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List of works by Erica Ollmann Saphire

133 Structural basis for ebolavirus matrix assembly and budding; protein plasticity allows multiple functions.

scientific article

A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses

scientific article

A Conserved Basic Patch and Central Kink in the Nipah Virus Phosphoprotein Multimerization Domain Are Essential for Polymerase Function

scientific article published on 21 February 2019

A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus

scientific article published on 01 August 2018

A Vaccine against Ebola Virus

scientific article published on 01 April 2020

A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine.

scientific article published on 18 January 2018

A glimpse into immune responses evolving against Ebola virus

scientific article published on 01 October 2019

A model for neutralization of viruses based on antibody coating of the virion surface

scientific article

A shared structural solution for neutralizing ebolaviruses

scientific article

Achieving cross-reactivity with pan-ebolavirus antibodies

scientific article published on 01 February 2019

An Outbreak of Ebola Virus Disease in the Lassa Fever Zone

scientific article published on 11 July 2016

An efficient platform for screening expression and crystallization of glycoproteins produced in human cells

scientific article published on January 2009

An emergent Ebola virus nucleoprotein variant influences virion budding, oligomerization, transcription and replication

An intranasal vaccine durably protects against SARS-CoV-2 variants in mice

scientific article

An update on the use of antibodies against the filoviruses

scientific article

Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization

scientific article published on 04 February 2020

Analytical Validation of the ReEBOV Antigen Rapid Test for Point-of-Care Diagnosis of Ebola Virus Infection

scientific article published on 31 August 2016

Antibodies from Sierra Leonean and Nigerian Lassa fever survivors cross-react with recombinant proteins representing Lassa viruses of divergent lineages

scientific article published on 29 September 2020

Antibodies to the Glycoprotein GP2 Subunit Cross-React between Old and New World Arenaviruses.

scientific article

Antibody Repertoires to the Same Ebola Vaccine Antigen Are Differentially Affected by Vaccine Vectors

scientific article published on 01 August 2018

Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site

scientific article published on 4 May 2016

Antibody therapy for Lassa fever

scientific article published on 08 August 2019

Antibody-mediated protection against Ebola virus

scholarly article by Erica Ollmann Saphire et al published November 2018 in Nature Immunology

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

scientific article published on 16 September 2020

Assembly of the Ebola Virus Nucleoprotein from a Chaperoned VP35 Complex

scientific article published on 25 June 2015

Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2-MPER region.

scientific article

Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.

scientific article

Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change

scientific article

Complex of a Protective Antibody with Its Ebola Virus GP Peptide Epitope: Unusual Features of a Vλx Light Chain

scientific article

Contrasting IgG Structures Reveal Extreme Asymmetry and Flexibility

scientific article published on 01 May 2002

Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization

scientific article published on 01 August 2019

Correction: Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs.

scientific article published on 9 October 2015

Correction: The Ebola Virus Interferon Antagonist VP24 Directly Binds STAT1 and Has a Novel, Pyramidal Fold.

scientific article

Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection

scientific article published on 20 January 2016

Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk

scientific article published on 17 April 2019

Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex

Crystal Structure of Marburg Virus VP24

scientific article

Crystal Structure of Marburg Virus VP40 Reveals a Broad, Basic Patch for Matrix Assembly and a Requirement of the N-Terminal Domain for Immunosuppression

scientific article published on 9 December 2015

Crystal Structure of the Marburg Virus VP35 Oligomerization Domain

scientific article

Crystal Structure of the Nipah Virus Phosphoprotein Tetramerization Domain

scientific article

Crystal Structure of the Oligomeric Form of Lassa Virus Matrix Protein Z.

scientific article

Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design

scientific article

Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design.

scientific article published on January 2003

Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding

scientific article

Crystal structure of the prefusion surface glycoprotein of the prototypic arenavirus LCMV

scientific article published on 25 April 2016

Crystallization and preliminary structure determination of an intact human immunoglobulin, b12: an antibody that broadly neutralizes primary isolates of HIV-1

article

Development of Prototype Filovirus Recombinant Antigen Immunoassays

scientific article

Discussions and decisions of the 2012–2014 International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group, January 2012–June 2013.

scientific article published on April 2014

Diverse Morphology and Structural Features of Old and New World Hantaviruses

scientific article published on 16 September 2019

Early Human B Cell Response to Ebola Virus in Four U.S. Survivors of Infection

scholarly article by Lauren E Williamson et al published 15 April 2019 in Journal of Virology

Ebola vaccine–induced protection in nonhuman primates correlates with antibody specificity and Fc-mediated effects

scientific article published in 2021

Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling

scientific article

Ebola virus glycoprotein needs an additional trigger, beyond proteolytic priming for membrane fusion

scientific article

Ebolavirus VP35 Coats the Backbone of Double-Stranded RNA for Interferon Antagonism

scientific article

Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression

scientific article

Ebolavirus glycoprotein structure and mechanism of entry

scientific article (publication date: 2009)

Editorial overview

Feverish Quest for Ebola Immunotherapy: Straight or Cocktail?

scientific article published on 20 June 2016

Field validation of recombinant antigen immunoassays for diagnosis of Lassa fever

scientific article published on 12 April 2018

Filovirus RefSeq entries: evaluation and selection of filovirus type variants, type sequences, and names

scientific article published on 26 September 2014

Filovirus Structural Biology: The Molecules in the Machine

scientific article published on 10 August 2017

Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120.

scientific article

Hiding the evidence: two strategies for innate immune evasion by hemorrhagic fever viruses

scientific article

High-resolution Crystal Structure of Dimeric VP40 From Sudan ebolavirus

scientific article

Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies

scientific article

How to turn competitors into collaborators

scientific article published on January 2017

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

scientific article published on 06 January 2021

In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model

scientific article published on 01 November 2018

Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak

scientific article published on 18 February 2016

Lassa fever in post-conflict sierra leone

scientific article

Lassa virus glycoprotein: stopping a moving target

Lifted Up from Lockdown

scientific article published on 01 October 2020

Listening for viral infection

scholarly article by Erica Ollmann Saphire & Paul Whi Parren published September 2001 in Nature Biotechnology

Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism

scientific article

Measles and Nipah virus assembly: Specific lipid binding drives matrix polymerization

scientific article published on 20 July 2022

Measles virus fusion shifts into gear

scientific article published in February 2011

Mechanism of human antibody-mediated neutralization of Marburg virus

scientific article

Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120.

scientific article

More than Meets the Eye: Hidden Structures in the Proteome

scientific article

Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits

scientific article

Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein

scientific article published on 21 August 2018

Multiple circulating infections can mimic the early stages of viral hemorrhagic fevers and possible human exposure to filoviruses in Sierra Leone prior to the 2014 outbreak

scientific article

Neutralizing ebolavirus: structural insights into the envelope glycoprotein and antibodies targeted against it

scientific article (publication date: August 2009)

New Advances in the Effort against Ebola

scientific article published on May 2015

Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies

scientific article published on 08 April 2020

Oxidation-sensitive polymersomes as vaccine nanocarriers enhance humoral responses against Lassa virus envelope glycoprotein

scientific article published on 27 September 2017

Pan-Filovirus Serum Neutralizing Antibodies in a Subset of Congolese Ebolavirus Infection Survivors

scientific article published on 13 August 2018

Pan-ebolavirus and Pan-filovirus Mouse Monoclonal Antibodies: Protection against Ebola and Sudan Viruses

scientific article

Pan-ebolavirus serology study of healthcare workers in the Mbandaka Health Region, Democratic Republic of the Congo

scientific article published on 07 March 2022

Potent Antibody Protection against an Emerging Alphavirus Threat

scientific article

Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs

scientific article published on 26 June 2015

Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop ⬇️

scientific article published on October 10, 2003

Reporter Assays for Ebola Virus Nucleoprotein Oligomerization, Virion-Like Particle Budding, and Minigenome Activity Reveal the Importance of Nucleoprotein Amino Acid Position 111

scientific article published on 15 January 2020

Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein.

scientific article published on 14 November 2017

SARS-CoV-2 infection generates tissue-localized immunological memory in humans

scientific article published on 19 November 2021

SnapShot: Enveloped Virus Entry

scientific article published on 01 August 2020

Spiking Pandemic Potential: Structural and Immunological aspects of SARS-CoV-2

scientific article published on 20 May 2020

Stopping pandemics before they start: Lessons learned from SARS-CoV-2

scientific article published on 10 March 2022

Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope

scientific article published on 11 September 2018

Structural Characterization of Pan-Ebolavirus Antibody 6D6 Targeting the Fusion Peptide of the Surface Glycoprotein

scientific article published on 01 January 2019

Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle

scientific article

Structural basis for Marburg virus neutralization by a cross-reactive human antibody

scientific article

Structural basis for antibody-mediated neutralization of Lassa virus

scientific article

Structural basis for differential neutralization of ebolaviruses

scientific article

Structural basis for the dsRNA specificity of the Lassa virus NP exonuclease

scientific article published in 2012

Structural basis of broad ebolavirus neutralization by a human survivor antibody

scientific article published on 04 March 2019

Structural biology in the fight against COVID-19

scientific article

Structural insights into RNA encapsidation and helical assembly of the Toscana virus nucleoprotein

scientific article

Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies

scientific article

Structure of an Antibody in Complex with Its Mucin Domain Linear Epitope That Is Protective against Ebola Virus

scientific article

Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

scientific article

Structure of the Ebola virus nucleoprotein - RNA complex

Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression

scientific article

Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression

scientific article

Structure of theReston ebolavirusVP30 C-terminal domain

scientific article

Structure-based design of a highly stable, covalently-linked SARS-CoV-2 spike trimer with improved structural properties and immunogenicity

scientific article

Structures of Ebola virus GP and sGP in complex with therapeutic antibodies

scientific article published on 08 August 2016

Structures of protective antibodies reveal sites of vulnerability on Ebola virus

scientific article

Sudan Ebolavirus VP35-NP Crystal Structure Reveals a Potential Target for Pan-Filovirus Treatment

scientific article published on 23 July 2019

Swift antibodies to counter emerging viruses

scientific article

Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection

Techniques and tactics used in determining the structure of the trimericebolavirusglycoprotein

scientific article

The Ebola Virus Interferon Antagonist VP24 Directly Binds STAT1 and Has a Novel, Pyramidal Fold

scientific article

The Ebola Virus VP30-NP Interaction Is a Regulator of Viral RNA Synthesis

scientific article

The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding

scientific article published in January 2018

The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.

scientific article

The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12.

scientific article

The ebolavirus VP24 interferon antagonist: know your enemy

scientific article published on 15 August 2012

The structural basis for filovirus neutralization by monoclonal antibodies

Tracking changes in SARS-CoV-2 Spike: evidence that D614G increases infectivity of the COVID-19 virus

scientific article published on 03 July 2020

Two synthetic antibodies that recognize and neutralize distinct proteolytic forms of the ebola virus envelope glycoprotein

scientific article published on 30 October 2012

Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA

scientific article published on 5 November 2013

Virus nomenclature below the species level: a standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae

scientific article published on 29 January 2013

Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae

scientific article published on 23 September 2012

gp120: Biologic aspects of structural features

scientific article published in January 2001

gp41: HIV's shy protein

article

mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions

scientific article published on 18 May 2022

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