List of works - Claudio De Virgilio

A septin-based hierarchy of proteins required for localized deposition of chitin in the Saccharomyces cerevisiae cell wall.

scientific article

A spatially and functionally distinct pool of TORC1 defines signaling endosomes in yeast

scientific article published on 17 February 2019

Acquisition of thermotolerance in Saccharomyces cerevisiae without heat shock protein hsp 104 and in the absence of protein synthesis

scientific article published on 01 August 1991

Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2.

scientific article

Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.

scientific article

An EGOcentric view of TORC1 signaling.

scientific article

Bni5p, a septin-interacting protein, is required for normal septin function and cytokinesis in Saccharomyces cerevisiae

scientific article

Bud8p and Bud9p, proteins that may mark the sites for bipolar budding in yeast.

scientific article

Caffeine extends yeast lifespan by targeting TORC1.

scientific article

Cell growth control: little eukaryotes make big contributions.

scientific article

Composition and functional analysis of the Saccharomyces cerevisiae trehalose synthase complex.

scientific article

Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling

scientific article

Control of cellular physiology by TM9 proteins in yeast and Dictyostelium

scientific article

Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling.

scientific article

Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock

scientific article published on 05 November 2019

Disruption in Candida albicans of the TPS2 gene encoding trehalose-6-phosphate phosphatase affects cell integrity and decreases infectivity.

scientific article published in May 2002

Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 in the ego complex to activate TORC1

scientific article

Establishment of cell polarity in yeast.

scientific article published on January 1995

Expression of a functional barley sucrose-fructan 6-fructosyltransferase in the methylotrophic yeast Pichia pastoris

scientific article published on 01 December 1998

Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals.

scientific article published in July 2017

Functional mapping of yeast genomes by saturated transposition

scientific article

Genetic and physical localization of the acetyl-coenzyme A synthetase gene ACS1 on chromosome I of Saccharomyces cerevisiae

scientific article published on 01 April 1993

Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry

scientific article published in February 2012

Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway

scientific article

Initiation of the yeast G0 program requires Igo1 and Igo2, which antagonize activation of decapping of specific nutrient-regulated mRNAs

scientific article published on 01 January 2011

Leucyl-tRNA synthetase controls TORC1 via the EGO complex

scientific article

Membrane stress is coupled to a rapid translational control of gene expression in chlorpromazine-treated cells.

scientific article published on 21 August 2007

Mitochondrial genomic dysfunction causes dephosphorylation of Sch9 in the yeast Saccharomyces cerevisiae.

scientific article

Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger-dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae

scientific article published in May 2007

Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae.

scientific article

PKA and Sch9 control a molecular switch important for the proper adaptation to nutrient availability.

scientific article

Phosphatidylinositol 4-phosphate is required for translation initiation in Saccharomyces cerevisiae

scientific article published on 27 September 2006

Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson

scientific article published on 19 June 2008

Quantification of mRNA stability of stress-responsive yeast genes following conditional excision of open reading frames ⬇️

scientific article published on June 13, 2013

Regulation of G0 entry by the Pho80-Pho85 cyclin-CDK complex.

scientific article

Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling

scientific article published on 20 August 2019

Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway.

scientific article published on August 1995

SEACing the GAP that nEGOCiates TORC1 activation: evolutionary conservation of Rag GTPase regulation

scientific article

Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase ⬇️

scientific article published on September 15, 1998

Sch9 is a major target of TORC1 in Saccharomyces cerevisiae

scientific article

Spatially Distinct Pools of TORC1 Balance Protein Homeostasis

scientific article published on 06 December 2018

Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast.

scientific article

Structural insights into the EGO-TC-mediated membrane tethering of the TORC1-regulatory Rag GTPases

scientific article published on 25 September 2019

TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0.

scientific article

TORC1 controls G1-S cell cycle transition in yeast via Mpk1 and the greatwall kinase pathway

scientific article

TORC1 coordinates the conversion of Sic1 from a target to an inhibitor of cyclin-CDK-Cks1.

scientific article

TORC1 regulates Pah1 phosphatidate phosphatase activity via the Nem1/Spo7 protein phosphatase complex

scientific article

TORC1 specifically inhibits microautophagy through ESCRT-0

scientific article published on 30 April 2019

The 70-kilodalton heat-shock proteins of the SSA subfamily negatively modulate heat-shock-induced accumulation of trehalose and promote recovery from heat stress in the yeast, Saccharomyces cerevisiae

scientific article published on 01 November 1992

The Architecture of the Rag GTPase Signaling Network.

scientific article published on 30 June 2017

The Bud14p-Glc7p complex functions as a cortical regulator of dynein in budding yeast

scientific article

The Ccr4-Not complex independently controls both Msn2-dependent transcriptional activation--via a newly identified Glc7/Bud14 type I protein phosphatase module--and TFIID promoter distribution.

scientific article

The I-BAR protein Ivy1 is an effector of the Rab7 GTPase Ypt7 involved in vacuole membrane homeostasis

scientific article

The Impact of ESCRT on Aβ Induced Membrane Lesions in a Yeast Model for Alzheimer's Disease

scientific article published on 05 November 2018

The TOR and EGO protein complexes orchestrate microautophagy in yeast

scientific article

The Vam6 GEF controls TORC1 by activating the EGO complex

scientific article

The evolutionary conserved BER1 gene is involved in microtubule stability in yeast

scientific article

The role of trehalose synthesis for the acquisition of thermotolerance in yeast. I. Genetic evidence that trehalose is a thermoprotectant

scientific article published on 01 January 1994

The role of trehalose synthesis for the acquisition of thermotolerance in yeast. II. Physiological concentrations of trehalose increase the thermal stability of proteins in vitro

scientific article published on 01 January 1994

The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability

scientific article

Unsolved mysteries of Rag GTPase signaling in yeast.

scientific article published on 11 July 2016

Yeast endosulfines control entry into quiescence and chronological life span by inhibiting protein phosphatase 2A

scientific journal article

List of works by Claudio De Virgilio

A septin-based hierarchy of proteins required for localized deposition of chitin in the Saccharomyces cerevisiae cell wall.

A spatially and functionally distinct pool of TORC1 defines signaling endosomes in yeast

Acquisition of thermotolerance in Saccharomyces cerevisiae without heat shock protein hsp 104 and in the absence of protein synthesis

Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2.

Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.

An EGOcentric view of TORC1 signaling.

Bni5p, a septin-interacting protein, is required for normal septin function and cytokinesis in Saccharomyces cerevisiae

Bud8p and Bud9p, proteins that may mark the sites for bipolar budding in yeast.

Caffeine extends yeast lifespan by targeting TORC1.

Cell growth control: little eukaryotes make big contributions.

Composition and functional analysis of the Saccharomyces cerevisiae trehalose synthase complex.

Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling

Control of cellular physiology by TM9 proteins in yeast and Dictyostelium

Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling.

Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock

Disruption in Candida albicans of the TPS2 gene encoding trehalose-6-phosphate phosphatase affects cell integrity and decreases infectivity.

Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 in the ego complex to activate TORC1

Establishment of cell polarity in yeast.

Expression of a functional barley sucrose-fructan 6-fructosyltransferase in the methylotrophic yeast Pichia pastoris

Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals.

Functional mapping of yeast genomes by saturated transposition

Genetic and physical localization of the acetyl-coenzyme A synthetase gene ACS1 on chromosome I of Saccharomyces cerevisiae

Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry

Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway

Initiation of the yeast G0 program requires Igo1 and Igo2, which antagonize activation of decapping of specific nutrient-regulated mRNAs

Leucyl-tRNA synthetase controls TORC1 via the EGO complex

Membrane stress is coupled to a rapid translational control of gene expression in chlorpromazine-treated cells.

Mitochondrial genomic dysfunction causes dephosphorylation of Sch9 in the yeast Saccharomyces cerevisiae.

Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger-dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae

Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae.

PKA and Sch9 control a molecular switch important for the proper adaptation to nutrient availability.

Phosphatidylinositol 4-phosphate is required for translation initiation in Saccharomyces cerevisiae

Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson

Quantification of mRNA stability of stress-responsive yeast genes following conditional excision of open reading frames ⬇️

Regulation of G0 entry by the Pho80-Pho85 cyclin-CDK complex.

Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling

Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway.

SEACing the GAP that nEGOCiates TORC1 activation: evolutionary conservation of Rag GTPase regulation

Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase ⬇️

Sch9 is a major target of TORC1 in Saccharomyces cerevisiae

Spatially Distinct Pools of TORC1 Balance Protein Homeostasis

Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast.

Structural insights into the EGO-TC-mediated membrane tethering of the TORC1-regulatory Rag GTPases

TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0.

TORC1 controls G1-S cell cycle transition in yeast via Mpk1 and the greatwall kinase pathway

TORC1 coordinates the conversion of Sic1 from a target to an inhibitor of cyclin-CDK-Cks1.

TORC1 regulates Pah1 phosphatidate phosphatase activity via the Nem1/Spo7 protein phosphatase complex

TORC1 specifically inhibits microautophagy through ESCRT-0

The 70-kilodalton heat-shock proteins of the SSA subfamily negatively modulate heat-shock-induced accumulation of trehalose and promote recovery from heat stress in the yeast, Saccharomyces cerevisiae

The Architecture of the Rag GTPase Signaling Network.

The Bud14p-Glc7p complex functions as a cortical regulator of dynein in budding yeast

The Ccr4-Not complex independently controls both Msn2-dependent transcriptional activation--via a newly identified Glc7/Bud14 type I protein phosphatase module--and TFIID promoter distribution.

The I-BAR protein Ivy1 is an effector of the Rab7 GTPase Ypt7 involved in vacuole membrane homeostasis

The Impact of ESCRT on Aβ Induced Membrane Lesions in a Yeast Model for Alzheimer's Disease

The TOR and EGO protein complexes orchestrate microautophagy in yeast

The Vam6 GEF controls TORC1 by activating the EGO complex

The evolutionary conserved BER1 gene is involved in microtubule stability in yeast

The role of trehalose synthesis for the acquisition of thermotolerance in yeast. I. Genetic evidence that trehalose is a thermoprotectant

The role of trehalose synthesis for the acquisition of thermotolerance in yeast. II. Physiological concentrations of trehalose increase the thermal stability of proteins in vitro

The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability

Unsolved mysteries of Rag GTPase signaling in yeast.

Yeast endosulfines control entry into quiescence and chronological life span by inhibiting protein phosphatase 2A