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List of works by Yves Pommier

2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one-based HIV-1 integrase inhibitors

scientific article published on 21 December 2007

3-Hydroxypyrimidine-2,4-diones as an Inhibitor Scaffold of HIV Integrase ⬇️

scientific article published on March 7, 2011

4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors

scientific article

4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1

scientific article

5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.

scientific article

6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors ⬇️

scientific article published on October 27, 2012

6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach

scientific article published on 5 November 2013

6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase ⬇️

scientific article published on February 18, 2011

7-Azaindenoisoquinolines as Topoisomerase I Inhibitors and Potential Anticancer Agents ⬇️

scientific article published on August 8, 2011

8-Oxoguanine rearranges the active site of human topoisomerase I

scientific article

A Novel DNA Topoisomerase I Inhibitor with Different Mechanism from Camptothecin Induces G2/M Phase Cell Cycle Arrest to K562 Cells ⬇️

scientific article published on November 8, 2010

A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation

scientific article published on 13 November 2020

A homology model of HIV-1 integrase and analysis of mutations designed to test the model.

scientific article published on 27 March 2013

A kinetic clutch governs religation by type IB topoisomerases and determines camptothecin sensitivity ⬇️

scientific article published on September 18, 2012

A mutation in Escherichia coli DNA gyrase conferring quinolone resistance results in sensitivity to drugs targeting eukaryotic topoisomerase II

scientific article

A novel diketo phosphonic acid that exhibits specific, strand-transfer inhibition of HIV integrase and anti-HIV activity

scientific article published on 15 December 2006

A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

scientific article

A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes

scientific article published in June 2005

A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress

scientific article published on 27 February 2017

A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor

scientific article published on December 2006

ABCG2 mediates differential resistance to SN-38 (7-ethyl-10-hydroxycamptothecin) and homocamptothecins

scientific article published on 9 April 2004

ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses

scientific article

Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells.

scientific article

Abstract 4167: Harvesting knowledge from unexploited genomic data: Estimating relative telomere length from targeted-resequencing

article

Activation of RAF1 (c-RAF) by the Marine Alkaloid Lasonolide A Induces Rapid Premature Chromosome Condensation

scientific article published on 5 June 2015

Activation of aminoflavone (NSC 686288) by a sulfotransferase is required for the antiproliferative effect of the drug and for induction of histone gamma-H2AX.

scientific article published on October 2006

Activation of camptothecin derivatives by conjugation to triple helix-forming oligonucleotides

scientific article published on March 2005

Activities, Crystal Structures, and Molecular Dynamics of Dihydro-1 H -isoindole Derivatives, Inhibitors of HIV-1 Integrase

scientific article

Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA.

scientific article published on 31 August 2009

Adenovirus E1A oncogene induces rereplication of cellular DNA and alters DNA replication dynamics

scientific article published on 05 June 2013

Alcohol-, Diol-, and Carbohydrate-Substituted Indenoisoquinolines as Topoisomerase I Inhibitors: Investigating the Relationships Involving Stereochemistry, Hydrogen Bonding, and Biological Activity ⬇️

scientific article published on June 28, 2011

Altered serine/arginine-rich protein phosphorylation and exonic enhancer-dependent splicing in Mammalian cells lacking topoisomerase I.

scientific article published in December 2003

Aminoflavone induces oxidative DNA damage and reactive oxidative species-mediated apoptosis in breast cancer cells

scientific article published on April 2008

Analysis of human topoisomerase I inhibition and interaction with the cleavage site +1 deoxyguanosine, via in vitro experiments and molecular modeling studies

scientific article published in October 2004

Anti-tumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces single-strand breaks and DNA-protein cross-links in sensitive MCF-7 breast cancer cells

scientific article published on 6 December 2005

Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks

scientific article published on April 2004

Apoptosis induced by topoisomerase inhibitors

scientific article

Apoptotic susceptibility of cancer cells selected for camptothecin resistance: gene expression profiling, functional analysis, and molecular interaction mapping

scientific article

Apoptotic topoisomerase I-DNA complexes induced by oxygen radicals and mitochondrial dysfunction

scientific article published on 12 September 2004

Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions

scientific article published in October 2003

Authentic HIV-1 Integrase Inhibitors ⬇️

scientific article published on July 1, 2010

Azaindenoisoquinolines as Topoisomerase I Inhibitors and Potential Anticancer Agents: A Systematic Study of Structure–Activity Relationships ⬇️

scientific article published on February 13, 2012

Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors

scientific article published on March 2003

Azido-containing diketo acid derivatives inhibit human immunodeficiency virus type 1 integrase in vivo and influence the frequency of deletions at two-long-terminal-repeat-circle junctions

scientific article published on April 2004

BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers

scientific article published on 01 February 2020

Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase

scientific article

Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage

scientific article

Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants

scientific article published on 10 February 2014

Binding of an Indenoisoquinoline to the topoisomerase-DNA complex induces reduction of linker mobility and strengthening of protein-DNA interaction

scientific article

Biochemical and pharmacological analyses of HIV-1 integrase flexible loop mutants resistant to raltegravir

scientific article

Biochemical assays for the discovery of TDP1 inhibitors

scientific article

Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes

scientific article

Bisindenoisoquinoline bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity

scientific article published on 23 June 2006

Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress

scientific article published on 13 November 2007

Camptothecin analogs with enhanced activity against human breast cancer cells. I. Correlation of potency with lipophilicity and persistence in the cleavage complex

scientific article

Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer

scientific article published on 03 March 2016

Camptothecins and Topoisomerase I; A Foot in the Door. Targeting the Genome Beyond Topoisomerase I with Camptothecins and Novel Anticancer Drugs; Importance of DNA Replication, Repair and Cell Cycle Checkpoints

scientific article (publication date: September 2004)

Cell-permeable stapled peptides based on HIV-1 integrase inhibitors derived from HIV-1 gene products

scientific article published on 15 August 2013

CellMiner: A Web-Based Suite of Genomic and Pharmacologic Tools to Explore Transcript and Drug Patterns in the NCI-60 Cell Line Set ⬇️

scientific article published on July 15, 2012

CellMiner: a relational database and query tool for the NCI-60 cancer cell lines

scientific article published on 23 June 2009

CellMinerCDB for Integrative Cross-Database Genomics and Pharmacogenomics Analyses of Cancer Cell Lines

Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide].

scientific article

Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant gene associated with Angelman syndrome

article

Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I

scientific article

Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations

scientific article published on 31 March 2016

Characterization of mismatch and high-signal intensity probes associated with Affymetrix genechips

scientific article published on 6 June 2007

Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase

scientific article

Chk2 molecular interaction map and rationale for Chk2 inhibitors

scientific article published on 01 May 2006

Chromatin Regulators as a Guide for Cancer Treatment Choice

scientific article published on 16 May 2016

Chromatin challenges during DNA replication: a systems representation

scientific article

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

scientific article

Clinical and pharmacologic evaluation of two dosing schedules of indotecan (LMP400), a novel indenoisoquinoline, in patients with advanced solid tumors

scientific article published on 11 May 2016

Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair

scientific article

Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants

scientific article published on 15 August 2008

Concordance of gene expression and functional correlation patterns across the NCI-60 cell lines and the Cancer Genome Atlas glioblastoma samples

scientific article

Coordinated regulation of mitochondrial topoisomerase IB with mitochondrial nuclear encoded genes and MYC ⬇️

scientific article published on April 29, 2011

Correction to Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)–Topoisomerase I (Top1) Inhibitors ⬇️

scientific article published on August 14, 2012

Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites

scientific article

Cross-over of RNA 3'-phosphate ligase into the DNA world

scientific article

Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor ⬇️

scientific article

Cytokeratin-RNA cross-linking mediated by the antitumor aminoflavone, 5-amino-2,3-fluorophenyl-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one

scientific article published on 20 February 2008

Cytotoxicity, DNA strand breakage and DNA-protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells

scientific article

DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition

scientific article (publication date: 8 July 2009)

DNA cleavage assay for the identification of topoisomerase I inhibitors

scientific article

DNA double-strand breaks and ATM activation by transcription-blocking DNA lesions

scientific article published on 2 January 2010

DNA fingerprinting of the NCI-60 cell line panel

scientific article

DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1alpha gene locus

scientific article

DNA topoisomerases and their poisoning by anticancer and antibacterial drugs

scientific article

DNA-Targeted Precision Medicine; Have we Been Caught Sleeping?

scientific article published in January 2017

DNA-protein cross-links and replication-dependent histone H2AX phosphorylation induced by aminoflavone (NSC 686288), a novel anticancer agent active against human breast cancer cells

scientific article published on June 2005

Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways

scientific article published on 27 October 2008

Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2.

scientific article published on 29 April 2016

Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation ⬇️

scientific article published on November 11, 2011

Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks

scientific article published on 10 August 2006

Depicting combinatorial complexity with the molecular interaction map notation

scientific article

Design and synthesis of dimeric HIV-1 integrase inhibitory peptides

scientific article published in October 2003

Design and synthesis of photoactivatable aryl diketo acid-containing HIV-1 integrase inhibitors as potential affinity probes

scientific article published in March 2004

Design, Synthesis, and Biological Evaluation of Potential Prodrugs Related to the Experimental Anticancer Agent Indotecan (LMP400).

scientific article published on 20 April 2016

Design, Synthesis, and Evaluation of Dibenzo[c,h][1,6]naphthyridines as Topoisomerase I Inhibitors and Potential Anticancer Agents ⬇️

scientific article (publication date: 23 December 2010)

Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors

scientific article published on 17 July 2008

Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors

scientific article

Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids

scientific article

Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors

scientific article published on October 2004

Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen

scientific article published on December 2003

Detection of apoptosis-associated DNA fragmentation using a rapid and quantitative filter elution assay

Detection of in vitro kinase generated protein phosphorylation sites using gamma[18O4]-ATP and mass spectrometry

scientific article

Development and validation of an immunoassay for quantification of topoisomerase I in solid tumor tissues

scientific article

Development of a human immunodeficiency virus vector-based, single-cycle assay for evaluation of anti-integrase compounds

scientific article

Development of a validated immunofluorescence assay for γH2AX as a pharmacodynamic marker of topoisomerase I inhibitor activity

scientific article

Development of purely structure-based pharmacophores for the topoisomerase I-DNA-ligand binding pocket

scientific article published in December 2013

Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors

scientific article

Dibenzo[c,h][1,5]naphthyridinediones as topoisomerase I inhibitors: design, synthesis, and biological evaluation

scientific article

Different effects on human topoisomerase I by minor groove and intercalated deoxyguanosine adducts derived from two polycyclic aromatic hydrocarbon diol epoxides at or near a normal cleavage site

scientific article

Differential and common DNA repair pathways for topoisomerase I- and II-targeted drugs in a genetic DT40 repair cell screen panel

scientific article published on 15 October 2013

Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I ⬇️

scientific article published on November 1, 2003

Dihydroindenoisoquinolines function as prodrugs of indenoisoquinolines

scientific article

Diketoacid-genre HIV-1 integrase inhibitors containing enantiomeric arylamide functionality

scientific article published on 08 May 2009

Discovery and Structure–Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2 H )-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors

scientific article

Discovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties

scientific article published on 04 February 2016

Discovery of potent indenoisoquinoline topoisomerase I poisons lacking the 3-nitro toxicophore

scientific article published on 24 April 2015

Discovery of selective inhibitors of tyrosyl-DNA phosphodiesterase 2 by targeting the enzyme DNA-binding cleft

scientific article published on 24 May 2016

Distribution bias and biochemical characterization of TOP1MT single nucleotide variants

scientific article published on 17 August 2017

Drug specific resistance to oxaliplatin is associated with apoptosis defect in a cellular model of colon carcinoma

scientific article published on October 2002

Drug-Driven Synthetic Lethality: Bypassing Tumor Cell Genetics with a Combination of AsiDNA and PARP Inhibitors

scientific article

Drugging topoisomerases: lessons and challenges

scientific article

Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth

scientific article

Ecteinascidin 743 Interferes with the Activity of EWS-FLI1 in Ewing Sarcoma Cells ⬇️

scientific article published on February 1, 2011

Ecteinascidin 743: a novel anticancer drug with a unique mechanism of action

scientific article

Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: role of DNA backbone flexibility and an open catalytic site

scientific article published on 30 August 2006

Effect of HIV integrase inhibitors on the RAG1/2 recombinase

scientific article

Effects of Anticancer Drugs on Chromosome Instability and New Clinical Implications for Tumor-Suppressing Therapies

scientific article published on 2 February 2016

Effects of camptothecin or TOP1 overexpression on genetic stability in Saccharomyces cerevisiae

scientific article published on 18 September 2017

Elvitegravir overcomes resistance to raltegravir induced by integrase mutation Y143 ⬇️

scientific article published on June 1, 2011

Endogenous gamma-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase deficient cells is related to DNA replication arrested forks

scientific article

Endonuclease activation and chromosomal DNA fragmentation during apoptosis in leukemia cells

scientific article published on July 2006

Enhancement of camptothecin-induced topoisomerase I cleavage complexes by the acetaldehyde adduct N2-ethyl-2'-deoxyguanosine

scientific article published on 21 October 2004

Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panel

scientific article published on 16 December 2013

Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs

scientific article published on 27 November 2015

Erratum: Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

scholarly article published in Nature Cell Biology

Evaluation of HIV-1 integrase inhibitors on human primary macrophages using a luciferase-based single-cycle phenotypic assay.

scientific article

Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database

scientific article published on 07 July 2009

Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay

scientific article (publication date: August 2006)

Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones

scientific article published on 28 March 2009

Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron

scientific article (publication date: 15 March 2010)

Exploring DNA Topoisomerase I Ligand Space in Search of Novel Anticancer Agents ⬇️

scientific article published on September 22, 2011

Expression profiling identifies epoxy anthraquinone derivative as a DNA topoisomerase inhibitor

scientific article

F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death

scientific article published on 22 June 2016

Finding the interface: more than an image

scientific article

Functional categories associated with clusters of genes that are co-expressed across the NCI-60 cancer cell lines

scientific article

Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I.

scientific article published in August 2002

Gene expression correlations in human cancer cell lines define molecular interaction networks for epithelial phenotype

scientific article (publication date: 2014)

Gene expression profiles of the NCI-60 human tumor cell lines define molecular interaction networks governing cell migration processes

scientific article

Genome Organization Drives Chromosome Fragility

scientific article

Genome-wide Analysis of Novel Splice Variants Induced by Topoisomerase I Poisoning Shows Preferential Occurrence in Genes Encoding Splicing Factors ⬇️

scientific article published on September 3, 2010

Genome-wide depletion of replication initiation events in highly transcribed regions

scientific article

Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons

scientific article (publication date: December 2010)

HIV integrase inhibitors: 20-year landmark and challenges

scientific article published on January 2013

HIV-1 IN inhibitors: 2010 update and perspectives

scientific article

HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence

article

HIV-1 integrase inhibitors: a decade of research and two drugs in clinical trial

scientific article published on January 2004

HIV-1 integrase inhibitors: update and perspectives

scientific article published on January 2008

Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response

scientific article

Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes

scientific article published on 28 August 2006

High resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMiner

scientific article

Histone γH2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic Biomarkers ⬇️

scientific article published on September 7, 2010

Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cells

scientific article published on January 2008

Human apurinic/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis

scientific article published on 3 July 2003

Human topoisomerase I inhibition: docking camptothecin and derivatives into a structure-based active site model

scientific article published in February 2002

Identification of Natural Products That Inhibit the Catalytic Function of Human Tyrosyl-DNA Phosphodiesterase (TDP1)

article published in 2017

Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase

scientific article published on 6 July 2007

Identification of a predominant co-regulation among kinetochore genes, prospective regulatory elements, and association with genomic instability

scientific article

Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction

scientific article

Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform

scientific article

Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay

scientific article

Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I

scientific article published on 7 December 2012

Impact of p53 knockout and topotecan treatment on gene expression profiles in human colon carcinoma cells: a pharmacogenomic study.

scientific article

Importance of the fourth alpha-helix within the CAP homology domain of type II topoisomerase for DNA cleavage site recognition and quinolone action

scientific article

In vitro evaluation of dimethane sulfonate analogues with potential alkylating activity and selective renal cell carcinoma cytotoxicity.

scientific article published in July 2004

Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIα and IIβ in vertebrate mitochondria

scientific article

Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis

scientific article

Induction of a Common Pathway of Apoptosis by Staurosporine

scientific article (publication date: April 1994)

Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin

scientific article published on 07 July 2009

Inhibition of histone deacetylase in cancer cells slows down replication forks, activates dormant origins, and induces DNA damage

scientific article

Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA ⬇️

scientific article published on November 1, 2003

Inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) developed by virtual screening using ligand-based pharmacophores

scientific article

Integrase inhibitors to treat HIV/AIDS.

scientific article

Integration of human immunodeficiency virus as a target for antiretroviral therapy

scientific article published on September 2006

Integration requires a specific interaction of the donor DNA terminal 5'-cytosine with glutamine 148 of the HIV-1 integrase flexible loop

scientific article

Integrative analysis of pharmacogenomics in major cancer cell line databases using CellMinerCDB

Interaction of human nuclear topoisomerase I with guanosine quartet-forming and guanosine-rich single-stranded DNA and RNA oligonucleotides

scientific article published on 26 December 2001

Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery

scientific article

Interfacial inhibitors

scientific article published on 18 July 2015

Interfacial inhibitors of protein-nucleic acid interactions

scientific article

Interfacial inhibitors: targeting macromolecular complexes ⬇️

scientific article published on December 16, 2011

Investigation of the Structure-Activity Relationships of Aza-A-Ring Indenoisoquinoline Topoisomerase I Poisons

scientific article published on 12 April 2016

Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures

scientific article published on 3 April 2007

Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2).

scientific article published on 24 February 2016

Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration

scientific article

Lasonolide A, a potent and reversible inducer of chromosome condensation ⬇️

scientific article published on November 16, 2012

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

scientific article published on October 2016

MDC1 Cleavage by Caspase-3: A Novel Mechanism for Inactivating the DNA Damage Response during Apoptosis ⬇️

scientific article published on December 8, 2010

MK-0536 Inhibits HIV-1 Integrases Resistant to Raltegravir ⬇️

scientific article published on August 29, 2011

Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H.

scientific article

Mapping topoisomerase sites in mitochondrial DNA with a poisonous mitochondrial topoisomerase I (Top1mt).

scientific article

Mass homozygotes accumulation in the NCI-60 cancer cell lines as compared to HapMap Trios, and relation to fragile site location

scientific article

Mechanisms and inhibition of HIV integration

scientific article

Mechanisms of camptothecin resistance by human topoisomerase I mutations

scientific article

Metal-dependent inhibition of HIV-1 integrase

scientific article published on December 2002

Metal-dependent inhibition of HIV-1 integrase by beta-diketo acids and resistance of the soluble double-mutant (F185K/C280S).

scientific article published in September 2003

Mining the NCI antiviral compounds for HIV-1 integrase inhibitors

scientific article published on 7 February 2006

Mitochondrial Topoisomerase I is Critical for Mitochondrial Integrity and Cellular Energy Metabolism ⬇️

scientific article published on July 20, 2012

Mitochondrial topoisomerase I (top1mt) is a novel limiting factor of doxorubicin cardiotoxicity

scientific article

Mitochondrial topoisomerase I sites in the regulatory D-loop region of mitochondrial DNA.

scientific article published on October 2008

Mitochondrial topoisomerases and alternative splicing of the human TOP1mt gene

scientific article published on 27 November 2006

Mitochondrial tyrosyl-DNA phosphodiesterase 2 and its TDP2S short isoform

scientific article published on 9 February 2018

Molecular Dynamics Approaches Estimate the Binding Energy of HIV-1 Integrase Inhibitors and Correlate with In Vitro Activity ⬇️

scientific article published on October 28, 2011

Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282.

scientific article

Molecular interaction map of the p53 and Mdm2 logic elements, which control the Off-On switch of p53 in response to DNA damage

scientific article

Molecular interaction maps of bioregulatory networks: a general rubric for systems biology

scientific article

Molecular interaction maps--a diagrammatic graphical language for bioregulatory networks

scientific article published on 24 February 2004

Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes ⬇️

scientific article published on November 28, 2011

Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I ⬇️

scientific article published on June 24, 2011

Mutational study of the "catalytic tetrad" of DNA topoisomerase IB from the hemoflagellate Leishmania donovani: Role of Asp-353 and Asn-221 in camptothecin resistance

scientific article

N-3 Hydroxylation of Pyrimidine-2,4-diones Yields Dual Inhibitors of HIV Reverse Transcriptase and Integrase

scientific article

N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase

scientific article

NCI-60 whole exome sequencing and pharmacological CellMiner analyses

scientific article (publication date: 2014)

Negative regulation of mitochondrial transcription by mitochondrial topoisomerase I.

scientific article published on 27 August 2013

Network architecture of signaling from uncoupled helicase-polymerase to cell cycle checkpoints and trans-lesion DNA synthesis

scientific article

Neuroprotection and repair of 3'-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1).

scientific article

Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization

scientific article published on 15 August 2007

Non-camptothecin DNA topoisomerase I inhibitors in cancer therapy

scientific article

Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analyses

scientific article

Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters

scientific article published on December 2007

Novel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage

scientific article published on 19 August 2016

Novel autoxidative cleavage reaction of 9-fluoredenes discovered during synthesis of a potential DNA-threading indenoisoquinoline

scientific article

Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of action

scientific article published on March 2006

Novel clinical indenoisoquinoline topoisomerase I inhibitors: a twist around the camptothecins

Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1

scientific article

Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance

scientific article

Novel quinolinonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, and biological activities

scientific article published on 23 July 2008

Novel regulation of nuclear factor-YB by miR-485-3p affects the expression of DNA topoisomerase IIα and drug responsiveness

scientific article

Novel screen for anti-cancer drugs that elevate chromosome instability (CIN) using human artificial chromosome (HAC)

ONC201 kills breast cancer cells in vitro by targeting mitochondria.

scientific article published on 6 April 2018

On the binding of indeno[1,2-c]isoquinolines in the DNA-topoisomerase I cleavage complex

scientific article

Ontogenomic study of the relationship between number of gene splice variants and GO categorization

scientific article

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK

scientific article

Optimization of the indenone ring of indenoisoquinoline topoisomerase I inhibitors

scientific article published on 4 August 2007

Optimization of the lactam side chain of 7-azaindenoisoquinoline topoisomerase I inhibitors and mechanism of action studies in cancer cells

scientific article published on 06 February 2014

Overcoming multidrug drug resistance in P-glycoprotein/MDR1-overexpressing cell lines by ecteinascidin 743.

scientific article published on December 2002

Overcoming resistance to DNA targeted agents by epigenetic activation of Schlafen 11 (SLFN11) expression with class I histone deacetylase inhibitors

scientific article

Overexpression of the atypical protein kinase C zeta reduces topoisomerase II catalytic activity, cleavable complexes formation, and drug-induced cytotoxicity in monocytic U937 leukemia cells

scientific article published on 24 June 2002

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation

scientific article published on 18 August 2021

PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexes

scientific article published on 30 April 2018

Par-4 binds to topoisomerase 1 and attenuates its DNA relaxation activity

scientific article published on August 2008

Parallel analysis of ribonucleotide-dependent deletions produced by yeast Top1 in vitro and in vivo

scientific article published on June 2016

Phase I Study of ATR Inhibitor M6620 in Combination With Topotecan in Patients With Advanced Solid Tumors

scientific article published on 18 December 2017

Phase I Study of PARP Inhibitor ABT-888 in Combination with Topotecan in Adults with Refractory Solid Tumors and Lymphomas ⬇️

scientific article published on July 27, 2011

Phenanthriplatin Acts As a Covalent Poison of Topoisomerase II Cleavage Complexes

scientific article published on 20 September 2016

Phenotypic Screening Reveals Topoisomerase I as a Breast Cancer Stem Cell Therapeutic Target ⬇️

scientific article published on September 1, 2012

Phenylpyrazolo[1,5-a]quinazolin-5(4H)-one: a suitable scaffold for the development of noncamptothecin topoisomerase I (Top1) inhibitors

scientific article published on 16 September 2013

Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay

scientific article

Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage

scientific article

Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivity

scientific article

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

scientific article published on 25 March 2003

Poisoning of mitochondrial topoisomerase I by lamellarin D

scientific article

Poly(ADP-ribose) polymerase and XPF–ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells ⬇️

scientific article published on January 11, 2011

Poly(ADP-ribose) polymerase inhibition enhances p53-dependent and -independent DNA damage responses induced by DNA damaging agent ⬇️

scientific article published on December 1, 2011

Position- and orientation-specific enhancement of topoisomerase I cleavage complexes by triplex DNA structures

scientific article published on 04 October 2004

Position-specific suppression and enhancement of HIV-1 integrase reactions by minor groove benzo[a]pyrene diol epoxide deoxyguanine adducts: implications for molecular interactions between integrase and substrates

scientific article

Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: implications for interactions with intercalating anticancer agents

scientific article

Potentiation of the Novel Topoisomerase I Inhibitor Indenoisoquinoline LMP-400 by the Cell Checkpoint and Chk1-Chk2 Inhibitor AZD7762 ⬇️

scientific article published on December 21, 2011

Preferential inhibition of the magnesium-dependent strand transfer reaction of HIV-1 integrase by alpha-hydroxytropolones

scientific article published on 17 January 2006

Probing chelation motifs in HIV integrase inhibitors ⬇️

scientific article published on January 27, 2012

Processing of nucleopeptides mimicking the topoisomerase I-DNA covalent complex by tyrosyl-DNA phosphodiesterase

scientific article

Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional Activity

scientific article

Properties of switch-like bioregulatory networks studied by simulation of the hypoxia response control system

scientific article published on 23 April 2004

Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2⋅DNA and Top2⋅RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)

scientific article

Proteomic identification of heat shock protein 90 as a candidate target for p53 mutation reactivation by PRIMA-1 in breast cancer cells

scientific article

Rapid proteotyping reveals cancer biology and drug response determinants in the NCI-60 cells

Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition

scientific article

Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines

scientific article

Repair of and checkpoint response to topoisomerase I-mediated DNA damage

scientific article (publication date: 27 November 2003)

Repair of topoisomerase I-mediated DNA damage

scientific article published on January 2006

Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells

scientific article

Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition

scientific article published on 27 September 2016

Resistance to integrase inhibitors

scientific article

Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication

scientific article

Role of a tryptophan anchor in human topoisomerase I structure, function and inhibition

scientific article published on May 2008

Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria

scientific article

Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

scientific article published on 21 September 2016

SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing

scientific article

SLFN11 Blocks Stressed Replication Forks Independently of ATR.

scientific article published in February 2018

Scaffold rearrangement of dihydroxypyrimidine inhibitors of HIV integrase: Docking model revisited

scientific article published on 21 April 2010

Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site

scientific article published on July 2016

Sequence selectivity of the cleavage sites induced by topoisomerase I inhibitors: a molecular dynamics study

scientific article published on 09 September 2013

Sequence-specific targeting of IGF-I and IGF-IR genes by camptothecins

scientific article

Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors

scientific article

Small cell lung cancer: Time to revisit DNA-damaging chemotherapy

scientific article

Solvent dependency of the UV-Vis spectrum of indenoisoquinolines: role of keto-oxygens as polarity interaction probes

scientific article (publication date: 2013)

Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib

scientific article published on 19 December 2013

Structural Basis for Topoisomerase I Inhibition by Nucleoside Analogs ⬇️

scientific article published on May 1, 2003

Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)

scientific article

Structural basis for recognition of 5′-phosphotyrosine adducts by Tdp2

scientific article

Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy

scientific article

Structural determinants for HIV-1 integrase inhibition by beta-diketo acids

scientific article published on 22 January 2002

Structural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complex

scientific article

Structural insights on the small subunit of DNA topoisomerase I from the unicellular parasite Leishmania donovani

scientific article published on 31 July 2007

Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain

scientific article published on 11 February 2015

Structure-based design, synthesis, and biological studies of new anticancer norindenoisoquinoline topoisomerase I inhibitors

scientific article

Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex

scientific article published in April 2005

Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis.

scientific article

Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)–Topoisomerase I (Top1) Inhibitors ⬇️

scientific article published on April 26, 2012

Synthesis and Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Nitrogen Heterocycles

scientific article (publication date: October 2006)

Synthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin

scientific article published in November 2004

Synthesis and HIV-1 integrase inhibitory activity of spiroundecane(ene) derivatives

scientific article published on 3 December 2006

Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings

scientific article

Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin

scientific article published on 21 June 2006

Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: Investigating the hypothesis of shared structure–activity relationships

scientific article (publication date: October 2009)

Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors

scientific article

Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1)

scientific article published on 21 December 2012

Synthesis and biological evaluation of new carbohydrate-substituted indenoisoquinoline topoisomerase I inhibitors and improved syntheses of the experimental anticancer agents indotecan (LMP400) and indimitecan (LMP776).

scientific article published on 11 February 2014

Synthesis and biological evaluation of new fluorinated and chlorinated indenoisoquinoline topoisomerase I poisons

scientific article published on 9 February 2016

Synthesis and biological evaluation of nitrated 7-, 8-, 9-, and 10-hydroxyindenoisoquinolines as potential dual topoisomerase I (Top1)-tyrosyl-DNA phosphodiesterase I (TDP1) inhibitors.

scientific article published on 26 March 2015

Synthesis and evaluation of new antitumor 3-aminomethyl-4,11-dihydroxynaphtho[2,3-f]indole-5,10-diones

scientific article published on 8 September 2014

Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis

scientific article published on July 2005

Synthesis of benz[d]indeno[1,2-b]pyran-5,11-diones: versatile intermediates for the design and synthesis of topoisomerase I inhibitors

scientific article published on 25 January 2006

Synthesis of dihydropyrimidine α,γ-diketobutanoic acid derivatives targeting HIV integrase

scientific article

Synthesis of new dihydroindeno[1,2-c]isoquinoline and indenoisoquinolinium chloride topoisomerase I inhibitors having high in vivo anticancer activity in the hollow fiber animal model

scientific article published in January 2002

Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors

scientific article published on July 2004

Synthesis of substituted diarylmethylenepiperidines (DAMPs), a novel class of anti-HIV agents

scientific article

Synthesis, anti-cancer screening and tyrosyl-DNA phosphodiesterase 1 (Tdp1) inhibition activity of novel piperidinyl sulfamides

scientific article published on 13 October 2017

TDP1 is critical for the repair of DNA breaks induced by sapacitabine, a nucleoside also targeting ATM- and BRCA-deficient tumors

scientific article

TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs

scientific article published on 17 June 2013

TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining

article published in 2018

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

scientific article

Targeting chk2 kinase: molecular interaction maps and therapeutic rationale

scientific journal article

Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2.

scientific article published on August 2008

Temozolomide in the Era of Precision Medicine

scientific article published on 3 February 2017

Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1.

scientific article published in December 2004

The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase

scientific article

The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage

scientific article

The NCI-60 Methylome and Its Integration into CellMiner

scientific article

The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ.

scientific article

The antitumor activity of CYB-L10, a human topoisomerase IB catalytic inhibitor

The apoptotic ring: a novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases

scientific article

The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks

scientific article

The evolving landscape of predictive biomarkers of response to PARP inhibitors

scientific article published on 16 April 2018

The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology

scientific article published on 15 July 2013

The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives

scientific article

The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses

scientific article

The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIalpha in breast cancer cells

scientific article

The mammalian DNA replication elongation checkpoint: implication of Chk1 and relationship with origin firing as determined by single DNA molecule and single cell analyses

scientific article published on 22 August 2007

The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA-topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts

scientific article published on 10 June 2008

The nuclear γ-H2AX apoptotic ring: implications for cancers and autoimmune diseases

scientific article

The structure–activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode

scientific article (publication date: August 2010)

Thirteen-exon-motif signature for vertebrate nuclear and mitochondrial type IB topoisomerases

scientific article

Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states

scientific article published on 10 January 2022

Topoisomerase I alone is sufficient to produce short DNA deletions and can also reverse nicks at ribonucleotide sites

scientific article

Topoisomerase I inhibitors: selectivity and cellular resistance.

scientific article

Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity

scientific article published on 07 July 2009

Topoisomerase I requirement for death receptor-induced apoptotic nuclear fission

scientific article

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

scientific article

Topoisomerase I-DNA complexes contribute to arsenic trioxide-induced apoptosis

scientific article

Topoisomerase I-mediated cleavage at unrepaired ribonucleotides generates DNA double-strand breaks

scientific article

Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications

scientific article published on February 2004

Topoisomerase II and tubulin inhibitors both induce the formation of apoptotic topoisomerase I cleavage complexes

scientific article

Total and semisynthesis and in vitro studies of both enantiomers of 20-fluorocamptothecin

scientific article

Total synthesis and biological evaluation of 22-hydroxyacuminatine

scientific article published on February 2006

Transcription poisoning by Topoisomerase I is controlled by gene length, splice sites, and miR-142-3p

scientific article published on 20 June 2013

Transcription profiling suggests that mitochondrial topoisomerase IB acts as a topological barrier and regulator of mitochondrial DNA transcription

scientific article published on 11 October 2017

Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex

scientific article

Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells

scientific journal article

Transcriptomic analysis of the NCI-60 cancer cell lines

scientific article published on October 2003

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

scientific article

Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors

scientific article

Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells

scientific article published on 27 February 2012

Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy

scientific article published on May 2008

Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).

scientific article

UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.

scientific article published in October 2002

Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone).

scientific article

Von Hippel-Lindau-coupled and transcription-coupled nucleotide excision repair-dependent degradation of RNA polymerase II in response to trabectedin

scientific article

X-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocket ⬇️

scientific article published on September 7, 2011

Zalypsis (PM00104) is a potent inducer of gamma-H2AX foci and reveals the importance of the C ring of trabectedin for transcription-coupled repair inhibition.

scientific article published on 7 July 2009

mRNA and microRNA expression profiles of the NCI-60 integrated with drug activities

scientific article

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