List of works - Jacques-Philippe Colletier

Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations

scientific article

Chromophore twisting in the excited state of a photoswitchable fluorescent protein captured by time-resolved serial femtosecond crystallography

scientific article published on 11 September 2017

Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime

scientific article

De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals

scientific article published in 2022

De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure

scientific article

Development of an in-vivo active reversible butyrylcholinesterase inhibitor.

scientific article published on 21 December 2016

Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor

scientific article

Hydration water mobility is enhanced around tau amyloid fibers

scientific article

Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry

scientific article

Molecular basis for amyloid- polymorphism

scientific article

Reaction of Cresyl Saligenin Phosphate, the Organophosphorus Agent Implicated in Aerotoxic Syndrome, with Human Cholinesterases: Mechanistic Studies Employing Kinetics, Mass Spectrometry, and X-ray Structure Analysis

scientific article

Sampling the conformational energy landscape of a hyperthermophilic protein by engineering key substitutions

scientific article

Serial Femtosecond Crystallography and Ultrafast Absorption Spectroscopy of the Photoswitchable Fluorescent Protein IrisFP

scientific article

Serial femtosecond crystallography on in vivo-grown crystals drives elucidation of mosquitocidal Cyt1Aa bioactivation cascade

scientific article published on 02 March 2020

Shoot-and-Trap: Use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography

scientific article

Slow conformational exchange and overall rocking motion in ubiquitin protein crystals

scientific article

Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation

scientific article

Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents

scientific article

Structure-guided simulations illuminate the mechanism of ATP transport through VDAC1

scientific article

The C. elegans GATA transcription factor elt-2 mediates distinct transcriptional responses and opposite infection outcomes towards different Bacillus thuringiensis strains

scientific article published on 24 September 2020

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

scientific article published on 11 December 2017

The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating

scientific article

Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation

scientific article published on 26 February 2015

Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography

scientific article

List of works by Jacques-Philippe Colletier

Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations

Chromophore twisting in the excited state of a photoswitchable fluorescent protein captured by time-resolved serial femtosecond crystallography

Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime

De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals

De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure

Development of an in-vivo active reversible butyrylcholinesterase inhibitor.

Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor

Hydration water mobility is enhanced around tau amyloid fibers

Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry

Molecular basis for amyloid- polymorphism

Reaction of Cresyl Saligenin Phosphate, the Organophosphorus Agent Implicated in Aerotoxic Syndrome, with Human Cholinesterases: Mechanistic Studies Employing Kinetics, Mass Spectrometry, and X-ray Structure Analysis

Sampling the conformational energy landscape of a hyperthermophilic protein by engineering key substitutions

Serial Femtosecond Crystallography and Ultrafast Absorption Spectroscopy of the Photoswitchable Fluorescent Protein IrisFP

Serial femtosecond crystallography on in vivo-grown crystals drives elucidation of mosquitocidal Cyt1Aa bioactivation cascade

Shoot-and-Trap: Use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography

Slow conformational exchange and overall rocking motion in ubiquitin protein crystals

Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation

Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents

Structure-guided simulations illuminate the mechanism of ATP transport through VDAC1

The C. elegans GATA transcription factor elt-2 mediates distinct transcriptional responses and opposite infection outcomes towards different Bacillus thuringiensis strains

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating

Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation

Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography