Search filters

List of works by Margaret Kielian

A Stable Prefusion Intermediate of the Alphavirus Fusion Protein Reveals Critical Features of Class II Membrane Fusion

scientific article

A conserved histidine in the ij loop of the Semliki Forest virus E1 protein plays an important role in membrane fusion

scientific article

A key interaction between the alphavirus envelope proteins responsible for initial dimer dissociation during fusion

scientific article published on 16 January 2013

A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion

scientific article published in 2013

A single point mutation controls the cholesterol dependence of Semliki Forest virus entry and exit

scientific article published in January 1998

A toggle switch controls the low pH-triggered rearrangement and maturation of the dengue virus envelope proteins

scientific article

Alphavirus Entry and Membrane Fusion

scientific article

Alphavirus entry: NRAMP leads the way.

scientific article

An Alphavirus E2 Membrane-Proximal Domain Promotes Envelope Protein Lateral Interactions and Virus Budding

scientific article published on 7 November 2017

An alphavirus temperature-sensitive capsid mutant reveals stages of nucleocapsid assembly

scientific article

An epitope of the Semliki Forest virus fusion protein exposed during virus-membrane fusion

scientific article

An interaction site of the envelope proteins of Semliki Forest virus that is preserved after proteolytic activation

scientific article

Analysis of a Chinese hamster ovary cell mutant with defective mobilization of cholesterol from the plasma membrane to the endoplasmic reticulum ⬇️

scientific article published on October 1, 1997

BST2/tetherin inhibition of alphavirus exit

scientific article published on 22 April 2015

Berberine Chloride is an Alphavirus Inhibitor That Targets Nucleocapsid Assembly

scientific article published on 30 June 2020

Biosynthesis, maturation, and acid activation of the Semliki Forest virus fusion protein

scientific article

Calcium-Dependent Rubella Virus Fusion Occurs in Early Endosomes

scientific article published on 27 April 2016

Cell-cell interactions in blast transformation of rat lymphocytes by neuraminidase and galactose oxidase*1

scientific article published on 01 October 1977

Cholesterol is required for infection by Semliki Forest virus

scientific article

Cholesterol is required in the exit pathway of Semliki Forest virus

scientific article

Cholesterol-depleted cells that are relatively permissive for Semliki Forest virus infection.

scientific article published on October 1996

Cholesterol-independent Targeting of Golgi Membrane Proteins in Insect Cells ⬇️

scientific article published on November 1, 1997

Class II virus membrane fusion proteins

scientific article

Comprehensive mapping of functional epitopes on dengue virus glycoprotein E DIII for binding to broadly neutralizing antibodies 4E11 and 4E5A by phage display

scientific article published on September 2015

Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virus

scientific article

Cross-inhibition of chikungunya virus fusion and infection by alphavirus E1 domain III proteins

scientific article published on May 2013

Dealing with low pH: entry and exit of alphaviruses and flaviviruses

scientific article

Differential Cholesterol Binding by Class II Fusion Proteins Determines Membrane Fusion Properties

scientific article (publication date: September 2008)

Differential roles of two conserved glycine residues in the fusion peptide of Semliki Forest virus

scientific article

Domain III from class II fusion proteins functions as a dominant-negative inhibitor of virus membrane fusion

scientific article (publication date: 10 October 2005)

E1 Mutants Identify a Critical Region in the Trimer Interface of the Semliki Forest Virus Fusion Protein

scientific article

Effects of membrane potential and sphingolipid structures on fusion of Semliki Forest virus

scientific article

Engineered Dengue Virus Domain III Proteins Elicit Cross-Neutralizing Antibody Responses in Mice

article

Enhancing host cell infection by SARS-CoV-2

scientific article published on 01 November 2020

Flaviviruses: braking the entering

scientific article

Formation and characterization of the trimeric form of the fusion protein of Semliki Forest Virus

scientific article (publication date: September 2000)

Functions of the Stem Region of the Semliki Forest Virus Fusion Protein during Virus Fusion and Assembly

scientific article

Furin Processing and Proteolytic Activation of Semliki Forest Virus

scientific article (publication date: March 2003)

Fusion induced by a class II viral fusion protein, semliki forest virus E1, is dependent on the voltage of the target cell

scientific article published on 8 August 2007

Genome-wide RNAi screen identifies novel host proteins required for alphavirus entry

scientific article

Growth and stability of a cholesterol-independent Semliki Forest virus mutant in mosquitoes.

scientific article published on September 1999

Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion

scientific article published on 30 June 2015

Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins.

scientific article published on 7 November 2019

Identification of a specific region in the e1 fusion protein involved in zinc inhibition of semliki forest virus fusion

scientific article published on 18 January 2012

Imaging of the alphavirus capsid protein during virus replication

scientific article published on 19 June 2013

Imaging the alphavirus exit pathway

scientific article

In vitro and in vivo studies identify important features of dengue virus pr-E protein interactions

scientific article

In vitro reconstitution reveals key intermediate states of trimer formation by the dengue virus membrane fusion protein

scientific article

In vivo generation and characterization of a soluble form of the Semliki forest virus fusion protein

scientific article published on September 2001

Insertion of dengue E into lipid bilayers studied by neutron reflectivity and molecular dynamics simulations.

scientific article published on 12 February 2018

Interactions involved in pH protection of the alphavirus fusion protein

scientific article

Intercellular Extensions Are Induced by the Alphavirus Structural Proteins and Mediate Virus Transmission

scientific article

Intralysosomal accumulation of polyanions. I. Fusion of pinocytic and phagocytic vacuoles with secondary lysosomes ⬇️

scientific article published on June 1, 1982

Intralysosomal accumulation of polyanions. II. Polyanion internalization and its influence on lysosomal pH and membrane fluidity.

scientific article

Kinetics of endosome acidification detected by mutant and wild-type Semliki Forest virus

scientific article

Mechanism of Tetherin Inhibition of Alphavirus Release

scientific article published on 21 March 2019

Mechanisms of Virus Membrane Fusion Proteins

scientific article

Mechanisms of mutations inhibiting fusion and infection by Semliki Forest virus.

scientific article

Membrane and protein interactions of a soluble form of the Semliki Forest virus fusion protein

scientific article

Membrane fusion and the alphavirus life cycle

scientific article published on January 1995

Membrane fusion proteins of enveloped animal viruses ⬇️

scientific article published on May 1, 1983

Method for measuring the unbinding energy of strongly-bound membrane-associated proteins

scientific article published on 14 July 2016

Molecular dissection of the Semliki Forest virus homotrimer reveals two functionally distinct regions of the fusion protein

scientific article

Multiple capsid protein binding sites mediate selective packaging of the alphavirus genomic RNA

scientific article published on 17 September 2020

Multistep regulation of membrane insertion of the fusion peptide of Semliki Forest virus

scientific article published on April 2004

Mutagenesis of the putative fusion domain of the Semliki Forest virus spike protein

scientific article

Mutations in the putative fusion peptide of Semliki Forest virus affect spike protein oligomerization and virus assembly.

scientific article published on April 1995

Mutations that promote furin-independent growth of Semliki Forest virus affect p62-E1 interactions and membrane fusion

scientific article published on October 2004

Novel mutations that control the sphingolipid and cholesterol dependence of the Semliki Forest virus fusion protein

scientific article

Potent Antibody Protection against an Emerging Alphavirus Threat

scientific article

Preface to Volume 100: History and Looking Forward.

scientific article

Pseudorevertants of a Semliki forest virus fusion-blocking mutation reveal a critical interchain interaction in the core trimer

scientific article

Purification and crystallization reveal two types of interactions of the fusion protein homotrimer of Semliki Forest virus

scientific article published on April 2004

Role of Conserved Histidine Residues in the Low-pH Dependence of the Semliki Forest Virus Fusion Protein

scientific article (publication date: May 2009)

Role of TSPAN9 in Alphavirus Entry and Early Endosomes

scientific article published on 10 February 2016

Role of spike protein conformational changes in fusion of Semliki Forest virus

scientific article

Rubella virus: first calcium-requiring viral fusion protein

scientific article

Second-Site Revertants of a Semliki Forest Virus Fusion-Block Mutation Reveal the Dynamics of a Class II Membrane Fusion Protein

scientific article (publication date: June 2006)

Site-Directed Antibodies against the Stem Region Reveal Low pH-Induced Conformational Changes of the Semliki Forest Virus Fusion Protein

scientific article

Specific roles for lipids in virus fusion and exit. Examples from the alphaviruses.

scientific article

Structural biology: An alphavirus puzzle solved

scientific article published on December 2010

Structural surprises from the flaviviruses and alphaviruses

scientific article published in March 2002

The Alphavirus E2 Membrane-Proximal Domain Impacts Capsid Interaction and Glycoprotein Lattice Formation

scientific article published on 05 February 2019

The Alphavirus Exit Pathway: What We Know and What We Wish We Knew.

scientific article

The Role of Low pH and Disulfide Shuffling in the Entry and Fusion of Semliki Forest Virus and Sindbis Virus ⬇️

scientific article published on September 1, 1998

The cholesterol requirement for sindbis virus entry and exit and characterization of a spike protein region involved in cholesterol dependence

scientific article

The conserved glycine residues in the transmembrane domain of the Semliki Forest virus fusion protein are not required for assembly and fusion.

scientific article published on February 2005

The domain I-domain III linker plays an important role in the fusogenic conformational change of the alphavirus membrane fusion protein

scientific article

The fusion peptide of Semliki Forest virus associates with sterol-rich membrane domains

scientific article

The interaction of alphavirus E1 protein with exogenous domain III defines stages in virus-membrane fusion

scientific article published on 21 September 2011

The role of E3 in pH protection during alphavirus assembly and exit

scientific article published on 17 July 2013

Transcriptional and Translational Dynamics of Zika and Dengue Virus Infection

scientific article published in 2022

Ubiquitin Depletion and Dominant-Negative VPS4 Inhibit Rhabdovirus Budding without Affecting Alphavirus Budding

scientific article

Virus membrane-fusion proteins: more than one way to make a hairpin

scientific article (publication date: 2006)

Visualization of the target-membrane-inserted fusion protein of Semliki Forest virus by combined electron microscopy and crystallography

scientific article published on September 2003

Wortmannin-sensitive Trafficking Pathways in Chinese Hamster Ovary Cells

article

[11] Assay of phagosome-lysosome fusion

scientific article published on 01 January 1986

fus-1 , a pH Shift Mutant of Semliki Forest Virus, Acts by Altering Spike Subunit Interactions via a Mutation in the E2 Subunit ⬇️

scientific article published on May 1, 1998

pH-induced alterations in the fusogenic spike protein of Semliki Forest virus

scientific article

Paulina is supported by:

About Paulina

Help