Search filters

List of works by Markus Zweckstetter

A ligand-induced switch in the periplasmic domain of sensor histidine kinase CitA

scientific article

A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor

scientific article published in October 2009

Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome

scientific article published on 21 June 2012

Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons

scientific article published on 14 December 2011

Amyloidogenic potential of alpha-chymotrypsin in different conformational states

scientific article

An Adiabatic Multiple Spin–Echo Pulse Sequence: Removal of Systematic Errors Due to Pulse Imperfections and Off-Resonance Effects ⬇️

scientific article published on July 1, 1998

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease

scientific article

Assignment-free solution NMR method reveals CesT as an unswapped homodimer

scientific article published on 7 August 2008

Automatic assignment of the intrinsically disordered protein Tau with 441-residues

scientific article published in September 2010

Backbone and side-chain resonance assignment of the A147T polymorph of mouse TSPO in complex with a high-affinity radioligand

scientific article published on 12 September 2015

Backbone assignment of proteins with known structure using residual dipolar couplings

scientific article published on September 2004

Bioinorganic Chemistry of Parkinson’s Disease: Structural Determinants for the Copper-Mediated Amyloid Formation of Alpha-Synuclein

scientific article published on 22 October 2010

Burial of the Polymorphic Residue 129 in Amyloid Fibrils of Prion Stop Mutants ⬇️

scientific article published on December 3, 2012

Challenges and approaches to understand cholesterol-binding impact on membrane protein function: an NMR view

scientific article published on 08 March 2018

Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress

scientific article published in 2023

Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket

scientific article

Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure

scientific article

Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils

scientific article published on 09 July 2021

Cold denaturation of a protein dimer monitored at atomic resolution ⬇️

scientific article published on February 10, 2013

Cold-induced changes in the protein ubiquitin

scientific article

Conformational Flexibility in the Transmembrane Protein TSPO ⬇️

scientific article published on 23 September 2015

Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules

scientific article published in October 2009

Conserved amyloid core structure of stop mutants of the human prion protein

scientific article published on 13 February 2013

Conserved core of amyloid fibrils of wild type and A30P mutant α‐synuclein ⬇️

scientific article published on February 1, 2011

Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex

scientific article

Copper binding to the N-terminally acetylated, naturally occurring form of alpha-synuclein induces local helical folding

scientific article published on 15 May 2015

Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

scientific article published on 5 April 2017

Correlation of amyloid fibril beta-structure with the unfolded state of alpha-synuclein

scientific article

Determination of Complex Small-Molecule Structures Using Molecular Alignment Simulation

scientific article published on 24 February 2020

Determination of amyloid core structure using chemical shifts ⬇️

scientific article published on October 26, 2012

Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation

scientific article

Effect of zinc binding on β-amyloid structure and dynamics: implications for Aβ aggregation

scientific article published on September 2011

Elucidating the structure of an infectious protein

scientific article

Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity

scientific article

Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.

scientific article published on 05 October 2016

Exploring free-energy landscapes of intrinsically disordered proteins at atomic resolution using NMR spectroscopy

scientific article published on 11 April 2014

Exploring the Structural Details of Cu(I) Binding to α-Synuclein by NMR Spectroscopy ⬇️

scientific article published on December 15, 2010

Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease

scientific article

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation

scientific article

Fast high-resolution protein structure determination by using unassigned NMR data

scientific article

Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease

scientific article published on 22 April 2016

Folding of the Tau Protein on Microtubules

scientific article

Functional dynamics in the voltage-dependent anion channel

scientific article

Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics

scientific article published on 20 June 2018

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

scientific article published on 10 April 2017

High-Resolution NMR Determination of the Dynamic Structure of Membrane Proteins

scientific article

High-resolution structure determination of the CylR2 homodimer using paramagnetic relaxation enhancement and structure-based prediction of molecular alignment

scientific article

Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation

scientific article published on 27 March 2007

Hsp90-Tau complex reveals molecular basis for specificity in chaperone action

scientific article

Human cyclophilin 40 unravels neurotoxic amyloids

scientific article

Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action

scientific article

Imbalance of Hsp70 family variants fosters tau accumulation

scientific article published on 27 December 2012

Improved validation of IDP ensembles by one-bond Cα-Hα scalar couplings.

scientific article

Inhibition of Tau Filament Formation by Conformational Modulation ⬇️

scientific article published on February 5, 2013

Insights into Cholesterol/Membrane Protein Interactions Using Paramagnetic Solid-State NMR

scientific article published on 05 November 2018

Integrated analysis of the conformation of a protein-linked spin label by crystallography, EPR and NMR spectroscopy ⬇️

scientific article published on January 28, 2011

Interaction between amyloid beta peptide and an aggregation blocker peptide mimicking islet amyloid polypeptide

scientific article

Interaction of the intermembrane space domain of Tim23 protein with mitochondrial membranes

scientific article published on 27 October 2014

Internalization routes of cell-penetrating melanoma antigen peptides into human dendritic cells

scientific article published on January 2014

Intrinsically disordered proteins: from sequence and conformational properties toward drug discovery

scientific article published on 13 April 2012

Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau.

scientific article

Lost in translocation: the functions of the 18-kD translocator protein

scientific article published on 28 May 2015

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation

scientific article published on 30 April 2018

Mapping the potential energy landscape of intrinsically disordered proteins at amino acid resolution

scientific article

Mars -- robust automatic backbone assignment of proteins

scientific article

Measurement of long range H,C couplings in natural products in orienting media: a tool for structure elucidation of natural products

scientific article

Mechanistic Basis of Phenothiazine‐Driven Inhibition of Tau Aggregation ⬇️

scientific article published on February 11, 2013

Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90.

scientific article published on 20 February 2017

Methylation of lysine 9 in histone H3 directs alternative modes of highly dynamic interaction of heterochromatin protein hHP1β with the nucleosome

scientific article published on 19 July 2012

Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment

scientific article published on 17 August 2006

Molecular Plasticity of the Human Voltage-Dependent Anion Channel Embedded Into a Membrane

scientific article

Molecular basis of the dynamic structure of the TIM23 complex in the mitochondrial intermembrane space

scientific article

Molecular basis of the interaction of Hsp90 with its co-chaperone Hop

scientific article published on 11 October 2020

Multiple paramagnetic effects through a tagged reporter protein

scientific article published on 7 October 2014

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau.

scientific article published on 7 December 2017

Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork

scientific article (publication date: 2013)

N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits

scientific article published on 18 May 2013

NMR-based detection of hydrogen/deuterium exchange in liposome-embedded membrane proteins

scientific article

NMR: prediction of molecular alignment from structure using the PALES software

scientific article published in January 2008

Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates

scientific article published on 27 November 2020

Nucleotide interactions of the human voltage-dependent anion channel

scientific article

Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo

scientific article

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

scientific article

Phosphorylation drives a dynamic switch in serine/arginine-rich proteins

scientific article published on 31 October 2013

Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2.

scientific article published on 22 November 2013

Phosphorylation of synucleins by members of the Polo-like kinase family

scientific article

Pre-Fibrillar α-Synuclein Mutants Cause Parkinson's Disease-Like Non-Motor Symptoms in Drosophila ⬇️

scientific article published on September 8, 2011

Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

scientific article

Prediction of charge-induced molecular alignment of biomolecules dissolved in dilute liquid-crystalline phases

scientific article

Predictive atomic resolution descriptions of intrinsically disordered hTau40 and α-synuclein in solution from NMR and small angle scattering

scientific article published on 19 December 2013

Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution

scientific article published on 22 July 2020

Quantitative determination of the conformational properties of partially folded and intrinsically disordered proteins using NMR dipolar couplings

scientific article published on September 2009

RNA polymerase II clustering through carboxy-terminal domain phase separation

scientific article published on 20 August 2018

Rapid and accurate structure determination of coiled-coil domains using NMR dipolar couplings: application to cGMP-dependent protein kinase Ialpha

scientific article published on September 2005

Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

scientific article

Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer

scientific article published on 3 March 2016

Reorientational Dynamics of Amyloid-β from NMR Spin Relaxation and Molecular Simulation

scientific article published on 06 June 2019

Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau

scientific article published on 22 May 2019

Retention and splicing complex (RES) - the importance of cooperativity

scientific article published on 19 October 2015

Robust refocusing of 13C magnetization in multidimensional NMR experiments by adiabatic fast passage pulses

scientific article published on 01 December 1999

Single-Step Determination of Protein Substructures Using Dipolar Couplings: Aid to Structural Genomics

scientific article published on 01 September 2001

Site-specific interactions of Cu(II) with alpha and beta-synuclein: bridging the molecular gap between metal binding and aggregation

scientific article

Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions

scientific article published on 26 April 2005

Small-Molecule-Induced Soluble Oligomers of α-Synuclein with Helical Structure

scientific article published in August 2017

Solid-Phase Synthesis and Characterization of N-Terminally Elongated Aβ-3-x -Peptides

scientific article published on 11 May 2016

Solid-state NMR, electrophysiology and molecular dynamics characterization of human VDAC2.

scientific article published on 16 November 2014

Structural Ensembles of Intrinsically Disordered Proteins Depend Strongly on Force Field: A Comparison to Experiment

scientific article published on 22 October 2015

Structural Impact of Proline-Directed Pseudophosphorylation at AT8, AT100, and PHF1 Epitopes on 441-Residue Tau ⬇️

scientific article published on September 15, 2011

Structural Impact of Tau Phosphorylation at Threonine 231.

scientific article published on 9 July 2015

Structural Integrity of the A147T Polymorph of Mammalian TSPO

scientific article

Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2

scientific article published on 23 January 2020

Structural and mechanistic basis behind the inhibitory interaction of PcTS on alpha-synuclein amyloid fibril formation

scholarly article

Structural characterization of binding of Cu(II) to tau protein

scientific article published on 20 September 2008

Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease

scientific article

Structural determinants for Ca2+ and phosphatidylinositol 4,5-bisphosphate binding by the C2A domain of rabphilin-3A

scientific article

Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts

scientific article published on 04 December 2019

Structural plasticity in human heterochromatin protein 1β

scientific article

Structural polymorphism of 441-residue tau at single residue resolution

scientific article

Structural properties of pore-forming oligomers of alpha-synuclein

article by Hai-Young Kim et al published 2 December 2009 in Journal of the American Chemical Society

Structure and DNA-binding properties of the cytolysin regulator CylR2 from Enterococcus faecalis

scientific article published on 9 September 2004

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

scientific article published in Nature Communications

Structure of Monomeric Transthyretin Carrying the Clinically Important T119M Mutation

scientific article

Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site

scientific article

Structure of the human voltage-dependent anion channel

scientific article

Structure of the mammalian TSPO/PBR protein

scientific article

Structure of the mitochondrial translocator protein in complex with a diagnostic ligand

scientific article

Structures of intermediates during RES complex assembly

scientific article published on 27 July 2015

Targeting intrinsically disordered proteins in rational drug discovery

scientific article published on 7 November 2015

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

scientific article published on June 2015

The "jaws" of the tau-microtubule interaction

scientific article published on 15 February 2007

The C2A-C2B linker defines the high affinity Ca(2+) binding mode of rabphilin-3A

scientific article

The Caenorhabditis elegans GARP complex contains the conserved Vps51 subunit and is required to maintain lysosomal morphology ⬇️

scientific article published on May 25, 2011

The Molecular Basis of the Interaction of Cyclophilin A with α-Synuclein

scientific article published on 29 January 2020

The NMR structure of the sensory domain of the membranous two-component fumarate sensor (histidine protein kinase) DcuS of Escherichia coli

scientific article

The Native Conformation of the Human VDAC1 N Terminus

article

The PIP2 binding mode of the C2 domains of rabphilin-3A

scientific article published on 23 April 2008

The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics

scientific article published on 16 April 2015

The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor

scientific article

The extracellular human melanoma inhibitory activity (MIA) protein adopts an SH3 domain-like fold

scientific article

The intermembrane space domain of Tim23 is intrinsically disordered with a distinct binding region for presequences

scientific article

The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

scientific article

The protonation state of histidine 111 regulates the aggregation of the evolutionary most conserved region of the human prion protein

scientific article published on 17 May 2016

Toward the functional oligomerization state of tryptophan-rich sensory proteins

scientific article published on 22 May 2014

Translocator Protein Ligand Protects against Neurodegeneration in the MPTP Mouse Model of Parkinsonism

scientific article published on 22 February 2019

VDAC, a multi-functional mitochondrial protein regulating cell life and death

scientific article published on 23 March 2010

Voltage Dependence of Conformational Dynamics and Subconducting States of VDAC-1.

scientific article published on September 2016

Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity

scientific article published on 18 November 2015

α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner

scientific article

β-Barrel mobility underlies closure of the voltage-dependent anion channel

scientific article

β-Sheet core of tau paired helical filaments revealed by solid-state NMR.

scientific article published on 15 August 2012

β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons

scientific article

Paulina is supported by:

About Paulina

Help