List of works - Ramón Hurtado-Guerrero

A Trapped Covalent Intermediate of a Glycoside Hydrolase on the Pathway to Transglycosylation. Insights from Experiments and Quantum Mechanics/Molecular Mechanics Simulations

scientific article

A hydrogen bond network in the active site of Anabaena ferredoxin-NADP(+) reductase modulates its catalytic efficiency

scientific article

A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor

scientific article published on 24 March 2020

A perspective on structural and mechanistic aspects of protein O-fucosylation

scientific article published on 26 July 2018

A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2.

scientific article published on 8 February 2016

Anti-tumoral potential of a human granulysin-based, CEA-targeted cytolytic immunotoxin

scientific article published on 22 July 2019

Characterization of the cDNA and in vitro expression of the ram seminal plasma protein RSVP14.

scientific article published on 24 February 2013

Choline kinase active site provides features for designing versatile inhibitors

scientific article published on January 2014

Citrobacter rodentium NleB Protein Inhibits Tumor Necrosis Factor (TNF) Receptor-associated Factor 3 (TRAF3) Ubiquitination to Reduce Host Type I Interferon Production

scientific article published on 7 July 2016

Cross-Link Formation of the Cysteine 228−Tyrosine 272 Catalytic Cofactor of Galactose Oxidase Does Not Require Dioxygen † ‡

scientific article

Crystal Structure of the FAD-Containing Ferredoxin-NADP+Reductase from the Plant PathogenXanthomonas axonopodispv. citri

scientific article

Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti-MUC1 Antibody

scientific article

Design of α-S-Neoglycopeptides Derived from MUC1 with a Flexible and Solvent-Exposed Sugar Moiety

scientific article

Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1)

scientific article published on 31 March 2016

Detection of tumor-associated glycopeptides by lectins: the peptide context modulates carbohydrate recognition

scientific article

Determination of potential scaffolds for human choline kinase α1 by chemical deconvolution studies

scientific article

Discovery of a new binding site on human choline kinase α1: design, synthesis, crystallographic studies, and biological evaluation of asymmetrical bispyridinium derivatives

scientific article

Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis.

scientific article

Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions

scientific article published on 01 September 2018

Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation.

scientific article published on 5 May 2015

Evidence for substrate-assisted catalysis in -acetylphosphoglucosamine mutase

article

Fucosyltransferase-specific inhibition via next generation of fucose mimetics

scientific article published on 07 January 2021

Genetic and structural validation ofAspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target

scientific article

Glucose-6-phosphate as a probe for the glucosamine-6-phosphate N-acetyltransferase Michaelis complex

scientific article

Glycomimetics Targeting Glycosyltransferases: Synthetic, Computational and Structural Studies of Less-Polar Conjugates

scientific article

Inhibitors against Fungal Cell Wall Remodeling Enzymes.

scientific article

Kinetic and functional properties of human mitochondrial phosphoenolpyruvate carboxykinase

scientific article published on 8 June 2016

Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase.

scientific article published in January 2002

Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases

scientific article published on 10 April 2019

Molecular Mechanisms of Yeast Cell Wall Glucan Remodeling

scientific article

Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3

scientific article published on 13 January 2020

Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase

scientific article

Molecular mechanisms of O-GlcNAcylation.

scientific article published on 06 October 2008

Mucin architecture behind the immune response: design, evaluation and conformational analysis of an antitumor vaccine derived from an unnatural MUC1 fragment.

scientific article published on 15 December 2015

Natural Product–Guided Discovery of a Fungal Chitinase Inhibitor

scientific article

NleB/SseK effectors from Citrobacter rodentium, Escherichia coli, and Salmonella enterica display distinct differences in host substrate specificity.

scientific article published on 18 May 2017

Pharmacophore-Based Virtual Screening to Discover New Active Compounds for Human Choline Kinase α1

scientific article

Plasmodium falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite Death

scientific article (publication date: 12 September 2016)

Polypeptide GalNAc-Ts: from redundancy to specificity

scientific article published on 28 January 2019

Production of a Granulysin-Based, Tn-Targeted Cytolytic Immunotoxin Using Pulsed Electric Field Technology

scientific article published on 26 August 2020

Rational Design of Glycomimetic Compounds Targeting the Saccharomyces cerevisiae Transglycosylase Gas2.

scientific article published on 17 August 2015

Recent advances in the design of choline kinase α inhibitors and the molecular basis of their inhibition

scientific article published on 25 October 2020

Recent progress on fucosyltransferase inhibitors.

scientific article published on December 2012

Recent structural and mechanistic insights into protein O-GalNAc glycosylation.

scientific article published on February 2016

Serine versus threonine glycosylation with α-O-GalNAc: unexpected selectivity in their molecular recognition with lectins.

scientific article published on 8 August 2014

Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions

scientific article published on 01 May 2019

Streptococcus pneumoniae TIGR4 Flavodoxin: Structural and Biophysical Characterization of a Novel Drug Target

scientific article

Structural Insights into the Mechanism of Protein O-Fucosylation

scientific article published in 2011

Structural analysis of a GalNAc-T2 mutant reveals an induced-fit catalytic mechanism for GalNAc-Ts.

scientific article published on 30 March 2018

Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4

scientific article published on 14 September 2018

Structural and functional analysis of yeast Crh1 and Crh2 transglycosylases.

scientific article published on 19 January 2015

Structural and functional characterization of a putative polysaccharide deacetylase of the human parasiteEncephalitozoon cuniculi

scientific article

Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase

scientific article

Structural and kinetic studies of a series of mutants of galactose oxidase identified by directed evolution.

scientific article published on 12 January 2004

Structural and mechanistic basis of the interaction between a pharmacological chaperone and human phenylalanine hydroxylase

scientific article

Structural basis for arginine glycosylation of host substrates by bacterial effector proteins

scientific article published in Nature Communications

Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase

scientific article published on 20 February 2020

Structural basis for the synthesis of the core 1 structure by C1GalT1

scientific article published on 03 May 2022

Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody

scientific article published on 19 November 2020

Structural insights into mechanism and specificity of O-GlcNAc transferase

scientific article

Structure of Saccharomyces cerevisiae chitinase 1 and screening-based discovery of potent inhibitors

scientific article

Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage

scientific article published on 20 February 2019

Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2

scientific article

Synthesis of O- and C-glycosides derived from β-(1,3)-D-glucans.

scientific article published on 30 July 2013

Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment

scientific article published on 27 March 2020

The FAD synthetase from the human pathogen Streptococcus pneumoniae: a bifunctional enzyme exhibiting activity-dependent redox requirements.

scientific article

The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer.

scientific article published on 22 November 2017

The Vibrio cholerae Colonization Factor GbpA Possesses a Modular Structure that Governs Binding to Different Host Surfaces

scientific article

The closed conformation of the LDL receptor is destabilized by the low Ca(++) concentration but favored by the high Mg(++) concentration in the endosome

scientific journal article

The closed conformation of the LDL receptor is destabilized by the low Ca(++) concentration but favored by the high Mg(++) concentration in the endosome

scientific article published on 01 July 2016

The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences

scientific article published on 5 December 2017

The mechanism of allosteric coupling in choline kinase α1 revealed by the action of a rationally designed inhibitor

scientific article

The small molecule luteolin inhibits N-acetyl-α-galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein

scientific article

Water Sculpts the Distinctive Shapes and Dynamics of the Tumor-Associated Carbohydrate Tn Antigens: Implications for Their Molecular Recognition

scientific article published on 30 July 2018

List of works by Ramón Hurtado-Guerrero

A Trapped Covalent Intermediate of a Glycoside Hydrolase on the Pathway to Transglycosylation. Insights from Experiments and Quantum Mechanics/Molecular Mechanics Simulations

A hydrogen bond network in the active site of Anabaena ferredoxin-NADP(+) reductase modulates its catalytic efficiency

A mechanism-inspired UDP-<i>N</i>-acetylglucosamine pyrophosphorylase inhibitor

A perspective on structural and mechanistic aspects of protein O-fucosylation

A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2.

Anti-tumoral potential of a human granulysin-based, CEA-targeted cytolytic immunotoxin

Characterization of the cDNA and in vitro expression of the ram seminal plasma protein RSVP14.

Choline kinase active site provides features for designing versatile inhibitors

Citrobacter rodentium NleB Protein Inhibits Tumor Necrosis Factor (TNF) Receptor-associated Factor 3 (TRAF3) Ubiquitination to Reduce Host Type I Interferon Production

Cross-Link Formation of the Cysteine 228−Tyrosine 272 Catalytic Cofactor of Galactose Oxidase Does Not Require Dioxygen † ‡

Crystal Structure of the FAD-Containing Ferredoxin-NADP+Reductase from the Plant PathogenXanthomonas axonopodispv. citri

Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti-MUC1 Antibody

Design of α-S-Neoglycopeptides Derived from MUC1 with a Flexible and Solvent-Exposed Sugar Moiety

Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1)

Detection of tumor-associated glycopeptides by lectins: the peptide context modulates carbohydrate recognition

Determination of potential scaffolds for human choline kinase α1 by chemical deconvolution studies

Discovery of a new binding site on human choline kinase α1: design, synthesis, crystallographic studies, and biological evaluation of asymmetrical bispyridinium derivatives

Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis.

Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions

Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation.

Evidence for substrate-assisted catalysis in -acetylphosphoglucosamine mutase

Fucosyltransferase-specific inhibition <i>via</i> next generation of fucose mimetics

Genetic and structural validation ofAspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target

Glucose-6-phosphate as a probe for the glucosamine-6-phosphate N-acetyltransferase Michaelis complex

Glycomimetics Targeting Glycosyltransferases: Synthetic, Computational and Structural Studies of Less-Polar Conjugates

Inhibitors against Fungal Cell Wall Remodeling Enzymes.

Kinetic and functional properties of human mitochondrial phosphoenolpyruvate carboxykinase

Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase.

Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases

Molecular Mechanisms of Yeast Cell Wall Glucan Remodeling

Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3

Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase

Molecular mechanisms of O-GlcNAcylation.

Mucin architecture behind the immune response: design, evaluation and conformational analysis of an antitumor vaccine derived from an unnatural MUC1 fragment.

Natural Product–Guided Discovery of a Fungal Chitinase Inhibitor

NleB/SseK effectors from Citrobacter rodentium, Escherichia coli, and Salmonella enterica display distinct differences in host substrate specificity.

Pharmacophore-Based Virtual Screening to Discover New Active Compounds for Human Choline Kinase α1

Plasmodium falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite Death

Polypeptide GalNAc-Ts: from redundancy to specificity

Production of a Granulysin-Based, Tn-Targeted Cytolytic Immunotoxin Using Pulsed Electric Field Technology

Rational Design of Glycomimetic Compounds Targeting the Saccharomyces cerevisiae Transglycosylase Gas2.

Recent advances in the design of choline kinase α inhibitors and the molecular basis of their inhibition

Recent progress on fucosyltransferase inhibitors.

Recent structural and mechanistic insights into protein O-GalNAc glycosylation.

Serine versus threonine glycosylation with α-O-GalNAc: unexpected selectivity in their molecular recognition with lectins.

Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions

Streptococcus pneumoniae TIGR4 Flavodoxin: Structural and Biophysical Characterization of a Novel Drug Target

Structural Insights into the Mechanism of Protein O-Fucosylation

Structural analysis of a GalNAc-T2 mutant reveals an induced-fit catalytic mechanism for GalNAc-Ts.

Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4

Structural and functional analysis of yeast Crh1 and Crh2 transglycosylases.

Structural and functional characterization of a putative polysaccharide deacetylase of the human parasiteEncephalitozoon cuniculi

Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase

Structural and kinetic studies of a series of mutants of galactose oxidase identified by directed evolution.

Structural and mechanistic basis of the interaction between a pharmacological chaperone and human phenylalanine hydroxylase

Structural basis for arginine glycosylation of host substrates by bacterial effector proteins

Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase

Structural basis for the synthesis of the core 1 structure by C1GalT1

Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody

Structural insights into mechanism and specificity of O-GlcNAc transferase

Structure of Saccharomyces cerevisiae chitinase 1 and screening-based discovery of potent inhibitors

Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage

Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2

Synthesis of O- and C-glycosides derived from β-(1,3)-D-glucans.

Synthesis, conformational analysis and <i>in vivo</i> assays of an anti-cancer vaccine that features an unnatural antigen based on an sp<sup>2</sup>-iminosugar fragment

The FAD synthetase from the human pathogen Streptococcus pneumoniae: a bifunctional enzyme exhibiting activity-dependent redox requirements.

The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer.

The Vibrio cholerae Colonization Factor GbpA Possesses a Modular Structure that Governs Binding to Different Host Surfaces

The closed conformation of the LDL receptor is destabilized by the low Ca(++) concentration but favored by the high Mg(++) concentration in the endosome

The closed conformation of the LDL receptor is destabilized by the low Ca(++) concentration but favored by the high Mg(++) concentration in the endosome

The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences

The mechanism of allosteric coupling in choline kinase α1 revealed by the action of a rationally designed inhibitor

The small molecule luteolin inhibits N-acetyl-α-galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein

Water Sculpts the Distinctive Shapes and Dynamics of the Tumor-Associated Carbohydrate Tn Antigens: Implications for Their Molecular Recognition