List of works by Federica Di Nicolantonio

A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology

scientific article published on 07 March 2019

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin

scientific article published on 12 December 2019

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility.

scientific article published in April 2016

A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer

scientific article

ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer.

scientific article published in December 2017

Absence of BRAF gene mutations in uveal melanomas in contrast to cutaneous melanomas.

scientific article published on May 2003

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer.

scientific article published on 8 December 2016

Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer.

scientific article published on 6 November 2015

Acquired resistance to EGFR-targeted therapies in colorectal cancer

scientific article published on 14 May 2014

Adaptive mutability of colorectal cancers in response to targeted therapies

scientific article published on 07 November 2019

Adipocytes sustain pancreatic cancer progression through a non-canonical WNT paracrine network inducing ROR2 nuclear shuttling.

scientific article published on 20 November 2017

Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer

scientific article

An FGFR3 Autocrine Loop Sustains Acquired Resistance to Trastuzumab in Gastric Cancer Patients.

scientific article published on 7 June 2016

Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab

scientific article

BCAM and LAMA5 Mediate the Recognition between Tumor Cells and the Endothelium in the Metastatic Spreading of KRAS Mutant Colorectal Cancer

scientific article published on 3 May 2016

BRAF V600E is a determinant of sensitivity to proteasome inhibitors

scientific article

Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer.

scientific article published on 13 February 2018

Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer

scientific article published on 08 September 2009

Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer.

scientific article published in February 2014

Bromodomain inhibition exerts its therapeutic potential in malignant pleural mesothelioma by promoting immunogenic cell death and changing the tumor immune-environment.

scientific article published on 27 November 2017

Cancer cell adaptation to chemotherapy.

scientific article

Capecitabine and Temozolomide versus FOLFIRI in RAS-Mutated, MGMT-Methylated Metastatic Colorectal Cancer

scientific article published on 18 November 2019

Chemosensitization of solid tumor cells by alteration of their susceptibility to apoptosis.

scientific article

Chemosensitization of solid tumors by modulation of resistance mechanisms.

scientific article

Circulating Methylated DNA to Monitor the Dynamics of RAS Mutation Clearance in Plasma from Metastatic Colorectal Cancer Patients

scientific article published on 04 December 2020

Cisplatin, doxorubicin and paclitaxel induce mdr1 gene transcription in ovarian cancer cell lines

scientific article published on January 2003

Climbing RAS, the Everest of Oncogenes

scientific article published on 01 January 2014

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.

scientific article

Colorectal cancer early methylation alterations affect the crosstalk between cell and surrounding environment, tracing a biomarker signature specific for this tumor.

scientific article published on 15 March 2018

Combination chemotherapy in advanced gastrointestinal cancers: ex vivo sensitivity to gemcitabine and mitomycin C.

scientific article

Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus

scientific article

Digital PCR assessment of MGMT promoter methylation coupled with reduced protein expression optimises prediction of response to alkylating agents in metastatic colorectal cancer patients.

scientific article published on 16 December 2016

Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer.

scientific article published on 25 June 2015

Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer

scientific article

EGFR blockade reverts resistance to KRAS G12C inhibition in colorectal cancer

scientific article published on 19 May 2020

Effect of culture conditions on the chemosensitivity of ovarian cancer cell lines

scientific article published on September 2006

Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer

scientific article

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

scientific article

Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer

scientific article

Emergence of Multiple EGFR Extracellular Mutations during Cetuximab Treatment in Colorectal Cancer.

scientific article

Erratum to: Integrated molecular dissection of the epidermal growth factor receptor (EGFR) oncogenic pathway to predict response to EGFR-targeted monoclonal antibodies in metastatic colorectal cancer

scholarly article published in Targeted oncology

Erratum: Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

scientific article published on 01 July 2015

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

scientific article published on 28 June 2019

Ex vivo characterization of XR11576 (MLN576) against ovarian cancer and other solid tumors

scientific article published in October 2004

Ex vivo reversal of chemoresistance by tariquidar (XR9576).

scientific article published in October 2004

Exploiting DNA repair defects in colorectal cancer

scientific article published on 02 March 2019

Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study

scientific article published in May 2005

Heterogeneity of chemosensitivity of colorectal adenocarcinoma determined by a modified ex vivo ATP-tumor chemosensitivity assay (ATP-TCA).

scientific article

Heterogeneity of chemosensitivity of esophageal and gastric carcinoma

scientific article

High-dose vitamin C enhances cancer immunotherapy

scientific article published on 01 February 2020

Higher metastatic efficiency of KRas G12V than KRas G13D in a colorectal cancer model

scientific article

Homeobox B9 Mediates Resistance to Anti-VEGF Therapy in Colorectal Cancer Patients.

scientific article published on 15 March 2017

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth.

scientific article published on 29 November 2017

Increased detection sensitivity for KRAS mutations enhances the prediction of anti-EGFR monoclonal antibody resistance in metastatic colorectal cancer.

scientific article

Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas

scientific article

Integrated molecular dissection of the epidermal growth factor receptor (EGFR) [corrected] oncogenic pathway to predict response to EGFR-targeted monoclonal antibodies in metastatic colorectal cancer.

scientific article published on March 2010

Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3.

scientific article

Isogenic mutant human cells: a new tool for personalized cancer medicine.

scientific article

KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy

scientific article

Kinase mutations in cancer: chinks in the enemy's armour?

scientific article

Liquid biopsy: monitoring cancer-genetics in the blood

scientific article

MET-Driven Resistance to Dual EGFR and BRAF Blockade May Be Overcome by Switching from EGFR to MET Inhibition in BRAF-Mutated Colorectal Cancer.

scientific article

MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations.

scientific article published on February 2016

Modeling tumor progression by the sequential introduction of genetic alterations into the genome of human normal cells.

scientific article

Modulation of cerebellar and hepatic nitric oxide synthase by exogenous arginine and endotoxin

scientific article published in April 2001

Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer

scientific article published on 16 June 2016

Mouse models of Kras-mutant colorectal cancer: valuable GEMMs for drug testing?

scientific article published on 23 April 2013

Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer

scientific article

Mutation-Enrichment Next-Generation Sequencing for Quantitative Detection of KRAS Mutations in Urine Cell-Free DNA from Patients with Advanced Cancers

scientific article published on 17 January 2017

Neuropilin-1 upregulation elicits adaptive resistance to oncogene-targeted therapies

scientific article published on 13 August 2018

Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies.

scientific article

Outcome of ATP-based tumor chemosensitivity assay directed chemotherapy in heavily pre-treated recurrent ovarian carcinoma

scientific article

PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies

scientific article

PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs

scientific article published on 9 September 2015

Parallel Evaluation of Circulating Tumor DNA and Circulating Tumor Cells in Metastatic Colorectal Cancer

scientific article published in November 2017

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer

scientific article published on 02 August 2019

Prognostic significance of cyclooxygenase-2 (COX-2) expression in patients with surgically resectable adenocarcinoma of the oesophagus

scientific article

RAF suppression synergizes with MEK inhibition in KRAS mutant cancer cells

scientific article

RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer

scientific article published on 29 October 2020

RET fusions in a small subset of advanced colorectal cancers at risk of being neglected.

scientific article published on 10 March 2018

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

scientific article published on 01 July 2018

Rapid up-regulation of cyclooxygenase-2 by 5-fluorouracil in human solid tumors.

scientific article published in June 2005

Refining the selection of patients with metastatic colorectal cancer for treatment with temozolomide using proteomic analysis of O6-methylguanine-DNA-methyltransferase

scientific article published on 19 December 2018

Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies.

scientific article

Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses

scientific article

Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution

scientific article published on 07 October 2014

Retrospective Multicenter Study Investigating the Role of Targeted Next-Generation Sequencing of Selected Cancer Genes in Mucinous Adenocarcinoma of the Lung.

scientific article

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

scientific article

Selective cytotoxicity of a bicyclic Ras inhibitor in cancer cells expressing K-Ras(G13D).

scientific article

Small Nucleolar RNAs Determine Resistance to Doxorubicin in Human Osteosarcoma

scientific article published on 24 June 2020

TGFα and amphiregulin paracrine network promotes resistance to EGFR blockade in colorectal cancer cells

scientific article

Targeted knock-in of the polymorphism rs61764370 does not affect KRAS expression but reduces let-7 levels

scientific article published on 27 December 2013

Targeted therapies: Tivantinib--a cytotoxic drug in MET inhibitor's clothes?

scientific article published on 28 May 2013

Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia

scientific article published on 27 December 2011

Temozolomide and irinotecan (TEMIRI regimen) as salvage treatment of irinotecan-sensitive advanced colorectal cancer patients bearing MGMT methylation

scientific article published on 01 August 2018

The cholesterol biosynthesis enzyme oxidosqualene cyclase is a new target to impair tumour angiogenesis and metastasis dissemination

scientific article

The effect of imatinib mesylate (Glivec) on human tumor-derived cells

scientific article published on July 2006

The ex vivo characterization of XR5944 (MLN944) against a panel of human clinical tumor samples.

scientific article

The in vitro effect of gefitinib ('Iressa') alone and in combination with cytotoxic chemotherapy on human solid tumours

scientific article

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets

scientific article published on 30 April 2015

Therapeutic implications of resistance to molecular therapies in metastatic colorectal cancer.

scientific article

Toll-like receptor 9 agonist IMO cooperates with cetuximab in K-ras mutant colorectal and pancreatic cancers

scientific article

Tracking a CAD-ALK gene rearrangement in urine and blood of a colorectal cancer patient treated with an ALK inhibitor.

scientific article published on 24 March 2017

Transfection and DNA-mediated gene transfer

scientific article

Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer

scientific article

Tumor MGMT promoter hypermethylation changes over time limit temozolomide efficacy in a phase II trial for metastatic colorectal cancer

scientific article published on 24 February 2016

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

scientific article

Use of an ATP-based chemosensitivity assay to design new combinations of high-concentration doxorubicin with other drugs for recurrent ovarian cancer

scientific article published in July 2002

VEGF blockade enhances the antitumor effect of BRAFV600E inhibition.

scientific article published on 14 December 2016

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers.

scientific article published on 22 September 2015

Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer

scientific article

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