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List of works by Jean-Philippe Julien

A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure

scientific article

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

scientific article

A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene

scientific article

A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies

scientific article

A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands

scientific article published on 09 October 2020

Ablation of the complementarity-determining region H3 apex of the anti-HIV-1 broadly neutralizing antibody 2F5 abrogates neutralizing capacity without affecting core epitope binding

scientific article published on 10 February 2010

Antibodies against Plasmodium falciparum malaria at the molecular level

scientific article published on 28 August 2019

Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env

scientific article

Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope

scientific article published in Science

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

scientific article published on 20 February 2013

B cell targeting by molecular adjuvants for enhanced immunogenicity

scientific article published on 30 November 2020

Broad neutralization coverage of HIV by multiple highly potent antibodies

scientific article (publication date: 22 September 2011)

Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

scientific article

CD4-induced activation in a soluble HIV-1 Env trimer

scientific article

Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation

scientific article published on 21 October 2013

Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer

scientific article

Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope

scientific article

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

scientific article

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

scientific article

Crystal structure of the complex between the F(ab)' fragment of the cross-neutralizing anti-HIV-1 antibody 2F5 and the F(ab) fragment of its anti-idiotypic antibody 3H6

scientific article

Crystallographic Definition of the Epitope Promiscuity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5: Vaccine Design Implications

scientific article

De novo protein design enables the precise induction of RSV-neutralizing antibodies

scientific article published on 01 May 2020

Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens

scientific article

Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits

scientific article

Discrete TCR Binding Kinetics Control Invariant NKT Cell Selection and Central Priming.

scientific article

Ebolavirus VP35 Coats the Backbone of Double-Stranded RNA for Interferon Antagonism

scientific article

EspP, an Extracellular Serine Protease from Enterohemorrhagic E. coli, Reduces Coagulation Factor Activities, Reduces Clot Strength, and Promotes Clot Lysis

scientific article

Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs

scientific article published on 25 May 2020

HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

scientific article

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

scientific article

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

scientific article

Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization

scientific article

Influences on trimerization and aggregation of soluble, cleaved HIV-1 SOSIP envelope glycoprotein

scientific article published on 03 July 2013

Interaction of anti-HIV type 1 antibody 2F5 with phospholipid bilayers and its relevance for the mechanism of virus neutralization

scientific article published on 15 January 2011

Key Residues at Third CDR3β Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs.

scientific article published on 21 December 2016

Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice

scientific article published on 01 December 2021

Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism

scientific article

Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.

scientific article

Molecular basis of human CD22 function and therapeutic targeting

scientific article published on 2 October 2017

Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.

scientific article published on 16 November 2017

Molecular recognition of the native HIV-1 MPER revealed by STED microscopy of single virions

scientific article published in Nature Communications

Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

scientific article published on 16 June 2021

Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies

scientific article published on 28 November 2017

Neutralizing epitopes in the membrane-proximal external region of HIV-1 gp41 are influenced by the transmembrane domain and the plasma membrane

scientific article published on 11 January 2012

Origins of a Vaccine-Induced, Human Anti-HIV-1 Antibody

scientific article published on 16 July 2015

Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers

scientific article

Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25

scientific article published on 24 September 2019

Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV.

scientific article published on May 2014

Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection

scientific article published on 22 November 2017

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

scientific article

Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex

scientific article

Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth

scientific article

Structural Basis of Enhanced Crystallizability Induced by a Molecular Chaperone for Antibody Antigen-Binding Fragments

scientific article published on 22 December 2017

Structural and functional characterization of PseC, an aminotransferase involved in the biosynthesis of pseudaminic acid, an essential flagellar modification in Helicobacter pylori

scientific article

Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers

scientific article published on 03 July 2013

Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies

scientific article published on 08 October 2020

Structural constraints imposed by the conserved fusion peptide on the HIV-1 gp41 epitope recognized by the broadly neutralizing antibody 2F5

scientific article

Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers

scientific article

Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site

scientific article

Structural evolution of glycan recognition by a family of potent HIV antibodies

scientific article

Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA.

scientific article

Structural ordering of the <i>Plasmodium berghei</i> circumsporozoite protein repeats by inhibitory antibody 3D11

scientific article published on 30 November 2020

Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy

scientific article

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

scientific article

Structure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing Epitope

scientific article

Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies

scientific article published on 20 March 2019

Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

scientific article

The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

scientific article

The structural basis of modified nucleosome recognition by 53BP1

scientific article

Toward a Carbohydrate-Based HIV-1 Vaccine

article

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