphate-induced brain injuries in a convulsive mouse model of diisopropylfluorophosphate exposure

scientific article published on 02 May 2020

Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products

scientific article

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase ⬇️

scientific article published on August 1, 2013

Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime

scientific article

Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos

scientific article

Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

scientific article published on 04 June 2020

Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization

scientific article published in January 2002

Evolution of acetylcholinesterase and butyrylcholinesterase in the vertebrates: an atypical butyrylcholinesterase from the Medaka Oryzias latipes

scientific article

Exposure to tri-o-cresyl phosphate detected in jet airplane passengers ⬇️

scientific article published on June 24, 2011

Impact of Sucrose as Osmolyte on Molecular Dynamics of Mouse Acetylcholinesterase

scientific article published on 12 December 2020

Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry

scientific article

Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel

scientific article published on 15 April 2008

Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates

scientific article

Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase

scientific article

New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease

scientific article published on 25 May 2019

Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase

scientific article published on 08 November 2018

Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease

scientific article published on 27 February 2019

On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach.

scientific article published on 19 January 2017

Potent 3-hydroxy-2-pyridine aldoxime reactivators of organophosphate-inhibited cholinesterases with predicted blood-brain barrier penetration

scientific article published on 19 April 2018

Purification of recombinant human butyrylcholinesterase on Hupresin®

scientific article published on 25 October 2018

Reactibodies generated by kinetic selection couple chemical reactivity with favorable protein dynamics

scientific article

Reaction of Cresyl Saligenin Phosphate, the Organophosphorus Agent Implicated in Aerotoxic Syndrome, with Human Cholinesterases: Mechanistic Studies Employing Kinetics, Mass Spectrometry, and X-ray Structure Analysis

scientific article

Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents

scientific article published on 23 February 2012

Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging

scientific article

Structural Study of the Complex Stereoselectivity of Human Butyrylcholinesterase for the Neurotoxic V-agents

scientific article

Structural approach to the aging of phosphylated cholinesterases

scientific article published on 23 March 2010

Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation

scientific article

Structure, activities and biomedical applications of human butyrylcholinesterase

scientific article published on January 2009

Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents

scientific article published on 31 August 2018

Substrate activation in acetylcholinesterase induced by low pH or mutation in the pi-cation subsite

scientific article published in February 2002

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

scientific article published on 11 December 2017

The reactant state for substrate-activated turnover of acetylthiocholine by butyrylcholinesterase is a tetrahedral intermediate

scientific article published on October 2005

Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography

scientific article

X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger

scientific article

X-ray structures of human bile-salt activated lipase conjugated to nerve agents surrogates

scientific article published on 22 October 2018

List of works by Florian Nachon

A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides

A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters

A step toward the reactivation of aged cholinesterases – Crystal structure of ligands binding to aged human butyrylcholinesterase ⬇️

Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation

Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry

Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase.

Binding and hydrolysis of soman by human serum albumin

Characterization of four BCHE mutations associated with prolonged effect of suxamethonium

Characterization of organophosphate-induced brain injuries in a convulsive mouse model of diisopropylfluorophosphate exposure

Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase ⬇️

Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime

Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos

Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization

Evolution of acetylcholinesterase and butyrylcholinesterase in the vertebrates: an atypical butyrylcholinesterase from the Medaka Oryzias latipes

Exposure to tri-o-cresyl phosphate detected in jet airplane passengers ⬇️

Impact of Sucrose as Osmolyte on Molecular Dynamics of Mouse Acetylcholinesterase

Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry

Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel

Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates

Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase

New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease

Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase

Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease

On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach.

Potent 3-hydroxy-2-pyridine aldoxime reactivators of organophosphate-inhibited cholinesterases with predicted blood-brain barrier penetration

Purification of recombinant human butyrylcholinesterase on Hupresin®

Reactibodies generated by kinetic selection couple chemical reactivity with favorable protein dynamics

Reaction of Cresyl Saligenin Phosphate, the Organophosphorus Agent Implicated in Aerotoxic Syndrome, with Human Cholinesterases: Mechanistic Studies Employing Kinetics, Mass Spectrometry, and X-ray Structure Analysis

Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents

Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging

Structural Study of the Complex Stereoselectivity of Human Butyrylcholinesterase for the Neurotoxic V-agents

Structural approach to the aging of phosphylated cholinesterases

Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation

Structure, activities and biomedical applications of human butyrylcholinesterase

Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents

Substrate activation in acetylcholinesterase induced by low pH or mutation in the pi-cation subsite

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

The reactant state for substrate-activated turnover of acetylthiocholine by butyrylcholinesterase is a tetrahedral intermediate

Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography

X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger

X-ray structures of human bile-salt activated lipase conjugated to nerve agents surrogates