List of works - Alexandra Cousido-Siah

2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors

scientific article

Crystal packing modifies ligand binding affinity: The case of aldose reductase

scientific article

Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury ⬇️

scientific article published on March 8, 2013

Frataxin from Psychromonas ingrahamii as a model to study stability modulation within the CyaY protein family

scientific article

IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors

scientific article

Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design

scientific article

Linear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10

scientific article

Neutron structure of type-III antifreeze protein allows the reconstruction of AFP-ice interface

scientific article

New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM

scientific article

Probing the roles of two tryptophans surrounding the unique zinc coordination site in lipase family I.5

scientific article

Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase

scientific article

Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10

scientific article

Structural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10

scientific article

Structural and functional studies of ReP1-NCXSQ, a protein regulating the squid nerve Na+/Ca2+ exchanger

scientific article

Structural characterization of metal binding to a cold-adapted frataxin

scientific article

Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction

scientific article

The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition

scientific article

The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase

scientific article

X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity

scientific article

X-ray-induced deterioration of disulfide bridges at atomic resolution

scientific article

List of works by Alexandra Cousido-Siah

2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors

Crystal packing modifies ligand binding affinity: The case of aldose reductase

Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury ⬇️

Frataxin from Psychromonas ingrahamii as a model to study stability modulation within the CyaY protein family

IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors

Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design

Linear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10

Neutron structure of type-III antifreeze protein allows the reconstruction of AFP-ice interface

New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM

Probing the roles of two tryptophans surrounding the unique zinc coordination site in lipase family I.5

Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase

Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10

Structural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10

Structural and functional studies of ReP1-NCXSQ, a protein regulating the squid nerve Na+/Ca2+ exchanger

Structural characterization of metal binding to a cold-adapted frataxin

Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction

The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition

The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase

X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity

X-ray-induced deterioration of disulfide bridges at atomic resolution