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List of works by Jean-Yves Winum

(Hetero)aryl substituted thiazol-2,4-yl scaffold as human carbonic anhydrase I, II, VII and XIV activators

scientific article published on 01 December 2019

A Novel Inhibitor of Carbonic Anhydrases Prevents Hypoxia-Induced TNBC Cell Plasticity

scientific article published on 09 November 2020

A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth

scientific article published on 30 December 2010

A spectrophotometric and thermodynamic study of the charge-transfer complexes of N-aryl-N′-isopropyloxycarbonylsulfamides with DDQ and TCNE ⬇️

scientific article published on February 9, 2013

Anion inhibitors of the β-carbonic anhydrase from the pathogenic bacterium responsible of tularemia, Francisella tularensis

scientific article published on 17 July 2017

Anti-virulence strategy against Brucella suis: synthesis, biological evaluation and molecular modeling of selective histidinol dehydrogenase inhibitors

scientific article published on 01 April 2011

Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts.

scientific article published on 5 June 2012

Benzoxaborole as a new chemotype for carbonic anhydrase inhibition

scientific article

Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study

scientific article published on 20 October 2017

Binding of carbonic anhydrase IX to 45S rDNA genes is prevented by exportin-1 in hypoxic cells

scientific article

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6

scientific article published on 28 December 2019

Brucella suis carbonic anhydrases and their inhibitors: Towards alternative antibiotics?

scientific article published on December 2017

Brucella suis histidinol dehydrogenase: synthesis and inhibition studies of substituted N-L-histidinylphenylsulfonyl hydrazide

scientific article published on 01 June 2008

Carbonic Anhydrase Activators: Gold Nanoparticles Coated with Derivatized Histamine, Histidine, and Carnosine Show Enhanced Activatory Effects on Several Mammalian Isoforms

scientific article published on 03 February 2011

Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series.

scientific article published on 2 June 2015

Carbonic Anhydrase Inhibitor Coated Gold Nanoparticles Selectively Inhibit the Tumor-Associated Isoform IX over the Cytosolic Isozymes I and II

scientific article published on 01 December 2008

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

scientific article published on 14 October 2020

Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on and Studies

scientific article

Carbonic Anhydrase Inhibitors: Clash with Ala65 as a Means for Designing Inhibitors with Low Affinity for the Ubiquitous Isozyme II, Exemplified by the Crystal Structure of the Topiramate Sulfamide Analogue†

scientific article published on 01 November 2006

Carbonic Anhydrase Inhibitors: Hypoxia-Activatable Sulfonamides Incorporating Disulfide Bonds that Target the Tumor-Associated Isoform IX†

scientific article published on 01 September 2006

Carbonic Anhydrase Inhibitors: Synthesis and Inhibition of Cytosolic/Membrane-Associated Carbonic Anhydrase Isozymes I, II, and IX with Sulfonamides Incorporating Hydrazino Moieties

scientific article published on 01 March 2005

Carbonic anhydrase I and II activation with mono- and dihalogenated histamine derivatives

scientific article published on 22 June 2011

Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases

scientific article published on 17 September 2009

Carbonic anhydrase IX inhibitors in cancer therapy: an update

scientific article

Carbonic anhydrase IX: a new druggable target for the design of antitumor agents.

scientific article published on May 2008

Carbonic anhydrase activators: activation of human isozymes I, II and IX with phenylsulfonylhydrazido l-histidine derivatives.

scientific article

Carbonic anhydrase enzymes for regulating mast cell hematopoiesis and type-2 inflammation: a patent evaluation (WO2017/058370)

scientific article published on 19 July 2018

Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors

scientific article

Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.

scientific article published on July 2005

Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors

scientific article published in May 2003

Carbonic anhydrase inhibitors. Inhibition of human cytosolic isoforms I and II with (reduced) Schiff's bases incorporating sulfonamide, carboxylate and carboxymethyl moieties.

scientific article

Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose–thioureido tails

scientific article published on 12 March 2007

Carbonic anhydrase inhibitors. Inhibition of the fungal β-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids

scientific article published on 05 April 2009

Carbonic anhydrase inhibitors. N-Cyanomethylsulfonamides—a new zinc binding group in the design of inhibitors targeting cytosolic and membrane-anchored isoforms

Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of [...]

scientific article published in July 2005

Carbonic anhydrase inhibitors: 2-Substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV

scientific article published on 01 November 2008

Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits

scientific article published in January 2004

Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides

scientific article published on 13 July 2007

Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase

scientific article published in January 2004

Carbonic anhydrase inhibitors: aliphatic N-phosphorylated sulfamates--a novel zinc-anchoring group leading to nanomolar inhibitors

scientific article published in June 2004

Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties

scientific article

Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV

scientific article

Carbonic anhydrase inhibitors: design of membrane-impermeant copper(II) complexes of DTPA-, DOTA-, and TETA-tailed sulfonamides targeting the tumor-associated transmembrane isoform IX.

scientific article published in November 2008

Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.

scientific article published on 17 May 2008

Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives

scientific article

Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates

scientific article

Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.

scientific article published in June 2005

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.

scientific article

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.

scientific article published in December 2004

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.

scientific article

Carbonic anhydrase inhibitors: the X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors

scientific article

Carbonic anhydrase-encoded dynamic constitutional libraries: toward the discovery of isozyme-specific inhibitors

scientific article published in August 2009

Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.

scientific article published in March 2010

Co-targeting intracellular pH and essential amino acid uptake cooperates to induce cell death of T-ALL/LL cells.

scientific article published on 22 June 2017

Cytotoxicity, DNA damage, and apoptosis induced by new fotemustine analogs on human melanoma cells in relation to O6-methylguanine DNA-methyltransferase expression.

scientific article published on 11 September 2003

Design of zinc binding functions for carbonic anhydrase inhibitors.

scientific article published on January 2008

Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series

scientific article published on 01 December 2020

Designing carbonic anhydrase inhibitors for the treatment of breast cancer.

scientific article published on 20 April 2015

Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups

scientific article

Dominant behaviours in the expression of human carbonic anhydrase hCA I activity

scientific article published on 01 July 2014

Effective Access to Multivalent Inhibitors of Carbonic Anhydrases Promoted by Peptide Bioconjugation.

scientific article

Emerging trends in enzyme inhibition by multivalent nanoconstructs.

scientific article published on 04 September 2015

Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models.

scientific article

Exploring benzoxaborole derivatives as carbonic anhydrase inhibitors: a structural and computational analysis reveals their conformational variability as a tool to increase enzyme selectivity

scientific article published on 01 December 2019

Ferrier sulfamidoglycosylation of glycals catalyzed by nitrosonium tetrafluoroborate: towards new carbonic anhydrase glycoinhibitors

scientific article published on 02 October 2014

Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins

scientific article published on 27 March 2012

Fluorescent Silica Nanoparticles with Multivalent Inhibitory Effects towards Carbonic Anhydrases

scientific article published on 12 May 2015

Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.

scientific article published on 22 November 2011

Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors.

scientific article published on July 2015

Hypoxia-Activated Prodrug Derivatives of Carbonic Anhydrase Inhibitors in Benzenesulfonamide Series: Synthesis and Biological Evaluation

scientific article published on 18 May 2020

Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates

scientific article

Inclusion complexes of 2-chloroethylnitrososulfamides (CENS) with beta-cyclodextrin.

scientific article

Inhibition of beta-carbonic anhydrases from the bacterial pathogen Brucella suis with inorganic anions

scientific article published on 24 February 2012

Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding

scientific article published on 01 September 2018

Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety

scientific article published on 13 February 2015

Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides.

scientific article published on 21 February 2010

Insights into the binding mode of sulphamates and sulphamides to hCA II: crystallographic studies and binding free energy calculations

scientific article published in December 2017

Kinetic investigation on aqueous decomposition of 2-chloroethylnitrososulfamide.

scientific article

Metal-based carboxamide-derived compounds endowed with antibacterial and antifungal activity.

scientific article published on 5 August 2013

Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators

scientific article published on 10 July 2014

Multivalent Carbonic Anhydrases Inhibitors

scientific article published on 28 October 2019

N-(tert-butoxycarbonyl)-N-[4-(dimethylazaniumylidene)-1,4-dihydropyridin-1-ylsulfonyl]azanide: a new sulfamyolating agent. Structure and reactivity toward amines

scientific article published on 01 July 2001

N-glycosyl-N-hydroxysulfamides as potent inhibitors of Brucella suis carbonic anhydrases

scientific article published on 20 March 2015

New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs

scientific article published on 19 October 2016

New ways to image and target tumour hypoxia and its molecular responses

scientific article

New zinc binding motifs in the design of selective carbonic anhydrase inhibitors.

scientific article published on August 2006

Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes

scientific article published on 01 December 2018

Novel Re(I) tricarbonyl coordination compounds based on 2-pyridyl-1,2,3-triazole derivatives bearing a 4-amino-substituted benzenesulfonamide arm: synthesis, crystal structure, computational studies and inhibitory activity against carbonic anhydrase

scientific article published on 01 December 2019

Novel antibody to a carbonic anhydrase: patent evaluation of WO2011138279A1 ⬇️

scientific article published on February 27, 2013

Novel method of treating macular degeneration: a patent evaluation (WO2018/107005)

scientific article published on 01 September 2019

Oxo- and thiooxo-imidazo[1,5-c]pyrimidine molecule library: beyond their interest in inhibition of Brucella suis histidinol dehydrogenase, a powerful protection tool in the synthesis of histidine analogues.

scientific article

Poly(amidoamine) Dendrimers with Carbonic Anhydrase Inhibitory Activity and Antiglaucoma Action

scientific article published on 15 April 2015

Polyhedral Oligomeric Silsesquioxane (POSS) Bearing Glyoxylic Aldehyde as Clickable Platform Towards Multivalent Conjugates.

scientific article published on 11 September 2017

Recent advances in the discovery of zinc-binding motifs for the development of carbonic anhydrase inhibitors.

scientific article

Recent developments in targeting carbonic anhydrase IX for cancer therapeutics

scientific article

Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase

scientific article published in December 2021

Response to Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors

scientific article published on 08 December 2020

Structural basis for the rational design of new anti-Brucella agents: the crystal structure of the C366S mutant of L-histidinol dehydrogenase from Brucella suis

scientific article

Study on the decomposition of 2-chloroethylnitro- sosulfamides (CENS) in serum using HPLC on-line solid phase extraction

scientific article published on 01 September 2006

Sulfamates and their therapeutic potential

scientific article

Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII

scientific article published on 21 March 2011

Synthesis and biological activity of glycosyl conjugates of N-(4-hydroxyphenyl)retinamide.

scientific article published in April 2001

Synthesis and biological evaluation of Fotemustine analogues on human melanoma cell lines.

scientific article published on March 2003

Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors: a patent evaluation of US20160011199A1.

scientific article

Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor

scientific article published on 01 June 2006

Synthesis and properties of isocannabinoid and cholesterol derivatized rhamnosurfactants: application to liposomal targeting of keratinocytes and skin

scientific article published on 13 June 2005

Synthesis of substituted N-aryl-N'-Sulfamoyloxazolidin-2-ones with potential antibacterial activity

scientific article

Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: a new concept of dual targeting drugs.

scientific article published on 9 July 2013

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche.

scientific article published on 3 December 2012

Targeting of the Brucella suis virulence factor histidinol dehydrogenase by histidinol analogues results in inhibition of intramacrophagic multiplication of the pathogen.

scientific article published on 13 August 2007

Targeting the Human 80S Ribosome in Cancer: From Structure to Function and Drug Design for Innovative Adjuvant Therapeutic Strategies

scientific article published on 05 March 2020

Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

scientific article published on 17 March 2011

The anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog strongly inhibit carbonic anhydrases: solution and X-ray crystallographic studies

scientific article

Therapeutic applications of glycosidic carbonic anhydrase inhibitors.

scientific article published on May 2009

Therapeutic potential of sulfamides as enzyme inhibitors.

scientific article

Thiol-ene click chemistry for the synthesis of highly effective glycosyl sulfonamide carbonic anhydrase inhibitors.

scientific article published on 20 May 2013

Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines.

scientific article

Zinc metalloenzymes as new targets against the bacterial pathogen Brucella ⬇️

scientific article published on December 1, 2011

tert-Butyl N-[N,N-bis-(2-chloro-ethyl)sulfamo-yl]-N-(2-chloro-ethyl)carbamate.

scientific article published on 26 September 2009

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