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List of works by Mark Hochstrasser

A Conserved C-terminal Element in the Yeast Doa10 and Human MARCH6 Ubiquitin Ligases Required for Selective Substrate Degradation

scientific article published on 11 April 2016

A Single α Helix Drives Extensive Remodeling of the Proteasome Lid and Completion of Regulatory Particle Assembly

scientific article

A WLM protein with SUMO-directed protease activity

scientific article

A Wolbachia deubiquitylating enzyme induces cytoplasmic incompatibility

scientific article (publication date: 27 February 2017)

A Wolbachia nuclease and its binding partner provide a distinct mechanism for cytoplasmic incompatibility

scientific article published on 15 October 2019

A conserved 20S proteasome assembly factor requires a C-terminal HbYX motif for proteasomal precursor binding

scientific article

A conserved late endosome-targeting signal required for Doa4 deubiquitylating enzyme function

scientific article

A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway

scientific article

A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matα2 repressor degradation ⬇️

scientific article published on October 15, 2001

A deubiquitylase with an unusually high-affinity ubiquitin-binding domain from the scrub typhus pathogen Orientia tsutsugamushi

scientific article published on 11 May 2020

A multimeric assembly factor controls the formation of alternative 20S proteasomes

scientific article

A new class of SUMO proteases.

scientific article published on 2 April 2012

A nuclear envelope protein linking nuclear pore basket assembly, SUMO protease regulation, and mRNA surveillance

scientific article

A superfamily of protein tags: ubiquitin, SUMO and related modifiers

scientific article

A tetrahedral transition state at the active sites of the 20S proteasome is coupled to opening of the alpha-ring channel

scientific article published on August 2009

A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome.

scientific article published on 11 March 2016

AMPK regulates ESCRT-dependent microautophagy of proteasomes concomitant with proteasome storage granule assembly during glucose starvation

scientific article published on 18 November 2019

Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase.

scientific article

Adaptive aneuploidy counters a dysregulated SUMO system

scientific article published on 18 November 2016

An Evolutionarily Conserved Gene on Human Chromosome 5q33–q34,UBH1,Encodes a Novel Deubiquitinating Enzyme ⬇️

scientific article published on May 1, 1998

An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery

scientific article

An unusual transmembrane helix in the endoplasmic reticulum ubiquitin ligase Doa10 modulates degradation of its cognate E2 enzyme.

scientific article

Analysis of protein ubiquitination

scientific article published on 01 November 2002

Analysis of protein ubiquitination.

scientific article

Assaying protein ubiquitination in Saccharomyces cerevisiae

scientific article

Assembly of an Evolutionarily Conserved Alternative Proteasome Isoform in Human Cells.

scientific article

Assembly of the 20S proteasome.

scientific article published on 16 March 2013

Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue

scientific article published on 21 February 2007

Caution Does Not Preclude Predictive and Testable Models of Cytoplasmic Incompatibility: A Reply to Shropshire et al.

scientific article

Cecile M. Pickart 1954-2006.

scientific article published in June 2006

Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation

scientific article published on 13 December 2018

Crystal structure of a guanine nucleotide exchange factor encoded by the scrub typhus pathogen Orientia tsutsugamushi

scientific article published on 12 November 2020

DNA Binding by the MATα2 Transcription Factor Controls its Access to Alternative Ubiquitin-modification Pathways

scientific article published on 3 January 2018

Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae

scientific article published on 6 December 2004

Degradation Signal Masking by Heterodimerization of MATα2 and MATa1 Blocks Their Mutual Destruction by the Ubiquitin-Proteasome Pathway ⬇️

scientific article published on July 24, 1998

Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type II

scientific article published on November 2008

Designed proteins to modulate cellular networks

scientific article

Desumoylation of the endoplasmic reticulum membrane VAP family protein Scs2 by Ulp1 and SUMO regulation of the inositol synthesis pathway

scientific article published on 24 October 2011

Distinct Elements in the Proteasomal β5 Subunit Propeptide Required for Autocatalytic Processing and Proteasome Assembly

scientific article

Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease

scientific article published in Nature Communications

Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein

scientific article

Disulfide engineering to map subunit interactions in the proteasome and other macromolecular complexes.

scientific article published on January 2012

Diversity of degradation signals in the ubiquitin-proteasome system

scientific article

Endoplasmic reticulum stress differentially inhibits endoplasmic reticulum and inner nuclear membrane protein quality control degradation pathways

scientific article published on 13 November 2019

Epigenetic Mechanisms Contribute to Evolutionary Adaptation of Gene Network Activity under Environmental Selection

scientific article published on 01 October 2020

Essential role of nuclear localization for yeast Ulp2 SUMO protease function.

scientific article published on 18 February 2009

Function and regulation of SUMO proteases

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

article by Daniel J Klionsky et al published January 2021 in Autophagy

Gyre and gimble in the proteasome

scientific article

Heterohexameric ring arrangement of the eukaryotic proteasomal ATPases: implications for proteasome structure and assembly.

scientific article

Histone sumoylation promotes Set3 histone-deacetylase complex-mediated transcriptional regulation

scientific article published on 24 November 2020

Identification of SUMO-interacting proteins by yeast two-hybrid analysis

scientific article

Incorporation of the Rpn12 subunit couples completion of proteasome regulatory particle lid assembly to lid-base joining

scientific article

Introduction to intracellular protein degradation.

scientific article published in April 2009

Lingering mysteries of ubiquitin-chain assembly

scientific article

Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy.

scientific article published on August 2016

Mechanism and function of deubiquitinating enzymes

scientific article

Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways

scientific article published on 26 January 2006

Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI)

scientific article

Microautophagy regulates proteasome homeostasis

scientific article published on 20 February 2020

Modification of proteins by ubiquitin and ubiquitin-like proteins

scientific article (publication date: 2006)

Molecular architecture and assembly of the eukaryotic proteasome

scientific article

Molecular biology. New proteases in a ubiquitin stew

scientific article published in October 2002

Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle base

scientific article

N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates

scientific article

NF-kappaB signaling: flipping the switch with polyubiquitin chains

scientific article published in October 2004

New structural clues to substrate specificity in the "ubiquitin system"

scientific article published on 01 March 2002

Order of the proteasomal ATPases and eukaryotic proteasome assembly

scientific article

Origin and function of ubiquitin-like proteins

scientific article

Plasticity in eucaryotic 20S proteasome ring assembly revealed by a subunit deletion in yeast

scientific article

Preface

Preface

Preparation and characterization of yeast and human desumoylating enzymes

scientific article published in January 2005

Proteasome Structure and Assembly

scientific article published on 2 June 2017

Proteasomes: Isolation and Activity Assays.

scientific article

Protein Modification: Bacterial Effectors Rewrite the Rules of Ubiquitylation.

scientific article published in July 2016

Protein quality control degron-containing substrates are differentially targeted in the cytoplasm and nucleus by ubiquitin ligases

scientific article published on 01 March 2021

Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

scientific article

Rapid degradation of progressive ankylosis protein (ANKH) in craniometaphyseal dysplasia

scientific article published in Scientific Reports

Recent progress in ubiquitin and ubiquitin-like protein (Ubl) signaling.

scientific article published on April 2016

Redundancy and variation in the ubiquitin-mediated proteolytic targeting of a transcription factor

scientific article published on 22 November 2010

Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing

scientific article

STUbL-mediated degradation of the transcription factor MATα2 requires degradation elements that coincide with corepressor binding sites

scientific article

SUMO Pathway Modulation of Regulatory Protein Binding at the Ribosomal DNA Locus in Saccharomyces cerevisiae

scientific article published on 02 February 2016

SUMO and cellular adaptive mechanisms

scientific article published on 26 June 2020

SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase toward a short-lived transcription factor.

scientific article published on 13 April 2010

Sem1, the yeast ortholog of a human BRCA2-binding protein, is a component of the proteasome regulatory particle that enhances proteasome stability

scientific article

Site-specific cation release drives actin filament severing by vertebrate cofilin.

scientific article

Small epitope-linker modules for PCR-based C-terminal tagging in Saccharomyces cerevisiae

scientific article published on March 2009

Some assembly required: dedicated chaperones in eukaryotic proteasome biogenesis

scientific article published on September 2008

Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase

scientific article

Split-Doa10: a naturally split polytopic eukaryotic membrane protein generated by fission of a nuclear gene

scientific article

Substrate specificity of the ubiquitin and Ubl proteases

scientific article

The Biochemistry of Cytoplasmic Incompatibility Caused by Endosymbiotic Bacteria

scientific article published on 25 July 2020

The CinB Nuclease from <i>w</i>No <i>Wolbachia</i> Is Sufficient for Induction of Cytoplasmic Incompatibility in <i>Drosophila</i>

scientific article published on 25 January 2022

The DUB blade goes snicker-snack: Novel ubiquitin cleavage by a Legionella effector protein

scientific article published on 2 June 2017

The Regulation of Chromatin by Dynamic SUMO Modifications.

scientific article published in January 2016

The SUMO-targeted ubiquitin ligase subunit Slx5 resides in nuclear foci and at sites of DNA breaks.

scientific article

The Sts1 nuclear import adapter uses a non-canonical bipartite nuclear localization signal and is directly degraded by the proteasome

scientific article published on 19 March 2020

The Toxin-Antidote Model of Cytoplasmic Incompatibility: Genetics and Evolutionary Implications

article

The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity

scientific article

The Ulp2 SUMO protease is required for cell division following termination of the DNA damage checkpoint

scientific article

The Ulp2 SUMO protease promotes transcription elongation through regulation of histone sumoylation

scientific article published on 17 July 2019

The Wolbachia cytoplasmic incompatibility enzyme CidB targets nuclear import and protamine-histone exchange factors.

scientific article published on 27 November 2019

The intrinsically disordered Sem1 protein functions as a molecular tether during proteasome lid biogenesis.

scientific article published on 09 January 2014

The short-lived MAT alpha 2 transcriptional regulator is ubiquitinated in vivo ⬇️

scientific article published on June 1, 1991

The short-lived Matalpha2 transcriptional repressor is protected from degradation in vivo by interactions with its corepressors Tup1 and Ssn6

scientific article

The yeast Hex3.Slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation

scientific article

There's the Rub: a novel ubiquitin-like modification linked to cell cycle regulation ⬇️

scientific article published on 01 April 1998

Ubiquitin and intracellular protein degradation

scientific article published on December 1, 1992

Ubiquitin ligation without a ligase

scientific article published on July 2007

Ubiquitin signalling: what's in a chain?

scientific article

Ubiquitin-dependent Protein Degradation at the Endoplasmic Reticulum and Nuclear Envelope

scientific article published on 09 October 2018

Ubiquitin-dependent control of development in Saccharomyces cerevisiae

scientific article

Ubiquitin-dependent degradation of the yeast Mat(alpha)2 repressor enables a switch in developmental state

scientific article

Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope.

scientific article

Ulp2 and the DNA damage response: desumoylation enables safe passage through mitosis

scientific article published on 28 October 2007

Varshavsky's contributions.

scientific article

beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint

scientific article

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