List of works - Joachim Grötzinger

A disintegrin and metalloprotease 17 dynamic interaction sequence, the sweet tooth for the human interleukin 6 receptor

scientific article (publication date: 6 June 2014)

A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells

scientific article

A novel horse alpha-defensin: gene transcription, recombinant expression and characterization of the structure and function

scientific article

A positive genotype-phenotype correlation in a large cohort of patients with Pseudohypoparathyroidism Type Ia and Pseudo-pseudohypoparathyroidism and 33 newly identified mutations in the GNAS gene

scientific article

A role for IL-27p28 as an antagonist of gp130-mediated signaling

scientific article

A secreted antibacterial neuropeptide shapes the microbiome of Hydra

scientific article published on 26 September 2017

Abrogation of viral interleukin-6 (vIL-6)-induced signaling by intracellular retention and neutralization of vIL-6 with an anti-vIL-6 single-chain antibody selected by phage display

scientific article

Alteration of the substrate specificity of benzoylformate decarboxylase from Pseudomonas putida by directed evolution

scientific article published in August 2003

An exceptional salt-tolerant antimicrobial peptide derived from a novel gene family of haemocytes of the marine invertebrate Ciona intestinalis

scientific article

An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer

scientific article published on 3 December 2012

Analysis of the leukemia inhibitory factor receptor functional domains by chimeric receptors and cytokines

scientific article published in May 2003

Ancient weapons: the three-dimensional structure of amoebapore A.

scientific article

Antimicrobial activity of bovine psoriasin

scientific article published on 6 December 2008

Antimicrobial peptides and proteins of the horse--insights into a well-armed organism

scientific article

CD30 on extracellular vesicles from malignant Hodgkin cells supports damaging of CD30 ligand-expressing bystander cells with Brentuximab-Vedotin, in vitro

scientific article published on 20 April 2016

Caenopore-5: the three-dimensional structure of an antimicrobial protein from Caenorhabditis elegans

scientific article

Caenopores are antimicrobial peptides in the nematode Caenorhabditis elegans instrumental in nutrition and immunity

scientific article published on 21 October 2009

Carboxyl-terminal mutations in 3beta-hydroxysteroid dehydrogenase type II cause severe salt-wasting congenital adrenal hyperplasia

scientific article published on 5 February 2008

Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis

scientific article

Characterization and function of the first antibiotic isolated from a vent organism: the extremophile metazoan Alvinella pompejana

scientific article (publication date: 2014)

Characterization of a potent human interleukin-11 agonist

scientific article

Characterization of human gene encoding SLA/LP autoantigen and its conserved homologs in mouse, fish, fly, and worm

scientific article published on February 2006

Characterization of the rat oncostatin M receptor complex which resembles the human, but differs from the murine cytokine receptor

scientific article

Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17.

scientific article published on 6 May 2016

Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: functional consequences of four CYP11B1 mutations

scientific article published on 11 September 2013

Congenital adrenal hyperplasia due to 11-hydroxylase deficiency--insights from two novel CYP11B1 mutations (p.M92X, p.R453Q).

scientific article published on 19 October 2009

Congenital adrenal hyperplasia due to 11-hydroxylase deficiency: functional characterization of two novel point mutations and a three-base pair deletion in the CYP11B1 gene

scientific article

Congenital lipoid adrenal hyperplasia: functional characterization of three novel mutations in the STAR gene

scientific article published on 15 January 2010

Development of sandwich ELISA for detection and quantification of human and murine a disintegrin and metalloproteinase17.

scientific article published on 24 June 2011

Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy

scientific article (publication date: 2 January 2004)

Disulphide-reduced psoriasin is a human apoptosis-inducing broad-spectrum fungicide

scientific article

Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane

scientific article published on March 2005

Erratum: Control of ADAM17 activity by regulation of its cellular localisation

scientific article

Expression and function of psoriasin (S100A7) and koebnerisin (S100A15) in the brain

scientific article published on 11 March 2013

Extracellular Juxtamembrane Segment of ADAM17 Interacts with Membranes and Is Essential for Its Shedding Activity

scientific article published on 8 September 2015

Four novel missense mutations in the CYP21A2 gene detected in Russian patients suffering from the classical form of congenital adrenal hyperplasia: identification, functional characterization, and structural analysis

scientific journal article

Functional and structural consequences of a novel point mutation in the CYP21A2 gene causing congenital adrenal hyperplasia: potential relevance of helix C for P450 oxidoreductase-21-hydroxylase interaction

scientific article published on 29 April 2008

Functional characterization of GNAS mutations found in patients with pseudohypoparathyroidism type Ic defines a new subgroup of pseudohypoparathyroidism affecting selectively Gsα-receptor interaction

scientific article

Functional characterization of two novel point mutations in the CYP21 gene causing simple virilizing forms of congenital adrenal hyperplasia due to 21-hydroxylase deficiency

scientific article published on 13 October 2004

Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling

scientific article published on September 2006

Human beta-defensin 2 and beta-defensin 3 chimeric peptides reveal the structural basis of the pathogen specificity of their parent molecules

scientific article

Hydramacin-1 in action: scrutinizing the barnacle model

scientific article published on 15 April 2013

Hydramacin-1, structure and antibacterial activity of a protein from the basal metazoan Hydra

scientific article

Identification of an interleukin-15alpha receptor-binding site on human interleukin-15

scientific article (publication date: 4 June 2004)

Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor

scientific article published on 14 May 2013

Identification of structural traits that increase the antimicrobial activity of a chimeric peptide of human β-defensins 2 and 3

scientific article

Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor

scientific article published on 11 October 2011

Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice

scientific article published on March 2006

Interleukin-6 receptor specific RNA aptamers for cargo delivery into target cells

scientific article

Macin Family of Antimicrobial Proteins Combines Antimicrobial and Nerve Repair Activities

scientific article

Membrane-proximal domain of a disintegrin and metalloprotease-17 represents the putative molecular switch of its shedding activity operated by protein-disulfide isomerase

scientific article

Minimal interleukin 6 (IL-6) receptor stalk composition for IL-6 receptor shedding and IL-6 classic signaling

scientific article published on 5 April 2013

Molecular insights into the multilayered regulation of ADAM17: The role of the extracellular region

scientific article published on 29 May 2017

Molecular mechanisms of cytokine receptor activation

scientific article

Mutagenesis of catalytically important residues of cupin type phosphoglucose isomerase from Archaeoglobus fulgidus

scientific article

Mutations in the interleukin receptor IL11RA cause autosomal recessive Crouzon-like craniosynostosis

scientific article published on 19 August 2013

N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130.

scientific article

NMR analysis of viral protein structures.

scientific article published in January 2008

Non-canonical interleukin 23 receptor complex assembly: p40 protein recruits interleukin 12 receptor β1 via site II and induces p19/interleukin 23 receptor interaction via site III.

scientific article

PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation

scientific article

Phosphatidylserine exposure is required for ADAM17 sheddase function

scientific article

Plasticity and cross-talk of interleukin 6-type cytokines

scientific article published on 15 May 2012

Proteolytic Cleavage Governs Interleukin-11 Trans-signaling

scientific article published on 10 February 2016

Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation

scientific article

RAID3--An interleukin-6 receptor-binding aptamer with post-selective modification-resistant affinity

scientific article published on September 2015

Reaction mechanism and structural model of ADP-forming Acetyl-CoA synthetase from the hyperthermophilic archaeon Pyrococcus furiosus: evidence for a second active site histidine residue

scientific article

Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35

scientific article

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

scientific article

Significance of the cyclic structure and of arginine residues for the antibacterial activity of arenicin-1 and its interaction with phospholipid and lipopolysaccharide model membranes

scientific article published in April 2009

Solution structure of the pore-forming protein of Entamoeba histolytica

scientific article

Stabilized Interleukin-6 receptor binding RNA aptamers

scientific article published on 20 December 2013

Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles

scientific article (publication date: 11 April 2003)

Structure and function of a unique pore-forming protein from a pathogenic acanthamoeba

scientific article

Structure and mode of action of the antimicrobial peptide arenicin

scientific article

Synthetic Deletion of the Interleukin 23 Receptor (IL-23R) Stalk Region Led to Autonomous IL-23R Homodimerization and Activation

scientific article published on 19 June 2017

The CSRP2BP histone acetyltransferase drives smooth muscle gene expression

scientific article

The IL-6/sIL-6R complex as a novel target for therapeutic approaches

scientific article published on May 2007

The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR).

scientific article published on 6 May 2014

The disintegrin domain of ADAM17 antagonises fibroblast‑carcinoma cell interactions

scientific article published on 26 March 2013

The equine antimicrobial peptide eCATH1 is effective against the facultative intracellular pathogen Rhodococcus equi in mice

scientific article published on July 2013

The matrix metalloproteinase 9 (mmp-9) hemopexin domain is a novel gelatin binding domain and acts as an antagonist

scientific article

The residue E351 is essential for the activity of human 21-hydroxylase: evidence from a naturally occurring novel point mutation compared with artificial mutants generated by single amino acid substitutions

scientific article published on 14 April 2005

The upper cytokine-binding module and the Ig-like domain of the leukaemia inhibitory factor (LIF) receptor are sufficient for a functional LIF receptor complex

scientific article published on January 2002

Trans-sialidase-like sequences from Trypanosoma congolense conserve most of the critical active site residues found in other trans-sialidases

scientific article

Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence

scientific article published on 12 November 2008

Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor

scientific article published on 4 March 2009

Unusual function of the activation loop in the protein kinase DYRK1A.

scientific article published in March 2003

Upd3--an ancestor of the four-helix bundle cytokines

scientific article published on 22 May 2013

Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization

scientific article published on 21 December 2010

d(GGGT) 4 and r(GGGU) 4 are both HIV-1 inhibitors and interleukin-6 receptor aptamers

scientific article

List of works by Joachim Grötzinger

A disintegrin and metalloprotease 17 dynamic interaction sequence, the sweet tooth for the human interleukin 6 receptor

A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells

A novel horse alpha-defensin: gene transcription, recombinant expression and characterization of the structure and function

A positive genotype-phenotype correlation in a large cohort of patients with Pseudohypoparathyroidism Type Ia and Pseudo-pseudohypoparathyroidism and 33 newly identified mutations in the GNAS gene

A role for IL-27p28 as an antagonist of gp130-mediated signaling

A secreted antibacterial neuropeptide shapes the microbiome of Hydra

Abrogation of viral interleukin-6 (vIL-6)-induced signaling by intracellular retention and neutralization of vIL-6 with an anti-vIL-6 single-chain antibody selected by phage display

Alteration of the substrate specificity of benzoylformate decarboxylase from Pseudomonas putida by directed evolution

An exceptional salt-tolerant antimicrobial peptide derived from a novel gene family of haemocytes of the marine invertebrate Ciona intestinalis

An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer

Analysis of the leukemia inhibitory factor receptor functional domains by chimeric receptors and cytokines

Ancient weapons: the three-dimensional structure of amoebapore A.

Antimicrobial activity of bovine psoriasin

Antimicrobial peptides and proteins of the horse--insights into a well-armed organism

CD30 on extracellular vesicles from malignant Hodgkin cells supports damaging of CD30 ligand-expressing bystander cells with Brentuximab-Vedotin, in vitro

Caenopore-5: the three-dimensional structure of an antimicrobial protein from Caenorhabditis elegans

Caenopores are antimicrobial peptides in the nematode Caenorhabditis elegans instrumental in nutrition and immunity

Carboxyl-terminal mutations in 3beta-hydroxysteroid dehydrogenase type II cause severe salt-wasting congenital adrenal hyperplasia

Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis

Characterization and function of the first antibiotic isolated from a vent organism: the extremophile metazoan Alvinella pompejana

Characterization of a potent human interleukin-11 agonist

Characterization of human gene encoding SLA/LP autoantigen and its conserved homologs in mouse, fish, fly, and worm

Characterization of the rat oncostatin M receptor complex which resembles the human, but differs from the murine cytokine receptor

Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17.

Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: functional consequences of four CYP11B1 mutations

Congenital adrenal hyperplasia due to 11-hydroxylase deficiency--insights from two novel CYP11B1 mutations (p.M92X, p.R453Q).

Congenital adrenal hyperplasia due to 11-hydroxylase deficiency: functional characterization of two novel point mutations and a three-base pair deletion in the CYP11B1 gene

Congenital lipoid adrenal hyperplasia: functional characterization of three novel mutations in the STAR gene

Development of sandwich ELISA for detection and quantification of human and murine a disintegrin and metalloproteinase17.

Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy

Disulphide-reduced psoriasin is a human apoptosis-inducing broad-spectrum fungicide

Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane

Erratum: Control of ADAM17 activity by regulation of its cellular localisation

Expression and function of psoriasin (S100A7) and koebnerisin (S100A15) in the brain

Extracellular Juxtamembrane Segment of ADAM17 Interacts with Membranes and Is Essential for Its Shedding Activity

Four novel missense mutations in the CYP21A2 gene detected in Russian patients suffering from the classical form of congenital adrenal hyperplasia: identification, functional characterization, and structural analysis

Functional and structural consequences of a novel point mutation in the CYP21A2 gene causing congenital adrenal hyperplasia: potential relevance of helix C for P450 oxidoreductase-21-hydroxylase interaction

Functional characterization of GNAS mutations found in patients with pseudohypoparathyroidism type Ic defines a new subgroup of pseudohypoparathyroidism affecting selectively Gsα-receptor interaction

Functional characterization of two novel point mutations in the CYP21 gene causing simple virilizing forms of congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling

Human beta-defensin 2 and beta-defensin 3 chimeric peptides reveal the structural basis of the pathogen specificity of their parent molecules

Hydramacin-1 in action: scrutinizing the barnacle model

Hydramacin-1, structure and antibacterial activity of a protein from the basal metazoan Hydra

Identification of an interleukin-15alpha receptor-binding site on human interleukin-15

Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor

Identification of structural traits that increase the antimicrobial activity of a chimeric peptide of human β-defensins 2 and 3

Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor

Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice

Interleukin-6 receptor specific RNA aptamers for cargo delivery into target cells

Macin Family of Antimicrobial Proteins Combines Antimicrobial and Nerve Repair Activities

Membrane-proximal domain of a disintegrin and metalloprotease-17 represents the putative molecular switch of its shedding activity operated by protein-disulfide isomerase

Minimal interleukin 6 (IL-6) receptor stalk composition for IL-6 receptor shedding and IL-6 classic signaling

Molecular insights into the multilayered regulation of ADAM17: The role of the extracellular region

Molecular mechanisms of cytokine receptor activation

Mutagenesis of catalytically important residues of cupin type phosphoglucose isomerase from Archaeoglobus fulgidus

Mutations in the interleukin receptor IL11RA cause autosomal recessive Crouzon-like craniosynostosis

N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130.

NMR analysis of viral protein structures.

Non-canonical interleukin 23 receptor complex assembly: p40 protein recruits interleukin 12 receptor β1 via site II and induces p19/interleukin 23 receptor interaction via site III.

PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation

Phosphatidylserine exposure is required for ADAM17 sheddase function

Plasticity and cross-talk of interleukin 6-type cytokines

Proteolytic Cleavage Governs Interleukin-11 Trans-signaling

Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation

RAID3--An interleukin-6 receptor-binding aptamer with post-selective modification-resistant affinity

Reaction mechanism and structural model of ADP-forming Acetyl-CoA synthetase from the hyperthermophilic archaeon Pyrococcus furiosus: evidence for a second active site histidine residue

Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

Significance of the cyclic structure and of arginine residues for the antibacterial activity of arenicin-1 and its interaction with phospholipid and lipopolysaccharide model membranes

Solution structure of the pore-forming protein of Entamoeba histolytica

Stabilized Interleukin-6 receptor binding RNA aptamers

Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles

Structure and function of a unique pore-forming protein from a pathogenic acanthamoeba

Structure and mode of action of the antimicrobial peptide arenicin

Synthetic Deletion of the Interleukin 23 Receptor (IL-23R) Stalk Region Led to Autonomous IL-23R Homodimerization and Activation

The CSRP2BP histone acetyltransferase drives smooth muscle gene expression

The IL-6/sIL-6R complex as a novel target for therapeutic approaches

The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR).

The disintegrin domain of ADAM17 antagonises fibroblast‑carcinoma cell interactions