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List of works by Markus Ralser

1H-NMR as implemented in several origin of life studies artificially implies the absence of metabolism-like non-enzymatic reactions by being signal-suppressed

A High-Throughput Method for the Quantitative Determination of Free Amino Acids in Saccharomyces cerevisiae by Hydrophilic Interaction Chromatography-Tandem Mass Spectrometry.

scientific article published in September 2017

A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth

scientific article (publication date: 11 November 2008)

A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase

scientific article (publication date: 22 July 2014)

A haploproficient interaction of the transaldolase paralogue NQM1 with the transcription factor VHR1 affects stationary phase survival and oxidative stress resistance

scientific article

A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of random mutagenized yeast causes oxidant-resistance and premature aging

scientific article

A prototrophic deletion mutant collection for yeast metabolomics and systems biology.

scientific article published on December 2012

A roadmap for interpreting (13)C metabolite labeling patterns from cells

scientific article

A time-resolved proteomic and prognostic map of COVID-19

scientific article published on 14 June 2021

ATM is a redox sensor linking genome stability and carbon metabolism

scientific article published on 5 April 2011

An appeal to magic? The discovery of a non-enzymatic metabolism and its role in the origins of life

scholarly article by Markus Ralser published in August 2018

An efficient and economic enhancer mix for PCR

article

An integrative approach to gain insights into the cellular function of human ataxin-2

scientific article

An open invitation to the Understudied Proteins Initiative

scientific article published on 9 May 2022

Analysis of Drosophila melanogaster proteome dynamics during embryonic development by a combination of label-free proteomics approaches

scientific article

Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways

scientific article

Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules

scientific article

Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast

scientific article published on 10 May 2021

Building a new bridge between metabolism, free radicals and longevity

scientific article published on 26 September 2009

Cancer: Sacrifice for survival.

scientific article

Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan

scientific article published in January 2023

Cell-to-cell heterogeneity emerges as consequence of metabolic cooperation in a synthetic yeast community

scientific article published on 17 June 2016

Changes of Cell Biochemical States Are Revealed in Protein Homomeric Complex Dynamics

scientific article published on 25 October 2018

Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study

Clinical classifiers of COVID-19 infection from novel ultra-high-throughput proteomics

scientific article published on 03 May 2020

Combining SELEX and reverse yeast-2-hybrid system

Conditional iron and pH-dependent activity of a non-enzymatic glycolysis and pentose phosphate pathway

scientific article

Cost-effective generation of precise label-free quantitative proteomes in high-throughput by microLC and data-independent acquisition.

scientific article

Cytosine DNA methylation is found in Drosophila melanogaster but absent in Saccharomyces cerevisiae, Schizosaccharomyces pombe, and other yeast species

scientific article published on 25 March 2014

DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput

scientific article published on 25 November 2019

Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress

scientific article

Evolthon: A community endeavor to evolve lab evolution

scientific article published on 29 March 2019

Extraction and Integration of Genetic Networks from Short-Profile Omic Data Sets

scientific article published on 29 October 2020

Faculty of 1000 evaluation for Bleach activates a redox-regulated chaperone by oxidative protein unfolding

Faculty of 1000 evaluation for Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism

Faculty of 1000 evaluation for Metabolomic and transcriptomic stress response of Escherichia coli

scholarly article published 12 August 2010

Freeing Yeast from Alcohol Addiction (Just) to Make (It) Fat Instead

scientific article published on 01 September 2018

Functional Metabolomics Describes the Yeast Biosynthetic Regulome

scientific article published on 28 September 2016

Functional analysis of centrosomal kinase substrates in Drosophila melanogaster reveals a new function of the nuclear envelope component otefin in cell cycle progression

scientific article

Functional association of the polyglutamine proteins ataxin-2 and huntingtin

Generation of a yeast two-hybrid strain suitable for competitive protein binding analysis

scientific article published in August 2005

Genomanalyse von Modellorganismen: Saccharomyces cerevisiae

HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.

scientific article published in February 2014

Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signaling

scientific article

Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming

scientific article published on September 2011

Hyperpolarized [U-(2) H, U-(13) C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells

scientific article published on 17 December 2014

Ice-Age Climate Adaptations Trap the Alpine Marmot in a State of Low Genetic Diversity.

scientific article published on 9 May 2019

Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis

scientific article published on 05 March 2014

Interfering with glycolysis causes Sir2-dependent hyper-recombination of Saccharomyces cerevisiae plasmids

scientific article

Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase (TPI) deficiency

scientific article published on 11 June 2019

Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism

scientific article published on 31 July 2019

Machine Learning Predicts the Yeast Metabolome from the Quantitative Proteome of Kinase Knockouts

scientific article published on 05 September 2018

Metabolic Remodeling in Times of Stress: Who Shoots Faster than His Shadow?

scientific article published in August 2015

Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans

scientific article published on 06 July 2016

Metabolic reconfiguration precedes transcriptional regulation in the antioxidant response.

scientific article published in July 2009

Metabolomics in Yeast

scientific article published in September 2017

Methionine Metabolism Alters Oxidative Stress Resistance via the Pentose Phosphate Pathway.

scientific article published on 23 November 2015

Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance

scientific article published on 21 March 2022

Mild hemolytic anemia, progressive neuromotor retardation and fatal outcome: a disorder of glycolysis, triose- phosphate isomerase deficiency

scientific article published in March 2013

MitoLoc: A method for the simultaneous quantification of mitochondrial network morphology and membrane potential in single cells

scientific article published on 13 July 2015

Mitochondria in ageing: there is metabolism beyond the ROS.

scientific article published on 16 January 2014

Monitoring protein expression in whole-cell extracts by targeted label- and standard-free LC-MS/MS.

scientific article published on 26 May 2011

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

scientific article

Non-enzymatic glycolysis and pentose phosphate pathway-like reactions in a plausible Archean ocean

scientific article

Nonenzymatic gluconeogenesis-like formation of fructose 1,6-bisphosphate in ice.

scientific article

Oxidative stress and neurodegeneration: the yeast model system

scientific article published on June 2013

Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure

scientific article published in November 2017

Precise label-free quantitative proteomes in high-throughput by microLC and data-independent SWATH acquisition

Primordial Krebs-cycle-like non-enzymatic reactions detected by mass spectrometry and nuclear magnetic resonance

Pyphe, a python toolbox for assessing microbial growth and cell viability in high-throughput colony screens

scientific article published on 16 June 2020

Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis

scientific article published in November 2012

Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells

scientific article

Quantification of Saccharomyces cerevisiae pentose-phosphate pathway intermediates by LC-MS/MS

Reductive stress on life span extension in C. elegans

scientific article

Regulation of ribosomal DNA amplification by the TOR pathway

scientific article

Regulatory crosstalk of the metabolic network

scientific article published on 07 January 2010

Remaining Mysteries of Molecular Biology: The Role of Polyamines in the Cell

scientific article

Reply to 'Do sulfate radicals really enable a non-enzymatic Krebs cycle precursor?'

scientific article published on 01 February 2019

Saccharomyces cerevisiae single-copy plasmids for auxotrophy compensation, multiple marker selection, and for designing metabolically cooperating communities

scientific article

Self-Establishing Communities: A Yeast Model to Study the Physiological Impact of Metabolic Cooperation in Eukaryotic Cells

scientific article published on 01 January 2019

Self-establishing communities enable cooperative metabolite exchange in a eukaryote

scientific article published on 26 October 2015

Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans

scientific article published on 29 May 2008

Sirtuins as regulators of the yeast metabolic network

scientific article published on 8 March 2012

Sulfate radicals enable a non-enzymatic Krebs cycle precursor.

scientific article

Surviving in the cold: yeast mutants with extended hibernating lifespan are oxidant sensitive

scientific article published on November 2009

THADA Regulates the Organismal Balance between Energy Storage and Heat Production.

scientific article

Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome.

scientific article

The Impact of Non-Enzymatic Reactions and Enzyme Promiscuity on Cellular Metabolism during (Oxidative) Stress Conditions

scientific article

The KRAB-containing zinc-finger transcriptional regulator ZBRK1 activates SCA2 gene transcription through direct interaction with its gene product, ataxin-2.

scientific article published on 6 October 2010

The RNA world and the origin of metabolic enzymes

scientific article

The beauty of being (label)-free: sample preparation methods for SWATH-MS and next-generation targeted proteomics

article by Jakob Vowinckel et al published 2013 in F1000Research

The difference between rare and exceptionally rare: molecular characterization of ribose 5-phosphate isomerase deficiency

scientific article

The evolution of the metabolic network over long timelines

scientific article published in 2021

The genomic and phenotypic diversity of Schizosaccharomyces pombe

scientific article published on 9 February 2015

The metabolic background is a global player in Saccharomyces gene expression epistasis

scientific article published on February 2016

The metabolic domestication syndrome of budding yeast

scientific article published on 8 March 2024

The metabolic growth limitations of petite cells lacking the mitochondrial genome

scientific article published in 2021

The next decade of metabolism

scientific article published on 01 January 2019

The pentose phosphate pathway is a metabolic redox sensor and regulates transcription during the antioxidant response

scientific article published on 19 May 2011

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway

scientific article published on 22 September 2014

The role of mitochondria in the aging processes of yeast

scientific article published on January 2012

The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization.

scientific article published on 10 July 2017

The widespread role of non-enzymatic reactions in cellular metabolism

scientific article

TheSaccharomyces cerevisiaeW303-K6001 cross-platform genome sequence: insights into ancestry and physiology of a laboratory mutt ⬇️

scientific article published on August 1, 2012

Time-resolved in vivo ubiquitinome profiling by DIA-MS reveals USP7 targets on a proteome-wide scale

scientific article published on 13 September 2021

Tpo1-mediated spermine and spermidine export controls cell cycle delay and times antioxidant protein expression during the oxidative stress response

scientific article

Triose phosphate isomerase deficiency is caused by altered dimerization--not catalytic inactivity--of the mutant enzymes

scientific article published in 2006

Unbiased Metabolomic Investigation of Alzheimer's Disease Brain Points to Dysregulation of Mitochondrial Aspartate Metabolism.

scientific article published on 30 December 2015

Using the canary genome to decipher the evolution of hormone-sensitive gene regulation in seasonal singing birds

scientific article

Variable repeats in the eukaryotic polyubiquitin gene ubi4 modulate proteostasis and stress survival

scientific article published on 30 August 2017

Warburg effect and translocation-induced genomic instability: two yeast models for cancer cells

scientific article published in 2012

Yeast Creates a Niche for Symbiotic Lactic Acid Bacteria through Nitrogen Overflow

scientific article

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