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List of works by Richard Bucala

A Leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses

scientific article

A Novel Allosteric Inhibitor of Macrophage Migration Inhibitory Factor (MIF) ⬇️

scientific article published on July 10, 2012

A Novel, Macrophage Migration Inhibitory Factor Suicide Substrate Inhibits Motility and Growth of Lung Cancer Cells

scientific article

A Plasmodium-encoded cytokine suppresses T-cell immunity during malaria

scientific article

A functional heteromeric MIF receptor formed by CD74 and CXCR4

scientific article

A genetic role for macrophage migration inhibitory factor (MIF) in adult-onset Still's disease.

scientific article

A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor

scientific article published in October 2009

A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation

scientific article published on 2 February 2009

Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion

scientific article (publication date: October 2007)

Activation of the JNK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on CXCR4 and CD74 ⬇️

scientific article published on August 31, 2010

Advanced glycation endproducts in nondiabetic patients with obstructive sleep apnea

scientific article

Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast

scientific article

Arthritis & Rheumatology: Evolving to Meet the Challenges of Rheumatology

scientific article published on 08 June 2020

Association of macrophage migration inhibitory factor (MIF) polymorphisms with risk of meningitis from Streptococcus pneumoniae ⬇️

scientific article published on January 3, 2011

Benzisothiazolones as modulators of macrophage migration inhibitory factor ⬇️

scientific article published on June 12, 2011

CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex

scientific article

CD74-Downregulation of Placental Macrophage-Trophoblastic Interactions in Preeclampsia

scientific article published on 19 May 2016

Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion

scientific article

Characterization of adipose tissue macrophages and adipose-derived stem cells in critical wounds.

scientific article published on 04 January 2017

Circulating Fibrocytes—Biology and Mechanisms in Wound Healing and Scar Formation

scientific article published on January 1, 2011

Cloning and chromosomal characterization of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 gene (PFKFB3, iPFK2)

scientific article (publication date: October 2003)

Construct and criterion validity of the Euro Qol-5D in patients with systemic lupus erythematosus

scientific article

Critical role for macrophage migration inhibitory factor (MIF) in Ross River virus-induced arthritis and myositis

scientific article

Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets—An Updated View ⬇️

scientific article published on June 18, 2013

D-dopachrome tautomerase (D-DT or MIF-2): Doubling the MIF cytokine family ⬇️

scientific article published on April 14, 2012

D-dopachrome tautomerase in adipose tissue inflammation and wound repair

scientific article published on 07 September 2016

Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting

scientific article published on 25 November 2020

Differential regulation of macrophage activation by the MIF cytokine superfamily members MIF and MIF-2 in adipose tissue during endotoxemia

scientific article published on 21 January 2020

Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening

scientific article published on January 2009

Down-regulation of MIF by NFκB under hypoxia accelerated neuronal loss during stroke

scientific article

Drug Repositioning and Pharmacophore Identification in the Discovery of Hookworm MIF Inhibitors

scientific article

Editorial: A Fresh New Look, and a Fresh New Journal

scientific article published on 01 January 2019

Editorial: A Fresh New Look, and a Fresh New Journal

scientific article published in January 2019

Endothelial CD74 mediates macrophage migration inhibitory factor protection in hyperoxic lung injury

scientific article published on 21 January 2015

Endotoxin-induced myocardial dysfunction: effects of macrophage migration inhibitory factor neutralization

scientific article

Expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase/PFKFB3 isoforms in adipocytes and their potential role in glycolytic regulation

scientific article

Extracellular MIF, but not its homologue D-DT, promotes fibroblast motility independent of its receptor CD74/CD44

scientific article published on 16 December 2020

Fibrocytes in Fibrotic Diseases and Wound Healing

scientific article published in February 2012

Glucocorticoid-induced MIF expression by human CEM T cells

scientific article published on 30 July 2009

HLA-DRα1 constructs block CD74 expression and MIF effects in experimental autoimmune encephalomyelitis

scientific article

High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers

scientific article (publication date: 15 October 2002)

Impaired macrophage migration inhibitory factor-AMP-activated protein kinase activation and ischemic recovery in the senescent heart

scientific article

Increased TLR4 expression and downstream cytokine production in immunosuppressed adults compared to non-immunosuppressed adults

scientific article

Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites

scientific article

Insight into the biology of macrophage migration inhibitory factor (MIF) revealed by the cloning of its cell surface receptor

scientific article

Interaction of MIF Family Proteins in Myocardial Ischemia/Reperfusion Damage and Their Influence on Clinical Outcome of Cardiac Surgery Patients

scientific article

Intraluminal blockade of cell-surface CD74 and glucose regulated protein 78 prevents substance P-induced bladder inflammatory changes in the rat

scientific article

Lack of macrophage migration inhibitory factor in mice does not affect hallmarks of the inflammatory/immune response during the first week after stroke

scientific article

Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis.

scientific article published on 9 November 2015

Limiting Cardiac Ischemic Injury by Pharmacological Augmentation of Macrophage Migration Inhibitory Factor–AMP-Activated Protein Kinase Signal Transduction ⬇️

scientific article published on June 10, 2013

MIF contributes to Trypanosoma brucei associated immunopathogenicity development

scientific article

MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations

scientific article

MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

scientific article

MIF signal transduction initiated by binding to CD74

scientific article

MIF-2/D-DT enhances proximal tubular cell regeneration through SLPI- and ATF4-dependent mechanisms.

scientific article published on 24 May 2017

MIF-Mediated Hemodilution Promotes Pathogenic Anemia in Experimental African Trypanosomosis

scientific article

Macrophage Migration Inhibitory Factor Is Detrimental in Pneumococcal Pneumonia and a Target for Therapeutic Immunomodulation

scientific article

Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74

scientific article published on 09 October 2015

Macrophage Migration Inhibitory Factor Promotes Cell Death and Aggravates Neurologic Deficits after Experimental Stroke ⬇️

scientific article published on November 10, 2010

Macrophage Migration Inhibitory Factor in Acute Adipose Tissue Inflammation

scientific article published on 8 September 2015

Macrophage migration inhibitory factor

scientific article

Macrophage migration inhibitory factor (MIF) exerts antifibrotic effects in experimental liver fibrosis via CD74

scientific article

Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis

scientific article published on 23 July 2013

Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: Regulatory role in the innate immune response ⬇️

scientific article published on December 26, 2001

Macrophage migration inhibitory factor (MIF): a promising biomarker

scientific article published on May 2010

Macrophage migration inhibitory factor anti-thrombin III complexes are decreased in bladder cancer patient serum: Complex formation as a mechanism of inactivation

scientific article

Macrophage migration inhibitory factor enzymatic activity, lung inflammation, and cystic fibrosis.

scientific article

Macrophage migration inhibitory factor increases neuronal delayed rectifier K+ current

scientific journal article

Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex

scientific journal article

Macrophage migration inhibitory factor inhibits the antiinflammatory effects of glucocorticoids via glucocorticoid-induced leucine zipper

scientific article

Macrophage migration inhibitory factor is a novel determinant of cigarette smoke-induced lung damage

scientific article

Macrophage migration inhibitory factor is released as a complex with alpha1-inhibitor-3 in the intraluminal fluid during bladder inflammation in the rat

scientific journal article

Macrophage migration inhibitory factor promoter polymorphisms are associated with disease activity in rheumatoid arthritis patients from Southern Mexico

scientific article published on 07 November 2019

Macrophage migration inhibitory factor promotes intestinal tumorigenesis

scientific article

Macrophage migration inhibitory factor protects from nonmelanoma epidermal tumors by regulating the number of antigen-presenting cells in skin

scientific article

Macrophage migration inhibitory factor reduces the growth of virulent Mycobacterium tuberculosis in human macrophages

scientific article

Macrophage migration inhibitory factor regulates innate γδ T-cell responses via IL-17 expression

scientific article published on 28 February 2019

Macrophage migration inhibitory factor: a critical neurohumoral mediator

scientific article

Macrophage migration inhibitory factor: critical role in obesity, insulin resistance, and associated comorbidities

scientific article

Mif-deficiency favors an atheroprotective autoantibody phenotype in atherosclerosis.

scientific article published on 15 March 2018

Modeling Informatively Missing Genotypes in Haplotype Analysis

scientific article

Molecular MRI of the Immuno-Metabolic Interplay in a Rabbit Liver Tumor Model: A Biomarker for Resistance Mechanisms in Tumor-targeted Therapy?

scientific article published on 07 July 2020

Multi-dimensional health assessment questionnaire in China: reliability, validity and clinical value in patients with rheumatoid arthritis

scientific article

Null mutation for macrophage migration inhibitory factor (MIF) is associated with less aggressive bladder cancer in mice

scientific article

Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF) ⬇️

scientific article published on August 3, 2010

Ostertagia ostertagi macrophage migration inhibitory factor is present in all developmental stages and may cross-regulate host functions through interaction with the host receptor

scientific article

Progress made towards enhancement of rheumatology education and practice in Zambia: review of an ILAR-supported project.

scientific article

Protective role of macrophage migration inhibitory factor in nonalcoholic steatohepatitis

scientific article

Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity

scientific article published on 24 August 2005

Receptor agonists of macrophage migration inhibitory factor ⬇️

scientific article published on September 29, 2010

Regulated secretion of macrophage migration inhibitory factor is mediated by a non-classical pathway involving an ABC transporter

scientific article published on September 2003

Regulation of lung injury and repair by Toll-like receptors and hyaluronan

scientific article

Ribosomal protein S19 interacts with macrophage migration inhibitory factor and attenuates its pro-inflammatory function

scientific article

Role of Macrophage Migration Inhibitory Factor in the Regulatory T Cell Response of Tumor-Bearing Mice ⬇️

scientific article published on September 12, 2012

Role of macrophage migration inhibitory factor in age-related lung disease

scientific article

Selective preservation of bone marrow mature recirculating but not marginal zone B cells in murine models of chronic inflammation

scientific article

Sex steroid regulation of macrophage migration inhibitory factor in normal and inflamed colon in the female rat

scientific journal article

Simultaneous detection of microsatellite repeats and SNPs in the macrophage migration inhibitory factor (MIF) gene by thin-film biosensor chips and application to rural field studies

scientific article

Small molecular modulation of macrophage migration inhibitory factor in the hyperoxia-induced mouse model of bronchopulmonary dysplasia

scientific article published on 28 February 2013

Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation

scientific article

Structural and Kinetic Analyses of Macrophage Migration Inhibitory Factor Active Site Interactions † ‡

scientific article

Structural and functional characterization of a secreted hookworm Macrophage Migration Inhibitory Factor (MIF) that interacts with the human MIF receptor CD74

scientific article

Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment

scientific article

The "Infodemic" of COVID-19

scientific article published on 02 August 2020

The D -dopachrome tautomerase ( DDT ) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF) ⬇️

scientific article published on August 4, 2011

The Effect of Antiseptics on Adipose-Derived Stem Cells

scientific article published on March 2017

The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor.

scientific article

The clinical significance of the MIF homolog d-dopachrome tautomerase (MIF-2) and its circulating receptor (sCD74) in burn

scientific article

The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor

scientific article

The immunobiology of MIF: function, genetics and prospects for precision medicine

scientific article published on 13 June 2019

The macrophage migration inhibitory factor (MIF)-homologue D-dopachrome tautomerase is a therapeutic target in a murine melanoma model

scientific article published on January 2014

The macrophage migration inhibitory factor protein superfamily in obesity and wound repair

scientific article published on May 2015

The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity

scientific article

The outcome of renal ischemia-reperfusion injury is unchanged in AMPK-β1 deficient mice

scientific article

The protective role of macrophage migration inhibitory factor in acute kidney injury after cardiac surgery

scientific article published on 01 May 2018

The role of macrophage migration inhibitory factor in autoimmune liver disease

scientific article published on 20 December 2013

The vestigial enzyme D-dopachrome tautomerase protects the heart against ischemic injury

scientific article

Tumor growth-promoting properties of macrophage migration inhibitory factor

scientific article

Virtual Screening and Optimization Yield Low-Nanomolar Inhibitors of the Tautomerase Activity of Plasmodium falciparum Macrophage Migration Inhibitory Factor ⬇️

scientific article published on October 26, 2012

What is the significance of perioperative release of macrophage migration inhibitory factor in cardiac surgery?

scientific article published on 09 January 2013

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