List of works by Karl Mechtler

14-3-3 proteins recognize a histone code at histone H3 and are required for transcriptional activation

scientific article published on 6 December 2007

3DSpectra: A 3-dimensional quantification algorithm for LC-MS labeled profile data

scientific article

A Chemical Proteomics Approach to Phosphatidylinositol 3-Kinase Signaling in Macrophages

article by Christian Pasquali et al published 7 July 2007 in Molecular & Cellular Proteomics

A Combination of CRISPR/Cas9 and Standardized RNAi as a Versatile Platform for the Characterization of Gene Function

scientific article

A DEK domain-containing protein modulates chromatin structure and function in Arabidopsis

scientific article published on 11 November 2014

A Dam1-based artificial kinetochore is sufficient to promote chromosome segregation in budding yeast

article

A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila

scientific article

A Symbolic Regression Based Scoring System Improving Peptide Identifications for MS Amanda

A cooperative mechanism drives budding yeast kinetochore assembly downstream of CENP-A.

scientific article

A new acid mix enhances phosphopeptide enrichment on titanium- and zirconium dioxide for mapping of phosphorylation sites on protein complexes

scientific article published on 22 December 2009

A novel approach to immunoapheresis of C3a/C3 and proteomic identification of associates

scientific article published on 16 December 2019

A proteomic survey of microtubule-associated proteins in a R402H TUBA1A mutant mouse

scientific article published on 02 November 2020

A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors

scientific article

A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors

scientific article published on 23 August 2011

ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity

scientific article published on 01 July 2020

APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.

scientific article published on 24 September 2012

ATP hydrolysis is required for cohesin's association with chromosomes

scientific article published in November 2003

Afamin is a novel human vitamin E-binding glycoprotein characterization and in vitro expression

scientific article

Altered Mascot search results by changing the m/z range of MS/MS spectra: analysis and potential applications

scientific article published on 15 December 2010

An improved method for tracking and reducing the void volume in nano HPLC-MS with micro trapping columns

scientific article published on 11 July 2003

An improved strategy for tandem affinity purification-tagging of Schizosaccharomyces pombe genes

scientific article published on October 2009

An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila

scientific article

An innovative method to study target protein-drug interactions by mass spectrometry

scientific article

Analysis of PNGase F-Resistant N-Glycopeptides Using SugarQb for Proteome Discoverer 2.1 Reveals Cryptic Substrate Specificities

scientific article published on 10 June 2018

Analysis of meiotic protein complexes from Arabidopsis and Brassica using affinity-based proteomics.

scientific article

Anion-exchange chromatography of phosphopeptides: weak anion exchange versus strong anion exchange and anion-exchange chromatography versus electrostatic repulsion-hydrophilic interaction chromatography

scientific article

Annexin A2/P11 interaction: new insights into annexin A2 tetramer structure by chemical crosslinking, high-resolution mass spectrometry, and computational modeling

scientific article

Application of different fragmentation techniques for the analysis of phosphopeptides using a hybrid linear ion trap-FTICR mass spectrometer

scientific article published on 3 October 2006

Arabidopsis PCH2 Mediates Meiotic Chromosome Remodeling and Maturation of Crossovers

scientific article published on 16 July 2015

Arginine phosphorylation marks proteins for degradation by a Clp protease

scientific article

Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.

scientific article published in March 2006

Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis

scientific article published on 19 September 2005

Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin

scientific article published on 30 July 2013

Automated, on-line two-dimensional nano liquid chromatography tandem mass spectrometry for rapid analysis of complex protein digests

article

Autophagy mediates temporary reprogramming and dedifferentiation in plant somatic cells

scientific article published on 13 January 2020

BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals

scientific article

Building sister chromatid cohesion: smc3 acetylation counteracts an antiestablishment activity.

scientific article published in March 2009

CCAN Assembly Configures Composite Binding Interfaces to Promote Cross-Linking of Ndc80 Complexes at the Kinetochore.

scientific article published on 10 August 2016

CENP-T proteins are conserved centromere receptors of the Ndc80 complex

scientific article

Carbohydrate receptor-mediated gene transfer to human T leukaemic cells

article

Casein Kinase 1 and Phosphorylation of Cohesin Subunit Rec11 (SA3) Promote Meiotic Recombination through Linear Element Formation

scientific article published on 20 May 2015

Casein kinase 1 is required for efficient removal of Rec8 during meiosis I.

scientific article published on July 2010

Cell-free tumor antigen peptide-based cancer vaccines

scientific article

Characterisation of the rubber elongation factor from ammoniated latex by electrophoresis and mass spectrometry.

scientific article

Charting the molecular network of the drug target Bcr-Abl

scientific article

Chasing Phosphoarginine Proteins: Development of a Selective Enrichment Method Using a Phosphatase Trap

scientific article

Chemical cross-linking and high-performance Fourier transform ion cyclotron resonance mass spectrometry for protein interaction analysis: application to a calmodulin/target peptide complex

scientific article

Cleaning of raw peptide MS/MS spectra: improved protein identification following deconvolution of multiply charged peaks, isotope clusters, and removal of background noise.

scientific article published in October 2006

Cleavable Cross-Linkers and Mass Spectrometry for the Ultimate Task of Profiling Protein-Protein Interaction Networks in Vivo

scientific article published on 05 November 2020

Comparative glycoproteomics of stem cells identifies new players in ricin toxicity.

scientific article

Comprehensive Cross-Linking Mass Spectrometry Reveals Parallel Orientation and Flexible Conformations of Plant HOP2-MND1.

scientific article published on 4 November 2015

Correction to “Comprehensive Cross-Linking Mass Spectrometry Reveals Parallel Orientation and Flexible Conformations of Plant HOP2–MND1”

article

Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes

scientific article published on July 1992

Crosstalk between H2A variant-specific modifications impacts vital cell functions

scientific article published on 04 June 2021

Deep and precise quantification of the mouse synaptosomal proteome reveals substantial remodeling during postnatal maturation

scientific article published on 22 September 2014

Development and performance evaluation of an ultralow flow nanoliquid chromatography-tandem mass spectrometry set-up

scientific article published on 14 July 2014

Differential cofactor dependencies define distinct types of human enhancers

scientific article published in 2022

Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2.

scientific article

Drosophila CPEB Orb2A mediates memory independent of Its RNA-binding domain

scientific article

Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion

scientific article

Enhanced detection and identification of multiply phosphorylated peptides using TiO2 enrichment in combination with MALDI TOF/TOF MS.

scientific article

Erratum: Corrigendum: BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals

scholarly article published in Nature Methods

Fast and Highly Efficient Affinity Enrichment of Azide-A-DSBSO Cross-Linked Peptides

scientific article published on 06 April 2020

First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study

scientific article published on 22 May 2019

From an electrophoretic mobility shift assay to isolated transcription factors: a fast genomic-proteomic approach

scientific article

General statistical modeling of data from protein relative expression isobaric tags.

scientific article

Generation and characterization of methyl-lysine histone antibodies

scientific article published on January 2004

Global analysis of muscle-specific kinase signaling by quantitative phosphoproteomics.

scientific article

H3S28 phosphorylation is a hallmark of the transcriptional response to cellular stress.

scientific article

HPLC techniques for proteomics analysis--a short overview of latest developments.

scientific article published on 22 November 2006

HSPC117 is the essential subunit of a human tRNA splicing ligase complex

scientific article

Heat shock protein 70 (Hsp70) subtype expression in neuroendocrine tissue and identification of a neuroendocrine tumour-specific Hsp70 truncation

scientific article published in June 2004

High Precision Quantitative Proteomics Using iTRAQ on an LTQ Orbitrap: A New Mass Spectrometric Method Combining the Benefits of All

scientific article

Identification of Cell Cycle‐Dependent Phosphorylation Sites on the Anaphase‐Promoting Complex/Cyclosome by Mass Spectrometry

scientific article published on 01 January 2005

Identification of a Subunit of a Novel Kleisin-β/SMC Complex as a Potential Substrate of Protein Phosphatase 2A

scientific article published on 01 December 2003

Improved Sensitivity in Low-Input Proteomics Using Micropillar Array-Based Chromatography

scientific article published on 31 October 2019

Improved precision of iTRAQ and TMT quantification by an axial extraction field in an Orbitrap HCD cell

scientific article

Influence of membrane-active peptides on lipospermine/DNA complex mediated gene transfer.

scientific article published on March 1997

Inter-homolog crossing-over and synapsis in Arabidopsis meiosis are dependent on the chromosome axis protein AtASY3

scientific article

Interlaboratory studies and initiatives developing standards for proteomics

scientific article published on 19 February 2013

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins

scholarly article

Intron excision from precursor tRNA molecules in mammalian cells requires ATP hydrolysis and phosphorylation of tRNA-splicing endonuclease components.

scientific article

Isotope-labeled cross-linkers and Fourier transform ion cyclotron resonance mass spectrometry for structural analysis of a protein/peptide complex

scientific article

Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense

scientific journal article

Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells

scientific journal article

LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma

scientific article published on 07 October 2020

Laser microsurgery provides evidence for merotelic kinetochore attachments in fission yeast cells lacking Pcs1 or Clr4.

scientific article

Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads

scientific article published on 18 November 2010

Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.

scientific article published on 04 October 2016

Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells

scientific article

Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability

scientific article (publication date: 2 November 2001)

Lymphatic Microvessels in the Rat Remnant Kidney Model of Renal Fibrosis: Aminopeptidase P and Podoplanin Are Discriminatory Markers for Endothelial Cells of Blood and Lymphatic Vessels

article

MASPECTRAS: a platform for management and analysis of proteomics LC-MS/MS data

scientific article

MS Amanda 2.0: Advancements in the standalone implementation

scientific article published on 01 June 2021

MS Amanda, a universal identification algorithm optimized for high accuracy tandem mass spectra

scientific article published on 26 June 2014

MS Annika: A New Cross-Linking Search Engine

scientific article published on 14 April 2021

McsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsR

scientific article

Mechanism of APC/CCDC20 activation by mitotic phosphorylation

scientific article published on 25 April 2016

Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage

scientific article

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

scientific article (publication date: March 2001)

Mitotic regulation of the human anaphase-promoting complex by phosphorylation

scientific article

Molecular basis for cytoplasmic RNA surveillance by uridylation-triggered decay in Drosophila

scientific article published on 11 October 2016

Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex

scientific article published on 11 February 2021

Monopolar attachment of sister kinetochores at meiosis I requires casein kinase 1.

scientific article

Musk Kinase Activity is Modulated By A Serine Phosphorylation Site in The Kinase Loop

scientific article published on 26 September 2016

Optimized Fragmentation Improves the Identification of Peptides Cross-Linked by MS-Cleavable Reagents

scientific article published on 18 February 2019

Optimized nonlinear gradients for reversed-phase liquid chromatography in shotgun proteomics

scientific article published on 24 July 2013

Optimizing the performance of tin dioxide microspheres for phosphopeptide enrichment.

scientific article published on 8 February 2009

PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC

scientific article published on 19 October 2021

Partitioning and plasticity of repressive histone methylation states in mammalian chromatin

scientific article (publication date: December 2003)

Peptide labeling with isobaric tags yields higher identification rates using iTRAQ 4-plex compared to TMT 6-plex and iTRAQ 8-plex on LTQ Orbitrap

scientific article published on August 2010

Peptide orientation affects selectivity in ion-exchange chromatography

scientific article

Phosphoproteomics strategies for the functional analysis of signal transduction

scientific article published on July 2006

Phosphoregulation of the budding yeast EB1 homologue Bim1p by Aurora/Ipl1p

scientific article published on August 2009

Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast

scientific article

Polysialylation controls dendritic cell trafficking by regulating chemokine recognition

scientific article published on 10 December 2015

Preventing carryover of peptides and proteins in nano LC-MS separations.

scientific article

Probing the phosphoproteome of HeLa cells using nanocast metal oxide microspheres for phosphopeptide enrichment

scientific article published in April 2010

Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

scientific article

Proteomic analysis of endosomes from genetically modified p14/MP1 mouse embryonic fibroblasts.

scientific article published on 2 November 2010

Proteomic analysis of the outer membrane of Protochlamydia amoebophila elementary bodies

scientific article

Proteomic analysis reveals a virtually complete set of proteins for translation and energy generation in elementary bodies of the amoeba symbiont Protochlamydia amoebophila

scientific article published on 18 April 2011

QIKS--Quantitative identification of kinase substrates

scientific article published on May 2010

Quality control in LC-MS/MS

Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome

scientific article

Quantitative phosphoproteomics of the ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-mutated and rad3-related (ATR) dependent DNA damage response in Arabidopsis thaliana

scientific article

Quantitative phosphoproteomics reveals the role of protein arginine phosphorylation in the bacterial stress response

scientific article published on 20 November 2013

Raman microspectroscopy reveals long-term extracellular activity of Chlamydiae

scientific article

Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing

scientific article

Reducing the haystack to find the needle: improved protein identification after fast elimination of non-interpretable peptide MS/MS spectra and noise reduction

scientific article

Regulation of gene expression through a transcriptional repressor that senses acyl-chain length in membrane phospholipids

scientific article published on June 2014

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase

scientific article

Rio1 promotes rDNA stability and downregulates RNA polymerase I to ensure rDNA segregation.

scientific article

SIMPATIQCO: a server-based software suite which facilitates monitoring the time course of LC-MS performance metrics on Orbitrap instruments

scientific article

SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation

scientific article published on 14 November 2016

Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling

scientific article published on 20 November 2020

Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase

scientific article

Sororin mediates sister chromatid cohesion by antagonizing Wapl

scientific article

Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling

scientific article

Spatial organization of a ubiquitous eukaryotic kinetochore protein network in Drosophila chromosomes

scientific article published on March 2007

Spatiotemporal regulation of Ipl1/Aurora activity by direct Cdk1 phosphorylation

scientific article

Spectral Clustering Improves Label-Free Quantification of Low-Abundant Proteins

scientific article published on 22 March 2019

Stoichiometry Determination of the MP1−p14 Complex Using a Novel and Cost-Efficient Method To Produce an Equimolar Mixture of Standard Peptides

article

Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex

scientific article

Studying the fragmentation behavior of peptides with arginine phosphorylation and its influence on phospho-site localization.

scientific article

Systematic analysis of human protein complexes identifies chromosome segregation proteins

scientific article

Systematic phosphorylation analysis of human mitotic protein complexes.

scientific article published on 8 November 2011

TORC1 signaling exerts spatial control over microtubule dynamics by promoting nuclear export of Stu2.

scientific article published on 29 September 2017

Tandem affinity purification of functional TAP-tagged proteins from human cells

scientific article published on January 2007

The 20S proteasome isolated from Alzheimer's disease brain shows post-translational modifications but unchanged proteolytic activity

scientific article published on 5 February 2007

The AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ribosomal RNA genes

scientific article

The H3 histone chaperone NASPSIM3 escorts CenH3 in Arabidopsis

scientific article published on 14 October 2019

The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl.

scientific article published on 9 March 2003

The biophysical, molecular, and anatomical landscape of pigeon CRY4: A candidate light-based quantal magnetosensor

scientific article published on 12 August 2020

The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion

scientific article published on 21 June 2018

Titanium dioxide as a chemo-affinity solid phase in offline phosphopeptide chromatography prior to HPLC-MS/MS analysis

article

Topology and organization of the Salmonella typhimurium type III secretion needle complex components

scientific article published in April 2010

Transcriptome and proteome quantification of a tumor model provides novel insights into post-transcriptional gene regulation

scientific article

Transloading of tumor antigen-derived peptides into antigen-presenting cells

scientific article

Ultra-High-Pressure RPLC Hyphenated to an LTQ-Orbitrap Velos Reveals a Linear Relation between Peak Capacity and Number of Identified Peptides

scientific article published in 2011

Ultrasensitive NanoLC-MS of Subnanogram Protein Samples Using Second Generation Micropillar Array LC Technology with Orbitrap Exploris 480 and FAIMS PRO

publication published on 17 June 2021

Unambiguous phosphosite localization using electron-transfer/higher-energy collision dissociation (EThcD)

scientific article

Universal and confident phosphorylation site localization using phosphoRS.

scientific article published on 10 November 2011

Urinary neprilysin in the critically ill patient

scientific article

Wapl controls the dynamic association of cohesin with chromatin

scientific article

Yeast protein phosphatase 2A-Cdc55 regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 chromatin recruitment

scientific article

Zebrafish Ski7 tunes RNA levels during the oocyte-to-embryo transition

scientific article published on 18 February 2021

qcML: an exchange format for quality control metrics from mass spectrometry experiments

scientific article published on 23 April 2014

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