List of works - Didier Vertommen

5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase-Independent Effect on Glucokinase Translocation

scientific article published on 01 April 2006

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis

scientific article

A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin

scientific article published in November 2003

A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast

scientific article

A draft map of the human ovarian proteome for tissue engineering and clinical applications.

scientific article published on 23 February 2018

A new role for Escherichia coli DsbC protein in protection against oxidative stress

scientific article published on 14 March 2014

A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L.

scientific article published on 13 April 2018

A periplasmic reducing system protects single cysteine residues from oxidation

scientific article published in November 2009

A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators.

scientific article

AMP-activated protein kinase induces actin cytoskeleton reorganization in epithelial cells

scientific article

AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase

scientific article published on 21 April 2008

AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase.

scientific article

AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B.

scientific article

Aberrant Membrane Composition and Biophysical Properties Impair Erythrocyte Morphology and Functionality in Elliptocytosis

scientific article published on 29 July 2020

Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis

scientific article (publication date: 20 August 2002)

An Unbiased Immunization Strategy Results in the Identification of Enolase as a Potential Marker for Nanobody-Based Detection of Trypanosoma evansi

scientific article published on 24 July 2020

Binding of mannose-binding lectin to fructosamines: a potential link between hyperglycaemia and complement activation in diabetes

scientific article published in May 2010

Cardiovirus leader proteins retarget RSK kinases toward alternative substrates to perturb nucleocytoplasmic traffic

scientific article published on 16 June 2022

Casein kinase 1delta activates human recombinant deoxycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity

scientific article published on 14 July 2010

Changes in the phosphoproteome of brown adipose tissue during hibernation in the ground squirrel, Ictidomys tridecemlineatus

scientific article published on 10 July 2017

Characterization of the cofactor-independent phosphoglycerate mutase from Leishmania mexicana mexicana. Histidines that coordinate the two metal ions in the active site show different susceptibilities to irreversible chemical modification

scientific article published on May 2004

Characterization of the role of the Escherichia coli periplasmic chaperone SurA using differential proteomics

scientific article

Characterization of the role of the receptors PEX5 and PEX7 in the import of proteins into glycosomes of Trypanosoma brucei

scientific article published on 20 January 2007

Clauss assay and fibrinogen protein estimated by capillary zone electrophoresis

scientific article published on 3 February 2011

Comprehensively Characterizing the Thioredoxin Interactome In Vivo Highlights the Central Role Played by This Ubiquitous Oxidoreductase in Redox Control.

scientific article published on 14 April 2016

Contribution of proteomics toward solving the fascinating mysteries of the biogenesis of the envelope of Escherichia coli

scientific article

Corynebacterium diphtheriae methionine sulfoxide reductase a exploits a unique mycothiol redox relay mechanism

scientific article published on 9 March 2015

Crystal Structure of the Outer Membrane Protein RcsF, a New Substrate for the Periplasmic Protein-disulfide Isomerase DsbC

scientific article

Detecting envelope stress by monitoring β-barrel assembly.

scientific article

Differential expression of glycosomal and mitochondrial proteins in the two major life-cycle stages of Trypanosoma brucei

scientific article published on 23 December 2007

Dissecting the Escherichia coli periplasmic chaperone network using differential proteomics

scientific article

Dissecting the Machinery That Introduces Disulfide Bonds in Pseudomonas aeruginosa

scientific article

Divide-and-Conquer Matrisome Protein (DC-MaP) Strategy: An MS-Friendly Approach to Proteomic Matrisome Characterization

scientific article published on 30 November 2020

Doxorubicin-induced activation of protein kinase D1 through caspase-mediated proteolytic cleavage: identification of two cleavage sites by microsequencing

scientific article

Effects of pharmacological AMP deaminase inhibition and Ampd1 deletion on nucleotide levels and AMPK activation in contracting skeletal muscle.

scientific article published in November 2014

Endoplasmic reticulum Ca(2+) content decrease by PKA-dependent hyperphosphorylation of type 1 IP3 receptor contributes to prostate cancer cell resistance to androgen deprivation

scientific article

Ethylmalonyl-CoA decarboxylase, a new enzyme involved in metabolite proofreading

scientific journal article

Eukaryotic elongation factor 2 kinase activity is controlled by multiple inputs from oncogenic signaling

scientific article

Evaluation of the role of protein kinase Cζ in insulin-induced heart 6-phosphofructo-2-kinase activation

Evidence for conformational changes within DsbD: possible role for membrane-embedded proline residues

scientific article published on October 2006

Evidence for new phosphorylation sites for protein kinase C and cyclic AMP-dependent protein kinase in bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

article

Extracellular vesicles from endothelial progenitor cells promote thyroid follicle formation.

scientific article

Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair

scientific article

Fructosamine 3-kinase-related protein and deglycation in human erythrocytes

scientific article

Fulfilling the Krebs and Beavo criteria for studying protein phosphorylation in the era of mass spectrometry-driven kinome research

scientific article published on December 2009

Generation of Organized Porcine Testicular Organoids in Solubilized Hydrogels from Decellularized Extracellular Matrix ⬇️

scientific article published on 03 November 2019

Glutathione S-transferases interact with AMP-activated protein kinase: evidence for S-glutathionylation and activation in vitro

scientific journal article

HDHD1, which is often deleted in X-linked ichthyosis, encodes a pseudouridine-5'-phosphatase

scientific article published on October 2010

HYGIEIA: HYpothesizing the Genesis of Infectious Diseases and Epidemics through an Integrated Systems Biology Approach

scientific article published on 24 June 2022

Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3).

scientific article published on October 2010

Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses

scientific article

ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan

scientific article published on 19 May 2016

Identification and functional implication of a Rho kinase-dependent moesin-EBP50 interaction in noradrenaline-stimulated artery

scientific article published on 6 October 2010

Identification of 3-deoxyglucosone dehydrogenase as aldehyde dehydrogenase 1A1 (retinaldehyde dehydrogenase 1).

scientific article published on 24 November 2006

Identification of RSK substrates using an analog-sensitive kinase approach

scientific article published in 2024

Identification of a dehydrogenase acting on D-2-hydroxyglutarate

scientific article

Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase

scientific article published on March 2012

Identification of fructosamine residues deglycated by fructosamine-3-kinase in human hemoglobin

scientific article

Identification of in vivo phosphorylation sites on human deoxycytidine kinase. Role of Ser-74 in the control of enzyme activity

scientific article published on 16 December 2005

Identification of peptidases in Nicotiana tabacum leaf intercellular fluid

scientific article published in June 2008

Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis

scientific article published on 21 May 2003

Identification of phosphorylation sites on human deoxycytidine kinase after overexpression in eucaryotic cells

scientific article published on January 2006

Identification of protein kinase D as a novel contraction-activated kinase linked to GLUT4-mediated glucose uptake, independent of AMPK.

scientific article published on 26 November 2007

Identification of protein-ribulosamine-5-phosphatase as human low-molecular-mass protein tyrosine phosphatase-A.

scientific article published on August 2007

Identification of substrates and chaperone from the Yersinia enterocolitica 1B Ysa type III secretion system

scientific article

Identification of the gene encoding hydroxyacid-oxoacid transhydrogenase, an enzyme that metabolizes 4-hydroxybutyrate

scientific article

Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase

scientific article

Identification, gene cloning and expression of serine proteases in the extracellular medium of Nicotiana tabacum cells

article

Increased protein glycation in fructosamine 3-kinase-deficient mice

scientific article

Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491.

scientific article

Interplay of Structural Disorder and Short Binding Elements in the Cellular Chaperone Function of Plant Dehydrin ERD14

scientific article published on 07 August 2020

Magnesium-dependent phosphatase-1 is a protein-fructosamine-6-phosphatase potentially involved in glycation repair

scientific journal article

Mammalian target of rapamycin-independent S6K1 and 4E-BP1 phosphorylation during contraction in rat skeletal muscle

scientific article published on 22 May 2013

Many fructosamine 3-kinase homologues in bacteria are ribulosamine/erythrulosamine 3-kinases potentially involved in protein deglycation.

scientific article published on 6 August 2007

Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as β-alanyl-lysine dipeptidase

scientific journal article

Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1)

scientific article

Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family

scientific article

Molecular identification of β-citrylglutamate hydrolase as glutamate carboxypeptidase 3

scientific journal article

Mutagenesis of the fructose‐6‐phosphate−binding site in the 2‐kinase domain of 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase ⬇️

scientific article published on June 15, 1998

Mycoredoxin-1 is one of the missing links in the oxidative stress defence mechanism of Mycobacteria

scientific article

Mycothiol/mycoredoxin 1-dependent reduction of the peroxiredoxin AhpE from Mycobacterium tuberculosis

scientific article published on 30 December 2013

Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2

scientific journal article

NAA80 bi-allelic missense variants result in high-frequency hearing loss, muscle weakness and developmental delay

scientific article published on 26 October 2021

New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases

scientific article

Optical and EPR spectroscopic studies of demetallation of hemin by L-chain apoferritins

Overexpression of the rhodanese PspE, a single cysteine-containing protein, restores disulphide bond formation to an Escherichia coli strain lacking DsbA.

scientific article

PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli

scientific article

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle

scientific article published on October 2013

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

scientific article published in Journal of Biological Chemistry

Protein phosphatase 2A controls the activity of histone deacetylase 7 during T cell apoptosis and angiogenesis

scientific article

Regulation of PIKfyve phosphorylation by insulin and osmotic stress

scientific article published in June 2010

Repairing oxidized proteins in the bacterial envelope using respiratory chain electrons

scientific article published on 7 December 2015

Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes

scientific article published on 21 February 2017

Stimulation of human and mouse erythrocyte Na(+)-K(+)-2Cl(-) cotransport by osmotic shrinkage does not involve AMP-activated protein kinase, but is associated with STE20/SPS1-related proline/alanine-rich kinase activation

scientific article published on 4 May 2010

Sulfenome mining in Arabidopsis thaliana

scientific article

The ATP-binding Site in the 2-Kinase Domain of Liver 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase

scientific article published in Journal of Biological Chemistry

The Corynebacterium glutamicum mycothiol peroxidase is a reactive oxygen species-scavenging enzyme that shows promiscuity in thiol redox control

scientific article published on 11 April 2015

The Human Ovary and Future of Fertility Assessment in the Post-Genome Era ⬇️

scientific article published on 28 August 2019

The Interferon-Inducible Mouse Apolipoprotein L9 and Prohibitins Cooperate to Restrict Theiler's Virus Replication

scientific article published on 21 July 2015

The crystal structure of Trypanosoma brucei enolase: visualisation of the inhibitory metal binding site III and potential as target for selective, irreversible inhibition

scientific article

The crystal structure of Trypanosoma cruzi glucokinase reveals features determining oligomerization and anomer specificity of hexose-phosphorylating enzymes

scientific article

The disulphide isomerase DsbC cooperates with the oxidase DsbA in a DsbD-independent manner

scientific article

The intra-mitochondrial O-GlcNAcylation system rapidly modulates OXPHOS function and ROS release in the heart

scientific article published on 12 April 2022

The protein-disulfide isomerase DsbC cooperates with SurA and DsbA in the assembly of the essential β-barrel protein LptD.

scientific article

Theiler's virus L protein is targeted to the mitochondrial outer membrane

scientific article

Variability in erythrocyte fructosamine 3-kinase activity in humans correlates with polymorphisms in the FN3K gene and impacts on haemoglobin glycation at specific sites

scientific article

Wheat germ in vitro translation to produce one of the most toxic sodium channel specific toxins

scientific article published on 29 July 2014

List of works by Didier Vertommen

5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase-Independent Effect on Glucokinase Translocation

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis

A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin

A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast

A draft map of the human ovarian proteome for tissue engineering and clinical applications.

A new role for Escherichia coli DsbC protein in protection against oxidative stress

A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L.

A periplasmic reducing system protects single cysteine residues from oxidation

A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators.

AMP-activated protein kinase induces actin cytoskeleton reorganization in epithelial cells

AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase

AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase.

AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B.

Aberrant Membrane Composition and Biophysical Properties Impair Erythrocyte Morphology and Functionality in Elliptocytosis

Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis

An Unbiased Immunization Strategy Results in the Identification of Enolase as a Potential Marker for Nanobody-Based Detection of Trypanosoma evansi

Binding of mannose-binding lectin to fructosamines: a potential link between hyperglycaemia and complement activation in diabetes

Cardiovirus leader proteins retarget RSK kinases toward alternative substrates to perturb nucleocytoplasmic traffic

Casein kinase 1delta activates human recombinant deoxycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity

Changes in the phosphoproteome of brown adipose tissue during hibernation in the ground squirrel, Ictidomys tridecemlineatus

Characterization of the cofactor-independent phosphoglycerate mutase from Leishmania mexicana mexicana. Histidines that coordinate the two metal ions in the active site show different susceptibilities to irreversible chemical modification

Characterization of the role of the Escherichia coli periplasmic chaperone SurA using differential proteomics

Characterization of the role of the receptors PEX5 and PEX7 in the import of proteins into glycosomes of Trypanosoma brucei

Clauss assay and fibrinogen protein estimated by capillary zone electrophoresis

Comprehensively Characterizing the Thioredoxin Interactome In Vivo Highlights the Central Role Played by This Ubiquitous Oxidoreductase in Redox Control.

Contribution of proteomics toward solving the fascinating mysteries of the biogenesis of the envelope of Escherichia coli

Corynebacterium diphtheriae methionine sulfoxide reductase a exploits a unique mycothiol redox relay mechanism

Crystal Structure of the Outer Membrane Protein RcsF, a New Substrate for the Periplasmic Protein-disulfide Isomerase DsbC

Detecting envelope stress by monitoring β-barrel assembly.

Differential expression of glycosomal and mitochondrial proteins in the two major life-cycle stages of Trypanosoma brucei

Dissecting the Escherichia coli periplasmic chaperone network using differential proteomics

Dissecting the Machinery That Introduces Disulfide Bonds in Pseudomonas aeruginosa

Divide-and-Conquer Matrisome Protein (DC-MaP) Strategy: An MS-Friendly Approach to Proteomic Matrisome Characterization

Doxorubicin-induced activation of protein kinase D1 through caspase-mediated proteolytic cleavage: identification of two cleavage sites by microsequencing

Effects of pharmacological AMP deaminase inhibition and Ampd1 deletion on nucleotide levels and AMPK activation in contracting skeletal muscle.

Endoplasmic reticulum Ca(2+) content decrease by PKA-dependent hyperphosphorylation of type 1 IP3 receptor contributes to prostate cancer cell resistance to androgen deprivation

Ethylmalonyl-CoA decarboxylase, a new enzyme involved in metabolite proofreading

Eukaryotic elongation factor 2 kinase activity is controlled by multiple inputs from oncogenic signaling

Evaluation of the role of protein kinase Cζ in insulin-induced heart 6-phosphofructo-2-kinase activation

Evidence for conformational changes within DsbD: possible role for membrane-embedded proline residues

Evidence for new phosphorylation sites for protein kinase C and cyclic AMP-dependent protein kinase in bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

Extracellular vesicles from endothelial progenitor cells promote thyroid follicle formation.

Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair

Fructosamine 3-kinase-related protein and deglycation in human erythrocytes

Fulfilling the Krebs and Beavo criteria for studying protein phosphorylation in the era of mass spectrometry-driven kinome research

Generation of Organized Porcine Testicular Organoids in Solubilized Hydrogels from Decellularized Extracellular Matrix ⬇️

Glutathione S-transferases interact with AMP-activated protein kinase: evidence for S-glutathionylation and activation in vitro

HDHD1, which is often deleted in X-linked ichthyosis, encodes a pseudouridine-5'-phosphatase

HYGIEIA: HYpothesizing the Genesis of Infectious Diseases and Epidemics through an Integrated Systems Biology Approach

Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3).

Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses

ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan

Identification and functional implication of a Rho kinase-dependent moesin-EBP50 interaction in noradrenaline-stimulated artery

Identification of 3-deoxyglucosone dehydrogenase as aldehyde dehydrogenase 1A1 (retinaldehyde dehydrogenase 1).

Identification of RSK substrates using an analog-sensitive kinase approach

Identification of a dehydrogenase acting on D-2-hydroxyglutarate

Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase

Identification of fructosamine residues deglycated by fructosamine-3-kinase in human hemoglobin

Identification of in vivo phosphorylation sites on human deoxycytidine kinase. Role of Ser-74 in the control of enzyme activity

Identification of peptidases in Nicotiana tabacum leaf intercellular fluid

Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis

Identification of phosphorylation sites on human deoxycytidine kinase after overexpression in eucaryotic cells

Identification of protein kinase D as a novel contraction-activated kinase linked to GLUT4-mediated glucose uptake, independent of AMPK.

Identification of protein-ribulosamine-5-phosphatase as human low-molecular-mass protein tyrosine phosphatase-A.

Identification of substrates and chaperone from the Yersinia enterocolitica 1B Ysa type III secretion system

Identification of the gene encoding hydroxyacid-oxoacid transhydrogenase, an enzyme that metabolizes 4-hydroxybutyrate

Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase

Identification, gene cloning and expression of serine proteases in the extracellular medium of Nicotiana tabacum cells

Increased protein glycation in fructosamine 3-kinase-deficient mice

Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491.

Interplay of Structural Disorder and Short Binding Elements in the Cellular Chaperone Function of Plant Dehydrin ERD14

Magnesium-dependent phosphatase-1 is a protein-fructosamine-6-phosphatase potentially involved in glycation repair

Mammalian target of rapamycin-independent S6K1 and 4E-BP1 phosphorylation during contraction in rat skeletal muscle

Many fructosamine 3-kinase homologues in bacteria are ribulosamine/erythrulosamine 3-kinases potentially involved in protein deglycation.

Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as β-alanyl-lysine dipeptidase

Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1)

Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family

Molecular identification of β-citrylglutamate hydrolase as glutamate carboxypeptidase 3

Mutagenesis of the fructose‐6‐phosphate−binding site in the 2‐kinase domain of 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase ⬇️