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List of works by Martin Weik

300-Fold Increase in Production of the Zn2+-Dependent Dechlorinase TrzN in Soluble Form via Apoenzyme Stabilization

scientific article

A Polymer Surfactant Corona Dynamically Replaces Water in Solvent-Free Protein Liquids and Ensures Macromolecular Flexibility and Activity

scientific article published on 02 August 2012

Activity, stability and structural studies of lactate dehydrogenases adapted to extreme thermal environments

scientific article

Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations

scientific article

Can soaked-in scavengers protect metalloprotein active sites from reduction during data collection?

scientific article

Chromophore twisting in the excited state of a photoswitchable fluorescent protein captured by time-resolved serial femtosecond crystallography

scientific article published on 11 September 2017

Coincidence of Dynamical Transitions in a Soluble Protein and Its Hydration Water: Direct Measurements by Neutron Scattering and MD Simulations

scientific article published on 14 March 2008

Colouring cryo-cooled crystals: online microspectrophotometry.

scientific article

Conformational flexibility in the peripheral site of Torpedo californica acetylcholinesterase revealed by the complex structure with a bifunctional inhibitor.

scientific article published in April 2006

Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds

scientific article

Cryophotolysis of caged compounds: a technique for trapping intermediate states in protein crystals

scientific article

Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime

scientific article

De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals

scientific article published in 2022

Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase

scientific article published on 15 March 2014

Dielectric and calorimetric studies of hydrated purple membrane

scientific article published on 29 July 2005

Direct correlation between molecular dynamics and enzymatic stability: a comparative neutron scattering study of native human butyrylcholinesterase and its "aged" soman conjugate.

scientific article published on February 2009

Dynamical coupling of intrinsically disordered proteins and their hydration water: comparison with folded soluble and membrane proteins

scientific article

Dynamical heterogeneity of specific amino acids in bacteriorhodopsin

scientific article published on 11 May 2008

Dynamics of hydration water in deuterated purple membranes explored by neutron scattering

scientific article published on 20 February 2008

Effects of soman inhibition and of structural differences on cholinesterase molecular dynamics: a neutron scattering study.

scientific article published on 12 August 2005

Energy landscapes of human acetylcholinesterase and its Huperzine A-inhibited counterpart

scientific article published on 13 December 2012

Evidence for the formation of disulfide radicals in protein crystals upon X-ray irradiation

article

Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability

scientific article

Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics

scientific article published on 23 May 2008

From shell to cell: neutron scattering studies of biological water dynamics and coupling to activity.

scientific article published in January 2009

Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography

scientific article

Hydration water mobility is enhanced around tau amyloid fibers

scientific article

Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design

scientific article published in April 2008

Infrared protein crystallography.

scientific article

Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry

scientific article

Kinetic insight into the mechanism of cholinesterasterase inhibition by aflatoxin B1 to develop biosensors

scientific article published on 18 November 2008

Ligand pathways in neuroglobin revealed by low-temperature photodissociation and docking experiments

scientific article published on 10 July 2019

Light-induced structural changes in a full-length cyanobacterial phytochrome probed by time-resolved X-ray scattering

scientific article published on 03 January 2019

Localization of glycolipids in membranes by in vivo labeling and neutron diffraction.

scientific article published in February 1998

Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesterase

scientific article

Low-dose X-ray radiation induces structural alterations in proteins.

scientific article

Low-temperature behavior of water confined by biological macromolecules and its relation to protein dynamics.

scientific article published on September 2003

Macromolecular crystallography radiation damage research: what's new?

scientific article

Mapping the Accessible Conformational Landscape of an Insect Carboxylesterase Using Conformational Ensemble Analysis and Kinetic Crystallography

scientific article

Mechanisms of cholinesterase inhibition by inorganic mercury

scientific article

Molecular Dynamics Simulations of a Powder Model of the Intrinsically Disordered Protein Tau.

scientific article published on 9 September 2015

Neutrons describe ectoine effects on water H-bonding and hydration around a soluble protein and a cell membrane

scientific article

Photochemical Mechanism of an Atypical Algal Phytochrome

scientific article published on 15 March 2018

Photoswitching mechanism of a fluorescent protein revealed by time-resolved crystallography and transient absorption spectroscopy

scientific article published on 06 February 2020

Porin self-association enables cell-to-cell contact in Providencia stuartii floating communities.

scientific article

Potent 3-hydroxy-2-pyridine aldoxime reactivators of organophosphate-inhibited cholinesterases with predicted blood-brain barrier penetration

scientific article published on 19 April 2018

Protein Surface and Core Dynamics Show Concerted Hydration-Dependent Activation

scientific article published on 14 November 2012

Protein dynamics studied by neutron scattering.

scientific article

Radiation Damage in Macromolecular Crystallography.

scientific article

Radiation damage and dose limits in serial synchrotron crystallography at cryo- and room temperatures

scientific article published on 11 February 2020

Radiation damage to biological macromolecules: some answers and more questions.

scientific article published on 19 December 2012

Radiation damage to macromolecules: kill or cure?

scientific article published on 27 February 2015

Raman-assisted crystallography suggests a mechanism of X-ray-induced disulfide radical formation and reparation

scientific article

Reaction of Cresyl Saligenin Phosphate, the Organophosphorus Agent Implicated in Aerotoxic Syndrome, with Human Cholinesterases: Mechanistic Studies Employing Kinetics, Mass Spectrometry, and X-ray Structure Analysis

scientific article

Reaction site-driven regioselective synthesis of AChE inhibitors

scientific article published on 11 November 2013

Relation between dynamics, activity and thermal stability within the cholinesterase family.

scientific article

Serial Femtosecond Crystallography and Ultrafast Absorption Spectroscopy of the Photoswitchable Fluorescent Protein IrisFP

scientific article

Serial femtosecond crystallography on in vivo-grown crystals drives elucidation of mosquitocidal Cyt1Aa bioactivation cascade

scientific article published on 02 March 2020

Shoot-and-Trap: Use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography

scientific article

Similarities and differences in radiation damage at 100 K versus 160 K in a crystal of thermolysin.

scientific article published on 9 April 2011

Simultaneous measurements of solvent dynamics and functional kinetics in a light-activated enzyme.

scientific article published on March 2009

Snapshots of Enzymatic Baeyer-Villiger Catalysis: OXYGEN ACTIVATION AND INTERMEDIATE STABILIZATION

scientific article

Solvent behaviour in flash-cooled protein crystals at cryogenic temperatures.

scientific article published in April 2001

Specific chemical and structural damage to proteins produced by synchrotron radiation

scientific article

Specific protein dynamics near the solvent glass transition assayed by radiation-induced structural changes

scientific article

Specific radiation damage to acidic residues and its relation to their chemical and structural environment

scientific article

Structural insights into substrate traffic and inhibition in acetylcholinesterase

scientific article published on 8 June 2006

Structure and function of an insect  -carboxylesterase ( Esterase7) associated with insecticide resistance

scientific article

Structure and hydration of the M-state of the bacteriorhodopsin mutant D96N studied by neutron diffraction

scientific article published on 01 January 1998

Supercooled liquid-like solvent in trypsin crystals: implications for crystal annealing and temperature-controlled X-ray radiation damage studies

scientific article published on 14 April 2005

Temperature derivative fluorescence spectroscopy as a tool to study dynamical changes in protein crystals.

scientific article

Temperature-dependent macromolecular X-ray crystallography.

scientific article

The influence of solvent composition on global dynamics of human butyrylcholinesterase powders: a neutron-scattering study.

scientific article published on May 2004

The low-temperature inflection observed in neutron scattering measurements of proteins is due to methyl rotation: direct evidence using isotope labeling and molecular dynamics simulations.

scientific article published in April 2010

The role of protein dynamics in the evolution of new enzyme function

scientific article

Translational diffusion of hydration water correlates with functional motions in folded and intrinsically disordered proteins

scientific article published on 16 March 2015

Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography

scientific article

X-ray radiation damage to biological macromolecules: further insights

scientific article published on January 2017

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