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List of works by Michele Vendruscolo

A Conformational Ensemble Derived Using NMR Methyl Chemical Shifts Reveals a Mechanical Clamping Transition That Gates the Binding of the HU Protein to DNA

scientific article published in 2014

A Coupled Equilibrium Shift Mechanism in Calmodulin-Mediated Signal Transduction

scientific article

A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins

scientific article

A PDZ domain recapitulates a unifying mechanism for protein folding

scholarly article

A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate

scientific article published on 20 July 2015

A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells.

scientific article published on 12 May 2018

A Rationally Designed Six-Residue Swap Generates Comparability in the Aggregation Behavior of α-Synuclein and β-Synuclein

scientific article published in 2012

A Relationship between the Aggregation Rates of α-Synuclein Variants and the β-Sheet Populations in Their Monomeric Forms ⬇️

scientific article published on September 9, 2013

A clear view of polymorphism, twist, and chirality in amyloid fibril formation

scientific article published on December 2013

A condensation-ordering mechanism in nanoparticle-catalyzed peptide aggregation ⬇️

scientific article

A generic mechanism of emergence of amyloid protofilaments from disordered oligomeric aggregates

scientific article

A geometrical parametrization of C1′-C5′ RNA ribose chemical shifts calculated by density functional theory ⬇️

scientific article published on July 21, 2013

A glimpse at the organization of the protein universe

scientific article

A method for partitioning the information contained in a protein sequence between its structure and function

scientific article published on 01 September 2018

A method of determining RNA conformational ensembles using structure-based calculations of residual dipolar couplings

scientific article published in June 2013

A method of incorporating rate constants as kinetic constraints in molecular dynamics simulations

scientific article published on 01 January 2021

A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli

scientific article published on 06 March 2019

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

scientific article

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

scientific article

A protein evolution model with independent sites that reproduces site-specific amino acid distributions from the Protein Data Bank

scientific article

A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease.

scientific article published on 10 August 2016

A relationship between mRNA expression levels and protein solubility in E. coli

scientific article published on 10 March 2009

A relationship between the transient structure in the monomeric state and the aggregation propensities of α-synuclein and β-synuclein

scientific article

A simple lattice model that captures protein folding, aggregation and amyloid formation

scientific article published on 15 January 2014

A stochastic method for the reconstruction of protein structures from one-dimensional structural profiles.

scientific article

A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding

scientific article

A superposition free method for protein conformational ensemble analyses and local clustering based on a differential geometry representation of backbone

scientific article published in April 2019

A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

scientific article published on 17 December 2018

A tensor-free method for the structural and dynamical refinement of proteins using residual dipolar couplings

scientific article

A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation

scientific article published on 11 April 2016

ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load

scientific article

ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load

ALMOST: an all atom molecular simulation toolkit for protein structure determination.

scientific article

ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism

scientific article published on 23 September 2011

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

scientific article

Accurate Random Coil Chemical Shifts from an Analysis of Loop Regions in Native States of Proteins

article

Accurate determination of interstrand distances and alignment in amyloid fibrils by magic angle spinning NMR ⬇️

scientific article

Adsorption free energy predicts amyloid protein nucleation rates

scientific article published in 2022

Amyloid-like Fibrils from an α-Helical Transmembrane Protein

scientific article published on 11 May 2017

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions

scientific article published on January 2011

An analytical solution to the kinetics of breakable filament assembly

scientific article

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease

scientific article published on 12 February 2016

An intrinsically disordered motif regulates the interaction between the p47 adaptor and the p97 AAA+ ATPase

scientific article published on 07 October 2020

Analysis of sub-tauc and supra-tauc motions in protein Gbeta1 using molecular dynamics simulations

scientific article

Analysis of the Contributions of Ring Current and Electric Field Effects to the Chemical Shifts of RNA Bases ⬇️

scientific article published on February 11, 2013

Analysis of the distributed computing approach applied to the folding of a small beta peptide

scientific article

Analysis of the hierarchical structure of the B. subtilis transcriptional regulatory network

scientific article published on 19 January 2015

Analysis of the performance of the CHESHIRE and YAPP methods at CASD-NMR round 3.

scientific article

Archaeal MBF1 binds to 30S and 70S ribosomes via its helix-turn-helix domain

scientific article

Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform

scientific article published on 20 May 2020

Assessment of the quality of energy functions for protein folding by using a criterion derived with the help of the noisy go model ⬇️

scientific article published on June 1, 2001

Assessment of the use of NMR chemical shifts as replica-averaged structural restraints in molecular dynamics simulations to characterize the dynamics of proteins

scientific article published in February 2013

Atomic force microscopy for single molecule characterisation of protein aggregation

scientific article published on 08 February 2019

Atomic structure and hierarchical assembly of a cross-  amyloid fibril

scientific article

Author Correction: Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

scientific article published on 17 April 2020

Author Correction: The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation

scientific article published in Scientific Reports

Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform

scientific article published on 28 November 2018

Automated assignment of SCOP and CATH protein structure classifications from FSSP scores.

scientific article

BPPred: a Web-based computational tool for predicting biophysical parameters of proteins

scientific article

Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation

scientific article published on 16 October 2019

Bayesian Weighing of Electron Cryo-Microscopy Data for Integrative Structural Modeling

scientific article published on 01 November 2018

Biological function in a non-native partially folded state of a protein

scientific article published on May 2008

Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates

scientific article published on 02 September 2015

Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases

scientific article published on 04 June 2020

Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases - ERRATUM

scientific article published on 18 November 2020

Blind testing of routine, fully automated determination of protein structures from NMR data

scientific article

Calculation of mutational free energy changes in transition states for protein folding

scientific article

Calculation of the free energy barriers in the oligomerisation of Ab

scientific article published on 01 May 2008

Can a pairwise contact potential stabilize native protein folds against decoys obtained by threading?

scientific article published in February 2000

Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alphaA-, alphaB- and R120G alphaB-crystallins

article

Characterisation of transition state structures for protein folding using 'high', 'medium' and 'low' {Phi}-values

scientific article published on March 2008

Characterization of the conformational equilibrium between the two major substates of RNase A using NMR chemical shifts

scientific article

Characterization of the conformational fluctuations in the Josephin domain of ataxin-3.

scientific article

Characterization of the free-energy landscapes of proteins by NMR-guided metadynamics

scientific article published on 9 April 2013

Characterization of the interdomain motions in hen lysozyme using residual dipolar couplings as replica-averaged structural restraints in molecular dynamics simulations

scientific article published on 9 September 2013

Characterization of the nucleation barriers for protein aggregation and amyloid formation

scientific article published on 27 July 2007

Characterization of the residual structure in the unfolded state of the Δ131Δ fragment of staphylococcal nuclease

article

Characterizing the first steps of amyloid formation for the ccbeta peptide

scientific article

Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.

scientific article published on 28 February 2018

Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's β-amyloid aggregation

scientific article published on 11 January 2019

Chemical biology: More charges against aggregation

scientific article published in October 2007

Chemical kinetics for drug discovery to combat protein aggregation diseases

scientific article published on 20 February 2014

Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

scientific article

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

scientific article published on 07 May 2018

Chris Dobson (1949-2019)

scientific article published on 01 February 2020

Chromatin Unfolding by Epigenetic Modifications Explained by Dramatic Impairment of Internucleosome Interactions: A Multiscale Computational Study

scientific article

Coarse-grained model for protein folding based on structural profiles

scientific article published on 28 October 2011

Comparison of sequence-based and structure-based energy functions for the reversible folding of a peptide

scientific article published on 4 March 2005

Comparison of successive transition states for folding reveals alternative early folding pathways of two homologous proteins

scientific article

Comparison of the transition state ensembles for folding of Im7 and Im9 determined using all-atom molecular dynamics simulations with phi value restraints

scientific article (publication date: 15 February 2004)

Comparison of the transition states for folding of two Ig-like proteins from different superfamilies

scientific article published in October 2004

Competition between folding, native-state dimerisation and amyloid aggregation in beta-lactoglobulin

scientific article published on 24 December 2008

Competition between intramolecular and intermolecular interactions in an amyloid-forming protein

scientific article published on 23 April 2009

Connectivity of Neutral Networks, Overdispersion, and Structural Conservation in Protein Evolution

article published in 2003

Cooperative Assembly of Hsp70 Subdomain Clusters

scientific article published on 29 May 2018

Correlation between mRNA expression levels and protein aggregation propensities in subcellular localisations

Corrigendum: Structural basis of synaptic vesicle assembly promoted by α-synuclein.

scientific article published on 11 May 2017

Cucurbit[8]uril and blue-box: high-energy water release overwhelms electrostatic interactions

scientific article published on 24 September 2013

Cyclophilin A catalyzes proline isomerization by an electrostatic handle mechanism

scientific article

Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins

scientific article published on 20 July 2021

Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles

scientific article published on 8 November 2017

Derivation of a solubility condition for proteins from an analysis of the competition between folding and aggregation.

scientific article published on 18 October 2010

Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease

scientific article published on 18 February 2011

Determination of Conformational Equilibria in Proteins Using Residual Dipolar Couplings

scientific article

Determination of Secondary Structure Populations in Disordered States of Proteins Using Nuclear Magnetic Resonance Chemical Shifts

scientific article published on 06 March 2012

Determination of Structural Ensembles of Proteins: Restraining vs Reweighting

scientific article published on 28 November 2018

Determination of a Structural Ensemble Representing the Dynamics of a G-Quadruplex DNA

scientific article published on 23 December 2019

Determination of a transition state at atomic resolution from protein engineering data

scientific article published in November 2002

Determination of an ensemble of structures representing the denatured state of the bovine acyl-coenzyme a binding protein

scientific article published in March 2004

Determination of an ensemble of structures representing the intermediate state of the bacterial immunity protein Im7.

scholarly article

Determination of conformationally heterogeneous states of proteins

scientific article published on 18 January 2007

Determination of protein structural ensembles using cryo-electron microscopy

scientific article published on 28 November 2018

Determination of protein structures consistent with NMR order parameters

scientific article published in July 2004

Determination of protein structures in the solid state from NMR chemical shifts

scientific article

Determination of structural fluctuations of proteins from structure-based calculations of residual dipolar couplings

scientific article

Determination of the conformational states of strychnine in solution using NMR residual dipolar couplings in a tensor-free approach

scientific article published on 21 July 2018

Determination of the folding transition states of barnase by using PhiI-value-restrained simulations validated by double mutant PhiIJ-values

scientific article

Determination of the free energy landscape of alpha-synuclein using spin label nuclear magnetic resonance measurements

scientific article

Determination of the individual roles of the linker residues in the interdomain motions of calmodulin using NMR chemical shifts

scientific article published on 12 February 2014

Determination of the transition state ensemble for the folding of ubiquitin from a combination of Phi and Psi analyses

scientific article published on 15 January 2008

Developing NMR methods for macromolecular machines: Measurement of residual dipolar couplings to probe dynamic regions of the ribosome

scholarly article published 10 May 2018

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

article

Differential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomers

scientific article published on 02 August 2019

Diffusion in disordered media as a process with memory.

scientific article published in August 1996

Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation

scientific article published on 10 August 2020

Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

scientific article

Disordered flat phase and phase diagram for restricted solid-on-solid models of fcc (110) surfaces

scientific article published on 01 May 1996

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide.

scientific article published on 26 March 2018

Druggability of Intrinsically Disordered Proteins

scientific article published on January 2015

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

scientific article

Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

scientific article published on 13 April 2020

Effective interactions between chaotropic agents and proteins

scientific article published on 01 November 2005

Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I

article

Efficient identification of near-native conformations in ab initio protein structure prediction using structural profiles.

scientific article

Emergence and evolution of an interaction between intrinsically disordered proteins

scientific article

Energetics of enzyme stability ⬇️

scientific article published on 01 January 2002

Enzymatic activity in disordered states of proteins ⬇️

scientific article published on 09 September 2010

Equilibrium simulations of proteins using molecular fragment replacement and NMR chemical shifts.

scientific article

Erratum: Prediction of variable translation rate effects on cotranslational protein folding

scientific article published in Nature Communications

Excited-State Control of Protein Activity ⬇️

scientific article published on July 27, 2011

Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility

scientific article

Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding.

scientific article

Expression of the amyloid-β peptide in a single pair of C. elegans sensory neurons modulates the associated behavioural response

scientific article published on 31 May 2019

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.

scientific article published in April 2018

Factors That Affect the Degree of Twist in β-Sheet Structures: A Molecular Dynamics Simulation Study of a Cross-β Filament of the GNNQQNY Peptide

Factors that affect the degree of twist in beta-sheet structures: a molecular dynamics simulation study of a cross-beta filament of the GNNQQNY peptide

scientific article published on 01 February 2009

Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans

scientific article published on 27 June 2019

Fast and accurate predictions of protein NMR chemical shifts from interatomic distances.

scientific article

Fibrillogenic propensity of the GroEL apical domain: a Janus-faced minichaperone

scientific article

Focus on physical principles of protein behavior in the cell

Folding of small proteins by Monte Carlo simulations with chemical shift restraints without the use of molecular fragment replacement or structural homology

scientific article published in June 2009

Formation of native and non-native interactions in ensembles of denatured ACBP molecules from paramagnetic relaxation enhancement studies

scientific article published on 27 January 2005

From macroscopic measurements to microscopic mechanisms of protein aggregation

scientific article published on 08 March 2012

Functional interactions as a survival strategy against abnormal aggregation

scientific article

Geometry, energetics, and dynamics of hydrogen bonds in proteins: structural information derived from NMR scalar couplings

scientific article published on 01 November 2006

Hamiltonian Dynamics of Protein Filament Formation

scientific article published on 22 January 2016

Higher order amyloid fibril structure by MAS NMR and DNP spectroscopy

scientific article published on 13 December 2013

How to guarantee optimal stability for most representative structures in the Protein Data Bank.

scientific article published in August 2001

Identification and Structural Characterization of an Intermediate in the Folding of the Measles Virus X Domain

scientific article

Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein.

scientific article published on 12 September 2014

Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies

scientific article (publication date: 19 October 2015)

Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation

scientific article published on March 2017

Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide

scientific article published on July 2013

Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming

scientific article published on 18 April 2019

Importance of metastable states in the free energy landscapes of polypeptide chains

scientific article published on 26 October 2007

In support of the BMRB.

scientific article published in September 2012

In vitro and in silico Activity of Iridoids Against Leishmania amazonensis

scientific article published on 01 January 2019

In vitro and in silico assessment of the developability of a designed monoclonal antibody library

scientific article published on 18 January 2019

In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome

scientific article

In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-synuclein within E. coli cells

scientific article (publication date: 2013)

Influence of Harvest Season and Cultivar on the Variation of Phenolic Compounds Composition and Antioxidant Properties in Vaccinium ashei Leaves.

scientific article published on 30 September 2017

Influence of the fluctuations of the alignment tensor on the analysis of the structure and dynamics of proteins using residual dipolar couplings

scientific article published on 21 November 2007

Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region

scientific article

Inhibition of protein crystallization by evolutionary negative design

scientific article

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species

scientific article published on 23 February 2017

Interactions in the native state of monellin, which play a protective role against aggregation

article

Interpreting Dynamically-Averaged Scalar Couplings in Proteins

article

Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide

scientific article

Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in

scientific article published on 03 May 2019

Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation

scientific article published on 13 October 2011

Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in <i>C. elegans</i>

scientific article published on 8 March 2021

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

scientific article published on 24 March 2016

Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies

scientific article published on 28 September 2020

Kinetic modelling indicates that fast-translating codons can coordinate cotranslational protein folding by avoiding misfolded intermediates

scientific article published in January 2014

Lack of self-averaging in neutral evolution of proteins

scientific article published in Physical Review Letters

Large-scale visualisation of α-synuclein oligomers in Parkinson's disease brain tissue

Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity

scientific article published on 14 September 2015

Life on the edge: a link between gene expression levels and aggregation rates of human proteins

article

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

scientific article

Looking at structure, stability, and evolution of proteins through the principal eigenvector of contact matrices and hydrophobicity profiles.

scientific article

Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR.

scientific article

MOAG-4 promotes the aggregation of α-synuclein by competing with self-protective electrostatic interactions

scientific article

Making biological membrane resistant to the toxicity of misfolded protein oligomers: a lesson from trodusquemine

scientific article published on 05 November 2020

Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations

article

Mapping of two networks of residues that exhibit structural and dynamical changes upon binding in a PDZ domain protein

scientific article

Mapping the Protein Fold Universe Using the CamTube Force Field in Molecular Dynamics Simulations

scientific article published on 27 October 2015

Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery

scientific article published on 13 February 2018

Metadynamic metainference: Enhanced sampling of the metainference ensemble using metadynamics

scientific article

Metainference: A Bayesian inference method for heterogeneous systems

scientific article published on 22 January 2016

Metastability of Native Proteins and the Phenomenon of Amyloid Formation

article

Methods of probing the interactions between small molecules and disordered proteins

scientific article published on 19 June 2017

Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions

scientific article published on 17 December 2015

Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity

scientific article published in Nature Communications

Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons

scientific article published on 22 October 2019

MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins.

scientific article published on 10 November 2017

Model of correlated evolution

scientific article published on 01 December 1996

Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein

scientific article published on 25 February 2016

Molecular determinants of the aggregation behavior of alpha- and beta-synuclein

scientific article published in May 2008

Molecular determinants of the interaction of EGCG with ordered and disordered proteins

scientific article published on 30 March 2018

Molecular dynamics ensemble refinement of the heterogeneous native state of NCBD using chemical shifts and NOEs

scientific article published on 04 July 2018

Molecular dynamics simulations from putative transition states of alpha-spectrin SH3 domain

scientific article

Molecular dynamics simulations with replica-averaged structural restraints generate structural ensembles according to the maximum entropy principle

scientific article published on 01 March 2013

Molecular dynamics studies of the process of amyloid aggregation of peptide fragments of transthyretin

scientific article published in July 2004

Molecular mechanisms of protein aggregation from global fitting of kinetic models.

scientific article published on 7 January 2016

Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates

scientific article

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

article

Mutational analysis of the aggregation-prone and disaggregation-prone regions of acylphosphatase

scientific article published on 12 September 2008

Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation

scientific article

NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain

scientific article published on 5 September 2014

Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages

scientific article published on 01 April 2013

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

scientific article published on 3 July 2017

Native and non-native interactions along protein folding and unfolding pathways

scientific article published on 01 May 2002

Networks of Dynamic Allostery Regulate Enzyme Function

scientific article published on 27 December 2016

Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation

scientific article published on 10 December 2021

Neutral evolution of model proteins: diffusion in sequence space and overdispersion

article

New opportunities for tensor-free calculations of residual dipolar couplings for the study of protein dynamics

scientific article published on 30 January 2014

New scenarios of protein folding can occur on the ribosome

scientific article published on 04 January 2011

Nucleated polymerisation in the presence of pre-formed seed filaments

scientific article

Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments

scientific article

Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations

scientific article published on August 2011

Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations

scientific article

On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and lacmoid

scientific article published in September 2009

Optimal Protein Design Procedure

scientific article published on 01 August 1996

Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo

scientific article published on 2 October 2017

Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo

Parapred: antibody paratope prediction using convolutional and recurrent neural networks

scientific article published on 01 September 2018

Parmbsc1: a refined force field for DNA simulations ⬇️

scientific article

Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication ⬇️

scientific article

Physical principles of protein behavior in the cell

scientific article published in June 2009

Physicochemical determinants of chaperone requirements.

scientific article

Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins

scholarly article

Position-dependent electrostatic protection against protein aggregation

scientific article published in May 2009

Prediction by graph theoretic measures of structural effects in proteins arising from non-synonymous single nucleotide polymorphisms

scientific article

Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases

scientific article

Prediction of Local Structural Stabilities of Proteins from Their Amino Acid Sequences

Prediction of aggregation-prone regions in structured proteins

scientific article published on 13 May 2008

Prediction of site-specific amino acid distributions and limits of divergent evolutionary changes in protein sequences

scientific article published in 2005

Prediction of the Absolute Aggregation Rates of Amyloidogenic Polypeptide Chains

Prediction of variable translation rate effects on cotranslational protein folding

scientific article published on 29 May 2012

Principal eigenvector of contact matrices and hydrophobicity profiles in proteins

Principles of protein structural ensemble determination

scientific article

Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies

scientific article published on 14 May 2019

Probing the Residual Structure of the Low Populated Denatured State of ADA2h under Folding Conditions by Relaxation Dispersion Nuclear Magnetic Resonance Spectroscopy

scientific article

Probing the dynamic stalk region of the ribosome using solution NMR

scientific article published on 19 September 2019

Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

scientific article

Protein dynamics under light control

scientific article published on 01 August 2008

Protein dynamics: Moore's law in molecular biology.

scientific article published in January 2011

Protein folding and misfolding: a paradigm of self-assembly and regulation in complex biological systems

scientific article published on June 2003

Protein folding and the organization of the protein topology universe.

scientific article

Protein folding using contact maps.

scientific article

Protein folding: bringing theory and experiment closer together

scientific article

Protein homeostasis of a metastable subproteome associated with Alzheimer's disease

scientific article

Protein regulation: the statistical theory of allostery

scientific article

Protein solubility and protein homeostasis: a generic view of protein misfolding disorders

scientific article published on December 2011

Protein structure determination from NMR chemical shifts

scientific article

Protein structure validation using side-chain chemical shifts

scientific article

Proteome folding and aggregation ⬇️

scientific article published on 07 February 2012

Proteome-level interplay between folding and aggregation propensities of proteins.

scientific article

Proteome-wide observation of the phenomenon of life on the edge of solubility

scientific article published on 31 December 2019

Quantitative approaches to defining normal and aberrant protein homeostasis

scientific article published on 01 January 2009

Quenched disorder, memory, and self-organization.

scientific article published in January 1996

Rapid and accurate in silico solubility screening of a monoclonal antibody library.

scientific article

Rare fluctuations of native proteins sampled by equilibrium hydrogen exchange

scientific article published in December 2003

Rational design of a conformation-specific antibody for the quantification of Aβ oligomers

scientific article published on 03 June 2020

Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins

scientific article

Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability

scientific article published on 6 May 2016

Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers

scientific article published on 25 June 2020

Reconstruction of protein structures from a vectorial representation

scientific article published in Physical Review Letters

Recovery of protein structure from contact maps ⬇️

scientific article published on January 1, 1997

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

scientific article published on 01 June 2020

Relation between native ensembles and experimental structures of proteins

scholarly article

Replica-Averaged Metadynamics

scientific article published on 21 November 2013

Reply to “Comment on ‘A Tensor-Free Method for the Structural and Dynamic Refinement of Proteins using Residual Dipolar Couplings’”

Reversible inhibition of the ClpP protease via an N-terminal conformational switch

article published in the Proceedings of the National Academy of Sciences of the United States of America

Role of intermolecular forces in defining material properties of protein nanofibrils

scientific article

SAR by kinetics for drug discovery in protein misfolding diseases

article published in the Proceedings of the National Academy of Sciences of the United States of America

Scaling behaviour and rate-determining steps in filamentous self-assembly

scientific article

Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates

scientific article published on 17 April 2019

Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method

scientific article

Self-consistent determination of the transition state for protein folding: application to a fibronectin type III domain

scientific article

Self-templated nucleation in peptide and protein aggregation

scientific article published on 17 December 2008

Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide

scientific article

Sequence-Based Prediction of Protein Behavior

Sequence-based prediction of protein binding mode landscapes

scientific article published on 26 May 2020

Sequence-based prediction of protein solubility.

scientific article

Similarities in the thermodynamics and kinetics of aggregation of disease-related Abeta(1-40) peptides

scientific article published on June 2007

Simultaneous Determination of Protein Structure and Dynamics Using Cryo-Electron Microscopy

scientific article published in April 2018

Simultaneous NMR characterisation of multiple minima in the free energy landscape of an RNA UUCG tetraloop

scientific article published on 9 January 2017

Simultaneous Production of Amyloglucosidase and Exo-Polygalacturonase by Aspergillus niger in a Rotating Drum Reactor.

scientific article published on 4 October 2016

Simultaneous determination of protein structure and dynamics.

scientific article

Simultaneous quantification of protein order and disorder

scientific article published in March 2017

Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy

scientific article published on 10 June 2020

Single-molecule measurements of transient biomolecular complexes through microfluidic dilution.

scientific article published on 27 June 2013

Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease

scientific article published on 04 November 2020

Small-world view of the amino acids that play a key role in protein folding

scientific article published on 25 June 2002

Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

scientific article

Spatial Propagation of Protein Polymerization

scientific article published in Physical Review Letters

Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.

scientific article

Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic

scientific article published in 2022

Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions

scientific article published on 10 August 2018

Statistical mechanics of the denatured state of a protein using replica-averaged metadynamics

scientific article published on 17 June 2014

Statistical properties of contact vectors

scientific article published on 18 March 2002

Statistical properties of neutral evolution

scientific article published in January 2003

Stochastic reconstruction of protein structures from effective connectivity profiles

scientific article published on 26 November 2008

Structural Characterization of the Early Events in the Nucleation-Condensation Mechanism in a Protein Folding Process

scientific article published on 12 April 2017

Structural Effects of Two Camelid Nanobodies Directed to Distinct C-Terminal Epitopes on α-Synuclein

scientific article

Structural Ensemble Modulation upon Small-Molecule Binding to Disordered Proteins

scientific article published on 26 March 2018

Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity

scientific article published on 8 June 2016

Structural Insights into the Calcium-Mediated Allosteric Transition in the C-Terminal Domain of Calmodulin from Nuclear Magnetic Resonance Measurements.

scientific article published on 30 November 2015

Structural Interpretation of Hydrogen Exchange Protection Factors in Proteins: Characterization of the Native State Fluctuations of CI2

scientific article published on 01 January 2006

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

scientific article

Structural basis of synaptic vesicle assembly promoted by α-synuclein

scientific article published on 19 September 2016

Structural biology. Dynamic visions of enzymatic reactions

scientific article

Structural biology: Protein self-assembly intermediates

scientific article published in April 2013

Structural characterization of a misfolded intermediate populated during the folding process of a PDZ domain

article published in 2010

Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor

scientific article published on 18 April 2016

Structural comparison of the two alternative transition states for folding of TI I27.

scientific article

Structural differences between toxic and nontoxic HypF-N oligomers

article

Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils

scientific article

Structure and Dynamics of GeoCyp: A Thermophilic Cyclophilin with a Novel Substrate Binding Mechanism That Functions Efficiently at Low Temperatures

scientific article published on 14 May 2015

Structure and Dynamics of Intrinsically Disordered Proteins

scientific article published on January 2015

Structure and dynamics of a partially folded protein are decoupled from its mechanism of aggregation

scientific article published on 4 September 2008

Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms

scientific article published on 12 March 2015

Structure determination of protein-protein complexes using NMR chemical shifts: case of an endonuclease colicin-immunity protein complex

scientific article

Structure of a Misfolded Intermediate of a PDZ Domain

Structure of a low-population binding intermediate in protein-RNA recognition

scientific article published on 10 June 2016

Structure of a low-population intermediate state in the release of an enzyme product

scientific article published on 9 January 2015

Structure of an intermediate state in protein folding and aggregation

scientific article

Structure-Free Validation of Residual Dipolar Coupling and Paramagnetic Relaxation Enhancement Measurements of Disordered Proteins

scientific article published on 11 November 2015

Structure-based prediction of methyl chemical shifts in proteins

scientific article

Structures and relative free energies of partially folded states of proteins

scientific article

Structures of the Excited States of Phospholamban and Shifts in Their Populations upon Phosphorylation

scientific article

Subdomain architecture and stability of a giant repeat protein.

scientific article published on 20 September 2013

Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases

scientific article

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease

scientific article

Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity

scientific article

Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis

article published in the Proceedings of the National Academy of Sciences of the United States of America

Systematic mapping of the free energy landscapes of a growing immunoglobulin domain identifies a kinetic intermediate associated with co-translational proline isomerization

Targeting disordered proteins with small molecules using entropy

scientific article published on 11 August 2015

Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease

scientific article

The A53T mutation is key in defining the differences in the aggregation kinetics of human and mouse α-synuclein

scientific article

The CamSol method of rational design of protein mutants with enhanced solubility

scientific article published on 14 October 2014

The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein.

scientific article

The MUMO (minimal under-restraining minimal over-restraining) method for the determination of native state ensembles of proteins

scientific article

The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State

scientific article published on 14 January 2020

The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage.

scientific article published on 13 April 2017

The Structurally Constrained Neutral Model of Protein Evolution

article

The Zyggregator method for predicting protein aggregation propensities

scientific article published on 27 May 2008

The amyloid state and its association with protein misfolding diseases.

scientific article

The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation

scientific article published on 07 October 2021

The distribution of residues in a polypeptide sequence is a determinant of aggregation optimized by evolution.

scientific article

The diversity of<i>SNCA</i>transcripts in neurons, and its impact on antisense oligonucleotide therapeutics

The dynamics of interleukin-8 and its interaction with human CXC receptor I peptide.

scientific article published on 12 February 2014

The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions

The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster

scientific article published on 23 June 2011

The inverted free energy landscape of an intrinsically disordered peptide by simulations and experiments

scientific article

The mechanism of folding of Im7 reveals competition between functional and kinetic evolutionary constraints

scientific article published in March 2009

The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation

scientific article

The s2D method: simultaneous sequence-based prediction of the statistical populations of ordered and disordered regions in proteins

scientific article

Theoretical approaches to protein aggregation

scientific article

Therapeutic Strategies to Reduce the Toxicity of Misfolded Protein Oligomers

scientific article published on 17 November 2020

Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors

scientific article published on 14 September 2020

Third generation antibody discovery methods: in silico rational design

scientific article published on 01 December 2018

Time averaging of NMR chemical shifts in the MLF peptide in the solid state

scientific article published in May 2010

Toward an accurate determination of free energy landscapes in solution states of proteins

scientific article published in March 2009

Towards a structural biology of the hydrophobic effect in protein folding

scientific article

Towards complete descriptions of the free-energy landscapes of proteins

scientific article

Towards quantitative predictions in cell biology using chemical properties of proteins

scientific article published on 04 September 2008

Transient tertiary structure formation within the ribosome exit port

scientific article

Transition state contact orders correlate with protein folding rates

scientific article published in September 2005

Transition states for protein folding have native topologies despite high structural variability

scientific article

Translationally optimal codons associate with aggregation-prone sites in proteins

scientific article

Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers

scientific article published on 17 February 2020

Trigger factor slows co-translational folding through kinetic trapping while sterically protecting the nascent chain from aberrant cytosolic interactions.

scientific article published on 22 June 2012

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

scientific article published on 13 August 2020

Trodusquemine enhances Aβ aggregation but suppresses its toxicity by displacing oligomers from cell membranes

scientific article published in Nature Communications

Twisting transition between crystalline and fibrillar phases of aggregated peptides

scientific article published in Physical Review Letters

Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein

scientific article

Understanding the influence of codon translation rates on cotranslational protein folding

scientific article published on May 2014

Using NMR chemical shifts as structural restraints in molecular dynamics simulations of proteins

scientific article

Using Pseudocontact Shifts and Residual Dipolar Couplings as Exact NMR Restraints for the Determination of Protein Structural Ensembles

scientific article published in December 2015

Using Side-Chain Aromatic Proton Chemical Shifts for a Quantitative Analysis of Protein Structures

Using chemical shifts to determine structural changes in proteins upon complex formation

scientific article published on 08 July 2011

Using side-chain aromatic proton chemical shifts for a quantitative analysis of protein structures.

scientific article published on 2 September 2011

Validity of Gō models: comparison with a solvent-shielded empirical energy decomposition

scientific article

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

scientific article

Widespread Proteome Remodeling and Aggregation in Aging C. elegans.

scientific article

Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins

scientific article published on 31 October 2013

Widespread occurrence of the droplet state of proteins in the human proteome

scientific article published on 14 December 2020

Widespread remodeling of proteome solubility in response to different protein homeostasis stresses

scientific article published on 21 January 2020

pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins

scientific article

¹H, ¹³C and ¹⁵N resonance assignments of human muscle acylphosphatase

scientific article

β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.

scientific article published on 3 November 2016

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