List of works - Bernhard Schermer

A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.

scientific article

A Single-Cell Transcriptome Atlas of the Mouse Glomerulus

scientific article published on 24 May 2018

A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (PHB) domain protein podocin

scientific article

A mammalian microRNA expression atlas based on small RNA library sequencing

scientific article

A molecular mechanism explaining albuminuria in kidney disease

scientific article published on 11 May 2020

A protein-RNA interaction atlas of the ribosome biogenesis factor AATF

scientific article published on 30 July 2019

AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer

scientific article published on 11 January 2018

AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis

scientific article

An approach to cystic kidney diseases: the clinician's view

scientific article published on 30 September 2014

An optimized electroporation approach for efficient CRISPR/Cas9 genome editing in murine zygotes.

scientific article

Casein kinase 1 α phosphorylates the Wnt regulator Jade-1 and modulates its activity

scientific article (publication date: 19 September 2014)

Challenges in establishing genotype-phenotype correlations in ARPKD: case report on a toddler with two severe PKHD1 mutations

scientific article published on 31 March 2017

Characterization of a short isoform of the kidney protein podocin in human kidney

scientific article

Clinical spectrum and pathogenesis of nephronophthisis ⬇️

scientific article published on May 1, 2012

Comparative analysis of Neph gene expression in mouse and chicken development

scientific article

Comparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture

scientific article published on 19 January 2015

Conditional loss of kidney microRNAs results in congenital anomalies of the kidney and urinary tract (CAKUT).

scientific article published on 24 January 2013

Construction of a viral T2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes

scientific article published on 7 February 2017

Cysteine S-Glutathionylation Promotes Stability and Activation of the Hippo Downstream Effector Transcriptional Co-activator with PDZ-binding Motif (TAZ).

scientific article published on 05 April 2016

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage

scientific article published on 24 November 2014

Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1

scientific article published in 2009

Dysregulated autophagy contributes to podocyte damage in Fabry's disease

scientific article

Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling

scientific article

Genome-Wide Analysis of Wilms' Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms

scientific article

Inactivation of Apoptosis Antagonizing Transcription Factor in tubular epithelial cells induces accumulation of DNA damage and nephronophthisis

scientific article published on 13 February 2019

Inhibition of the production of endothelium-derived hyperpolarizing factor by cannabinoid receptor agonists

scientific article

Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha

scientific article (publication date: 6 September 2002)

Intrinsic proinflammatory signaling in podocytes contributes to podocyte damage and prolonged proteinuria

scientific article published on 12 September 2012

Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

scientific article (publication date: May 2005)

Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression

scientific article published on 26 February 2016

KIBRA modulates directional migration of podocytes

scientific article

Label-free quantitative proteomic analysis of the YAP/TAZ interactome

scientific article published on 26 February 2014

Light microscopic visualization of podocyte ultrastructure demonstrates oscillating glomerular contractions.

scientific article

Lipid-protein interactions along the slit diaphragm of podocytes

scientific article published on 25 February 2009

Listeria monocytogenes infection in macrophages induces vacuolar-dependent host miRNA response

scientific article

Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation

scientific article published on 14 April 2015

Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia

scientific article

Loss of the Birt-Hogg-Dubé gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner

scientific article published on 15 May 2013

Low-molecular weight heparin increases circulating sFlt-1 levels and enhances urinary elimination

scientific article

Magnetic resonance T2 mapping and diffusion-weighted imaging for early detection of cystogenesis and response to therapy in a mouse model of polycystic kidney disease

scientific article published on 26 July 2017

Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure

scientific article

Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination

scientific article (publication date: August 2003)

Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics

scientific article

Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression

scientific article

Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis

scientific article

N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton.

scientific article published on 19 July 2017

NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway

scientific article

Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity

scientific article

Neph2/Kirrel3 regulates sensory input, motor coordination, and home-cage activity in rodents

scientific article published on 14 September 2018

Nephrocystin specifically localizes to the transition zone of renal and respiratory cilia and photoreceptor connecting cilia

scientific article

Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia

scientific article published on 28 February 2011

Oral Supplementation of Glucosamine Fails to Alleviate Acute Kidney Injury in Renal Ischemia-Reperfusion Damage

scientific article

PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome

scientific article

Par3A is dispensable for the function of the glomerular filtration barrier of the kidney.

scientific article

Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier

scientific article

Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia

scientific article

Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels

scholarly article

Podocin organizes ion channel-lipid supercomplexes: implications for mechanosensation at the slit diaphragm.

scientific article

Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease

scientific article published on 05 September 2008

Preoperative Short-Term Calorie Restriction for Prevention of Acute Kidney Injury After Cardiac Surgery: A Randomized, Controlled, Open-Label, Pilot Trial.

scientific article published on 13 March 2018

Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier.

scientific article

Protein half-life determines expression of proteostatic networks in podocyte differentiation

scientific article published on 25 April 2018

Putting the brakes on p53-driven apoptosis

scientific article published on 14 September 2012

Quantitative deep mapping of the cultured podocyte proteome uncovers shifts in proteostatic mechanisms during differentiation

scientific article published on 29 June 2016

Rapid SARS-CoV-2 testing in primary material based on a novel multiplex RT-LAMP assay

scientific article published on 02 November 2020

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

scientific article published on 14 August 2011

Single and Transient Ca(2+) Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion

scientific article published on 19 October 2016

Single nephron proteomes connect morphology and function in proteinuric kidney disease.

scientific article published on 9 March 2018

Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.

scientific article published on 28 June 2018

The BAR domain protein PICK1 regulates cell recognition and morphogenesis by interacting with Neph proteins

scientific article published on 20 June 2011

The NF-κB essential modulator (NEMO) controls podocyte cytoskeletal dynamics independently of NF-κB.

scientific article published on 12 August 2015

The RNA-Protein Interactome of Differentiated Kidney Tubular Epithelial Cells

scientific article published on 13 March 2019

The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1

scientific article (publication date: 11 April 2003)

The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1

scientific article

The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia

scientific article published on 14 July 2017

The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling

scientific journal article

The ciliopathy disease protein NPHP9 promotes nuclear delivery and activation of the oncogenic transcriptional regulator TAZ.

scientific article published in October 2012

The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation

scientific article

The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury

scientific article published on 03 December 2018

The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes

scientific article published on 19 January 2016

The von Hippel Lindau tumor suppressor limits longevity

scientific article published on 24 September 2009

The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth

scientific article

Three-layered proteomic characterization of a novel ACTN4 mutation unravels its pathogenic potential in FSGS.

scientific article published on 5 January 2016

Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags.

scientific article

Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation

scientific article

Transcriptional profiling reveals progeroid Ercc1(-/Δ) mice as a model system for glomerular aging

scientific article

Transition zone proteins and cilia dynamics ⬇️

scientific article published on July 27, 2011

Upregulation of RGS7 may contribute to tumor necrosis factor-induced changes in central nervous function

scientific article published on August 1999

Vasopressin-2 receptor signaling and autosomal dominant polycystic kidney disease: from bench to bedside and back again

scientific article

WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals

scientific article

YAP-mediated mechanotransduction determines the podocyte's response to damage.

scientific article published on 11 April 2017

[Genome Editing with CRISPR/Cas9: First Steps Towards a new Era in Medicine?]

scientific article published on 13 February 2019

p35, the non-cyclin activator of Cdk5, protects podocytes against apoptosis in vitro and in vivo.

scientific article published on 3 February 2010

List of works by Bernhard Schermer

A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.

A Single-Cell Transcriptome Atlas of the Mouse Glomerulus

A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (PHB) domain protein podocin

A mammalian microRNA expression atlas based on small RNA library sequencing

A molecular mechanism explaining albuminuria in kidney disease

A protein-RNA interaction atlas of the ribosome biogenesis factor AATF

AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer

AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis

An approach to cystic kidney diseases: the clinician's view

An optimized electroporation approach for efficient CRISPR/Cas9 genome editing in murine zygotes.

Casein kinase 1 α phosphorylates the Wnt regulator Jade-1 and modulates its activity

Challenges in establishing genotype-phenotype correlations in ARPKD: case report on a toddler with two severe PKHD1 mutations

Characterization of a short isoform of the kidney protein podocin in human kidney

Clinical spectrum and pathogenesis of nephronophthisis ⬇️

Comparative analysis of Neph gene expression in mouse and chicken development

Comparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture

Conditional loss of kidney microRNAs results in congenital anomalies of the kidney and urinary tract (CAKUT).

Construction of a viral T2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes

Cysteine S-Glutathionylation Promotes Stability and Activation of the Hippo Downstream Effector Transcriptional Co-activator with PDZ-binding Motif (TAZ).

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage

Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1

Dysregulated autophagy contributes to podocyte damage in Fabry's disease

Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling

Genome-Wide Analysis of Wilms' Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms

Inactivation of Apoptosis Antagonizing Transcription Factor in tubular epithelial cells induces accumulation of DNA damage and nephronophthisis

Inhibition of the production of endothelium-derived hyperpolarizing factor by cannabinoid receptor agonists

Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha

Intrinsic proinflammatory signaling in podocytes contributes to podocyte damage and prolonged proteinuria

Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression

KIBRA modulates directional migration of podocytes

Label-free quantitative proteomic analysis of the YAP/TAZ interactome

Light microscopic visualization of podocyte ultrastructure demonstrates oscillating glomerular contractions.

Lipid-protein interactions along the slit diaphragm of podocytes

Listeria monocytogenes infection in macrophages induces vacuolar-dependent host miRNA response

Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation

Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia

Loss of the Birt-Hogg-Dubé gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner

Low-molecular weight heparin increases circulating sFlt-1 levels and enhances urinary elimination

Magnetic resonance T2 mapping and diffusion-weighted imaging for early detection of cystogenesis and response to therapy in a mouse model of polycystic kidney disease

Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure

Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination

Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics

Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression

Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis

N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton.

NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway

Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity

Neph2/Kirrel3 regulates sensory input, motor coordination, and home-cage activity in rodents

Nephrocystin specifically localizes to the transition zone of renal and respiratory cilia and photoreceptor connecting cilia

Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia

Oral Supplementation of Glucosamine Fails to Alleviate Acute Kidney Injury in Renal Ischemia-Reperfusion Damage

PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome

Par3A is dispensable for the function of the glomerular filtration barrier of the kidney.

Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier

Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia

Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels

Podocin organizes ion channel-lipid supercomplexes: implications for mechanosensation at the slit diaphragm.

Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease

Preoperative Short-Term Calorie Restriction for Prevention of Acute Kidney Injury After Cardiac Surgery: A Randomized, Controlled, Open-Label, Pilot Trial.

Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier.

Protein half-life determines expression of proteostatic networks in podocyte differentiation

Putting the brakes on p53-driven apoptosis

Quantitative deep mapping of the cultured podocyte proteome uncovers shifts in proteostatic mechanisms during differentiation

Rapid SARS-CoV-2 testing in primary material based on a novel multiplex RT-LAMP assay

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

Single and Transient Ca(2+) Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion

Single nephron proteomes connect morphology and function in proteinuric kidney disease.

Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.

The BAR domain protein PICK1 regulates cell recognition and morphogenesis by interacting with Neph proteins

The NF-κB essential modulator (NEMO) controls podocyte cytoskeletal dynamics independently of NF-κB.

The RNA-Protein Interactome of Differentiated Kidney Tubular Epithelial Cells

The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1

The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1

The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia

The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling

The ciliopathy disease protein NPHP9 promotes nuclear delivery and activation of the oncogenic transcriptional regulator TAZ.

The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation

The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury