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List of works by Jürg Tschopp

A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses

scientific article published on 15 April 2007

A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity

scientific article published in November 1994

A pilot study of IL-1 inhibition by anakinra in acute gout

scientific article

A role for mitochondria in NLRP3 inflammasome activation ⬇️

scientific article (publication date: 13 January 2011)

A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth

scientific article

A unique epitope exposed in native complement component C9 and hidden in the terminal SC5b-9 complex enables selective detection and quantification of non-activated C9

scientific article published on 01 June 1987

APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth

scientific article

APRIL, a new member of the tumor necrosis factor family, modulates death ligand-induced apoptosis

scientific article

Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells

scientific article published in August 2001

Activated B cells express functional Fas ligand

scientific article published on 01 March 1996

Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L)

scientific article published on December 1999

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

scientific article (publication date: September 2007)

Activation of the NLRP3 inflammasome byMycobacterium tuberculosisis uncoupled from susceptibility to active tuberculosis

scholarly article by Anca Dorhoi et al published 20 December 2011 in European Journal of Immunology

Activation-dependent epitopes in the terminal complement pathway.

scientific article published on January 1989

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity ⬇️

scientific article published on March 13, 2011

Antibody-independent activation of C1. II. Evidence for two classes of nonimmune activators of the classical pathway of complement.

scientific article

Antibody-independent activation of the complement system by mitochondria is mediated by cardiolipin

scientific article published on January 1988

Antigenic crossreactivity of the alpha subunit of complement component C8 with the cysteine-rich domain shared by complement component C9 and low density lipoprotein receptor

scientific article published on June 1986

Antiviral antibodies target adenovirus to phagolysosomes and amplify the innate immune response

scientific article

Apoptosis induced by death receptors

scientific article

Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis

scientific article

Apoptosis. Searching for FLASH domains

scientific article

Apoptosis: Silencing the death receptors

scientific article

Appearance of cytolytic granules upon induction of cytolytic activity in CTL-hybrids

scientific article published on October 1985

Appearance of granule-associated molecules during activation of cytolytic T-lymphocyte precursors by defined stimuli

scientific article published on 01 May 1988

Assembly of macromolecular pores by immune defense systems

scientific article

Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome

scientific article

Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren’s syndrome

Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis

scientific article published on September 2002

Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome ⬇️

scientific article published on March 31, 2011

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation ⬇️

scientific article published on January 12, 2011

Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway

scientific article

BAFF and the regulation of B cell survival

scientific article

BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population

scientific article published in July 2000

BAFF mediates survival of peripheral immature B lymphocytes

scientific article published on November 2000

BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF

scientific article (publication date: 14 September 2001)

Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum

scientific article published on May 2000

Bcl-2 protects from oxidative damage and apoptotic cell death without interfering with activation of NF-kappa B by TNF.

scientific article published on August 1994

Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension

scientific article

Biochemical Mechanisms of IL-2–Regulated Fas-Mediated T Cell Apoptosis ⬇️

scientific article published on May 1, 1998

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

scientific article

Caspase activation is required for T cell proliferation

scientific article

Caspase-independent cell death in T lymphocytes

scientific article

Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis

scientific article

Cell specificity of granzyme gene expression

scientific article published on November 1990

Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6.

scientific article

Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activation

scientific article

Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8.

scientific article published in July 2005

Cellular FLIP long form-transgenic mice manifest a Th2 cytokine bias and enhanced allergic airway inflammation

scientific article published in April 2004

Ceramide enables fas to cap and kill

scientific article published on 3 April 2001

Characterization of Fas (Apo-1, CD95)-Fas ligand interaction

scientific article (publication date: 25 July 1997)

Characterization of the non-functional Fas ligand of gld mice

article

Characterization of two receptors for TRAIL1 ⬇️

scientific article published on October 27, 1997

Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells

Circular polymerization of the ninth component of complement. Ring closure of the tubular complex confers resistance to detergent dissociation and to proteolytic degradation.

scientific article

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

scientific article

Cleavage of caspase family members by granzyme B: a comparative study in vitro

scientific article

Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system

scientific article

Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome

scientific article published on 13 April 2010

Clusterin (complement lysis inhibitor) forms a high density lipoprotein complex with apolipoprotein A-I in human plasma.

scientific article published in June 1991

Clusterin gene expression in the rat thymus is not modulated by dexamethasone treatment

scientific article published on 01 June 1994

Clusterin gene expression mediates resistance to apoptotic cell death induced by heat shock and oxidative stress

scientific article published on March 1999

Clusterin in renal tissue: preferential localization with the terminal complement complex and immunoglobulin deposits in glomeruli ⬇️

scientific article published on June 1, 1992

Clusterin, the human apolipoprotein and complement inhibitor, binds to complement C7, C8 beta, and the b domain of C9.

scientific article published in August 1993

Clusterin: modulation of complement function

scientific article published on August 1994

Comparative molecular modelling of the Fas-ligand and other members of the TNF family

article

Comparison of Fas(Apo-1/CD95)- and perforin-mediated cytotoxicity in primary T lymphocytes

scientific article

Complement activation by pulsed tunable dye laser in normal skin and hemangioma

scientific article

Complementary DNA cloning of complement C8 beta and its sequence homology to C9.

scholarly article

Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6

scientific article

Constitutive Fas ligand expression in several non-lymphoid mouse tissues: implications for immune-protection and cell turnover

scientific article

Contribution of TNF/TNF receptor and of Fas ligand to toxicity in murine models of endotoxemia and bacterial peritonitis

scientific article published in January 1995

Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity ⬇️

scientific article published on April 20, 1998

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

scientific article published in Nature

Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease

scientific article

Cytotoxic T cells: more weapons for new targets?

Cytotoxic T lymphocyte mediated cytolysis

scientific article published on April 1988

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB

scientific article

DNA fragmentation during apoptosis is caused by frequent single-strand cuts

scientific article

Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization

scientific article published in May 2008

Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex

scientific article

Death receptors in cutaneous biology and disease

scientific article

Debate: the mechanism of lymphocyte-mediated killing. Perforin-induced pore formation

scientific article published on November 1991

Defective death receptor signaling as a cause of tumor immune escape

scientific article

Differential expression of NLRP3 among hematopoietic cells

scientific article published on 21 January 2011

Differential expression of perforin in muscle-infiltrating T cells in polymyositis and dermatomyositis

scientific article published on June 1996

Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4.

scientific article published in April 1997

Dissection of functional domains in Bcl-2α by site-directed mutagenesis ⬇️

scientific article published on November 1, 1994

Distinct sites of production and deposition of the putative cell death marker clusterin in the human thymus ⬇️

scientific article published on November 1, 1992

Distribution of deoxyribonuclease I in rat tissues and its correlation to cellular turnover and apoptosis (programmed cell death).

scientific article

Dynamic correlation of apoptosis and immune activation during treatment of HIV infection

scientific article published in May 1999

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

scientific article published on 26 January 2012

Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis

scientific article

Effects of purified perforin and granzyme A from cytotoxic T lymphocytes on guinea pig ventricular myocytes

scientific article

Elimination of P. berghei liver stages is independent of Fas (CD95/Apo-I) or perforin-mediated cytotoxicity

scientific article published in March 1997

Expression level of c-FLIP versus Fas determines susceptibility to Fas ligand-induced cell death in murine thymoma EL-4 cells

scientific article published on February 2002

Expression of the CTL-associated protein TIA-1 during murine embryogenesis.

scientific article published in August 1996

FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation

scientific article

FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation.

scientific article

Fas and Fas ligand expression in tumor cells and in vascular smooth-muscle cells of colonic and renal carcinomas

scientific article published on May 1999

Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover

scientific article

Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction: a new role for Fas ligand in inflammatory res

scientific article published on December 2000

Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain?

scientific article published on March 1997

Fas ligand-induced c-Jun kinase activation in lymphoid cells requires extensive receptor aggregation but is independent of DAXX, and Fas-mediated cell death does not involve DAXX, RIP, or RAIDD.

scientific article published on August 2000

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

scientific article

Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway

scientific article published on 30 May 2001

Fas-dependent tissue turnover is implicated in tumor cell clearance

scientific article published on March 2000

Fas-mediated cell death in toxic epidermal necrolysis and graft-versus-host disease: potential for therapeutic inhibition

scientific article

Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9

scientific article published in Nature

Frequent downregulation of Fas (CD95) expression and function in melanoma.

scientific article

From inflammasomes to fevers, crystals and hypertension: how basic research explains inflammatory diseases

scientific article published on 05 September 2007

Functional characterisation of serum DNase I in MRL-lprlpr mice

scientific article published on 01 July 1992

Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes. A potential role for the acidic sphingomyelinase pathway in normal immunoregulation

scientific article

Genomic organisation and expression of mouse deoxyribonuclease I.

scientific article published on February 1995

Genomic organization and subchromosomal in situ localization of the murine granzyme F, a serine protease expressed in CD8+ T cells

scientific article published in August 1991

Gout-associated uric acid crystals activate the NALP3 inflammasome

scientific article (publication date: 9 March 2006)

Granules of cytolytic T-lymphocytes contain two serine esterases

scientific article

Granzyme A is an interleukin 1 beta-converting enzyme

scientific article

Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes

scientific article published on August 1994

Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation

scientific article

Histones trigger sterile inflammation by activating the NLRP3 inflammasome

scientific article published on 6 September 2013

Human clusterin (CLI) maps to 8p21 in proximity to the lipoprotein lipase (LPL) gene

scientific article published on 01 May 1993

Human clusterin gene expression is confined to surviving cells during in vitro programmed cell death

scientific article

Human megakaryocytes express clusterin and package it without apolipoprotein A-1 into alpha-granules

scientific article published on 01 July 1993

Human perforin (PRF1) maps to 10q22, a region that is syntenic with mouse chromosome 10.

scientific article

IRAK2 takes its place in TLR signaling

IRF-3 partners Bax in a viral-induced dance macabre

scientific article

Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes

scientific article

Identification of CARDIAK, a RIP-like kinase that associates with caspase-1 ⬇️

scientific article published on July 16, 1998

Identification of a human C5 beta-chain epitope exposed in the native complement component but concealed in the SC5b-9 complex

scientific article published on 01 September 1988

Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

scientific journal article

Identification of granzyme A isolated from cytotoxic T-lymphocyte-granules as one of the proteases encoded by CTL-specific genes

scientific article

Immunohistochemical localization of granzyme B antigen in cytotoxic cells in human tissues

scientific article published in May 1991

In Vitro– and Ex Vivo–derived Cytolytic Leukocytes from Granzyme A × B Double Knockout Mice Are Defective in Granule-mediated Apoptosis but not Lysis of Target Cells ⬇️

scientific article published on November 17, 1997

Increased hemolytic activity of the trypsin-cleaved ninth component of complement.

scientific article published in January 1986

Increased p34cdc2-dependent kinase activity during apoptosis: a possible activation mechanism of DNase I leading to DNA breakdown.

scientific article published on February 1996

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

scientific article

Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1.

scientific article published in March 2012

Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response

scientific article

Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes

scientific article published on 29 March 2012

Inflammatory caspases and inflammasomes: master switches of inflammation

scientific article

Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases

scientific article

Inhibition of death receptor signaling by FLICE-inhibitory protein as a mechanism for immune escape of tumors

scientific article published on October 1999

Inhibition of death receptor signals by cellular FLIP

scientific article

Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

scientific journal article

Inhibition of lymphocyte mediated cytotoxicity by perforin antisense oligonucleotides

scientific article

Inhibition of lymphocyte protease granzyme A by antithrombin III

scientific article published on 01 December 1988

Inhibition of the lytic activity of perforin (cytolysin) and of late complement components by proteoglycans

scientific article published on 01 September 1987

Inhibition of the lytic activity of perforin by lipoproteins

scientific article published on 01 September 1986

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation

scientific article published in February 2012

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

scientific article

Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome

scientific article

Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome

scientific article published in March 2009

Interaction between a Ca2+-Binding Protein Calreticulin and Perforin, a Component of the Cytotoxic T-Cell Granules ⬇️

scientific article published on July 21, 1998

Interaction of Fas(Apo‐1/CD95) with proteins implicated in the ubiquitination pathway ⬇️

scientific article (publication date: 21 July 1997)

Interaction of chondroitin sulfate with perforin and granzymes of cytolytic T-cells is dependent on pH.

scientific article published on December 1990

Interaction of peptides derived from the Fas ligand with the Fyn-SH3 domain

scientific article

Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human

scientific article

Intracellular pattern recognition receptors in the host response

scientific article published on July 2006

Intracellular pattern-recognition receptors

scientific article published on 31 December 2007

Involvement of granule proteins in T-cell-mediated cytolysis

scientific article published on January 1990

Involvement of the N-methyl-D-aspartate receptor in neuronal cell death induced by cytotoxic T cell-derived secretory granules

scientific article published on 01 October 1999

Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.

scientific article

Isolation and complete structure of the lymphocyte serine protease granzyme G, a novel member of the granzyme multigene family in murine cytolytic T lymphocytes. Evolutionary origin of lymphocyte proteases.

scientific article published on September 1989

Isolation of a lytic, pore-forming protein (perforin) from cytolytic T-lymphocytes

scientific article published on 01 August 1985

Lack of DNA degradation in target cells lysed by granules derived from cytolytic T lymphocytes

scientific article published on 01 August 1988

Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction

scientific article published in October 2004

Localization and molecular modelling of the membrane-inserted domain of the ninth component of human complement and perforin

scientific article

Malarial hemozoin is a Nalp3 inflammasome activating danger signal

scientific article

Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape

scientific article published on 01 November 1996

Membrane attack by complement

scientific article published on July 1984

Membrane attack complex (MAC) deposits in skin are not always accompanied by S-protein and clusterin

scientific article published on May 1, 1992

Membranolysis by the ninth component of human complement ⬇️

scientific article published on June 16, 1981

Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling

scientific article published on 30 April 2015

Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations

scientific article

Mitochondria: Sovereign of inflammation?

scientific article published on May 2011

Modulation of death receptor signalling

scientific article

Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid

scientific article

Molecular weight of poly(C9). 12 to 18 C9 molecules form the transmembrane channel of complement.

scientific article published on February 1984

Monoclonal antibodies recognizing a neoantigen of poly(C9) detect the human terminal complement complex in tissue and plasma

scientific article

Murine Thy-1+ dendritic epidermal T cell lines express granule-associated perforin and a family of granzyme molecules

scientific article published on April 1, 1992

Murine clusterin: molecular cloning and mRNA localization of a gene associated with epithelial differentiation processes during embryogenesis

scientific article

Mutations in the putative lipid-interaction domain of complement C9 result in defective secretion of the functional protein

scientific article published on January 1993

Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A.

scientific article published on 14 March 2001

MyD88, an Adapter Protein Involved in Interleukin-1 Signaling ⬇️

scientific article published on May 15, 1998

MyD88S, a splice variant of MyD88, differentially modulates NF-kappaB- and AP-1-dependent gene expression

scientific article published in July 2003

Myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis is chronic/relapsing in perforin knockout mice, but monophasic in Fas- and Fas ligand-deficient lpr and gld mice

scientific article published in December 1997

N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway

scientific journal article

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

scientific article

NALP3 is not necessary for early protection against experimental tuberculosis

scientific article published on 4 June 2010

NALPs: a novel protein family involved in inflammation

scientific article (publication date: February 2003)

NF-kappaB signals induce the expression of c-FLIP.

scientific article published on August 2001

NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8⁺ T cells

scientific article published on 8 January 2012

NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells

scientific article

NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?

scientific article (publication date: March 2010)

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

scientific article

NLRP3 suppresses NK cell-mediated responses to carcinogen-induced tumors and metastases

scientific article

NLRX1/NOD5 deficiency does not affect MAVS signalling

scientific article

NLRX1: friend or foe?

scientific article

NLRs join TLRs as innate sensors of pathogens

scientific article

NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain

scientific article

Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β

scientific article

Neurons induced to express major histocompatibility complex class I antigen are killed via the perforin and not the Fas (APO-1/CD95) pathway

scientific article published on 01 September 1996

New insights into the mechanism of IL-1beta maturation

scientific article

Occurrence of an incomplete C8 molecule in homozygous C8 deficiency in man

scientific article

Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas.

scientific article

Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation

scientific article

Overexpression of deoxyribonuclease I (DNase I) transfected into COS-cells: its distribution during apoptotic cell death

scientific article published on December 1993

PIDD Death-Domain Phosphorylation by ATM Controls Prodeath versus Prosurvival PIDDosome Signaling ⬇️

scientific article published on July 30, 2012

PIDD mediates NF-kappaB activation in response to DNA damage

scientific article

PIDD orchestrates translesion DNA synthesis in response to UV irradiation ⬇️

scientific article published on March 18, 2011

Perforin and granzymes: crucial effector molecules in cytolytic T lymphocyte and natural killer cell-mediated cytotoxicity.

scientific article published on January 1995

Perforin is present only in normal activated Lyt2+ T lymphocytes and not in L3T4+ cells, but the serine protease granzyme A is made by both subsets

scientific article

Perforin-mediated target cell lysis by cytolytic T lymphocytes

scientific article published on January 1990

Peripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and upregulate Fas and Fas ligand

scientific article published on February 1996

Phosphorylcholine acts as a Ca2+-dependent receptor molecule for lymphocyte perforin

scientific article published in Nature

Polymerization of the ninth component of complement (C9): formation of poly(C9) with a tubular ultrastructure resembling the membrane attack complex of complement

scientific article

Propidium iodide staining correlates with the extent of DNA degradation in isolated nuclei

scientific article published on 01 March 1992

Protein-based therapeutic approaches targeting death receptors

scientific article

Quantitation of vitronectin and clusterin. Pitfalls and solutions in enzyme immunoassays for adhesive proteins

scientific article published on 01 March 1993

RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

scientific article

Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes

scientific article

Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation

scientific article published in May 2003

Regulation of Fas ligand-induced apoptosis by TNF.

scientific article

Regulation of Fas(Apo-1/CD95)- and perforin-mediated lytic pathways of primary cytotoxic T lymphocytes by the protooncogene bcl-2

scientific article published on 01 December 1995

Regulation of PIDD auto-proteolysis and activity by the molecular chaperone Hsp90 ⬇️

scientific article published on October 22, 2010

Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88

scientific article (publication date: 19 March 2002)

Regulation of lymphocyte proliferation and death by FLIP.

scientific article

Resistance of CTL to perforin-mediated lysis. Evidence for a lymphocyte membrane protein interacting with perforin.

scientific article

Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses

scientific article

Selective expression of FLIP in malignant melanocytic skin lesions

scientific article

Sequence similarity of phospholipase A2 activating protein and the G protein beta-subunits: a new concept of effector protein activation in signal transduction?

scientific article

Simian immunodeficiency virus (SIVsm) infection of cynomolgus monkeys: effects on follicular dendritic cells in lymphoid tissue

scientific article published in December 1992

Smac mimetics and TNFalpha: a dangerous liaison?

scientific article

Structural homology of human complement component C8 gamma and plasma protein HC: identity of the cysteine bond pattern

scientific article published in December 1987

Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis

scientific article

Structure of the PRYSPRY-domain: implications for autoinflammatory diseases

scientific article

Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3)

scientific article (publication date: 24 November 2000)

Subunit interactions of tryptophan synthase from Escherichia coli as revealed by binding studies with pyridoxal phosphate analogues

scientific article published on September 1980

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

scientific article

T cell costimulation by the TNF ligand BAFF.

scientific article published in December 2001

T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes

scientific article

TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts

scientific article

TCR-induced NF-kappaB activation: a crucial role for Carma1, Bcl10 and MALT1.

scientific article

TGF-beta induces the expression of the FLICE-inhibitory protein and inhibits Fas-mediated apoptosis of microglia.

scientific article

TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

scientific article (publication date: April 2000)

TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)

scientific article

TWEAK can induce cell death via endogenous TNF and TNF receptor 1.

scientific article

The CARD domain: a new apoptotic signalling motif

scientific article (publication date: May 1997)

The NLRP3 inflammasome promotes renal inflammation and contributes to CKD.

scientific article

The NLRP3 inflammasome: a sensor for metabolic danger?

scientific article

The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

scientific article

The RIP kinases: crucial integrators of cellular stress

scientific article

The TRAF3-binding site of human molluscipox virus FLIP molecule MC159 is critical for its capacity to inhibit Fas-induced apoptosis

scientific article published on 20 January 2006

The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases

scientific article published on 29 August 2008

The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes

scientific article published on January 1993

The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes

scientific article

The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

scientific article (publication date: June 2000)

The combination of chemotherapy and intraperitoneal MegaFas Ligand improves treatment of ovarian carcinoma

scientific article

The death domain motif found in Fas (Apo-1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance

scientific article

The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade

scientific article

The dissociation properties of native C1 ⬇️

scientific article published on July 30, 1982

The fight of viruses against apoptosis ⬇️

scientific article published on February 1, 1998

The heparin binding domain of S-protein/vitronectin binds to complement components C7, C8, and C9 and perforin from cytolytic T-cells and inhibits their lytic activities

scientific article published on 01 May 1988

The inflammasome

scientific article

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

scientific article (publication date: 6 March 2008)

The inflammasome: a danger sensing complex triggering innate immunity

scientific article published on 30 October 2007

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

scientific article

The inflammasome: an integrated view

scientific article published on September 2011

The inflammasomes

scientific article

The inflammasomes: guardians of the body

scientific article (publication date: 2009)

The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex

scientific article (publication date: 22 November 2002)

The membrane attack complex of complement: C5b-8 complex as accelerator of C9 polymerization.

scientific article

The molecular architecture of the TNF superfamily

scientific article

The mycobacterial cord factor adjuvant analogue trehalose-6,6′-dibehenate (TDB) activates the Nlrp3 inflammasome ⬇️

scientific article published on August 7, 2012

The neutrophil NLRC4 inflammasome selectively promotes IL-1β maturation without pyroptosis during acute Salmonella challenge

scientific article published on 17 July 2014

The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis

scientific article

The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation

scientific article (publication date: 20 February 2001)

The role of interleukin-1 and the inflammasome in gout: implications for therapy

scientific article published on October 2007

The role of potassium in inflammasome activation by bacteria

scientific article

The role of the inflammasome in nonmyeloid cells

scientific article published on 27 June 2010

The sequence and topology of human complement component C9

scientific article

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

scientific article (publication date: February 2010)

Thogoto virus infection induces sustained type I interferon responses that depend on RIG-I-like helicase signaling of conventional dendritic cells

scientific article published on 22 September 2010

Three adenovirus E3 proteins cooperate to evade apoptosis by tumor necrosis factor-related apoptosis-inducing ligand receptor-1 and -2.

scientific article

Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis ⬇️

scientific article published on October 22, 2012

Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses

scientific article published on June 2006

Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide

scientific article

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

scientific article

Transients of perforin pore formation observed by fluorescence microscopic single channel recording ⬇️

scientific article published on August 1, 1990

Type I IFN controls chikungunya virus via its action on nonhematopoietic cells

scientific article

Ubiquitination of the Epstein-Barr virus-encoded latent membrane protein 1 depends on the integrity of the TRAF binding site

scientific article published in August 2003

Ultrastructure of the membrane attack complex of complement: detection of the tetramolecular C9-polymerizing complex C5b-8.

scientific article

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

scholarly article

Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis

scientific article published on 12 February 2009

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

scientific article published on April 1997

Viruses under the control of RIP kinases

scientific article published in February 2010

[5] Granzyme B

scientific article published on 01 January 1994

cDNA cloning of granzyme C, a granule-associated serine protease of cytolytic T lymphocytes

scientific article published in January 1988

cFLIP regulation of lymphocyte activation and development

scientific article

p53-induced protein with a death domain (PIDD) isoforms differentially activate nuclear factor-kappaB and caspase-2 in response to genotoxic stress

scientific article

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