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List of works by John Hiscott

A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization

scientific article

A high-throughput pharmacoviral approach identifies novel oncolytic virus sensitizers

scientific article

A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.

scientific article

Acetylated Tat regulates human immunodeficiency virus type 1 splicing through its interaction with the splicing regulator p32.

scientific article published in April 2006

Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity

scientific article

Additive activity between the trans-activation response RNA-binding protein, TRBP2, and cyclin T1 on HIV type 1 expression and viral production in murine cells

scientific article (publication date: September 2003)

An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation

scientific article published on 28 August 2019

Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon.

scientific article published on 24 April 2015

BCL-2 inhibitors sensitize therapy-resistant chronic lymphocytic leukemia cells to VSV oncolysis

scientific article published on 21 May 2013

Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes

scientific article

Cellular oxidative stress response controls the antiviral and apoptotic programs in dengue virus-infected dendritic cells

scientific article

Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis.

scholarly article

Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral response

scientific article published on 13 August 2007

Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosis

scientific article published on December 2003

Coxsackievirus cloverleaf RNA containing a 5' triphosphate triggers an antiviral response via RIG-I activation

scientific article

Defining New Therapeutics Using a More Immunocompetent Mouse Model of Antibody-Enhanced Dengue Virus Infection

scientific article

Dengue Virus Immunopathogenesis: Lessons Applicable to the Emergence of Zika Virus

scientific article

Differential regulation of HIV-1 clade-specific B, C, and E long terminal repeats by NF-kappaB and the Tat transactivator.

scientific article

Differential regulation of human interferon A gene expression by interferon regulatory factors 3 and 7

scientific article (publication date: June 2009)

Differential regulation of human papillomavirus type 8 by interferon regulatory factors 3 and 7

scientific article published on 27 October 2010

Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage

scientific article

Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages

scientific article

Enhanced Influenza Virus-Like Particle Vaccination with a Structurally Optimized RIG-I Agonist as Adjuvant

scientific article

Functional analysis of a dominant negative mutation of interferon regulatory factor 5

scientific article

Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells

scientific article

Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors

scientific article published on 27 February 2015

HIV-1 Tat Recruits HDM2 E3 Ligase To Target IRF-1 for Ubiquitination and Proteasomal Degradation

scientific article published on 18 October 2016

HTLV-1 Evades Type I Interferon Antiviral Signaling by Inducing the Suppressor of Cytokine Signaling 1 (SOCS1) ⬇️

scientific article published on November 4, 2010

HTLV-1 Tax-mediated inhibition of FOXO3a activity is critical for the persistence of terminally differentiated CD4+ T cells

scientific article (publication date: December 2014)

Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression

scientific article (publication date: September 2006)

Hostile takeovers: viral appropriation of the NF-kB pathway

scientific article

IRF-4 activities in HTLV-I-induced T cell leukemogenesis

scientific article (publication date: 2002)

Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon

scientific article

Intact type I Interferon production and IRF7 function in sooty mangabeys

scientific article

Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma

scientific article

MasterCARD: a priceless link to innate immunity

scientific article published in February 2006

Mechanisms of Zika Virus Infection and Neuropathogenesis

scientific article

Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses.

scientific article published on 10 September 2015

Multiple signaling pathways leading to the activation of interferon regulatory factor 3.

scientific article

On the TRAIL to apoptosis

scientific article

Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription

scientific article (publication date: 8 March 2002)

Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon

scientific article

RIG-I-Mediated Antiviral Signaling Is Inhibited in HIV-1 Infection by a Protease-Mediated Sequestration of RIG-I ⬇️

scientific article published on November 17, 2010

Recruitment of Histone Deacetylase 3 to the Interferon-A Gene Promoters Attenuates Interferon Expression ⬇️

scientific article published on June 7, 2012

Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease

scientific article

Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells

scientific article (publication date: 15 September 2002)

Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins.

scientific article

Repression of DNA repair mechanisms in IRF-4-expressing and HTLV-I-infected T lymphocytes

scientific article

Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines

scientific article

STING-ing the antiviral pathway

scientific article

Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists

scientific article published on 27 May 2015

Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKε To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection

scientific article published on 9 June 2017

Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity

scientific article

Targeting the apoptotic pathway with BCL-2 inhibitors sensitizes primary chronic lymphocytic leukemia cells to vesicular stomatitis virus-induced oncolysis

scientific article published on 25 June 2008

The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation

scientific article

The interferon antiviral response: from viral invasion to evasion

scientific article

The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.

scientific article

Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes

scientific article

Triggering the innate antiviral response through IRF-3 activation

scientific article published on 29 March 2007

Triggering the interferon antiviral response through an IKK-related pathway

scientific article

Triptolide-mediated inhibition of interferon signaling enhances vesicular stomatitis virus-based oncolysis

scientific article published on 28 August 2013

Tumor necrosis factor alpha enhances influenza A virus-induced expression of antiviral cytokines by activating RIG-I gene expression.

scientific article

Ub surprised: viral ovarian tumor domain proteases remove ubiquitin and ISG15 conjugates

scientific article published on December 2007

Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter

scientific article published on 20 April 2009

VSV Oncolysis in Combination With the BCL-2 Inhibitor Obatoclax Overcomes Apoptosis Resistance in Chronic Lymphocytic Leukemia ⬇️

scientific article published on September 14, 2010

VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents

scientific article

Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation

scientific article published on 16 April 2008

Vesicular stomatitis virus oncolytic treatment interferes with tumor-associated dendritic cell functions and abrogates tumor antigen presentation

scientific article published on 14 September 2011

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