Search filters

List of works by Menico Rizzi

A covalent modification of NADP+ revealed by the atomic resolution structure of FprA, a Mycobacterium tuberculosis oxidoreductase

scientific article

A nicotinamide phosphoribosyltransferase-GAPDH interaction sustains the stress-induced NMN/NAD+ salvage pathway in the nucleus

scientific article published on 27 January 2020

A novel fold revealed by Mycobacterium tuberculosis NAD kinase, a key allosteric enzyme in NADP biosynthesis

scientific article published on 21 July 2004

A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells

scientific article published on 21 December 2021

Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis

scientific article published in 2011

Biochemical and Structural Studies of the Mycobacterium tuberculosis O6-Methylguanine Methyltransferase and Mutated Variants

scientific article

Biochemical and structural investigations on phosphoribosylpyrophosphate synthetase from Mycobacterium smegmatis

scientific article

Biochemical mechanisms leading to tryptophan 2,3-dioxygenase activation

scientific article published on February 2007

Crystal Structure of Mycobacterium tuberculosis Zinc-dependent Metalloprotease-1 (Zmp1), a Metalloprotease Involved in Pathogenicity

scientific article

Crystal Structure-Based Selective Targeting of the Pyridoxal 5′-Phosphate Dependent Enzyme Kynurenine Aminotransferase II for Cognitive Enhancement

scientific article

Crystal structure of Haemophilus influenzae 3-isopropylmalate dehydrogenase (LeuB) in complex with the inhibitor O-isobutenyl oxalylhydroxamate

scientific article published on 12 February 2020

Crystal structure of Mycobacterium tuberculosis O6-methylguanine-DNA methyltransferase protein clusters assembled on to damaged DNA

scientific article

Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD(+) and retinoic acid

scientific journal article

Crystal structure of human kynurenine aminotransferase I

scientific article

Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia

scientific article

Crystal structure of human nicotinic acid phosphoribosyltransferase.

scientific article published on 7 May 2015

Crystal structure of the Anopheles gambiae 3-hydroxykynurenine transaminase

scholarly article

Crystal structure of the Mycobacterium tuberculosis phosphate binding protein PstS3

scientific article

Crystal structures of Aedes aegypti alanine glyoxylate aminotransferase

scientific article published on 21 September 2006

Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis

scientific article

Design, synthesis, SAR and biological investigation of 3-(carboxymethyl)rhodanine and aminothiazole inhibitors of Mycobacterium tuberculosis Zmp1.

scientific article published on 30 January 2018

Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor

scientific article

Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis

scientific article

Every OGT Is Illuminated … by Fluorescent and Synchrotron Lights.

scientific article published on 5 December 2017

Expanding benzoxazole based inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents.

scientific article published on 10 May 2018

Expression, purification and characterisation of Haemophilus influenzae 3-isopropylmalate dehydrogenase (LeuB).

scientific article published in January 2007

Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity

scientific article published on 20 January 2020

Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia

scientific article published on 3 November 2014

Functional characterization of the Mycobacterium tuberculosis zinc metallopeptidase Zmp1 and identification of potential substrates.

scientific article published in July 2012

Heterologous expression, purification, and enzymatic activity of Mycobacterium tuberculosis NAD(+) synthetase

scientific journal article

Hit discovery of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase, GuaB2, inhibitors.

scientific article published on 18 April 2018

Human kynurenine aminotransferase II - reactivity with substrates and inhibitors

scholarly article by Elisabetta Passera published in April 2011

Identification and biochemical characterization of the Anopheles gambiae 3-hydroxykynurenine transaminase.

scientific article

Interdomain interactions rearrangements control the reaction steps of a thermostable DNA alkyltransferase.

scientific article

Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets

scientific article published in February 2018

Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment

scientific article published on 18 May 2020

Mycobacterium tuberculosis UvrB forms dimers in solution and interacts with UvrA in the absence of ligands.

scientific article published on 30 October 2017

Mycobacterium tuberculosis UvrD1 and UvrA proteins suppress DNA strand exchange promoted by cognate and noncognate RecA proteins

scientific journal article

Mycobacterium tuberculosis phosphoribosylpyrophosphate synthetase: biochemical features of a crucial enzyme for mycobacterial cell wall biosynthesis

scientific article

Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-a]pyridines against the 1A Family

scientific article published on 25 March 2020

Purification and biochemical characterization of a recombinant Anopheles gambiae tryptophan 2,3-dioxygenase expressed in Escherichia coli

scientific article published on 17 July 2008

Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis.

scientific article

Structural studies on M. tuberculosis O6-methylguanine methyltransferase

scientific article published on 5 August 2014

Structure of Thermococcus litoralis trans-3-hydroxy-l-proline dehydratase in the free and substrate-complexed form

scientific article published on 14 June 2019

Structure of Thermococcus litoralis Δ1-pyrroline-2-carboxylate reductase in complex with NADH and L-proline

scientific article published on 29 April 2020

Structure of human NMN adenylyltransferase. A key nuclear enzyme for NAD homeostasis

scientific article

Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein

scientific article

Structures of citrate synthase and malate dehydrogenase of Mycobacterium tuberculosis

scientific article

Study of Anopheles gambiae 3-hydroxykynurenine transaminase activity and inhibition by LC-MS/MS method

scientific article published on 13 May 2019

Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH

scientific article published on 15 April 2019

Targeting Genome Integrity in Mycobacterium Tuberculosis: From Nucleotide Synthesis to DNA Replication and Repair

scientific article published on 07 March 2020

Targeting NAD-dependent dehydrogenases in drug discovery against infectious diseases and cancer

scientific article published on 20 April 2020

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

scientific article

The Synthesis of Kynurenic Acid in Mammals: An Updated Kynurenine Aminotransferase Structural KATalogue

scientific article published on 27 February 2019

The biological and structural characterization of Mycobacterium tuberculosis UvrA provides novel insights into its mechanism of action ⬇️

scientific article published on May 27, 2011

The crystal structure of human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis

scientific article

The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism

scientific article

X-ray crystallography, mass spectrometry and single crystal microspectrophotometry: a multidisciplinary characterization of catechol 1,2 dioxygenase

scientific article

Paulina is supported by:

About Paulina

Help